{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:34:40Z","timestamp":1740123280270,"version":"3.37.3"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009634","name":"Susan G. Komen","doi-asserted-by":"publisher","award":["CCR15332379"],"award-info":[{"award-number":["CCR15332379"]}],"id":[{"id":"10.13039\/100009634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA216515, R37CA235602 and R01CA246592"],"award-info":[{"award-number":["R21CA216515, R37CA235602 and R01CA246592"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10549-021-06321-5","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T08:05:09Z","timestamp":1625126709000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medication use and mammographic breast density"],"prefix":"10.1007","volume":"189","author":[{"given":"Yunan","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Teik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtnie R.","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana S.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Rakhmankulova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-2606","authenticated-orcid":false,"given":"Adetunji T.","family":"Toriola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"issue":"3","key":"6321_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1056\/NEJMoa062790","volume":"356","author":"NF Boyd","year":"2007","unstructured":"Boyd NF et al (2007) Mammographic density and the risk and detection of breast cancer. N Engl J Med 356(3):227\u2013236","journal-title":"N Engl J Med"},{"issue":"3","key":"6321_CR2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s12282-018-0857-5","volume":"25","author":"SS Nazari","year":"2018","unstructured":"Nazari SS, Mukherjee P (2018) An overview of mammographic density and its association with breast cancer. Breast Cancer 25(3):259\u2013267","journal-title":"Breast Cancer"},{"issue":"6","key":"6321_CR3","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1055-9965.EPI-06-0034","volume":"15","author":"VA McCormack","year":"2006","unstructured":"McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomark Prev 15(6):1159\u20131169","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"21","key":"6321_CR4","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1093\/jnci\/87.21.1622","volume":"87","author":"C Byrne","year":"1995","unstructured":"Byrne C et al (1995) Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 87(21):1622\u20131629","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"6321_CR5","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S1470-2045(05)70390-9","volume":"6","author":"NF Boyd","year":"2005","unstructured":"Boyd NF et al (2005) Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol 6(10):798\u2013808","journal-title":"Lancet Oncol"},{"issue":"1","key":"6321_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1158\/1055-9965.EPI-17-1175","volume":"28","author":"D Bond-Smith","year":"2019","unstructured":"Bond-Smith D, Stone J (2019) Methodological challenges and updated findings from a meta-analysis of the association between mammographic density and breast cancer. Cancer Epidemiol Biomarkers Prev 28(1):22\u201331","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"6321_CR7","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1001\/jamaoncol.2016.6326","volume":"3","author":"NJ Engmann","year":"2017","unstructured":"Engmann NJ et al (2017) Population-attributable risk proportion of clinical risk factors for breast cancer. JAMA Oncol 3(9):1228\u20131236","journal-title":"JAMA Oncol"},{"issue":"5","key":"6321_CR8","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1158\/1055-9965.EPI-05-0802","volume":"15","author":"DM Boudreau","year":"2006","unstructured":"Boudreau DM, Rutter CM, Buist DS (2006) The influence of statin use on breast density. Cancer Epidemiol Biomark Prev 15(5):1026\u20131029","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"3","key":"6321_CR9","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s10549-011-1858-7","volume":"131","author":"MJ Higgins","year":"2012","unstructured":"Higgins MJ et al (2012) A short-term biomarker modulation study of simvastatin in women at increased risk of a new breast cancer. Breast Cancer Res Treat 131(3):915\u2013924","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"6321_CR10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1158\/1940-6207.CAPR-15-0300","volume":"9","author":"Y Ji","year":"2016","unstructured":"Ji Y et al (2016) The effect of atorvastatin on breast cancer biomarkers in high-risk women. Cancer Prev Res (Phila) 9(5):379\u2013384","journal-title":"Cancer Prev Res (Phila)"},{"issue":"2","key":"6321_CR11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10549-013-2739-z","volume":"142","author":"S Vinayak","year":"2013","unstructured":"Vinayak S et al (2013) A clinical trial of lovastatin for modification of biomarkers associated with breast cancer risk. Breast Cancer Res Treat 142(2):389\u2013398","journal-title":"Breast Cancer Res Treat"},{"key":"6321_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/s12885-015-1457-9","volume":"15","author":"I Skarping","year":"2015","unstructured":"Skarping I et al (2015) Effects of statin use on volumetric mammographic density: results from the KARMA study. BMC Cancer 15:435","journal-title":"BMC Cancer"},{"issue":"1","key":"6321_CR13","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s10549-011-1834-2","volume":"132","author":"J Stone","year":"2012","unstructured":"Stone J et al (2012) The association between mammographic density measures and aspirin or other NSAID use. Breast Cancer Res Treat 132(1):259\u2013266","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"6321_CR14","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1158\/1055-9965.EPI-08-1088","volume":"18","author":"A McTiernan","year":"2009","unstructured":"McTiernan A et al (2009) No effect of aspirin on mammographic density in a randomized controlled clinical trial. Cancer Epidemiol Biomarkers Prev 18(5):1524\u20131530","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"6321_CR15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10549-007-9829-8","volume":"112","author":"G Maskarinec","year":"2008","unstructured":"Maskarinec G et al (2008) Nonsteroidal anti-inflammatory drugs (NSAIDs) and mammographic density. Breast Cancer Res Treat 112(1):133\u2013139","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"6321_CR16","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1158\/1055-9965.EPI-07-2836","volume":"17","author":"MB Terry","year":"2008","unstructured":"Terry MB et al (2008) Nonsteroidal anti-inflammatory drugs and change in mammographic density: a cohort study using pharmacy records on over 29,000 postmenopausal women. Cancer Epidemiol Biomarkers Prev 17(5):1088\u20131095","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"6321_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10549-017-4127-6","volume":"162","author":"ME Wood","year":"2017","unstructured":"Wood ME et al (2017) Aspirin use is associated with lower mammographic density in a large screening cohort. Breast Cancer Res Treat 162(3):419\u2013425","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"6321_CR18","doi-asserted-by":"publisher","first-page":"e461","DOI":"10.1016\/S1470-2045(14)70119-6","volume":"15","author":"TP Ahern","year":"2014","unstructured":"Ahern TP et al (2014) Statins and breast cancer prognosis: evidence and opportunities. Lancet Oncol 15(10):e461\u2013e468","journal-title":"Lancet Oncol"},{"issue":"3","key":"6321_CR19","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/j.1742-1241.2007.01668.x","volume":"62","author":"A Agrawal","year":"2008","unstructured":"Agrawal A, Fentiman IS (2008) NSAIDs and breast cancer: a possible prevention and treatment strategy. Int J Clin Pract 62(3):444\u2013449","journal-title":"Int J Clin Pract"},{"issue":"9","key":"6321_CR20","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1054\/bjoc.2000.1709","volume":"84","author":"SA Khuder","year":"2001","unstructured":"Khuder SA, Mutgi AB (2001) Breast cancer and NSAID use: a meta-analysis. Br J Cancer 84(9):1188\u20131192","journal-title":"Br J Cancer"},{"issue":"2","key":"6321_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7326\/0003-4819-128-2-199801150-00002","volume":"128","author":"HC Bucher","year":"1998","unstructured":"Bucher HC, Griffith LE, Guyatt GH (1998) Effect of HMGcoA reductase inhibitors on stroke. A meta-analysis of randomized, controlled trials. Ann Intern Med 128(2):89\u201395","journal-title":"Ann Intern Med"},{"issue":"4","key":"6321_CR22","first-page":"313","volume":"278","author":"PR Hebert","year":"1997","unstructured":"Hebert PR et al (1997) Cholesterol lowering with statin drugs, risk of stroke, and total mortality. Overv Randomized Trials JAMA 278(4):313\u2013321","journal-title":"Overv Randomized Trials JAMA"},{"issue":"2","key":"6321_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s10549-013-2473-6","volume":"138","author":"O Bjarnadottir","year":"2013","unstructured":"Bjarnadottir O, Romero Q, Bendahl PO, Jirstr\u00f6m K, Ryd\u00e9n L, Loman N, Uhl\u00e9n M, Johannesson H, Rose C, Grabau D, Borgquist S (2013) Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. Breast Cancer Res Treat 138(2):499\u2013508. https:\/\/doi.org\/10.1007\/s10549-013-2473-6 (Epub 2013 Mar 8 PMID: 23471651)","journal-title":"Breast Cancer Res Treat"},{"issue":"28","key":"6321_CR24","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1200\/JCO.2012.42.2006","volume":"30","author":"X Zhang","year":"2012","unstructured":"Zhang X et al (2012) Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence. J Clin Oncol 30(28):3468\u20133477","journal-title":"J Clin Oncol"},{"issue":"9","key":"6321_CR25","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1177\/0284185114554674","volume":"56","author":"HN Lee","year":"2015","unstructured":"Lee HN, Sohn Y-M, Han KH (2015) Comparison of mammographic density estimation by Volpara software with radiologists\u2019 visual assessment: analysis of clinical\u2013radiologic factors affecting discrepancy between them. Acta Radiol 56(9):1061\u20131068","journal-title":"Acta Radiol"},{"issue":"3","key":"6321_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3348\/kjr.2014.15.3.313","volume":"15","author":"SY Ko","year":"2014","unstructured":"Ko SY et al (2014) Mammographic density estimation with automated volumetric breast density measurement. Korean J Radiol 15(3):313\u2013321","journal-title":"Korean J Radiol"},{"issue":"1","key":"6321_CR27","doi-asserted-by":"publisher","first-page":"e85952","DOI":"10.1371\/journal.pone.0085952","volume":"9","author":"A Gubern-M\u00e9rida","year":"2014","unstructured":"Gubern-M\u00e9rida A et al (2014) Volumetric breast density estimation from full-field digital mammograms: a validation study. PLoS ONE 9(1):e85952","journal-title":"PLoS ONE"},{"issue":"12","key":"6321_CR28","doi-asserted-by":"publisher","first-page":"e81653","DOI":"10.1371\/journal.pone.0081653","volume":"8","author":"J Wang","year":"2013","unstructured":"Wang J et al (2013) Agreement of mammographic measures of volumetric breast density to MRI. PLoS ONE 8(12):e81653","journal-title":"PLoS ONE"},{"issue":"2","key":"6321_CR29","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1148\/radiol.15141686","volume":"275","author":"O Alonzo-Proulx","year":"2015","unstructured":"Alonzo-Proulx O et al (2015) Reliability of automated breast density measurements. Radiology 275(2):366\u2013376","journal-title":"Radiology"},{"issue":"1","key":"6321_CR30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10549-018-5062-x","volume":"174","author":"Y Han","year":"2019","unstructured":"Han Y et al (2019) Milk intake and mammographic density in premenopausal women. Breast Cancer Res Treat 174(1):249\u2013255","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"6321_CR31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1158\/1940-6207.CAPR-19-0549","volume":"13","author":"Y Han","year":"2020","unstructured":"Han Y et al (2020) Adiposity change over the life course and mammographic breast density in postmenopausal women. Cancer Prev Res 13(5):475\u2013482. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-19-0549","journal-title":"Cancer Prev Res"},{"issue":"1","key":"6321_CR32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13058-019-1198-9","volume":"21","author":"KR Brandt","year":"2019","unstructured":"Brandt KR et al (2019) Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer. Breast Cancer Res 21(1):118","journal-title":"Breast Cancer Res"},{"issue":"3","key":"6321_CR33","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1148\/radiol.2015151261","volume":"279","author":"KR Brandt","year":"2016","unstructured":"Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH et al (2016) Comparison of clinical and automated breast density measurements: implications for risk prediction and supplemental screening. Radiology 279(3):710\u2013719","journal-title":"Radiology"},{"issue":"7","key":"6321_CR34","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s40273-014-0234-y","volume":"33","author":"\u00c9 Gaudette","year":"2015","unstructured":"Gaudette \u00c9 et al (2015) Do statins reduce the health and health care costs of obesity? Pharmacoeconomics 33(7):723\u2013734","journal-title":"Pharmacoeconomics"},{"issue":"8","key":"6321_CR35","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1089\/154099903322447710","volume":"12","author":"JA Cauley","year":"2003","unstructured":"Cauley JA et al (2003) Lipid-lowering drug use and breast cancer in older women: a prospective study. J Womens Health (Larchmt) 12(8):749\u2013756","journal-title":"J Womens Health (Larchmt)"},{"issue":"36","key":"6321_CR36","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1200\/JCO.2008.21.7166","volume":"27","author":"A McTiernan","year":"2009","unstructured":"McTiernan A et al (2009) Conjugated equine estrogen influence on mammographic density in postmenopausal women in a substudy of the women\u2019s health initiative randomized trial. J Clin Oncol 27(36):6135\u20136143","journal-title":"J Clin Oncol"},{"issue":"17","key":"6321_CR37","doi-asserted-by":"publisher","first-page":"8707","DOI":"10.1158\/0008-5472.CAN-05-4061","volume":"66","author":"MJ Campbell","year":"2006","unstructured":"Campbell MJ et al (2006) Breast cancer growth prevention by statins. Cancer Res 66(17):8707\u20138714","journal-title":"Cancer Res"},{"issue":"9","key":"6321_CR38","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.7150\/jca.14941","volume":"7","author":"T Anothaisintawee","year":"2016","unstructured":"Anothaisintawee T et al (2016) Effect of lipophilic and hydrophilic statins on breast cancer risk in thai women: a cross-sectional study. J Cancer 7(9):1163\u20131168","journal-title":"J Cancer"},{"issue":"1","key":"6321_CR39","doi-asserted-by":"publisher","first-page":"72","DOI":"10.18433\/J3202B","volume":"19","author":"M Mansourian","year":"2016","unstructured":"Mansourian M et al (2016) Statins use and risk of breast cancer recurrence and death: a systematic review and meta-analysis of observational studies. J Pharm Pharm Sci 19(1):72\u201381","journal-title":"J Pharm Pharm Sci"},{"issue":"4","key":"6321_CR40","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/ijc.22366","volume":"120","author":"DR Browning","year":"2007","unstructured":"Browning DR, Martin RM (2007) Statins and risk of cancer: a systematic review and metaanalysis. Int J Cancer 120(4):833\u2013843","journal-title":"Int J Cancer"},{"issue":"6","key":"6321_CR41","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00404-017-4533-3","volume":"296","author":"MM Islam","year":"2017","unstructured":"Islam MM et al (2017) Exploring association between statin use and breast cancer risk: an updated meta-analysis. Arch Gynecol Obstet 296(6):1043\u20131053","journal-title":"Arch Gynecol Obstet"},{"key":"6321_CR42","first-page":"559","volume":"9","author":"RD Van Wyhe","year":"2017","unstructured":"Van Wyhe RD, Rahal OM, Woodward WA (2017) Effect of statins on breast cancer recurrence and mortality: a review. Breast Cancer (Dove Med Press) 9:559\u2013565","journal-title":"Breast Cancer (Dove Med Press)"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-021-06321-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-021-06321-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-021-06321-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T06:09:42Z","timestamp":1628662182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-021-06321-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["6321"],"URL":"https:\/\/doi.org\/10.1007\/s10549-021-06321-5","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"type":"print","value":"0167-6806"},{"type":"electronic","value":"1573-7217"}],"subject":[],"published":{"date-parts":[[2021,7,1]]},"assertion":[{"value":"16 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The studies involving human participants were reviewed and approved by the institutional review boards of the Washington University School of Medicine. Written informed consent to participate in this study was provided by all the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}