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Validated EORTC QLQ-C30\/BR23 questionnaires were used to asses HRQL. Multivariable linear regression models adjusted for confounding (age, comorbidity, pT, locoregional treatment, systemic therapy) were used to compare the impact of the RT regimens on HRQL at 12 and 24\u00a0months. Differences in HRQL over time (3\u201324\u00a0months) were evaluated using linear mixed models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no significant differences in HRQL at 12\u00a0months between groups except for breast symptoms which were better after IORT and EB-APBI compared to hypo-WBI at 12\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Over time,\u00a0breast symptoms, fatigue, global health status and role functioning were significantly better after IORT and EB-APBI than hypo-WBI. At 24\u00a0months, HRQL was comparable in all groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In women with early-stage breast cancer,\u00a0the radiotherapy regimen did not substantially influence long-term HRQL with the exception of breast symptoms.\u00a0Breast symptoms are more common\u00a0after WBI than after IORT or EB-APBI and improve slowly until no significant difference remains at 2\u00a0years posttreatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10549-021-06314-4","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T08:02:57Z","timestamp":1625299377000},"page":"387-398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Health-related quality of life of early-stage breast cancer patients after different radiotherapy regimens"],"prefix":"10.1007","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4732-1154","authenticated-orcid":false,"given":"Daphne H. 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