{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:32:37Z","timestamp":1784287957434,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA218429"],"award-info":[{"award-number":["R01CA218429"]}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"crossref","award":["BCRF-23-140"],"award-info":[{"award-number":["BCRF-23-140"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To study the association between clinicopathologic characteristics of ductal carcinoma in situ (DCIS) and risk of subsequent invasive breast cancer (IBC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a case\u2013control study nested in a multicenter, population-based cohort of 8175 women aged \u2265\u200918\u00a0years with DCIS diagnosed between 1987 and 2016 and followed for a median duration of 83\u00a0months. Cases (n\u2009=\u2009497) were women with a first diagnosis of DCIS who developed a subsequent IBC\u2009\u2265\u20096\u00a0months later; controls (2\/case; n\u2009=\u2009959) were matched to cases on age at and calendar year of DCIS diagnosis. Univariable and multivariable conditional logistic regression models were used to examine the associations between the DCIS characteristics of interest (non-screen detection of DCIS, tumor size, positive margins, grade of DCIS, necrosis, architectural pattern, microcalcification, and estrogen\u00a0receptor (ER), progesterone\u00a0receptor\u00a0(PR), and human epidermal growth factor receptor 2 (HER2) status) and risk of IBC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the total study population, the associations were largely null. In subgroup analyses, there were strong position associations with punctate necrosis (pre\/perimenopausal women), detection by physical exam (postmenopausal women), architectural patterns other than the main types (breast-conserving surgery [BCS]), and DCIS margins (ipsilateral cases), and inverse associations with HER2 positivity (BCS) and microcalcification (mastectomy); however, the associated confidence intervals were mostly very wide.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The results of this study provide limited support for associations of the DCIS clinicopathologic characteristics studied here and risk of IBC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10549-024-07599-x","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T15:24:30Z","timestamp":1737386670000},"page":"615-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathologic characteristics of ductal carcinoma in situ and risk of subsequent invasive breast cancer: a multicenter, population-based cohort study"],"prefix":"10.1007","volume":"210","author":[{"given":"Thomas E.","family":"Rohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Couch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Spencer","family":"Feigelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Greenlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Chitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Loudig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"7","key":"7599_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/s41379-019-0204-1","volume":"32","author":"WM Hanna","year":"2019","unstructured":"Hanna WM, Parra-Herran C, Lu FI, Slodkowska E, Rakovitch E, Nofech-Mozes S (2019) Ductal carcinoma in situ of the breast: an update for the pathologist in the era of individualized risk assessment and tailored therapies. Mod Pathol 32(7):896\u2013915. https:\/\/doi.org\/10.1038\/s41379-019-0204-1","journal-title":"Mod Pathol"},{"issue":"5","key":"7599_CR2","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.ajpath.2019.03.002","volume":"189","author":"WB Coleman","year":"2019","unstructured":"Coleman WB (2019) Breast ductal carcinoma in situ: precursor to invasive breast cancer. Am J Pathol 189(5):942\u2013945. https:\/\/doi.org\/10.1016\/j.ajpath.2019.03.002","journal-title":"Am J Pathol"},{"issue":"12","key":"7599_CR3","doi-asserted-by":"publisher","first-page":"djv290","DOI":"10.1093\/jnci\/djv290","volume":"107","author":"M Morrow","year":"2015","unstructured":"Morrow M, Katz SJ (2015) Addressing overtreatment in DCIS: what should physicians do now? J Natl Cancer Inst 107(12):djv290. https:\/\/doi.org\/10.1093\/jnci\/djv290","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"7599_CR4","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/jnci\/djt067","volume":"105","author":"LJ Solin","year":"2013","unstructured":"Solin LJ, Gray R, Baehner FL, Butler SM, Hughes LL, Yoshizawa C et al (2013) A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast. J Natl Cancer Inst 105(10):701\u2013710. https:\/\/doi.org\/10.1093\/jnci\/djt067","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"7599_CR5","doi-asserted-by":"publisher","first-page":"R81","DOI":"10.1186\/bcr1798","volume":"9","author":"M Dowsett","year":"2007","unstructured":"Dowsett M, Goldhirsch A, Hayes DF, Senn HJ, Wood W, Viale G (2007) International Web-based consultation on priorities for translational breast cancer research. Breast Cancer Res 9(6):R81. https:\/\/doi.org\/10.1186\/bcr1798","journal-title":"Breast Cancer Res"},{"issue":"3","key":"7599_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jamaoncol.2015.4854","volume":"2","author":"A Recht","year":"2016","unstructured":"Recht A, Rakovitch E, Solin LJ (2016) Treatment and long-term risks for patients with a diagnosis of ductal carcinoma in situ. JAMA Oncol 2(3):396. https:\/\/doi.org\/10.1001\/jamaoncol.2015.4854","journal-title":"JAMA Oncol"},{"issue":"41","key":"7599_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/jncimonographs\/lgq034","volume":"2010","author":"T Shamliyan","year":"2010","unstructured":"Shamliyan T, Wang SY, Virnig BA, Tuttle TM, Kane RL (2010) Association between patient and tumor characteristics with clinical outcomes in women with ductal carcinoma in situ. J Natl Cancer Inst Monogr 2010(41):121\u2013129. https:\/\/doi.org\/10.1093\/jncimonographs\/lgq034","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"5","key":"7599_CR8","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1158\/1055-9965.EPI-18-0976","volume":"28","author":"LL Visser","year":"2019","unstructured":"Visser LL, Groen EJ, van Leeuwen FE, Lips EH, Schmidt MK, Wesseling J (2019) Predictors of an invasive breast cancer recurrence after DCIS: a systematic review and meta-analyses. Cancer Epidemiol Biomarkers Prev 28(5):835\u2013845. https:\/\/doi.org\/10.1158\/1055-9965.EPI-18-0976","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"7599_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-011-1387-4","volume":"127","author":"SY Wang","year":"2011","unstructured":"Wang SY, Shamliyan T, Virnig BA, Kane R (2011) Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis. Breast Cancer Res Treat 127(1):1\u201314. https:\/\/doi.org\/10.1007\/s10549-011-1387-4","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"7599_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/CEJ.0000000000000131","volume":"25","author":"X Zhang","year":"2016","unstructured":"Zhang X, Dai H, Liu B, Song F, Chen K (2016) Predictors for local invasive recurrence of ductal carcinoma in situ of the breast: a meta-analysis. Eur J Cancer Prev 25(1):19\u201328. https:\/\/doi.org\/10.1097\/CEJ.0000000000000131","journal-title":"Eur J Cancer Prev"},{"key":"7599_CR11","doi-asserted-by":"publisher","first-page":"e076022","DOI":"10.1136\/bmj-2023-076022","volume":"383","author":"R Schmitz","year":"2023","unstructured":"Schmitz R, van den Belt-Dusebout AW, Clements K, Ren Y, Cresta C, Timbres J et al (2023) Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study. BMJ 383:e076022. https:\/\/doi.org\/10.1136\/bmj-2023-076022","journal-title":"BMJ"},{"issue":"15","key":"7599_CR12","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1158\/1078-0432.Ccr-18-0201","volume":"24","author":"LL Visser","year":"2018","unstructured":"Visser LL, Elshof LE, Schaapveld M, van de Vijver K, Groen EJ, Almekinders MM et al (2018) Clinicopathological risk factors for an invasive breast cancer recurrence after ductal carcinoma in situ\u2014a nested case-control study. Clin Cancer Res 24(15):3593\u20133601. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-18-0201","journal-title":"Clin Cancer Res"},{"issue":"10","key":"7599_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053397","volume":"11","author":"TE Rohan","year":"2021","unstructured":"Rohan TE, Ginsberg M, Wang Y, Couch FJ, Feigelson HS, Greenlee RT et al (2021) Molecular markers of risk of subsequent invasive breast cancer in women with ductal carcinoma in situ: protocol for a population-based cohort study. BMJ Open 11(10):e053397. https:\/\/doi.org\/10.1136\/bmjopen-2021-053397","journal-title":"BMJ Open"},{"issue":"1","key":"7599_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5858\/133.1.15","volume":"133","author":"SC Lester","year":"2009","unstructured":"Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL et al (2009) Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med 133(1):15\u201325. https:\/\/doi.org\/10.5858\/133.1.15","journal-title":"Arch Pathol Lab Med"},{"issue":"16","key":"7599_CR15","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1200\/JCO.2009.25.6529","volume":"28","author":"ME Hammond","year":"2010","unstructured":"Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S et al (2010) American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 28(16):2784\u20132795. https:\/\/doi.org\/10.1200\/JCO.2009.25.6529","journal-title":"J Clin Oncol"},{"issue":"1","key":"7599_CR16","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1200\/JCO.2006.09.2775","volume":"25","author":"AC Wolff","year":"2007","unstructured":"Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ et al (2007) American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25(1):118\u2013145. https:\/\/doi.org\/10.1200\/JCO.2006.09.2775","journal-title":"J Clin Oncol"},{"issue":"3","key":"7599_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"S van Buuren","year":"2011","unstructured":"van Buuren S, Groothuis-Oudshoorn C (2011) MICE: Multivariate imputation by chained equations in R. J Stat Softw 45(3):1\u201367. https:\/\/doi.org\/10.18637\/jss.v045.i03","journal-title":"J Stat Softw"},{"key":"7599_CR18","doi-asserted-by":"crossref","DOI":"10.1201\/9780429492259","volume-title":"Flexible imputation of missing data","author":"S van Buuren","year":"2018","unstructured":"van Buuren S (2018) Flexible imputation of missing data, 2nd edn. Chapman & Hall\/CRC, Boca Raton","edition":"2"},{"key":"7599_CR19","unstructured":"R Core Team (2023) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. https:\/\/www.R-project.org\/"},{"key":"7599_CR20","doi-asserted-by":"publisher","first-page":"q22","DOI":"10.1136\/bmj.q22","volume":"384","author":"MK Schmidt","year":"2024","unstructured":"Schmidt MK, Lips EH, Schmitz RS, Verschuur E, Wesseling J (2024) Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ. BMJ 384:q22. https:\/\/doi.org\/10.1136\/bmj.q22","journal-title":"BMJ"},{"key":"7599_CR21","doi-asserted-by":"publisher","first-page":"e075498","DOI":"10.1136\/bmj-2023-075498","volume":"384","author":"GS Mannu","year":"2024","unstructured":"Mannu GS, Wang Z, Dodwell D, Broggio J, Charman J, Darby SC (2024) Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population based cohort study. BMJ 384:e075498. https:\/\/doi.org\/10.1136\/bmj-2023-075498","journal-title":"BMJ"},{"issue":"5","key":"7599_CR22","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.ajpath.2018.07.031","volume":"189","author":"S Sanati","year":"2019","unstructured":"Sanati S (2019) Morphologic and molecular features of breast ductal carcinoma in situ. Am J Pathol 189(5):946\u2013955. https:\/\/doi.org\/10.1016\/j.ajpath.2018.07.031","journal-title":"Am J Pathol"},{"issue":"1","key":"7599_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13058-024-01875-w","volume":"26","author":"MR Van Bockstal","year":"2024","unstructured":"Van Bockstal MR, Wesseling J, Lips EH, Smidt M, Galant C, van Deurzen CHM (2024) Systematic assessment of HER2 status in ductal carcinoma in situ of the breast: a perspective on the potential clinical relevance. Breast Cancer Res 26(1):125. https:\/\/doi.org\/10.1186\/s13058-024-01875-w","journal-title":"Breast Cancer Res"},{"issue":"1","key":"7599_CR24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41392-024-01779-3","volume":"9","author":"J Wang","year":"2024","unstructured":"Wang J, Li B, Luo M, Huang J, Zhang K, Zheng S et al (2024) Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance. Signal Transduct Target Ther 9(1):83. https:\/\/doi.org\/10.1038\/s41392-024-01779-3","journal-title":"Signal Transduct Target Ther"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-024-07599-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-024-07599-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-024-07599-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:47:11Z","timestamp":1743382031000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-024-07599-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["7599"],"URL":"https:\/\/doi.org\/10.1007\/s10549-024-07599-x","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Institutional Review Boards of all participating institutions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"In accordance with the OHRP Guidance on Research Involving Coded Private Information or Biological Specimens, this study did not meet the definition of human subject research as defined by 45 CFR 46.102(f), as the data\/specimens were not collected specifically for the proposed research project and the data\/specimens received did not contain a code derived from individual personal information. Given the foregoing, consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}