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VS: Received research grants to institution from Abbvie, Biocept, Pfizer, Novartis, Puma Biotechnology, and QUE Oncology (previous); In kind clinical trial assays from Foundation Medicine (previous); Chair, Data Safety Monitoring Board, AstraZeneca (current), all outside the submitted work. CS: Research funding from Pfizer (current) and Genentech (previous) and consulting fees from Shionogi, all outside the submitted work. KLS: Received research grants to institution from Pfizer (previous), was previously employed at AstraZeneca, currently employed at Merck, has stock in Merck, and spouse has stock in Abbvie and ABT Labs, all outside the submitted work. The following authors reported no conflicts: RC, ALB, ES, AF, JJ, CH, JB, JE, MS, RS, SPC, MW, MA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The project was approved as a quality improvement effort by the Johns Hopkins School of Medicine Institutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}