{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:07:41Z","timestamp":1782169661662,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israeli Cancer Association","doi-asserted-by":"crossref","award":["Israeli Breast Cancer Consortium"],"award-info":[{"award-number":["Israeli Breast Cancer Consortium"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003975","name":"Israeli Cancer Association","doi-asserted-by":"crossref","award":["Identification of minorities with cancer genes"],"award-info":[{"award-number":["Identification of minorities with cancer genes"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s10549-022-06557-9","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:02:40Z","timestamp":1647082960000},"page":"217-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Common founder BRCA2 pathogenic variants and breast cancer characteristics in Ethiopian Jews"],"prefix":"10.1007","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-6444","authenticated-orcid":false,"given":"S.","family":"Lieberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chen-Shtoyerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shkedi-Rafid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bernstein-Molho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Reznick","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Shachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Flugelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Libman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kedar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Naftaly-Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lagovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Peretz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Karminsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Carmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Levy-Lahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"6557_CR1","doi-asserted-by":"publisher","first-page":"14205","DOI":"10.1073\/pnas.1415979111","volume":"30","author":"E Gabai-Kapara","year":"2014","unstructured":"Gabai-Kapara E, Lahad A, Kaufman, et al (2014) Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2. Proc Natl Acad Sci U S A 30:14205\u201314210. https:\/\/doi.org\/10.1073\/pnas.1415979111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"6557_CR2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1001\/jama.2019.8430","volume":"322","author":"HD Nelson","year":"2019","unstructured":"Nelson HD, Pappas M, Cantor A, Haney E, Holmes R (2019) Risk Assessment, genetic counseling, and genetic testing for BRCA-Related Cancer in Women: updated evidence report and systematic review for the us preventive services task force. JAMA 322(7):666\u2013685. https:\/\/doi.org\/10.1001\/jama.2019.8430","journal-title":"JAMA"},{"key":"6557_CR3","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1056\/NEJMoa2105215","volume":"24","author":"ANJ Tutt","year":"2021","unstructured":"Tutt ANJ, Garber JE, Kaufman B et al (2021) Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. N Engl J Med 24:2394\u20132405. https:\/\/doi.org\/10.1056\/NEJMoa2105215","journal-title":"N Engl J Med"},{"key":"6557_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.718761","volume":"20","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Meng XY, Deng NN et al (2021) Effect and safety of therapeutic regimens for patients with germline BRCA mutation-associated breast cancer: a network meta-analysis. Front Oncol 20:718761. https:\/\/doi.org\/10.3389\/fonc.2021.718761","journal-title":"Front Oncol"},{"key":"6557_CR5","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/humu.23804","volume":"40","author":"TM Friebel","year":"2019","unstructured":"Friebel TM, Andrulis IL, Balma\u00f1a J et al (2019) BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry. Hum Mutat 40:1781\u20131796. https:\/\/doi.org\/10.1002\/humu.23804","journal-title":"Hum Mutat"},{"key":"6557_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/annonc\/mdm234","volume":"18","author":"R Ferla","year":"2007","unstructured":"Ferla R, Cal\u00f2 V, Cascio S et al (2007) Founder mutations in BRCA1 and BRCA2 genes. Ann Oncol 18:93\u201398. https:\/\/doi.org\/10.1093\/annonc\/mdm234","journal-title":"Ann Oncol"},{"issue":"3","key":"6557_CR7","doi-asserted-by":"publisher","DOI":"10.1017\/gheg.2018.8","volume":"11","author":"A Abbad","year":"2018","unstructured":"Abbad A, Baba H, Dehbi H et al (2018) Genetics of breast cancer in African populations: a literature review. Glob Health Epidemiol Genom 11(3):e8. https:\/\/doi.org\/10.1017\/gheg.2018.8","journal-title":"Glob Health Epidemiol Genom"},{"key":"6557_CR8","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1200\/JCO.2018.78.3977","volume":"36","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Walsh T, Gulsuner S et al (2018) Inherited breast cancer in nigerian women. J Clin Oncol 36:2820\u20132825. https:\/\/doi.org\/10.1200\/JCO.2018.78.3977","journal-title":"J Clin Oncol"},{"key":"6557_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/ng1096-185","volume":"14","author":"BB Roa","year":"1996","unstructured":"Roa BB, Boyd AA, Volcik K, Richards CS (1996) Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nat Genet 14:185\u2013187. https:\/\/doi.org\/10.1038\/ng1096-185","journal-title":"Nat Genet"},{"key":"6557_CR10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10549-012-2006-8","volume":"133","author":"Y Laitman","year":"2012","unstructured":"Laitman Y, Simeonov M, Herskovitz L et al (2012) Recurrent germline mutations in BRCA1 and BRCA2 genes in high risk families in Israel. Breast Cancer Res Treat 133:1153\u20131157. https:\/\/doi.org\/10.1007\/s10549-012-2006-8","journal-title":"Breast Cancer Res Treat"},{"key":"6557_CR11","unstructured":"Kaplan S (2003) \u201cBeta Israel\u201d in Encyclopaedia Aethiopica ed.\u00a0Siegbert Uhlig, Wiesbaden: Harrassowitz Verlag, vol I, pp 552\u2013559."},{"key":"6557_CR12","doi-asserted-by":"publisher","first-page":"13865","DOI":"10.1073\/pnas.1204840109","volume":"109","author":"CL Campbell","year":"2012","unstructured":"Campbell CL, Palamara PF, Dubrovsky M et al (2012) North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. Proc Natl Acad Sci U S A 109:13865\u201313870. https:\/\/doi.org\/10.1073\/pnas.1204840109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6557_CR13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10549-018-4887-7","volume":"172","author":"I Barnes-Kedar","year":"2018","unstructured":"Barnes-Kedar I, Bernstein-Molho R et al (2018) The yield of full BRCA1\/2 genotyping in Israeli high-risk breast\/ovarian cancer patients who do not carry the predominant mutations. Breast cancer res treat 172:151\u2013157. https:\/\/doi.org\/10.1007\/s10549-018-4887-7","journal-title":"Breast cancer res treat"},{"key":"6557_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-021-00255-z","author":"MD Ludman","year":"2022","unstructured":"Ludman MD, Philipsborn SL, Hartmajer S, Shwartzman NS, Reinstein E (2022) Recurring pathogenic variants in the BRCA2 gene in the Ethiopian Jewish population. Founder mutations? Fam Cancer. https:\/\/doi.org\/10.1007\/s10689-021-00255-z","journal-title":"Fam Cancer"},{"key":"6557_CR15","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1056\/NEJMoa1800024","volume":"379","author":"A Weinberg-Shukron","year":"2018","unstructured":"Weinberg-Shukron A, Rachmiel M, Renbaum P et al (2018) Essential Role of BRCA2 in Ovarian Development and Function. N Engl J Med 379:1042\u20131049. https:\/\/doi.org\/10.1056\/NEJMoa1800024","journal-title":"N Engl J Med"},{"key":"6557_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13058-015-0653-5","volume":"1","author":"AR Brentnall","year":"2015","unstructured":"Brentnall AR, Harkness EF, Astley SM et al (2015) Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort. Breast Cancer Res 1:147. https:\/\/doi.org\/10.1186\/s13058-015-0653-5","journal-title":"Breast Cancer Res"},{"key":"6557_CR17","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1038\/gim.2016.31","volume":"18","author":"AJ Lee","year":"2016","unstructured":"Lee AJ, Cunningham AP, Tischkowitz M et al (2016) Incorporating truncating variants in PALB2, CHEK2, and ATM into the BOADICEA breast cancer risk model. Genet Med 18:1190\u20131198. https:\/\/doi.org\/10.1038\/gim.2016.31","journal-title":"Genet Med"},{"key":"6557_CR18","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.ajhg.2015.04.019","volume":"96","author":"L Pagani","year":"2015","unstructured":"Pagani L, Schiffels S, Gurdasani D et al (2015) Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians. Am J Hum Genet 96:986\u2013991. https:\/\/doi.org\/10.1016\/j.ajhg.2015.04.019","journal-title":"Am J Hum Genet"},{"key":"6557_CR19","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cell.2019.10.004","volume":"179","author":"D Gurdasani","year":"2019","unstructured":"Gurdasani D, Carstensen T, Fatumo S et al (2019) Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa. Cell 179:984\u20131002. https:\/\/doi.org\/10.1016\/j.cell.2019.10.004","journal-title":"Cell"},{"key":"6557_CR20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1371\/journal.pone.0170843","volume":"12","author":"H LaDuca","year":"2017","unstructured":"LaDuca H, Farwell KD, Vuong H et al (2017) Exome sequencing covers >98% of mutations identified on targeted next generation sequencing panels. PLoS ONE 12:2. https:\/\/doi.org\/10.1371\/journal.pone.0170843","journal-title":"PLoS ONE"},{"key":"6557_CR21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fgene.2020.00170","volume":"6","author":"R Torrorey-Sawe","year":"2020","unstructured":"Torrorey-Sawe R, van der Merwe N, Kipkoech Mining S, Kotze MJ (2020) Pioneering informed consent for return of research results to breast cancer patients facing barriers to implementation of genomic medicine: the kenyan BRCA1\/2 testing experience using whole exome sequencing. Front Genet 6:170. https:\/\/doi.org\/10.3389\/fgene.2020.00170","journal-title":"Front Genet"},{"key":"6557_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1177\/15353702211006047","volume":"246","author":"CA Anyigba","year":"2021","unstructured":"Anyigba CA, Awandare GA, Paemka L (2021) Breast cancer in sub-Saharan Africa: The current state and uncertain future. Exp Biol Med 246:1377\u20131387. https:\/\/doi.org\/10.1177\/15353702211006047","journal-title":"Exp Biol Med"},{"key":"6557_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12992-018-0446-6","volume":"8","author":"E Black","year":"2019","unstructured":"Black E, Richmond R (2019) Improving early detection of breast cancer in sub-Saharan Africa: why mammography may not be the way forward. Global Health 8:3. https:\/\/doi.org\/10.1186\/s12992-018-0446-6","journal-title":"Global Health"},{"key":"6557_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.576964","volume":"8","author":"O Prakash","year":"2020","unstructured":"Prakash O, Hossain F, Danos D, Lassak A, Scribner R, Miele L (2020) Racial disparities in triple negative breast cancer: A review of the role of biologic and non-biologic factors. Front Public Health 8:576964. https:\/\/doi.org\/10.3389\/fpubh.2020.576964","journal-title":"Front Public Health"},{"key":"6557_CR25","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1038\/s41467-018-06616-0","volume":"16","author":"JJ Pitt","year":"2018","unstructured":"Pitt JJ, Riester M, Zheng Y et al (2018) Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features. Nat Commun 16:4181. https:\/\/doi.org\/10.1038\/s41467-018-06616-0","journal-title":"Nat Commun"},{"key":"6557_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.breast.2019.10.012","volume":"49","author":"R Bernstein-Molho","year":"2020","unstructured":"Bernstein-Molho R, Kaufman B, Ben David MA et al (2020) Breast cancer surveillance for BRCA1\/2 mutation carriers \u2013 is \u201cearly detection\u201d early enough? The Breast 49:81\u201386. https:\/\/doi.org\/10.1016\/j.breast.2019.10.012","journal-title":"The Breast"},{"key":"6557_CR27","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1001\/jama.2017.7112","volume":"317","author":"KB Kuchenbaecker","year":"2017","unstructured":"Kuchenbaecker KB, Hopper JL, Barnes DR et al (2017) Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA 317:2402\u20132416. https:\/\/doi.org\/10.1001\/jama.2017.7112","journal-title":"JAMA"},{"key":"6557_CR28","unstructured":"Health status of Ethiopians Jews in Israel 2018, Ministry of health report. https:\/\/www.health.gov.il\/PublicationsFiles\/Ethiopian_01122019.pdf"},{"key":"6557_CR29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/ijc.26431","volume":"131","author":"J Zidan","year":"2012","unstructured":"Zidan J, Sikorsky N, Basher W, Sharabi A, Friedman E, Steiner M (2012) Differences in pathological and clinical features of breast cancer in Arab as compared to Jewish women in Northern Israel. Int J Cancer 131:924\u2013929. https:\/\/doi.org\/10.1002\/ijc.26431","journal-title":"Int J Cancer"},{"key":"6557_CR30","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10549-019-05340-7","volume":"177","author":"SS Coughlin","year":"2019","unstructured":"Coughlin SS (2019) Social determinants of breast cancer risk, stage, and survival. Breast Cancer Res Treat 177:537\u2013548. https:\/\/doi.org\/10.1007\/s10549-019-05340-7","journal-title":"Breast Cancer Res Treat"},{"key":"6557_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1126\/science.1088759","volume":"302","author":"MC King","year":"2003","unstructured":"King MC, Marks JH, Mandell JB (2003) Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302:643\u2013646. https:\/\/doi.org\/10.1126\/science.1088759","journal-title":"Science"},{"key":"6557_CR32","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.3390\/cancers12071929","volume":"17","author":"R Manchanda","year":"2020","unstructured":"Manchanda R, Sun L, Patel S et al (2020) Economic Evaluation of Population-Based BRCA1\/BRCA2 Mutation Testing across Multiple Countries and Health Systems. Cancers (Basel) 17:1929. https:\/\/doi.org\/10.3390\/cancers12071929","journal-title":"Cancers (Basel)"},{"key":"6557_CR33","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1001\/jamaoncol.2020.2059","volume":"1","author":"T Hadar","year":"2020","unstructured":"Hadar T, Mor P, Amit G, Lieberman S, Gekhtman D, Rabinovitch R, Levy-Lahad E (2020) Presymptomatic Awareness of Germline Pathogenic BRCA Variants and Associated Outcomes in Women with Breast Cancer. JAMA Oncol 1:1460\u20131463. https:\/\/doi.org\/10.1001\/jamaoncol.2020.2059","journal-title":"JAMA Oncol"},{"key":"6557_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.683656","volume":"2","author":"S Shraga","year":"2021","unstructured":"Shraga S, Grinshpun A, Zick A et al (2021) High-risk breast cancer screening in BRCA1\/2 carriers leads to early detection and improved survival after a breast cancer diagnosis. Front Oncol 2:683656. https:\/\/doi.org\/10.3389\/fonc.2021.683656","journal-title":"Front Oncol"},{"key":"6557_CR35","first-page":"452","volume":"9","author":"H Tandeter","year":"2007","unstructured":"Tandeter H, Masandilo I, Kemerly I, Biderman A (2007) Ethnic differences in preventive medicine: the example of Jewish Ethiopian women in Israel. Isr Med Assoc J 9:452\u2013456 (PMID: 17642393)","journal-title":"Isr Med Assoc J"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06557-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-022-06557-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06557-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T03:35:59Z","timestamp":1649475359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-022-06557-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,12]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["6557"],"URL":"https:\/\/doi.org\/10.1007\/s10549-022-06557-9","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,12]]},"assertion":[{"value":"25 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author S.L. has received a speaker honorarium from AstraZeneca Company. Author S.C. is a paid consultant at MyHeritage.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Boards of the participants\u2019 genetic institutes: Shaare Zedek (SZMC- 10\u201311) Rabin (RMC- 0161\u201317), Kaplan (KMC-156\u201313), Shiba (SZMC-8470\u201321), Rambam (RMB-0559\u201316), Hadassah (04401\u20139), and Shamir (ASF-0006\u201320).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patient consent was waived by IRB approval since the study is a retrospective study of anonymized data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors have read and approved the final version of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}