{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:49:48Z","timestamp":1789516188544,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["CA244670"],"award-info":[{"award-number":["CA244670"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s10549-024-07306-w","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:35:31Z","timestamp":1713929731000},"page":"295-305","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization"],"prefix":"10.1007","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-0806","authenticated-orcid":false,"given":"Cameron B.","family":"Haas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Gago-Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Castelao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjeet K.","family":"Bolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Michailidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Dunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis C.","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Marie","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Fasching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Haeberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Garcia-Closas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ahearn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen L.","family":"Gierach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Haiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertraud","family":"Maskarinec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J.","family":"Couch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geogia","family":"Chenevix-Trench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Berrington de Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristan J.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Wernli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Vachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"issue":"1","key":"7306_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrclinonc.2011.173","volume":"9","author":"V Assi","year":"2012","unstructured":"Assi V, Warwick J, Cuzick J, Duffy SW (2012) Clinical and epidemiological issues in mammographic density. Nat Rev Clin Oncol 9(1):33\u201340","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"7306_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10549-007-9840-0","volume":"112","author":"LM Butler","year":"2008","unstructured":"Butler LM, Gold EB, Greendale GA, Crandall CJ, Modugno F, Oestreicher N, Quesenberry CP, Habel LA (2008) Menstrual and reproductive factors in relation to mammographic density: the Study of Women\u2019s Health Across the Nation (SWAN). Breast Cancer Res Treat 112(1):165\u2013174","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"7306_CR3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10552-011-9733-8","volume":"22","author":"P Tehranifar","year":"2011","unstructured":"Tehranifar P, Reynolds D, Flom J, Fulton L, Liao Y, Kudadjie-Gyamfi E, Terry MB (2011) Reproductive and menstrual factors and mammographic density in African American, Caribbean, and white women. Cancer Causes Control 22(4):599\u2013610","journal-title":"Cancer Causes Control"},{"issue":"12","key":"7306_CR4","first-page":"2395","volume":"22","author":"TL Nguyen","year":"2013","unstructured":"Nguyen TL, Schmidt DF, Makalic E, Dite GS, Stone J, Apicella C, Bui M, Macinnis RJ, Odefrey F, Cawson JN et al (2013) Explaining variance in the cumulus mammographic measures that predict breast cancer risk: a twins and sisters study. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 22(12):2395\u20132403","journal-title":"Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol"},{"issue":"11","key":"7306_CR5","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1002\/ijc.22971","volume":"121","author":"Y Bremnes","year":"2007","unstructured":"Bremnes Y, Ursin G, Bjurstam N, Rinaldi S, Kaaks R, Gram IT (2007) Endogenous sex hormones, prolactin and mammographic density in postmenopausal Norwegian women. Int J Cancer 121(11):2506\u20132511","journal-title":"Int J Cancer"},{"issue":"5","key":"7306_CR6","doi-asserted-by":"publisher","first-page":"dju078","DOI":"10.1093\/jnci\/dju078","volume":"106","author":"A Pettersson","year":"2014","unstructured":"Pettersson A, Graff RE, Ursin G, Santos Silva ID, McCormack V, Baglietto L, Vachon C, Bakker MF, Giles GG, Chia KS et al (2014) Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 106(5):dju078","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"7306_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s12672-017-0321-6","volume":"9","author":"KA Bertrand","year":"2018","unstructured":"Bertrand KA, Eliassen AH, Hankinson SE, Rosner BA, Tamimi RM (2018) Circulating hormones and mammographic density in premenopausal women. Horm Cancer 9(2):117\u2013127","journal-title":"Horm Cancer"},{"issue":"3","key":"7306_CR8","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/ije\/dyz124","volume":"48","author":"BNS Ooi","year":"2019","unstructured":"Ooi BNS, Loh H, Ho PJ, Milne RL, Giles G, Gao C, Kraft P, John EM, Swerdlow A, Brenner H et al (2019) The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis. Int J Epidemiol 48(3):781\u2013794","journal-title":"Int J Epidemiol"},{"issue":"11 Pt 1","key":"7306_CR9","first-page":"2641","volume":"14","author":"RM Tamimi","year":"2005","unstructured":"Tamimi RM, Hankinson SE, Colditz GA, Byrne C (2005) Endogenous sex hormone levels and mammographic density among postmenopausal women. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 14(11 Pt 1):2641\u20132647","journal-title":"Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol"},{"issue":"4 Pt 1","key":"7306_CR10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00004","volume":"130","author":"JA Cauley","year":"1999","unstructured":"Cauley JA, Lucas FL, Kuller LH, Stone K, Browner W, Cummings SR (1999) Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group. Ann Intern Med 130(4 Pt 1):270\u2013277","journal-title":"Ann Intern Med"},{"issue":"8","key":"7306_CR11","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/jnci\/94.8.606","volume":"94","author":"T Key","year":"2002","unstructured":"Key T, Appleby P, Barnes I, Reeves G, Endogenous Hormones, Breast Cancer Collaborative Group (2002) Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94(8):606\u2013616","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"7306_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12672-009-0003-0","volume":"1","author":"SE Hankinson","year":"2010","unstructured":"Hankinson SE, Eliassen AH (2010) Circulating sex steroids and breast cancer risk in premenopausal women. Horm Cancer 1(1):2\u201310","journal-title":"Horm Cancer"},{"issue":"4","key":"7306_CR13","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1258\/136218006779160436","volume":"12","author":"NF Boyd","year":"2006","unstructured":"Boyd NF, Martin LJ, Yaffe MJ, Minkin S (2006) Mammographic density: a hormonally responsive risk factor for breast cancer. J Br Menopause Soc 12(4):186\u2013193","journal-title":"J Br Menopause Soc"},{"issue":"8","key":"7306_CR14","first-page":"1502","volume":"15","author":"R Warren","year":"2006","unstructured":"Warren R, Skinner J, Sala E, Denton E, Dowsett M, Folkerd E, Healey CS, Dunning A, Doody D, Ponder B et al (2006) Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 15(8):1502\u20131508","journal-title":"Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol"},{"issue":"8","key":"7306_CR15","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/sj.bjc.6600537","volume":"87","author":"NF Boyd","year":"2002","unstructured":"Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S (2002) The association of breast mitogens with mammographic densities. Br J Cancer 87(8):876\u2013882","journal-title":"Br J Cancer"},{"issue":"9","key":"7306_CR16","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/aje\/kwi286","volume":"162","author":"GA Greendale","year":"2005","unstructured":"Greendale GA, Palla SL, Ursin G, Laughlin GA, Crandall C, Pike MC, Reboussin BA (2005) The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen\/Progestin Interventions Mammographic Density Study. Am J Epidemiol 162(9):826\u2013834","journal-title":"Am J Epidemiol"},{"issue":"7","key":"7306_CR17","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s10552-009-9321-3","volume":"20","author":"M Yong","year":"2009","unstructured":"Yong M, Atkinson C, Newton KM, Aiello Bowles EJ, Stanczyk FZ, Westerlind KC, Holt VL, Schwartz SM, Leisenring WM, Lampe JW (2009) Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women. Cancer Causes Control 20(7):1039\u20131053","journal-title":"Cancer Causes Control"},{"issue":"3","key":"7306_CR18","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10552-014-0339-9","volume":"25","author":"MJ Borugian","year":"2014","unstructured":"Borugian MJ, Spinelli JJ, Gordon PB, Abanto Z, Brooks-Wilson A, Pollak MN, Warren LJ, Hislop TG, Gallagher RP (2014) Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada). Cancer Causes Control 25(3):385\u2013394","journal-title":"Cancer Causes Control"},{"issue":"1","key":"7306_CR19","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10549-013-2534-x","volume":"139","author":"CG Woolcott","year":"2013","unstructured":"Woolcott CG, Courneya KS, Boyd NF, Yaffe MJ, McTiernan A, Brant R, Jones CA, Stanczyk FZ, Terry T, Cook LS et al (2013) Association between sex hormones, glucose homeostasis, adipokines, and inflammatory markers and mammographic density among postmenopausal women. Breast Cancer Res Treat 139(1):255\u2013265","journal-title":"Breast Cancer Res Treat"},{"issue":"2\u20133","key":"7306_CR20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12672-015-0216-3","volume":"6","author":"GL Gierach","year":"2015","unstructured":"Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP et al (2015) Relationship of serum estrogens and metabolites with area and volume mammographic densities. Horm Cancer 6(2\u20133):107\u2013119","journal-title":"Horm Cancer"},{"issue":"1","key":"7306_CR21","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s12672-010-0056-0","volume":"2","author":"BL Sprague","year":"2011","unstructured":"Sprague BL, Trentham-Dietz A, Gangnon RE, Buist DSM, Burnside ES, Bowles EJA, Stanczyk FZ, Sisney GS (2011) Circulating sex hormones and mammographic breast density among postmenopausal women. Horm Cancer 2(1):62\u201372","journal-title":"Horm Cancer"},{"issue":"7726","key":"7306_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","volume":"562","author":"C Bycroft","year":"2018","unstructured":"Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O\u2019Connell J et al (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562(7726):203\u2013209","journal-title":"Nature"},{"issue":"7538","key":"7306_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature14177","volume":"518","author":"AE Locke","year":"2015","unstructured":"Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J et al (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197\u2013206","journal-title":"Nature"},{"issue":"1","key":"7306_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13058-022-01524-0","volume":"24","author":"H Chen","year":"2022","unstructured":"Chen H, Fan S, Stone J, Thompson DJ, Douglas J, Li S, Scott C, Bolla MK, Wang Q, Dennis J et al (2022) Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci. Breast Cancer Res 24(1):27\u201327","journal-title":"Breast Cancer Res"},{"issue":"2","key":"7306_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","volume":"26","author":"KS Ruth","year":"2020","unstructured":"Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS et al (2020) Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med 26(2):252\u2013258","journal-title":"Nat Med"},{"issue":"4","key":"7306_CR26","doi-asserted-by":"publisher","first-page":"bqac020","DOI":"10.1210\/endocr\/bqac020","volume":"163","author":"CB Haas","year":"2022","unstructured":"Haas CB, Hsu L, Lampe JW, Wernli KJ, Lindstr\u00f6m S (2022) Cross-ancestry genome-wide association studies of sex hormone concentrations in pre- and postmenopausal women. Endocrinology 163(4):bqac020","journal-title":"Endocrinology"},{"key":"7306_CR27","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","volume":"4","author":"S Burgess","year":"2019","unstructured":"Burgess S, Davey Smith G, Davies NM, Dudbridge F, Gill D, Glymour MM, Hartwig FP, Holmes MV, Minelli C, Relton CL, Theodoratou E (2019) Guidelines for performing Mendelian randomization investigations. Wellcome Open Res 4:186\u2013186","journal-title":"Wellcome Open Res"},{"issue":"3","key":"7306_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Daly MJ, Price AL, Neale BM (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47(3):291\u2013295","journal-title":"Nat Genet"},{"issue":"11","key":"7306_CR29","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/ng.3404","volume":"47","author":"HK Finucane","year":"2015","unstructured":"Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, Loh P-R, Anttila V, Xu H, Zang C, Farh K et al (2015) Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet 47(11):1228\u20131235","journal-title":"Nat Genet"},{"issue":"2","key":"7306_CR30","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/bioinformatics\/btw613","volume":"33","author":"J Zheng","year":"2017","unstructured":"Zheng J, Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L, Haycock PC, Hemani G, Tansey K, Laurin C, Pourcain BS et al (2017) LDHub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33(2):272\u2013279","journal-title":"Bioinformatics"},{"key":"7306_CR31","unstructured":"Neale B (2019) Rapid Gwas Of Thousands Of Phenotypes For 337,000 Samples In The Uk Biobank [Internet] 2019. Available from: https:\/\/www.nealelab.is\/blog\/2017\/7\/19\/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank"},{"issue":"5","key":"7306_CR32","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1177\/0962280215597579","volume":"26","author":"S Burgess","year":"2017","unstructured":"Burgess S, Small DS, Thompson SG (2017) A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res 26(5):2333\u20132355","journal-title":"Stat Methods Med Res"},{"issue":"2","key":"7306_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/art.41517","volume":"73","author":"B Tang","year":"2021","unstructured":"Tang B, Shi H, Alfredsson L, Klareskog L, Padyukov L, Jiang X (2021) Obesity-related traits and the development of rheumatoid arthritis: evidence from genetic data. Arthritis Rheumatol 73(2):203\u2013211","journal-title":"Arthritis Rheumatol"},{"key":"7306_CR34","unstructured":"Yavorska O, Staley J (2017) MendelianRandomization: Mendelian Randomization Package. R package version 041"},{"issue":"4","key":"7306_CR35","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","volume":"181","author":"S Burgess","year":"2015","unstructured":"Burgess S, Thompson SG (2015) Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol 181(4):251\u2013260","journal-title":"Am J Epidemiol"},{"issue":"5","key":"7306_CR36","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/sj.bjc.6606085","volume":"104","author":"CS Wong","year":"2011","unstructured":"Wong CS, Lim GH, Gao F, Jakes RW, Offman J, Chia KS, Duffy SW (2011) Mammographic density and its interaction with other breast cancer risk factors in an Asian population. Br J Cancer 104(5):871\u2013874","journal-title":"Br J Cancer"},{"issue":"1","key":"7306_CR37","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13058-016-0756-7","volume":"18","author":"MC Busana","year":"2016","unstructured":"Busana MC, Eng A, Denholm R, Dowsett M, Vinnicombe S, Allen S, Dos-Santos-Silva I (2016) Impact of type of full-field digital image on mammographic density assessment and breast cancer risk estimation: a case\u2013control study. Breast Cancer Res 18(1):96\u201396","journal-title":"Breast Cancer Res"},{"issue":"8","key":"7306_CR38","first-page":"2273","volume":"18","author":"AA Arslan","year":"2009","unstructured":"Arslan AA, Shore RE, Afanasyeva Y, Koenig KL, Toniolo P, Zeleniuch-Jacquotte A (2009) Circulating estrogen metabolites and risk for breast cancer in premenopausal women. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 18(8):2273\u20132279","journal-title":"Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol"},{"issue":"6","key":"7306_CR39","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1530\/ERC-14-0250","volume":"21","author":"L Quan","year":"2014","unstructured":"Quan L, Hong C-C, Zirpoli G, Roberts MR, Khoury T, Sucheston-Campbell LE, Bovbjerg DH, Jandorf L, Pawlish K, Ciupak G et al (2014) Variants of estrogen-related genes and breast cancer risk in European and African American women. Endocr Relat Cancer 21(6):853\u2013864","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"7306_CR40","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.18632\/oncotarget.13484","volume":"8","author":"MS Shawky","year":"2017","unstructured":"Shawky MS, Martin H, Hugo HJ, Lloyd T, Britt KL, Redfern A, Thompson EW (2017) Mammographic density: a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies. Oncotarget 8(3):5578\u20135591","journal-title":"Oncotarget"},{"issue":"8","key":"7306_CR41","doi-asserted-by":"publisher","first-page":"e1002105","DOI":"10.1371\/journal.pmed.1002105","volume":"13","author":"Y Guo","year":"2016","unstructured":"Guo Y, Warren Andersen S, Shu X-O, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL, Schmidt MK, Chang-Claude J et al (2016) Genetically predicted body mass index and breast cancer risk: Mendelian randomization analyses of data from 145,000 women of European descent. PLoS Med 13(8):e1002105","journal-title":"PLoS Med"},{"issue":"20","key":"7306_CR42","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.3390\/cancers13205053","volume":"13","author":"D Freuer","year":"2021","unstructured":"Freuer D, Linseisen J, O\u2019Mara TA, Leitzmann M, Baurecht H, Baumeister S-E, Meisinger C (2021) Body fat distribution and risk of breast, endometrial, and ovarian cancer: a two-sample Mendelian randomization study. Cancers 13(20):5053","journal-title":"Cancers"},{"issue":"1","key":"7306_CR43","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/s41598-021-04401-6","volume":"12","author":"HA Amin","year":"2022","unstructured":"Amin HA, Kaewsri P, Yiorkas AM, Cooke H, Blakemore AI, Drenos F (2022) Mendelian randomisation analyses of UK Biobank and published data suggest that increased adiposity lowers risk of breast and prostate cancer. Sci Rep 12(1):909\u2013909","journal-title":"Sci Rep"},{"issue":"2","key":"7306_CR44","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1158\/1055-9965.EPI-09-0532","volume":"19","author":"L Baglietto","year":"2010","unstructured":"Baglietto L, Severi G, English DR, Krishnan K, Hopper JL, McLean C, Morris HA, Tilley WD, Giles GG (2010) Circulating steroid hormone levels and risk of breast cancer for postmenopausal women. Cancer Epidemiol Biomarkers Prev 19(2):492\u2013502","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"7306_CR45","unstructured":"Endogenous Hormones, Breast Cancer Collaborative Group, Key TJ, Appleby PN, Reeves GK, Roddam AW, Helzlsouer KJ, Alberg AJ, Rollison DE, Dorgan JF et al (2011) Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer 105(5):709\u2013722"},{"issue":"1","key":"7306_CR46","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1186\/1471-2407-10-636","volume":"10","author":"I Dumas","year":"2010","unstructured":"Dumas I, Diorio C (2010) Polymorphisms in genes involved in the estrogen pathway and mammographic density. BMC Cancer 10(1):636\u2013636","journal-title":"BMC Cancer"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-024-07306-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-024-07306-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-024-07306-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:09:04Z","timestamp":1718683744000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-024-07306-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["7306"],"URL":"https:\/\/doi.org\/10.1007\/s10549-024-07306-w","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The family name of the 30th author was incorrect. Now it has been corrected from de Gonzalez to Berrington de Gonzalez","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. This is an observational study using publicly available published estimates and no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}