{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:04:25Z","timestamp":1789002265554,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10549-023-07181-x","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T11:02:37Z","timestamp":1701946957000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between prediabetes and breast cancer: a comprehensive meta-analysis"],"prefix":"10.1007","volume":"204","author":[{"given":"Praneeth Reddy","family":"Keesari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-4246","authenticated-orcid":false,"given":"Akhil","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendranath Reddy","family":"Ganampet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guna Sowmya Durga","family":"Subhasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Edusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Muslehuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyein Wint Yee","family":"Theik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spandana","family":"Palisetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Salibindla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritika Singh","family":"Manaktala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"1","key":"7181_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA A Cancer J Clin 73(1):17\u201348","journal-title":"CA A Cancer J Clin"},{"issue":"3","key":"7181_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"7181_CR3","unstructured":"World Health Organization (WHO) (2019) Cancer prevention. https:\/\/www.who.int\/cancer\/prevention\/en\/. Accessed 24 May 2019"},{"issue":"7","key":"7181_CR4","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.2337\/dc10-0666","volume":"33","author":"E Giovannucci","year":"2010","unstructured":"Giovannucci E, Harlan DM, Archer MC et al (2010) Diabetes and cancer: a consensus report. Diabetes Care 33(7):1674\u20131685","journal-title":"Diabetes Care"},{"issue":"11","key":"7181_CR5","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1007\/s00125-014-3361-2","volume":"57","author":"Y Huang","year":"2014","unstructured":"Huang Y, Cai X, Qiu M et al (2014) Prediabetes and the risk of cancer: a meta-analysis. Diabetologia 57(11):2261\u20132269","journal-title":"Diabetologia"},{"issue":"5","key":"7181_CR6","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/jcp.25579","volume":"232","author":"A Crispo","year":"2017","unstructured":"Crispo A, Augustin LSA, Grimaldi M et al (2017) Risk differences between prediabetes and diabetes according to breast cancer molecular subtypes. J Cell Physiol 232(5):1144\u20131150","journal-title":"J Cell Physiol"},{"issue":"1","key":"7181_CR7","doi-asserted-by":"publisher","first-page":"e001600","DOI":"10.1136\/bmjdrc-2020-001600","volume":"8","author":"CT Rentsch","year":"2020","unstructured":"Rentsch CT, Farmer RE, Eastwood SV et al (2020) Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank. BMJ Open Diabet Res Care 8(1):e001600","journal-title":"BMJ Open Diabet Res Care"},{"issue":"3","key":"7181_CR8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s10549-006-9166-3","volume":"98","author":"LL Lipscombe","year":"2006","unstructured":"Lipscombe LL, Goodwin PJ, Zinman B, McLaughlin JR, Hux JE (2006) Increased prevalence of prior breast cancer in women with newly diagnosed diabetes. Breast Cancer Res Treat 98(3):303\u2013309","journal-title":"Breast Cancer Res Treat"},{"key":"7181_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3389\/fonc.2017.00110","volume":"7","author":"GV Dall","year":"2017","unstructured":"Dall GV, Britt KL (2017) Estrogen effects on the mammary gland in early and late life and breast cancer risk. Front Oncol 7:110","journal-title":"Front Oncol"},{"key":"7181_CR10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fendo.2013.00037","volume":"4","author":"ME Cerf","year":"2013","unstructured":"Cerf ME (2013) Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) 4:37","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"7181_CR11","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.2337\/dc10-0666","volume":"33","author":"E Giovannucci","year":"2010","unstructured":"Giovannucci E, Harlan DM, Archer MC et al (2010) Diabetes and cancer. Diabet Care 33(7):1674\u20131685","journal-title":"Diabet Care"},{"key":"7181_CR12","doi-asserted-by":"publisher","first-page":"g7607","DOI":"10.1136\/bmj.g7607","volume":"350","author":"KK Tsilidis","year":"2015","unstructured":"Tsilidis KK, Kasimis JC, Lopez DS, Ntzani EE, Ioannidis JPA (2015) Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies. BMJ. 350:g7607\u2013g7607","journal-title":"BMJ."},{"issue":"5","key":"7181_CR13","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1172\/JCI114868","volume":"86","author":"V Papa","year":"1990","unstructured":"Papa V, Pezzino V, Costantino A et al (1990) Elevated insulin receptor content in human breast cancer. J Clin Invest 86(5):1503\u20131510","journal-title":"J Clin Invest"},{"issue":"9113","key":"7181_CR14","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0140-6736(97)10384-1","volume":"351","author":"SE Hankinson","year":"1998","unstructured":"Hankinson SE, Willett WC, Colditz GA et al (1998) Circulating concentrations of insulin-like growth factor I and risk of breast cancer. The Lancet 351(9113):1393\u20131396","journal-title":"The Lancet"},{"issue":"5","key":"7181_CR15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.2174\/156800907781386623","volume":"7","author":"SD Hursting","year":"2007","unstructured":"Hursting SD, Lashinger LM, Colbert LH et al (2007) Energy balance and carcinogenesis: underlying pathways and targets for intervention. Curr Cancer Drug Targets 7(5):484\u2013491","journal-title":"Curr Cancer Drug Targets"},{"issue":"6917","key":"7181_CR16","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860\u2013867","journal-title":"Nature"},{"issue":"3","key":"7181_CR17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.cmet.2017.01.008","volume":"25","author":"C Mauro","year":"2017","unstructured":"Mauro C, Smith J, Cucchi D et al (2017) Obesity-induced metabolic stress leads to biased effector memory cd4 + t cell differentiation via pi3k p110\u03b4-akt-mediated signals. Cell Metab 25(3):593\u2013609","journal-title":"Cell Metab"},{"issue":"5","key":"7181_CR18","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.trecan.2018.03.004","volume":"4","author":"E Lengyel","year":"2018","unstructured":"Lengyel E, Makowski L, DiGiovanni J, Kolonin MG (2018) Cancer as a matter of fat: the crosstalk between adipose tissue and tumors. Trends Cancer 4(5):374\u2013384","journal-title":"Trends Cancer"},{"issue":"5","key":"7181_CR19","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.arcmed.2014.06.004","volume":"45","author":"AM Salinas-Mart\u00ednez","year":"2014","unstructured":"Salinas-Mart\u00ednez AM, Flores-Cort\u00e9s LI, Cardona-Chavarr\u00eda JM et al (2014) Prediabetes, diabetes, and risk of breast cancer: a case-control study. Arch Med Res 45(5):432\u2013438","journal-title":"Arch Med Res"},{"issue":"1","key":"7181_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S0014-5793(99)00339-7","volume":"448","author":"A Rehman","year":"1999","unstructured":"Rehman A, Nourooz-Zadeh J, M\u00f6ller W, Tritschler H, Pereira P, Halliwell B (1999) Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus. FEBS Lett 448(1):120\u2013122","journal-title":"FEBS Lett"},{"issue":"6","key":"7181_CR21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/jnci\/djs648","volume":"105","author":"G Xue","year":"2013","unstructured":"Xue G, Hemmings BA (2013) Pkb\/akt-dependent regulation of cell motility. JNCI J Natl Cancer Inst 105(6):393\u2013404","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"1","key":"7181_CR22","doi-asserted-by":"publisher","first-page":"7758","DOI":"10.1038\/srep07758","volume":"5","author":"ZY Yang","year":"2015","unstructured":"Yang ZY, Di MY, Yuan JQ et al (2015) The prognostic value of phosphorylated Akt in breast cancer: a systematic review. Sci Rep 5(1):7758","journal-title":"Sci Rep"},{"issue":"3","key":"7181_CR23","first-page":"239","volume":"4","author":"K Hirose","year":"2003","unstructured":"Hirose K, Toyama T, Iwata H, Takezaki T, Hamajima N, Tajima K (2003) Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pac J Cancer Prev 4(3):239\u2013246","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6","key":"7181_CR24","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.annepidem.2007.01.037","volume":"17","author":"ML Garmendia","year":"2007","unstructured":"Garmendia ML, Pereira A, Alvarado ME, Atalah E (2007) Relation between insulin resistance and breast cancer among Chilean women. Ann Epidemiol 17(6):403\u2013409","journal-title":"Ann Epidemiol"},{"issue":"11","key":"7181_CR25","first-page":"1207","volume":"10","author":"G Yang","year":"2001","unstructured":"Yang G, Lu G, Jin F et al (2001) Population-based, case-control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10(11):1207\u20131211","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"7181_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00592-019-01396-5","volume":"57","author":"D Kobayashi","year":"2020","unstructured":"Kobayashi D, Kuriyama N, Noto H, Aida A, Takahashi O, Shimbo T (2020) Development of malignancies and changes in time-dependent hemoglobin A1c among a nondiabetic population: longitudinal analysis. Acta Diabetol 57(2):189\u2013196","journal-title":"Acta Diabetol"},{"issue":"5","key":"7181_CR27","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1158\/0008-5472.CAN-05-3922","volume":"66","author":"J Lin","year":"2006","unstructured":"Lin J, Ridker PM, Rifai N et al (2006) A prospective study of hemoglobin A1c concentrations and risk of breast cancer in women. Cancer Res 66(5):2869\u20132875","journal-title":"Cancer Res"},{"issue":"6","key":"7181_CR28","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.2337\/diacare.26.6.1752","volume":"26","author":"KB Michels","year":"2003","unstructured":"Michels KB, Solomon CG, Hu FB et al (2003) Type 2 diabetes and subsequent incidence of breast cancer in the nurses\u2019 health study. Diabetes Care 26(6):1752\u20131758","journal-title":"Diabetes Care"},{"issue":"46","key":"7181_CR29","doi-asserted-by":"publisher","first-page":"35893","DOI":"10.1074\/jbc.M006741200","volume":"275","author":"J Dupont","year":"2000","unstructured":"Dupont J, Karas M, LeRoith D (2000) The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. J Biol Chem 275(46):35893\u201335901","journal-title":"J Biol Chem"},{"issue":"28","key":"7181_CR30","doi-asserted-by":"publisher","first-page":"25823","DOI":"10.1074\/jbc.M100925200","volume":"276","author":"A Lai","year":"2001","unstructured":"Lai A, Sarcevic B, Prall OW, Sutherland RL (2001) Insulin\/insulin-like growth factor-I and estrogen cooperate to stimulate cyclin E-Cdk2 activation and cell Cycle progression in MCF-7 breast cancer cells through differential regulation of cyclin E and p21(Waf1\/cip1). J Biol Chem 276(28):25823\u201325833","journal-title":"J Biol Chem"},{"issue":"18","key":"7181_CR31","first-page":"6747","volume":"61","author":"M Bartucci","year":"2001","unstructured":"Bartucci M, Morelli C, Mauro L, And\u00f2 S, Surmacz E (2001) Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (Er)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Cancer Res 61(18):6747\u20136754","journal-title":"Cancer Res"},{"issue":"3","key":"7181_CR32","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s10549-008-9958-8","volume":"113","author":"AE Cust","year":"2009","unstructured":"Cust AE, Stocks T, Lukanova A et al (2009) The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study. Breast Cancer Res Treat 113(3):567\u2013576","journal-title":"Breast Cancer Res Treat"},{"issue":"9","key":"7181_CR33","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1089\/met.2014.0071","volume":"12","author":"HF Cordero-Franco","year":"2014","unstructured":"Cordero-Franco HF, Salinas-Mart\u00ednez AM, Abundis A, Espinosa-Flores EM, V\u00e1zquez-Lara J, Guerrero-Romero F (2014) The effect of insulin resistance on breast cancer risk in Latinas of Mexican origin. Metab Syndr Relat Disord 12(9):477\u2013483","journal-title":"Metab Syndr Relat Disord"},{"issue":"2","key":"7181_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/CEJ.0b013e32836162aa","volume":"23","author":"AA Onitilo","year":"2014","unstructured":"Onitilo AA, Stankowski RV, Berg RL et al (2014) Breast cancer incidence before and after diagnosis of type 2 diabetes mellitus in women: increased risk in the prediabetes phase. Eur J Cancer Prev 23(2):76\u201383","journal-title":"Eur J Cancer Prev"},{"key":"7181_CR35","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/978-3-642-38007-5_21","volume":"159","author":"A Leone","year":"2014","unstructured":"Leone A, Di Gennaro E, Bruzzese F, Avallone A, Budillon A (2014) New perspective for an old antidiabetic drug: metformin as anticancer agent. Cancer Treat Res 159:355\u2013376","journal-title":"Cancer Treat Res"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-023-07181-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-023-07181-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-023-07181-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T11:23:06Z","timestamp":1706008986000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-023-07181-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["7181"],"URL":"https:\/\/doi.org\/10.1007\/s10549-023-07181-x","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"assertion":[{"value":"23 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"We used publically available anonymous published articles from scientific journals and therefore did not require Institutional Review Board approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"We used publicly available anonymously published articles from scientific journals without any way to trace the identity of the patients and therefore informed consent was not obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}