{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:11:59Z","timestamp":1782969119308,"version":"3.54.5"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s10549-022-06774-2","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T18:02:56Z","timestamp":1666720976000},"page":"505-515","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Methylation of promoter region of BRCA1 gene versus pathogenic variants of gene: risk factor or clinical marker of breast cancer"],"prefix":"10.1007","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-5816","authenticated-orcid":false,"given":"Olga","family":"Lobanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-7220","authenticated-orcid":false,"given":"Nataliia","family":"Medvedieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-7389","authenticated-orcid":false,"given":"Liliia","family":"Fishchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-4589","authenticated-orcid":false,"given":"Olha","family":"Dubitska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-3752","authenticated-orcid":false,"given":"Valeriy","family":"Cheshuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-6823","authenticated-orcid":false,"given":"Roman","family":"Vereshchako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-9970","authenticated-orcid":false,"given":"Liubov","family":"Zakhartseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4767-7364","authenticated-orcid":false,"given":"Zoia","family":"Rossokha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-7166","authenticated-orcid":false,"given":"Natalia","family":"Gorovenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"6774_CR1","doi-asserted-by":"publisher","first-page":"R39","DOI":"10.1530\/JME-17-0189","volume":"60","author":"LRH Illum","year":"2018","unstructured":"Illum LRH, Bak ST, Lund S et al (2018) DNA methylation in epigenetic inheritance of metabolic diseases through the male germ line. J Mol Endocrinol 60:R39\u2013R56. https:\/\/doi.org\/10.1530\/JME-17-0189","journal-title":"J Mol Endocrinol"},{"key":"6774_CR2","doi-asserted-by":"publisher","first-page":"819","DOI":"10.7150\/jca.12174","volume":"6","author":"YH Cho","year":"2015","unstructured":"Cho YH, McCullough LE, Gammon MD et al (2015) Promoter hypermethylation in white blood cell DNA and breast cancer risk. J Cancer 6:819\u2013824. https:\/\/doi.org\/10.7150\/jca.12174","journal-title":"J Cancer"},{"key":"6774_CR3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.7326\/M17-0101","volume":"168","author":"PE L\u00f8nning","year":"2018","unstructured":"L\u00f8nning PE, Berge EO, Bj\u00f8rnslett M et al (2018) Blood cell BRCA1 promoter methylation status and ovarian cancer risk. Ann Intern Med 168:326\u2013334. https:\/\/doi.org\/10.7326\/M17-0101","journal-title":"Ann Intern Med"},{"key":"6774_CR4","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.3390\/cancers13061391","volume":"13","author":"I Ruscito","year":"2021","unstructured":"Ruscito I, Gasparri ML, De Marco MP et al (2021) The clinical and pathological profile of BRCA1 gene methylated breast cancer women: a meta-analysis. Cancers (Basel) 13:1391. https:\/\/doi.org\/10.3390\/cancers13061391","journal-title":"Cancers (Basel)"},{"key":"6774_CR5","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.4161\/epi.22561","volume":"7","author":"OA Stefansson","year":"2012","unstructured":"Stefansson OA, Villanueva A, Vidal A et al (2012) BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer. Epigenetics 7:1225\u20131229. https:\/\/doi.org\/10.4161\/epi.22561","journal-title":"Epigenetics"},{"key":"6774_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3389\/fphar.2019.00385","volume":"10","author":"AK Giri","year":"2019","unstructured":"Giri AK, Aittokallio T (2019) DNMT inhibitors increase methylation in the cancer genome. Front Pharmacol 10:385. https:\/\/doi.org\/10.3389\/fphar.2019.00385","journal-title":"Front Pharmacol"},{"key":"6774_CR7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/PPO.0000000000000279","volume":"23","author":"KW McMahon","year":"2017","unstructured":"McMahon KW, Karunasena E, Ahuja N (2017) The roles of DNA methylation in the stages of cancer. Cancer J 23:257\u2013261. https:\/\/doi.org\/10.1097\/PPO.0000000000000279","journal-title":"Cancer J"},{"key":"6774_CR8","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/s10038-020-0780-4","volume":"65","author":"MJD Aref-Eshghi","year":"2020","unstructured":"Aref-Eshghi MJD, Pedro VP et al (2020) Genetic and epigenetic profiling of BRCA1\/2 in ovarian tumors reveals additive diagnostic yield and evidence of a genomic BRCA1\/2 DNA methylation signature. J Hum Genet 65:865\u2013873. https:\/\/doi.org\/10.1038\/s10038-020-0780-4","journal-title":"J Hum Genet"},{"key":"6774_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.critrevonc.2018.05.008","volume":"127","author":"S Vos","year":"2018","unstructured":"Vos S, van Diest PJ, Moelans CB (2018) A systematic review on the frequency of BRCA promoter methylation in breast and ovarian carcinomas of BRCA germline mutation carriers: Mutually exclusive, or not? Crit Rev Oncol Hematol 127:29\u201341. https:\/\/doi.org\/10.1016\/j.critrevonc.2018.05.008","journal-title":"Crit Rev Oncol Hematol"},{"key":"6774_CR10","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672320000075","volume":"102","author":"T Nguyen-Dumont","year":"2020","unstructured":"Nguyen-Dumont T, Karpinski P, Sasiadek MM et al (2020) Genetic testing in Poland and Ukraine: should comprehensive germline testing of BRCA1 and BRCA2 be recommended for women with breast and ovarian cancer? Genet Res (Camb) 102:e6. https:\/\/doi.org\/10.1017\/S0016672320000075","journal-title":"Genet Res (Camb)"},{"key":"6774_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2161-1041.1000171","volume":"5","author":"N Kitsera","year":"2016","unstructured":"Kitsera N, Shparyk YA, Helner N et al (2016) Detection of gene mutation in the 185del AG BRCA1 in families with hereditary breast cancer. Hereditary Genetics 5:1\u20134. https:\/\/doi.org\/10.4172\/2161-1041.1000171","journal-title":"Hereditary Genetics"},{"key":"6774_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13053-015-0040-3","volume":"13","author":"I Gorodetska","year":"2015","unstructured":"Gorodetska I, Serga S, Levkovich N et al (2015) The frequency of BRCA1 founder mutation c.5266dupC (5382insC) in breast cancer patients from Ukraine. Hered Cancer Clin Pract 13:19. https:\/\/doi.org\/10.1186\/s13053-015-0040-3","journal-title":"Hered Cancer Clin Pract"},{"key":"6774_CR13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.5603\/NJO.2014.0039","volume":"64","author":"N Kitsera","year":"2014","unstructured":"Kitsera N, Ya S, Bilynsky B et al (2014) BRCA1 4153delA mutation (\u201dBaltic\/Black Sea\u201d) in breast cancer patients in Ukraine. J Nowotwory 64:246\u2013250. https:\/\/doi.org\/10.5603\/NJO.2014.0039","journal-title":"J Nowotwory"},{"key":"6774_CR14","first-page":"174","volume":"31","author":"LM Zakhartseva","year":"2009","unstructured":"Zakhartseva LM, Gorovenko NG, Podolskaya SV et al (2009) Breast cancer immunohistochemical features in young women with BRCA1\/2 mutations. Exp Oncol 31:174\u2013178","journal-title":"Exp Oncol"},{"key":"6774_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.32471\/exp-oncology.2312-8852.43(1):15703","volume":"43","author":"OE Lobanova","year":"2021","unstructured":"Lobanova OE, Rossokha ZI, Medvedieva NL et al (2021) Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue. Exp Oncol 43:56\u201360. https:\/\/doi.org\/10.32471\/exp-oncology.2312-8852.43(1):15703","journal-title":"Exp Oncol"},{"key":"6774_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.31768\/2312-8852.2018.40(1):59-67","volume":"40","author":"O Paliychuk","year":"2018","unstructured":"Paliychuk O, Polishchuk L, Rossokha Z et al (2018) Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer. Exp Oncol 40:59\u201367. https:\/\/doi.org\/10.31768\/2312-8852.2018.40(1):59-67","journal-title":"Exp Oncol"},{"key":"6774_CR17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s10689-017-9978-9","volume":"16","author":"I Gorodetska","year":"2017","unstructured":"Gorodetska I, Serga S, Lahuta T et al (2017) Prevalence of two BRCA1 mutations, 5382insC and 300T > G, in ovarian cancer patients from Ukraine. Fam Cancer 16:471\u2013476. https:\/\/doi.org\/10.1007\/s10689-017-9978-9","journal-title":"Fam Cancer"},{"key":"6774_CR18","doi-asserted-by":"publisher","first-page":"7147","DOI":"10.1007\/s11033-021-06705-2","volume":"48","author":"I Saif","year":"2021","unstructured":"Saif I, Bouziyane A, Benhessou M et al (2021) Detection of hypermethylation BRCA1\/2 gene promoter in breast tumours among Moroccan women. Mol Biol Rep 48:7147\u20137152. https:\/\/doi.org\/10.1007\/s11033-021-06705-2","journal-title":"Mol Biol Rep"},{"key":"6774_CR19","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s10038-021-00911-3","volume":"66","author":"A Morizono","year":"2021","unstructured":"Morizono A, Tanabe M, Ikemura M, Sasaki T, Ushiku T, Seto Y (2021) Loss of BRCA1 expression and morphological features associated with BRCA1 promoter methylation status in triple-negative breast cancer. J Hum Genet 66:785\u2013793. https:\/\/doi.org\/10.1038\/s10038-021-00911-3","journal-title":"J Hum Genet"},{"key":"6774_CR20","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1038\/s41467-020-17537-2","volume":"11","author":"D Glodzik","year":"2020","unstructured":"Glodzik D, Bosch A, Hartman J et al (2020) Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers. Nat Commun 11:3747. https:\/\/doi.org\/10.1038\/s41467-020-17537-2","journal-title":"Nat Commun"},{"key":"6774_CR21","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1002\/ijc.32655","volume":"146","author":"K Prajzendanc","year":"2019","unstructured":"Prajzendanc K, Domaga\u0142a P, Hybiak J et al (2019) BRCA1 promoter methylation in peripheral blood is associated with the risk of triple-negative breast cancer. Int J Cancer 146:1293\u20131298. https:\/\/doi.org\/10.1002\/ijc.32655","journal-title":"Int J Cancer"},{"key":"6774_CR22","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/s41591-019-0582-4","volume":"25","author":"J Staaf","year":"2019","unstructured":"Staaf J, Glodzik D, Bosch A et al (2019) Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. Nat Med 25:1526\u20131533. https:\/\/doi.org\/10.1038\/s41591-019-0582-4","journal-title":"Nat Med"},{"key":"6774_CR23","doi-asserted-by":"publisher","first-page":"pkz100","DOI":"10.1093\/jncics\/pkz100","volume":"4","author":"OA Stefansson","year":"2019","unstructured":"Stefansson OA, Hilmarsdottir H, Olafsdottir K et al (2019) BRCA1 promoter methylation status in 1031 primary breast cancers predicts favorable outcomes following chemotherapy. JNCI Cancer Spectr 4:pkz100. https:\/\/doi.org\/10.1093\/jncics\/pkz100","journal-title":"JNCI Cancer Spectr"},{"key":"6774_CR24","doi-asserted-by":"publisher","first-page":"13726","DOI":"10.1002\/jcb.28645","volume":"120","author":"P Paydar","year":"2019","unstructured":"Paydar P, Asadikaram G, Nejad HZ et al (2019) Epigenetic modulation of BRCA-1 and MGMT genes, and histones H4 and H3 are associated with breast tumors. J Cell Biochem 120:13726\u201313736. https:\/\/doi.org\/10.1002\/jcb.28645","journal-title":"J Cell Biochem"},{"key":"6774_CR25","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.22034\/APJCP.2018.19.7.1887","volume":"19","author":"TL Vu","year":"2018","unstructured":"Vu TL, Nguyen TT, Doan VTH et al (2018) Methylation profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese women with breast cancer. Asian Pac J Cancer Prev 19:1887\u20131893. https:\/\/doi.org\/10.22034\/APJCP.2018.19.7.1887","journal-title":"Asian Pac J Cancer Prev"},{"key":"6774_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ajhg.2018.07.002","volume":"103","author":"DGR Evans","year":"2018","unstructured":"Evans DGR, van Veen EM, Byers HJ et al (2018) A Dominantly inherited 5\u2019 UTR variant causing methylation-associated silencing of BRCA1 as a Cause of breast and ovarian cancer. Am J Hum Genet 103:213\u2013220. https:\/\/doi.org\/10.1016\/j.ajhg.2018.07.002","journal-title":"Am J Hum Genet"},{"key":"6774_CR27","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.22034\/APJCP.2018.19.9.2643","volume":"19","author":"WA Harahap","year":"2018","unstructured":"Harahap WA, Sudji IR, Nindrea RD (2018) BRCA1 promoter methylation and clinicopathological characteristics in sporadic breast cancer patients in Indonesia. Asian Pac J Cancer Prev 19:2643\u20132649. https:\/\/doi.org\/10.22034\/APJCP.2018.19.9.2643","journal-title":"Asian Pac J Cancer Prev"},{"key":"6774_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13058-017-0856-z","volume":"19","author":"S Vos","year":"2017","unstructured":"Vos S, Moelans CB, van Diest PJ (2017) BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers. Breast Cancer Res 19:64. https:\/\/doi.org\/10.1186\/s13058-017-0856-z","journal-title":"Breast Cancer Res"},{"key":"6774_CR29","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.18632\/oncotarget.13750","volume":"8","author":"PS Felicio","year":"2017","unstructured":"Felicio PS, Melendez ME, Arantes LM et al (2017) Genetic and epigenetic characterization of the BRCA1 gene in Brazilian women at-risk for hereditary breast cancer. Oncotarget 8:2850\u20132862. https:\/\/doi.org\/10.18632\/oncotarget.13750","journal-title":"Oncotarget"},{"key":"6774_CR30","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.22034\/APJCP.2017.18.12.3293","volume":"18","author":"M Kumar","year":"2017","unstructured":"Kumar M, Sahu RK, Goyal A et al (2017) BRCA1 Promoter methylation and expression - associations with ER+, PR+ and HER2+ subtypes of breast carcinoma. Asian Pac J Cancer Prev 18:3293\u20133299. https:\/\/doi.org\/10.22034\/APJCP.2017.18.12.3293","journal-title":"Asian Pac J Cancer Prev"},{"key":"6774_CR31","doi-asserted-by":"publisher","first-page":"9545241","DOI":"10.1155\/2016\/9545241","volume":"2016","author":"MM Hosny","year":"2016","unstructured":"Hosny MM, Sabek NA, El-Abaseri TB et al (2016) Promoter methylation status of breast cancer susceptibility gene 1 and 17 beta hydroxysteroid dehydrogenase type 1 gene in sporadic breast cancer patients. Int J Breast Cancer 2016:9545241. https:\/\/doi.org\/10.1155\/2016\/9545241","journal-title":"Int J Breast Cancer"},{"key":"6774_CR32","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.7754\/Clin.Lab.2016.160418","volume":"62","author":"H Shakeri","year":"2016","unstructured":"Shakeri H, Fakhrjou A, Nikanfar A et al (2016) Methylation analysis of BRCA1 and APC in breast cancer and it\u2019s relationship to clinicopathological features. Clin Lab 62:2333\u20132337. https:\/\/doi.org\/10.7754\/Clin.Lab.2016.160418","journal-title":"Clin Lab"},{"key":"6774_CR33","unstructured":"Guo Yu, Li J, Zhang W (2016) [Analysis the methylation and clinic significant of BRCA1 gene in Uyghur and Han nationality patients with sporadic breast cancer in Xinjiang]. J Xinjiang Med Univ 39:155\u2013159. https:\/\/xjyy.cbpt.cnki.net\/WKD2\/WebPublication\/paperDigest.aspx?paperID=31923de4-0b73-4210-8dd6-cd39f27ab680#. Accessed 20 Jan 2022."},{"key":"6774_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.11969\/j.issn.1673-548X.2016.11.021","volume":"11","author":"L Wu","year":"2016","unstructured":"Wu L, Wang J (2016) Study on the correlation between abnormal DNA methylation and clinical features of breast cancer. J Med 11:82\u201386. https:\/\/doi.org\/10.11969\/j.issn.1673-548X.2016.11.021","journal-title":"J Med"},{"key":"6774_CR35","doi-asserted-by":"publisher","first-page":"S2217","DOI":"10.3233\/BME-151527","volume":"26","author":"L Liu","year":"2015","unstructured":"Liu L, Sun L, Li C et al (2015) Quantitative detection of methylation of FHIT and BRCA1 promoters in the serum of ductal breast cancer patients. Biomed Mater Eng 26:S2217\u2013S2222. https:\/\/doi.org\/10.3233\/BME-151527","journal-title":"Biomed Mater Eng"},{"key":"6774_CR36","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3969\/j.issn.1671-8348.2015.09.007","volume":"9","author":"W Wei","year":"2015","unstructured":"Wei W, Li Q, Wei T et al (2015) Expression and abnormal methylation BRCA1 in sporadic breast cancer. Chongqing Med J 9:1174\u20131176. https:\/\/doi.org\/10.3969\/j.issn.1671-8348.2015.09.007","journal-title":"Chongqing Med J"},{"key":"6774_CR37","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10549-015-3338-y","volume":"150","author":"X Zhu","year":"2015","unstructured":"Zhu X, Shan L, Wang F et al (2015) Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer. Breast Cancer Res Treat 150:479\u2013486. https:\/\/doi.org\/10.1007\/s10549-015-3338-y","journal-title":"Breast Cancer Res Treat"},{"key":"6774_CR38","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.clbc.2015.06.009","volume":"15","author":"N Yamashita","year":"2015","unstructured":"Yamashita N, Tokunaga E, Kitao H et al (2015) Epigenetic inactivation of brca1 through promoter hypermethylation and its clinical importance in triple-negative breast cancer. Clin Breast Cancer 15:498\u2013504. https:\/\/doi.org\/10.1016\/j.clbc.2015.06.009","journal-title":"Clin Breast Cancer"},{"key":"6774_CR39","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10549-014-3179-0","volume":"148","author":"S Gupta","year":"2014","unstructured":"Gupta S, Jaworska-Bieniek K, Narod SA et al (2014) Methylation of the BRCA1 promoter in peripheral blood DNA is associated with triple-negative and medullary breast cancer. Breast Cancer Res Treat 148:615\u2013622. https:\/\/doi.org\/10.1007\/s10549-014-3179-0","journal-title":"Breast Cancer Res Treat"},{"key":"6774_CR40","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1111\/cas.12506","volume":"105","author":"Y Otani","year":"2014","unstructured":"Otani Y, Miyake T, Kagara N et al (2014) BRCA1 promoter methylation of normal breast epithelial cells as a possible precursor for BRCA1-methylated breast cancer. Cancer Sci 105:1369\u20131376. https:\/\/doi.org\/10.1111\/cas.12506","journal-title":"Cancer Sci"},{"issue":"4","key":"6774_CR41","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.3892\/ol.2015.2908","volume":"9","author":"Q Li","year":"2015","unstructured":"Li Q, Wei W, Jiang YI et al (2015) Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. Oncol Lett 9(4):1807\u20131813. https:\/\/doi.org\/10.3892\/ol.2015.2908","journal-title":"Oncol Lett"},{"key":"6774_CR42","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1186\/1471-2407-14-830","volume":"14","author":"N Al-Moghrabi","year":"2014","unstructured":"Al-Moghrabi N, Nofel A, Al-Yousef N et al (2014) The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females. BMC Cancer 14:830. https:\/\/doi.org\/10.1186\/1471-2407-14-830","journal-title":"BMC Cancer"},{"key":"6774_CR43","doi-asserted-by":"publisher","first-page":"906","DOI":"10.16190\/j.cnki.45-1211\/r.2014.06.006","volume":"6","author":"W Wei","year":"2014","unstructured":"Wei W, Tang W, Jiang Y et al (2014) Methylation status of BRCA1 promoter and expression of BRCA1 protein in sporadic triple negative breast cancer. J Guangxi Med Univ 6:906\u2013908. https:\/\/doi.org\/10.16190\/j.cnki.45-1211\/r.2014.06.006","journal-title":"J Guangxi Med Univ"},{"key":"6774_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7243\/2049-7962-3-2","volume":"3","author":"P Sharma","year":"2014","unstructured":"Sharma P, Stecklein SR, Kimler BF et al (2014) The prognostic value of BRCA1 promoter methylation in early stage triple negative breast cancer. J Cancer Ther Res 3:1\u201311. https:\/\/doi.org\/10.7243\/2049-7962-3-2","journal-title":"J Cancer Ther Res"},{"issue":"2","key":"6774_CR45","doi-asserted-by":"publisher","first-page":"e56256","DOI":"10.1371\/journal.pone.0056256","volume":"8","author":"NC Hsu","year":"2013","unstructured":"Hsu NC, Huang YF, Yokoyama KK et al (2013) Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer. PLoS ONE 8(2):e56256. https:\/\/doi.org\/10.1371\/journal.pone.0056256","journal-title":"PLoS ONE"},{"key":"6774_CR46","doi-asserted-by":"publisher","first-page":"9607","DOI":"10.7314\/apjcp.2014.15.22.9607","volume":"15","author":"PK Truong","year":"2014","unstructured":"Truong PK, Lao TD, Doan TP et al (2014) BRCA1 promoter hypermethylation signature for early detection of breast cancer in the Vietnamese population. Asian Pac J Cancer Prev 15:9607\u20139610. https:\/\/doi.org\/10.7314\/apjcp.2014.15.22.9607","journal-title":"Asian Pac J Cancer Prev"},{"key":"6774_CR47","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3969\/j.issn.1007-3969.2014.07.002","volume":"7","author":"D Fu","year":"2014","unstructured":"Fu D, Wei J, Zhu Yu et al (2014) Clinical signiifcance of BRCA1, GSTP1 and MGMT gene methylation status in breast cancer. China Oncol 7:487\u2013492. https:\/\/doi.org\/10.3969\/j.issn.1007-3969.2014.07.002","journal-title":"China Oncol"},{"key":"6774_CR48","doi-asserted-by":"publisher","first-page":"10585","DOI":"10.7314\/apjcp.2014.15.24.10585","volume":"15","author":"P Saelee","year":"2014","unstructured":"Saelee P, Chaiwerawattana A, Ogawa K et al (2014) Clinicopathological significance of BRCA1 promoter hypermethylation in Thai breast cancer patients. Asian Pac J Cancer Prev 15:10585\u201310589. https:\/\/doi.org\/10.7314\/apjcp.2014.15.24.10585","journal-title":"Asian Pac J Cancer Prev"},{"key":"6774_CR49","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3343\/alm.2013.33.6.431","volume":"33","author":"EJ Jung","year":"2013","unstructured":"Jung EJ, Kim IS, Lee EY et al (2013) Comparison of methylation profiling in cancerous and their corresponding normal tissues from korean patients with breast cancer. Ann Lab Med 33:431\u2013440. https:\/\/doi.org\/10.3343\/alm.2013.33.6.431","journal-title":"Ann Lab Med"},{"key":"6774_CR50","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1093\/annonc\/mdt011","volume":"24","author":"Y Xu","year":"2013","unstructured":"Xu Y, Diao L, Chen Y et al (2013) Promoter methylation of BRCA1 in triple-negative breast cancer predicts sensitivity to adjuvant chemotherapy. Ann Oncol 24:1498\u20131505. https:\/\/doi.org\/10.1093\/annonc\/mdt011","journal-title":"Ann Oncol"},{"key":"6774_CR51","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s12094-012-0968-y","volume":"15","author":"TN Hasan","year":"2013","unstructured":"Hasan TN, Leena Grace B, Shafi G et al (2013) Association of BRCA1 promoter methylation with rs11655505 (c.2265C>T) variants and decreased gene expression in sporadic breast cancer. Clin Transl Oncol 15:555\u2013562. https:\/\/doi.org\/10.1007\/s12094-012-0968-y","journal-title":"Clin Transl Oncol"},{"key":"6774_CR52","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1016\/j.canep.2012.02.001","volume":"36","author":"R Bosviel","year":"2012","unstructured":"Bosviel R, Garcia S, Lavediaux G et al (2012) BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls. Cancer Epidemiol 36:e177-182. https:\/\/doi.org\/10.1016\/j.canep.2012.02.001","journal-title":"Cancer Epidemiol"},{"key":"6774_CR53","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.4161\/epi.22220","volume":"7","author":"SR Sturgeon","year":"2012","unstructured":"Sturgeon SR, Balasubramanian R, Schairer C et al (2012) Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls. Epigenetics 7:1258\u20131267. https:\/\/doi.org\/10.4161\/epi.22220","journal-title":"Epigenetics"},{"key":"6774_CR54","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1093\/hmg\/dds308","volume":"21","author":"T Hansmann","year":"2012","unstructured":"Hansmann T, Pliushch G, Leubner M et al (2012) Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer. Hum Mol Genet 21:4669\u20134679. https:\/\/doi.org\/10.1093\/hmg\/dds308","journal-title":"Hum Mol Genet"},{"key":"6774_CR55","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.canep.2011.09.001","volume":"36","author":"R Ben Gacem","year":"2012","unstructured":"Ben Gacem R, Hachana M, Ziadi S et al (2012) Contribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients. Cancer Epidemiol 36:190\u2013197. https:\/\/doi.org\/10.1016\/j.canep.2011.09.001","journal-title":"Cancer Epidemiol"},{"key":"6774_CR56","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3892\/ijo.2011.1021","volume":"39","author":"N Al-Moghrabi","year":"2011","unstructured":"Al-Moghrabi N, Al-Qasem AJ, Aboussekhra A (2011) Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women. Int J Oncol 39:129\u2013135. https:\/\/doi.org\/10.3892\/ijo.2011.1021","journal-title":"Int J Oncol"},{"key":"6774_CR57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1158\/1940-6207.CAPR-10-0212","volume":"4","author":"EM Wong","year":"2011","unstructured":"Wong EM, Southey MC, Fox SB et al (2011) Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer. Cancer Prev Res (Phila) 4:23\u201333. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-10-0212","journal-title":"Cancer Prev Res (Phila)"},{"key":"6774_CR58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10549-010-1188-1","volume":"129","author":"T Iwamoto","year":"2011","unstructured":"Iwamoto T, Yamamoto N, Taguchi T et al (2011) BRCA1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with BRCA1 promoter methylation. Breast Cancer Res Treat 129:69\u201377. https:\/\/doi.org\/10.1007\/s10549-010-1188-1","journal-title":"Breast Cancer Res Treat"},{"key":"6774_CR59","doi-asserted-by":"publisher","first-page":"576","DOI":"10.16139\/j.1007-9610.a2766","volume":"6","author":"Wu Li","year":"2011","unstructured":"Li Wu, Wei-hong Ca0, Qing-feng C et al (2011) Study in BRCA1 gene methylation status and mRNA expression level in sporadic breast cancer. J Surg Concepts Pract 6:576\u2013580. https:\/\/doi.org\/10.16139\/j.1007-9610.a2766","journal-title":"J Surg Concepts Pract"},{"key":"6774_CR60","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.2217\/fon.11.123","volume":"7","author":"TK Wojdacz","year":"2011","unstructured":"Wojdacz TK, Thestrup BB, Cold S et al (2011) No difference in the frequency of locus-specific methylation in the peripheral blood DNA of women diagnosed with breast cancer and age-matched controls. Future Oncol 7:1451\u20131455. https:\/\/doi.org\/10.2217\/fon.11.123","journal-title":"Future Oncol"},{"key":"6774_CR61","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1089\/gte.1997.1.85","volume":"1","author":"A Ganguly","year":"1997","unstructured":"Ganguly A, Leahy K, Marshall AM et al (1997) Genetic testing for breast cancer susceptibility: frequency of BRCA1 and BRCA2 mutations. Genet Test 1:85\u201390. https:\/\/doi.org\/10.1089\/gte.1997.1.85","journal-title":"Genet Test"},{"key":"6774_CR62","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/humu.23406","volume":"39","author":"TR Rebbeck","year":"2018","unstructured":"Rebbeck TR, Friebel TM, Friedman E et al (2018) Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Hum Mutat 39:593\u2013620. https:\/\/doi.org\/10.1002\/humu.23406","journal-title":"Hum Mutat"},{"key":"6774_CR63","doi-asserted-by":"publisher","first-page":"228","DOI":"10.5195\/cajgh.2016.228","volume":"5","author":"A Abdikhakimov","year":"2016","unstructured":"Abdikhakimov A, Tukhtaboeva M, Adilov B et al (2016) The potential contribution of BRCA mutations to early onset and familial breast Cancer in Uzbekistan. Cent Asian J Glob Health 5:228. https:\/\/doi.org\/10.5195\/cajgh.2016.228","journal-title":"Cent Asian J Glob Health"},{"key":"6774_CR64","first-page":"44","volume":"14","author":"N Kitsera","year":"2012","unstructured":"Kitsera N, Ya S, Bilynskyy B et al (2012) Analysis of mutations in BRCA1\/2 gene in patient with family\/hereditary breast cancer from Lviv region (Ukraine). Oncol 14:44\u201349","journal-title":"Oncol"},{"key":"6774_CR65","unstructured":"Jin Y (2020) Blood DNA methylation as a surrogate epigenetic biomarker in study of night shift work and breast cancer\". Public Health Theses. 1952.https:\/\/elischolar.library.yale.edu\/ysphtdl\/1952"},{"key":"6774_CR66","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13058-019-1145-9","volume":"21","author":"C Bodelon","year":"2019","unstructured":"Bodelon C, Ambatipudi S, Dugu\u00e9 PA et al (2019) Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies. Breast Cancer Res 21:62. https:\/\/doi.org\/10.1186\/s13058-019-1145-9","journal-title":"Breast Cancer Res"},{"key":"6774_CR67","doi-asserted-by":"publisher","first-page":"e0192414","DOI":"10.1371\/journal.pone.0192414","volume":"13","author":"C Schr\u00f6der","year":"2018","unstructured":"Schr\u00f6der C, Steimer W (2018) gDNA extraction yield and methylation status of blood samples are affected by long-term storage conditions. PLoS ONE 13:e0192414. https:\/\/doi.org\/10.1371\/journal.pone.0192414","journal-title":"PLoS ONE"},{"issue":"7","key":"6774_CR68","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","volume":"92","author":"M Esteller","year":"2000","unstructured":"Esteller M, Silva JM, Dominguez G et al (2000) Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92(7):564\u2013569. https:\/\/doi.org\/10.1093\/jnci\/92.7.564","journal-title":"J Natl Cancer Inst"},{"key":"6774_CR69","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3892\/or.2020.7473","volume":"43","author":"N Al-Yousef","year":"2020","unstructured":"Al-Yousef N, Shinwari Z, Al-Shahrani B et al (2020) Curcumin induces re-expression of BRCA1 and suppression of \u03b3 synuclein by modulating DNA promoter methylation in breast cancer cell lines. Oncol Rep 43:827\u2013838. https:\/\/doi.org\/10.3892\/or.2020.7473","journal-title":"Oncol Rep"},{"key":"6774_CR70","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3389\/fonc.2019.01289","volume":"9","author":"E Franzese","year":"2019","unstructured":"Franzese E, Centonze S, Diana A et al (2019) Genomic profile and BRCA-1 promoter methylation status in BRCA mutated ovarian cancer: new insights in predictive biomarkers of olaparib response. Front Oncol 9:1289. https:\/\/doi.org\/10.3389\/fonc.2019.01289","journal-title":"Front Oncol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06774-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-022-06774-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06774-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T20:28:24Z","timestamp":1667507304000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-022-06774-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6774"],"URL":"https:\/\/doi.org\/10.1007\/s10549-022-06774-2","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"3 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Commission on Bioethical Expertise and Research Ethics of Bogomolets National Medical University (0120U100871).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent for the collection of biological material, medical examinations, and data processing was obtained from each participant included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}