{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:37:18Z","timestamp":1781195838794,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA266012-01"],"award-info":[{"award-number":["1R01CA266012-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020082","name":"Center for Biomedical Informatics and Information Technology, National Cancer Institute","doi-asserted-by":"publisher","award":["5T32CA083654"],"award-info":[{"award-number":["5T32CA083654"]}],"id":[{"id":"10.13039\/100020082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5TL1TR002242"],"award-info":[{"award-number":["5TL1TR002242"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s10549-022-06806-x","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T05:02:41Z","timestamp":1668315761000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between nociplastic pain and premature endocrine therapy discontinuation in breast cancer patients"],"prefix":"10.1007","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-2298","authenticated-orcid":false,"given":"Elizabeth","family":"Joyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Brummett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Kidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-5930","authenticated-orcid":false,"given":"N. Lynn","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"6806_CR1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.6004\/jnccn.2022.0030","volume":"20","author":"WJ Gradishar","year":"2022","unstructured":"Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R (2022) Breast cancer, version 3.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw 20:691\u2013722. https:\/\/doi.org\/10.6004\/jnccn.2022.0030","journal-title":"J Natl Compr Cancer Netw"},{"key":"6806_CR2","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1200\/jco.2011.38.0261","volume":"30","author":"NL Henry","year":"2012","unstructured":"Henry NL, Azzouz F, Desta Z, Li L, Nguyen AT, Lemler S, Hayden J, Tarpinian K, Yakim E, Flockhart DA, Stearns V, Hayes DF, Storniolo AM (2012) Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J Clin Oncol 30:936\u2013942. https:\/\/doi.org\/10.1200\/jco.2011.38.0261","journal-title":"J Clin Oncol"},{"key":"6806_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s10549-007-9612-x","volume":"108","author":"JE Mortimer","year":"2008","unstructured":"Mortimer JE, Flatt SW, Parker BA, Gold EB, Wasserman L, Natarajan L, Pierce JP, Group WS (2008) Tamoxifen, hot flashes and recurrence in breast cancer. Breast Cancer Res Treat 108:421\u2013426. https:\/\/doi.org\/10.1007\/s10549-007-9612-x","journal-title":"Breast Cancer Res Treat"},{"key":"6806_CR4","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1158\/1078-0432.ccr-20-3974","volume":"27","author":"LJ Collin","year":"2021","unstructured":"Collin LJ, Cronin-Fenton DP, Ahern TP, Goodman M, Mccullough LE, Waller LA, Kj\u00e6rsgaard A, Damkier P, Christiansen PM, Ejlertsen B, Jensen M-B, S\u00f8rensen HT, Lash TL (2021) Early discontinuation of endocrine therapy and recurrence of breast cancer among premenopausal women. Clin Cancer Res 27:1421\u20131428. https:\/\/doi.org\/10.1158\/1078-0432.ccr-20-3974","journal-title":"Clin Cancer Res"},{"key":"6806_CR5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1200\/op.20.00113","volume":"16","author":"A Gupta","year":"2020","unstructured":"Gupta A, Henry NL, Loprinzi CL (2020) Management of aromatase inhibitor-induced musculoskeletal symptoms. JCO Oncol Pract 16:733\u2013739. https:\/\/doi.org\/10.1200\/op.20.00113","journal-title":"JCO Oncol Pract"},{"key":"6806_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.04.007","volume":"33","author":"AP Trouvin","year":"2019","unstructured":"Trouvin AP, Perrot S (2019) New concepts of pain. Best Pract Res Clin Rheumatol 33:101415. https:\/\/doi.org\/10.1016\/j.berh.2019.04.007","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"6806_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.rdc.2021.01.001","volume":"47","author":"D Minhas","year":"2021","unstructured":"Minhas D, Clauw DJ (2021) Pain mechanisms in patients with rheumatic diseases. Rheum Dis Clin North Am 47:133\u2013148. https:\/\/doi.org\/10.1016\/j.rdc.2021.01.001","journal-title":"Rheum Dis Clin North Am"},{"key":"6806_CR8","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1007\/s10067-022-06229-5","volume":"10","author":"A Bidari","year":"2022","unstructured":"Bidari A, Ghavidel-Parsa B (2022) Nociplastic pain concept, a mechanistic basis for pragmatic approach to fibromyalgia. Clin Rheumatol 10:2939\u20132947. https:\/\/doi.org\/10.1007\/s10067-022-06229-5","journal-title":"Clin Rheumatol"},{"key":"6806_CR9","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.pain.2003.06.001","volume":"106","author":"L LeResche","year":"2003","unstructured":"LeResche L, Mancl L, Sherman JJ, Gandara B, Dworkin SF (2003) Changes in temporomandibular pain and other symptoms across the menstrual cycle. Pain 106:253\u2013261. https:\/\/doi.org\/10.1016\/j.pain.2003.06.001","journal-title":"Pain"},{"key":"6806_CR10","first-page":"1809","volume":"8","author":"S Kuiper","year":"2001","unstructured":"Kuiper S, Gestel AMv, Swinkels HL, Boo TMd, Silva HAd, Riel PLv (2001) Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol 8:1809\u20131816","journal-title":"J Rheumatol"},{"key":"6806_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","volume":"10","author":"A Latremoliere","year":"2009","unstructured":"Latremoliere A, Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10:895\u2013926. https:\/\/doi.org\/10.1016\/j.jpain.2009.06.012","journal-title":"J Pain"},{"key":"6806_CR12","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","volume":"157","author":"E Kosek","year":"2016","unstructured":"Kosek E, Cohen M, Baron R, Gebhart GF, Mico JA, Rice ASC, Rief W, Sluka AK (2016) Do we need a third mechanistic descriptor for chronic pain states? Pain 157:1382\u20131386. https:\/\/doi.org\/10.1097\/j.pain.0000000000000507","journal-title":"Pain"},{"key":"6806_CR13","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.3899\/jrheum.100594","volume":"38","author":"F Wolfe","year":"2011","unstructured":"Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, H\u00e4user W, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB (2011) Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol 38:1113\u20131122. https:\/\/doi.org\/10.3899\/jrheum.100594","journal-title":"J Rheumatol"},{"key":"6806_CR14","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.1523\/jneurosci.5223-05.2006","volume":"26","author":"YR Smith","year":"2006","unstructured":"Smith YR, Stohler CS, Nichols TE, Bueller JA, Koeppe RA, Zubieta J-K (2006) Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women. J Neurosci 26:5777\u20135785. https:\/\/doi.org\/10.1523\/jneurosci.5223-05.2006","journal-title":"J Neurosci"},{"key":"6806_CR15","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.15.21267864","author":"M Zawistowski","year":"2021","unstructured":"Zawistowski M, Fritsche LG, Pandit A, Vanderwerff B, Patil S, Schmidt EM, Vandehaar P, Brummett CM, Keterpal S, Zhou X, Boehnke M, Abecasis GR, Z\u00f6llner S (2021) The michigan genomics initiative: a biobank linking genotypes and electronic clinical records in michigan medicine patients. medRxiv. https:\/\/doi.org\/10.1101\/2021.12.15.21267864","journal-title":"medRxiv"},{"key":"6806_CR16","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1097\/ALN.0b013e3182a8eb1f","volume":"6","author":"CM Brummet","year":"2013","unstructured":"Brummet CM, Janda AM, Schueller CM, Tsodikov A, Morris M, Williams DA, Clauw DJ (2013) Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty. Anesthesiology 6:1434\u20131443","journal-title":"Anesthesiology"},{"key":"6806_CR17","doi-asserted-by":"publisher","first-page":"568.e561","DOI":"10.1016\/j.ajog.2021.08.038","volume":"225","author":"S As-Sanie","year":"2021","unstructured":"As-Sanie S, Till SR, Schrepf AD, Griffith KC, Tsodikov A, Missmer SA, Clauw DJ, Brummett CM (2021) Incidence and predictors of persistent pelvic pain following hysterectomy in women with chronic pelvic pain. Am J Obstet Gynecol 225:568.e561-568.e511. https:\/\/doi.org\/10.1016\/j.ajog.2021.08.038","journal-title":"Am J Obstet Gynecol"},{"key":"6806_CR18","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1097\/ALN.0000000000000637","volume":"122","author":"AM Janda","year":"2015","unstructured":"Janda AM, As-Sanie S, Rajala B, Tsodikov A, Moser SE, Clauw DJ, Brummett CM (2015) Fibromyalgia survey criteria are associated with increased postoperative opioid consumption in women undergoing hysterectomy. Anesthesiology 122:1103\u20131111","journal-title":"Anesthesiology"},{"key":"6806_CR19","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/art.24553","volume":"61","author":"F Wolfe","year":"2009","unstructured":"Wolfe F (2009) Fibromyalgianess. Arthritis Rheum 61:715\u2013716. https:\/\/doi.org\/10.1002\/art.24553","journal-title":"Arthritis Rheum"},{"key":"6806_CR20","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/art.39051","volume":"67","author":"CM Brummett","year":"2015","unstructured":"Brummett CM, Urquhart AG, Hassett AL, Tsodikov A, Hallstrom BR, Wood NI, Williams DA, Clauw DJ (2015) Characteristics of fibromyalgia independently predict poorer long-term analgesic outcomes following total knee and hip arthroplasty. Arthritis Rheumatol 67:1386\u20131394. https:\/\/doi.org\/10.1002\/art.39051","journal-title":"Arthritis Rheumatol"},{"key":"6806_CR21","volume-title":"Pain assessment: global use of the brief pain inventory","author":"CS Cleeland","year":"1994","unstructured":"Cleeland CS (1994) Pain assessment: global use of the brief pain inventory. Annals of the Academy of Medicine, Singapore"},{"key":"6806_CR22","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.3390\/ijms21165625","volume":"21","author":"S Tenti","year":"2020","unstructured":"Tenti S, Correale P, Cheleschi S, Fioravanti A, Pirtoli L (2020) Aromatase inhibitors\u2014induced musculoskeletal disorders: current knowledge on clinical and molecular aspects. Int J Mol Sci 21:5625. https:\/\/doi.org\/10.3390\/ijms21165625","journal-title":"Int J Mol Sci"},{"key":"6806_CR23","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1200\/jco.2017.74.6651","volume":"36","author":"NL Henry","year":"2018","unstructured":"Henry NL, Unger JM, Schott AF, Fehrenbacher L, Flynn PJ, Prow DM, Sharer CW, Burton GV, Kuzma CS, Moseley A, Lew DL, Fisch MJ, Moinpour CM, Hershman DL, Wade JL (2018) Randomized, multicenter, placebo-controlled clinical trial of duloxetine versus placebo for aromatase inhibitor-associated arthralgias in early-stage breast cancer: SWOG S1202. J Clin Oncol 36:326\u2013332. https:\/\/doi.org\/10.1200\/jco.2017.74.6651","journal-title":"J Clin Oncol"},{"key":"6806_CR24","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/s0140-6736(21)00392-5","volume":"397","author":"M-A Fitzcharles","year":"2021","unstructured":"Fitzcharles M-A, Cohen SP, Clauw DJ, Littlejohn G, Usui C, H\u00e4user W (2021) Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet 397:2098\u20132110. https:\/\/doi.org\/10.1016\/s0140-6736(21)00392-5","journal-title":"Lancet"},{"key":"6806_CR25","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1002\/cncr.32024","volume":"125","author":"NL Henry","year":"2019","unstructured":"Henry NL, Unger JM, Till C, Schott AF, Crew KD, Lew DL, Fisch MJ, Moinpour CM, Wade JL, Hershman DL (2019) Association between body mass index and response to duloxetine for aromatase inhibitor-associated musculoskeletal symptoms in SWOG S1202. Cancer 125:2123\u20132129. https:\/\/doi.org\/10.1002\/cncr.32024","journal-title":"Cancer"},{"key":"6806_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/jama.2018.8907","volume":"320","author":"DL Hershman","year":"2018","unstructured":"Hershman DL, Unger JM, Greenlee H, Capodice JL, Lew DL, Darke AK, Kengla AT, Melnik MK, Jorgensen CW, Kreisle WH, Minasian LM, Fisch MJ, Henry NL, Crew KD (2018) Effect of acupuncture vs sham acupuncture or waitlist control on joint pain related to aromatase inhibitors among women with early-stage breast cancer. JAMA 320:167\u2013176. https:\/\/doi.org\/10.1001\/jama.2018.8907","journal-title":"JAMA"},{"key":"6806_CR27","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1097\/j.pain.0000000000002113","volume":"162","author":"MA Shraim","year":"2021","unstructured":"Shraim MA, Masse-Alarie H, Hodges PW (2021) Methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system: a systematic review. Pain 162:1007\u20131037. https:\/\/doi.org\/10.1097\/j.pain.0000000000002113","journal-title":"Pain"},{"key":"6806_CR28","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","volume":"51","author":"MHJ Van Den Beuken-Van Everdingen","year":"2016","unstructured":"Van Den Beuken-Van Everdingen MHJ, Hochstenbach LMJ, Joosten EAJ, Tjan-Heijnen VCG, Janssen DJA (2016) Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manage 51:1070-1090.e1079. https:\/\/doi.org\/10.1016\/j.jpainsymman.2015.12.340","journal-title":"J Pain Symptom Manage"},{"key":"6806_CR29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1054\/jpai.2003.1","volume":"4","author":"MP Jensen","year":"2003","unstructured":"Jensen MP (2003) The validity and reliability of pain measures in adults with cancer. J Pain 4:2\u201321. https:\/\/doi.org\/10.1054\/jpai.2003.1","journal-title":"J Pain"},{"key":"6806_CR30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.pain.2010.02.018","volume":"149","author":"RH Dworkin","year":"2010","unstructured":"Dworkin RH, Turk DC, Peirce-Sandner S, Baron R, Bellamy N, Burke LB, Chappell A, Chartier K, Cleeland CS, Costello A, Cowan P, Dimitrova R, Ellenberg S, Farrar JT, French JA, Gilron I, Hertz S, Jadad AR, Jay GW, Kalliomaki J, Katz NP, Kerns RD, Manning DC, McDermott MP, McGrath PJ, Narayana A, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Reeve BB, Rhodes T, Sampaio C, Simpson DM, Stauffer JW, Stucki G, Tobias J, White RE, Witter J (2010) Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. Pain 149:177\u2013193. https:\/\/doi.org\/10.1016\/j.pain.2010.02.018","journal-title":"Pain"},{"key":"6806_CR31","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1093\/pm\/pnab077","volume":"22","author":"DE Harper","year":"2021","unstructured":"Harper DE, Sayre K, Schrepf A, Clauw DJ, Aronovich S (2021) Impact of fibromyalgia phenotype in temporomandibular disorders. Pain Med 22:2050\u20132056. https:\/\/doi.org\/10.1093\/pm\/pnab077","journal-title":"Pain Med"},{"key":"6806_CR32","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1002\/art.40451","volume":"70","author":"N Basu","year":"2018","unstructured":"Basu N, Kaplan CM, Ichesco E, Larkin T, Harris RE, Murray A, Waiter G, Clauw DJ (2018) Neurobiologic features of fibromyalgia are also present among rheumatoid arthritis patients. Arthritis Rheumatol 70:1000\u20131007. https:\/\/doi.org\/10.1002\/art.40451","journal-title":"Arthritis Rheumatol"},{"key":"6806_CR33","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/brain\/awab336","volume":"145","author":"Z Alshelh","year":"2022","unstructured":"Alshelh Z, Brusaferri L, Saha A, Morrissey E, Knight P, Kim M, Zhang Y, Hooker JM, Albrecht D, Torrado-Carvajal A, Placzek MS, Akeju O, Price J, Edwards RR, Lee J, Sclocco R, Catana C, Napadow V, Loggia ML (2022) Neuroimmune signatures in chronic low back pain subtypes. Brain 145:1098\u20131110. https:\/\/doi.org\/10.1093\/brain\/awab336","journal-title":"Brain"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06806-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-022-06806-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-022-06806-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:25:49Z","timestamp":1672982749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-022-06806-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,13]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["6806"],"URL":"https:\/\/doi.org\/10.1007\/s10549-022-06806-x","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,13]]},"assertion":[{"value":"28 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NLH reports research contracting to her institution from Blue Note Therapeutics, consulting from Myovant Pharmaceuticals, and royalties from Up-to-Date, none of which are related to this work. CMB is a consultant for Heron Therapeutics, Vertex Pharmaceuticals, Alosa Health and Benter Foundation; and he provides expert medical testimony, none of which are related to this work. The remaining authors have no disclosures to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"MGI was approved by the Institutional Review Board at the University of Michigan (IRBMED; HUM00028683), and this exploratory analysis was granted an exemption from IRBMED (HUM00169453).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the MGI study for participation and publishing.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}