{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:07Z","timestamp":1792783567689,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1A09081884"],"award-info":[{"award-number":["2018R1D1A1A09081884"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and ICT","award":["IITP-2020-0-01821"],"award-info":[{"award-number":["IITP-2020-0-01821"]}],"id":[{"id":"https:\/\/ror.org\/01wpjm123","id-type":"ROR","asserted-by":"crossref"}]},{"name":"SMC-SKKU Future Convergence Program","award":["Grant SMO1190341"],"award-info":[{"award-number":["Grant SMO1190341"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s10549-021-06500-4","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T04:02:50Z","timestamp":1656388970000},"page":"683-692","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Surgical margin status and survival outcomes of breast cancer patients treated with breast-conserving surgery and whole-breast irradiation after neoadjuvant chemotherapy"],"prefix":"10.1007","volume":"194","author":[{"given":"Jong-Ho","family":"Cheun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungil","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Whan","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeon","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Byoel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Joo","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonshik","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-2456","authenticated-orcid":false,"given":"Jeong Eon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"6500_CR1","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1245\/s10434-016-5733-y","volume":"24","author":"CA Puig","year":"2017","unstructured":"Puig CA, Hoskin TL, Day CN et al (2017) National trends in the use of neoadjuvant chemotherapy for hormone receptor-negative breast cancer: A national cancer data base study. Ann Surg Oncol 24:1242\u20131250. https:\/\/doi.org\/10.1245\/s10434-016-5733-y","journal-title":"Ann Surg Oncol"},{"key":"6500_CR2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1634\/theoncologist.2018-0228","volume":"24","author":"R Colomer","year":"2019","unstructured":"Colomer R, Saura C, S\u00e1nchez-Rovira P et al (2019) Neoadjuvant management of early breast cancer: A clinical and investigational position statement. Oncologist 24:603\u2013611. https:\/\/doi.org\/10.1634\/theoncologist.2018-0228","journal-title":"Oncologist"},{"key":"6500_CR3","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1200\/JCO.2011.41.3161","volume":"30","author":"AF Schott","year":"2012","unstructured":"Schott AF, Hayes DF (2012) Defining the benefits of neoadjuvant chemotherapy for breast cancer. J Clin Oncol 30:1747\u20131749. https:\/\/doi.org\/10.1200\/JCO.2011.41.3161","journal-title":"J Clin Oncol"},{"key":"6500_CR4","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1200\/JCO.2007.15.0235","volume":"26","author":"P Rastogi","year":"2008","unstructured":"Rastogi P, Anderson SJ, Bear HD et al (2008) Preoperative chemotherapy: updates of national surgical adjuvant breast and bowel project protocols B-18 and B-27. J Clin Oncol 26:778\u2013785. https:\/\/doi.org\/10.1200\/JCO.2007.15.0235","journal-title":"J Clin Oncol"},{"key":"6500_CR5","unstructured":"National Comprehensive Cancer Network (2021) Breast Cancer (Version 3.2021). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf. Accessed 19 Apr 2021"},{"key":"6500_CR6","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1093\/annonc\/mdz173","volume":"30","author":"F Cardoso","year":"2019","unstructured":"Cardoso F, Kyriakides S, Ohno S et al (2019) Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 30:1194\u20131220. https:\/\/doi.org\/10.1093\/annonc\/mdz173","journal-title":"Ann Oncol"},{"key":"6500_CR7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.ijrobp.2013.11.012","volume":"88","author":"MS Moran","year":"2014","unstructured":"Moran MS, Schnitt SJ, Giuliano AE et al (2014) Society of surgical oncology-American society for radiation oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages i and II invasive breast cancer. Int J Radiat Oncol Biol Phys 88:553\u2013564. https:\/\/doi.org\/10.1016\/j.ijrobp.2013.11.012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6500_CR8","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10549-013-2627-6","volume":"140","author":"AL Russo","year":"2013","unstructured":"Russo AL, Arvold ND, Niemierko A et al (2013) Margin status and the risk of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy. Breast Cancer Res Treat 140:353\u2013361. https:\/\/doi.org\/10.1007\/s10549-013-2627-6","journal-title":"Breast Cancer Res Treat"},{"key":"6500_CR9","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1200\/JCO.2000.18.8.1668","volume":"18","author":"CC Park","year":"2000","unstructured":"Park CC, Mitsumori M, Nixon A et al (2000) Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: Influence of margin status and systemic therapy on local recurrence. J Clin Oncol 18:1668\u20131675. https:\/\/doi.org\/10.1200\/JCO.2000.18.8.1668","journal-title":"J Clin Oncol"},{"key":"6500_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-020-06955-6","volume":"20","author":"J Lin","year":"2020","unstructured":"Lin J, Lin KJ, Wang YF et al (2020) Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy. BMC Cancer 20:1\u20139. https:\/\/doi.org\/10.1186\/s12885-020-06955-6","journal-title":"BMC Cancer"},{"key":"6500_CR11","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1200\/JCO.2004.09.062","volume":"22","author":"AM Chen","year":"2004","unstructured":"Chen AM, Meric-Bernstam F, Hunt KK et al (2004) Breast conservation after neoadjuvant chemotherapy: the M.D. Anderson cancer center experience. J Clin Oncol 22:2303\u20132312. https:\/\/doi.org\/10.1200\/JCO.2004.09.062","journal-title":"J Clin Oncol"},{"key":"6500_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13014-020-01501-x","volume":"15","author":"J Haussmann","year":"2020","unstructured":"Haussmann J, Corradini S, Nestle-Kraemling C et al (2020) Recent advances in radiotherapy of breast cancer. Radiat Oncol 15:71. https:\/\/doi.org\/10.1186\/s13014-020-01501-x","journal-title":"Radiat Oncol"},{"key":"6500_CR13","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.1200\/JCO.2016.68.3573","volume":"34","author":"M Morrow","year":"2016","unstructured":"Morrow M, van Zee KJ, Solin LJ et al (2016) Society of surgical oncology-American society for radiation oncology-American society of clinical oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ. J Clin Oncol 34:4040\u20134046. https:\/\/doi.org\/10.1200\/JCO.2016.68.3573","journal-title":"J Clin Oncol"},{"key":"6500_CR14","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1200\/JCO.19.02309","volume":"38","author":"KH Allison","year":"2020","unstructured":"Allison KH, Hammond MEH, Dowsett M et al (2020) Estrogen and progesterone receptor testing in breast cancer: ASCO\/CAP guideline update. J Clin Oncol 38:1346\u20131366. https:\/\/doi.org\/10.1200\/JCO.19.02309","journal-title":"J Clin Oncol"},{"key":"6500_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4143\/crt.2017.041","volume":"50","author":"TI Yoon","year":"2018","unstructured":"Yoon TI, Lee JW, Lee SB et al (2018) No association of positive superficial and\/or deep margins with local recurrence in invasive breast cancer treated with breast-conserving surgery. Cancer Res Treat 50:275\u2013282. https:\/\/doi.org\/10.4143\/crt.2017.041","journal-title":"Cancer Res Treat"},{"key":"6500_CR16","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1245\/s10434-019-08089-x","volume":"27","author":"K Wimmer","year":"2020","unstructured":"Wimmer K, Bolliger M, Bago-Horvath Z et al (2020) Impact of surgical margins in breast cancer after preoperative systemic chemotherapy on local recurrence and survival. Ann Surg Oncol 27:1700\u20131707. https:\/\/doi.org\/10.1245\/s10434-019-08089-x","journal-title":"Ann Surg Oncol"},{"key":"6500_CR17","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ijrobp.2018.03.005","volume":"101","author":"S Tyler","year":"2018","unstructured":"Tyler S, Truong PT, Lesperance M et al (2018) Close margins less than 2 mm are not associated with higher risks of 10-year local recurrence and breast cancer mortality compared with negative margins in women treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 101:661\u2013670. https:\/\/doi.org\/10.1016\/j.ijrobp.2018.03.005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6500_CR18","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.ejso.2016.02.252","volume":"42","author":"JH Volders","year":"2016","unstructured":"Volders JH, Haloua MH, Krekel NMA et al (2016) Neoadjuvant chemotherapy in breast-conserving surgery \u2013 consequences on margin status and excision volumes: a nationwide pathology study. Eur J Surg Oncol 42:986\u2013993. https:\/\/doi.org\/10.1016\/j.ejso.2016.02.252","journal-title":"Eur J Surg Oncol"},{"key":"6500_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.amjsurg.2014.09.029","volume":"210","author":"R Tang","year":"2015","unstructured":"Tang R, Coopey SB, Specht MC et al (2015) Lumpectomy specimen margins are not reliable in predicting residual disease in breast conserving surgery. Am J Surg 210:93\u201398. https:\/\/doi.org\/10.1016\/j.amjsurg.2014.09.029","journal-title":"Am J Surg"},{"key":"6500_CR20","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1148\/radiol.2019182947","volume":"292","author":"RM Mann","year":"2019","unstructured":"Mann RM, Cho N, Moy L (2019) Reviews and Commentary \u2022 State of the Art. Radiology 292:520\u2013536","journal-title":"Radiology"},{"key":"6500_CR21","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1200\/JCO.2010.31.1258","volume":"29","author":"CE Loo","year":"2011","unstructured":"Loo CE, Straver ME, Rodenhuis S et al (2011) Magnetic resonance imaging response monitoring of breast cancer during neoadjuvant chemotherapy: relevance of Breast Cancer Subtype. J Clin Oncol 29:660\u2013666. https:\/\/doi.org\/10.1200\/JCO.2010.31.1258","journal-title":"J Clin Oncol"},{"key":"6500_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.14449\/jbd.2017.5.2.51","volume":"5","author":"H Mo","year":"2017","unstructured":"Mo H, Kim Y, Rhu J et al (2017) Actual conversion rate from total mastectomy to breast conservation after neoadjuvant chemotherapy for stages II\u2013III breast cancer patients. J Breast Disease 5:51\u201356. https:\/\/doi.org\/10.14449\/jbd.2017.5.2.51","journal-title":"J Breast Disease"},{"key":"6500_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.breast.2019.06.005","volume":"47","author":"WK Cho","year":"2019","unstructured":"Cho WK, Choi DH, Park W et al (2019) Is higher dose radiation necessary for positive resection margin after breast-conserving surgery for breast cancer? Breast 47:16\u201321. https:\/\/doi.org\/10.1016\/j.breast.2019.06.005","journal-title":"Breast"},{"key":"6500_CR24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000322192","volume":"79","author":"S Kim","year":"2011","unstructured":"Kim S, il, Sohn J, Koo JS, et al (2011) Molecular subtypes and tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Oncology 79:324\u2013330. https:\/\/doi.org\/10.1159\/000322192","journal-title":"Oncology"},{"key":"6500_CR25","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1200\/JCO.2007.14.4147","volume":"26","author":"C Liedtke","year":"2008","unstructured":"Liedtke C, Mazouni C, Hess KR et al (2008) Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 26:1275\u20131281. https:\/\/doi.org\/10.1200\/JCO.2007.14.4147","journal-title":"J Clin Oncol"},{"key":"6500_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00714-5","author":"RG Pastorello","year":"2020","unstructured":"Pastorello RG, Laws A, Grossmith S et al (2020) Clinico-pathologic predictors of patterns of residual disease following neoadjuvant chemotherapy for breast cancer. Mod Pathol. https:\/\/doi.org\/10.1038\/s41379-020-00714-5","journal-title":"Mod Pathol"},{"key":"6500_CR27","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317694540","author":"L Ballesio","year":"2017","unstructured":"Ballesio L, Gigli S, di Pastena F et al (2017) Magnetic resonance imaging tumor regression shrinkage patterns after neoadjuvant chemotherapy in patients with locally advanced breast cancer: Correlation with tumor biological subtypes and pathological response after therapy. Tumor Biology. https:\/\/doi.org\/10.1177\/1010428317694540","journal-title":"Tumor Biology"},{"key":"6500_CR28","doi-asserted-by":"publisher","first-page":"5820","DOI":"10.1158\/1078-0432.CCR-18-0585","volume":"24","author":"P Sharma","year":"2018","unstructured":"Sharma P, L\u00f3pez-Tarruella S, Garc\u00eda-Saenz JA et al (2018) Pathological response and survival in triple-negative breast cancer following neoadjuvant carboplatin plus docetaxel. Clin Cancer Res 24:5820\u20135829. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-0585","journal-title":"Clin Cancer Res"},{"key":"6500_CR29","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/cncr.31221","volume":"124","author":"M Pilewskie","year":"2018","unstructured":"Pilewskie M, Morrow M (2018) Margins in breast cancer: how much is enough? Cancer 124:1335\u20131341. https:\/\/doi.org\/10.1002\/cncr.31221","journal-title":"Cancer"},{"key":"6500_CR30","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1200\/jco.2007.25.18_suppl.530","volume":"25","author":"C Mazouni","year":"2007","unstructured":"Mazouni C, Peintinger F, Wan-Kau S et al (2007) Effect on patient outcome of residual DCIS in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy. J Clin Oncol 25:530\u2013530. https:\/\/doi.org\/10.1200\/jco.2007.25.18_suppl.530","journal-title":"J Clin Oncol"},{"key":"6500_CR31","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/sj.bjc.6602950","volume":"94","author":"RL Jones","year":"2006","unstructured":"Jones RL, Lakhani SR, Ring AE et al (2006) Pathological complete response and residual DCIS following neoadjuvant chemotherapy for breast carcinoma. Br J Cancer 94:358\u2013362. https:\/\/doi.org\/10.1038\/sj.bjc.6602950","journal-title":"Br J Cancer"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-021-06500-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-021-06500-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-021-06500-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:25:58Z","timestamp":1657844758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-021-06500-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["6500"],"URL":"https:\/\/doi.org\/10.1007\/s10549-021-06500-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"assertion":[{"value":"11 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Han-Byoel Lee and Wonshik Han report being a member on the board of directors of and holding stock and ownership interests at DCGen, Co., Ltd., not relevant to this study. Other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki or comparable ethical standards. Approval was granted by the ethics committee or institutional review board at the participating sites.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Requirement for informed consent was waived for all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors have read the paper and consent to its publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}}]}}