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ZKS: immediate family member serves as a consultant in Ophthalmology for Alcon, Adverum Biotechnologies, Gyroscope Therapeutics Limited, Neurogene, and RegenxBio, JP: consulting from Abbott Labs; spouse is employed by GlaxoSmithKline and holds stock in GlaxoSmithKline. EPW: consultant honoraria from Athenex, Carrick Therapeutics, G1 Therapeutics, Genentech\/Roche, Genomic Health, GSK, Jounce, Leap, Lilly, Novartis, Seattle Genetics, Syros and Zymeworks; scientific advisory board for Leap; institutional research support from Genentech\/Roche. NUL: institutional research support from Genentech, Pfizer, Merck, Seattle Genetics; consulting honoraria from Puma, Seattle Genetics, AstraZeneca, Daiichi-Sankyo, Denali Therapeutics, Olema Pharma, Prelude Therapeutics, Aleta BioPharma, Voyager Therapeutics, Affinia Therapeutics, and Pfizer. 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