{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:36:01Z","timestamp":1772584561794,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Institutes of Health, the National Institute of Environmental Health Sciences","award":["Z01-ES044005"],"award-info":[{"award-number":["Z01-ES044005"]}]},{"name":"the Arkansas Breast Cancer Research Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10549-025-07648-z","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:07:07Z","timestamp":1740762427000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mammographic density as a predictor of invasive breast cancer and ductal carcinoma in situ in over six million South Korean women"],"prefix":"10.1007","volume":"211","author":[{"given":"Sung Hun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Moon Mark","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"7648_CR1","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1007\/s10552-010-9604-8","volume":"21","author":"HR Shin","year":"2010","unstructured":"Shin HR, Joubert C, Boniol M et al (2010) Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women. Cancer Causes Control 21:1777\u20131785","journal-title":"Cancer Causes Control"},{"key":"7648_CR2","first-page":"101","volume":"11","author":"DR Youlden","year":"2014","unstructured":"Youlden DR, Cramb SM, Yip CH, Baade PD (2014) Incidence and mortality of female breast cancer in the Asia-Pacific region. Cancer Biol Med 11:101\u2013115","journal-title":"Cancer Biol Med"},{"key":"7648_CR3","volume-title":"Breast cnacer facts & figures 2024","author":"Korean Breast Cancer Society","year":"2024","unstructured":"Korean Breast Cancer Society (2024) Breast cnacer facts & figures 2024. Korean Breast Cancer Society, Seoul"},{"key":"7648_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.7326\/M15-2934","volume":"165","author":"BL Sprague","year":"2016","unstructured":"Sprague BL, Conant EF, Onega T et al (2016) Variation in mammographic breast density assessments among radiologists in clinical practice: a multicenter observational study. Ann Intern Med 165:457\u2013464","journal-title":"Ann Intern Med"},{"key":"7648_CR5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1148\/rg.352140106","volume":"35","author":"PE Freer","year":"2015","unstructured":"Freer PE (2015) Mammographic breast density: impact on breast cancer risk and implications for screening. Radiographics 35:302\u2013315","journal-title":"Radiographics"},{"key":"7648_CR6","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1055-9965.EPI-06-0034","volume":"15","author":"VA McCormack","year":"2006","unstructured":"McCormack VA, dos Santos SI (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1159\u20131169","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"7648_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10549-015-3286-6","volume":"150","author":"L Yaghjyan","year":"2015","unstructured":"Yaghjyan L, Colditz GA, Rosner B, Tamimi RM (2015) Mammographic breast density and breast cancer risk: interactions of percent density, absolute dense, and non-dense areas with breast cancer risk factors. Breast Cancer Res Treat 150:181\u2013189","journal-title":"Breast Cancer Res Treat"},{"key":"7648_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/aje\/kwh028","volume":"159","author":"Z Chen","year":"2004","unstructured":"Chen Z, Wu AH, Gauderman WJ et al (2004) Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol 159:140\u2013147","journal-title":"Am J Epidemiol"},{"key":"7648_CR9","first-page":"213","volume":"67","author":"M Kawahara","year":"2013","unstructured":"Kawahara M, Sato S, Ida Y et al (2013) Factors influencing breast density in Japanese women aged 40\u201349 in breast cancer screening mammography. Acta Med Okayama 67:213\u2013217","journal-title":"Acta Med Okayama"},{"key":"7648_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10549-016-4054-y","volume":"161","author":"N Rajaram","year":"2017","unstructured":"Rajaram N, Mariapun S, Eriksson M et al (2017) Differences in mammographic density between Asian and caucasian populations: a comparative analysis. Breast Cancer Res Treat 161:353\u2013362","journal-title":"Breast Cancer Res Treat"},{"key":"7648_CR11","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1097\/gme.0b013e318032569c","volume":"14","author":"LA Habel","year":"2007","unstructured":"Habel LA, Capra AM, Oestreicher N et al (2007) Mammographic density in a multiethnic cohort. Menopause 14:891\u2013899","journal-title":"Menopause"},{"key":"7648_CR12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/cncr.11517","volume":"98","author":"MG del Carmen","year":"2003","unstructured":"del Carmen MG, Hughes KS, Halpern E et al (2003) Racial differences in mammographic breast density. Cancer 98:590\u2013596","journal-title":"Cancer"},{"key":"7648_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1047-2797(00)00225-8","volume":"11","author":"AY El-Bastawissi","year":"2001","unstructured":"El-Bastawissi AY, White E, Mandelson MT, Taplin S (2001) Variation in mammographic breast density by race. Ann Epidemiol 11:257\u2013263","journal-title":"Ann Epidemiol"},{"key":"7648_CR14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/ijc.20561","volume":"113","author":"KS Chia","year":"2005","unstructured":"Chia KS, Reilly M, Tan CS et al (2005) Profound changes in breast cancer incidence may reflect changes into a Westernized lifestyle: a comparative population-based study in Singapore and Sweden. Int J Cancer 113:302\u2013306","journal-title":"Int J Cancer"},{"key":"7648_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv107","author":"H Sung","year":"2015","unstructured":"Sung H, Rosenberg PS, Chen WQ et al (2015) Female breast cancer incidence among Asian and Western populations: more similar than expected. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djv107","journal-title":"J Natl Cancer Inst"},{"key":"7648_CR16","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s10549-012-2185-3","volume":"135","author":"H Razzaghi","year":"2012","unstructured":"Razzaghi H, Troester MA, Gierach GL, Olshan AF, Yankaskas BC, Millikan RC (2012) Mammographic density and breast cancer risk in White and African American Women. Breast Cancer Res Treat 135:571\u2013580","journal-title":"Breast Cancer Res Treat"},{"key":"7648_CR17","first-page":"1133","volume":"7","author":"NF Boyd","year":"1998","unstructured":"Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ (1998) Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 7:1133\u20131144","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"7648_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju078","author":"A Pettersson","year":"2014","unstructured":"Pettersson A, Graff RE, Ursin G et al (2014) Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/dju078","journal-title":"J Natl Cancer Inst"},{"key":"7648_CR19","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/CEJ.0000000000000353","volume":"27","author":"J Shin","year":"2018","unstructured":"Shin J, Lee JE, Ko HY et al (2018) Association between mammographic density and tumor marker-defined breast cancer subtypes: a case-control study. Eur J Cancer Prev 27:239\u2013247","journal-title":"Eur J Cancer Prev"},{"key":"7648_CR20","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/CEJ.0000000000000099","volume":"24","author":"BK Kim","year":"2015","unstructured":"Kim BK, Choi YH, Nguyen TL et al (2015) Mammographic density and risk of breast cancer in Korean women. Eur J Cancer Prev 24:422\u2013429","journal-title":"Eur J Cancer Prev"},{"key":"7648_CR21","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1002\/cncr.33138","volume":"126","author":"EY Kim","year":"2020","unstructured":"Kim EY, Chang Y, Ahn J et al (2020) Mammographic breast density, its changes, and breast cancer risk in premenopausal and postmenopausal women. Cancer 126:4687\u20134696","journal-title":"Cancer"},{"key":"7648_CR22","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/ijc.33455","volume":"148","author":"S Kim","year":"2021","unstructured":"Kim S, Park B (2021) Association between changes in mammographic density category and the risk of breast cancer: a nationwide cohort study in East-Asian women. Int J Cancer 148:2674\u20132684","journal-title":"Int J Cancer"},{"key":"7648_CR23","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220291","volume":"306","author":"TXM Tran","year":"2023","unstructured":"Tran TXM, Kim S, Song H, Lee E, Park B (2023) Association of longitudinal mammographic breast density changes with subsequent breast cancer risk. Radiology 306:e220291","journal-title":"Radiology"},{"key":"7648_CR24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/CEJ.0000000000000878","volume":"33","author":"S Kim","year":"2024","unstructured":"Kim S, Mai Tran TX, Kim MK et al (2024) Associations between breast cancer risk factors and mammographic breast density in a large cross-section of Korean women. Eur J Cancer Prev 33:407\u2013413","journal-title":"Eur J Cancer Prev"},{"key":"7648_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/pon.3369","volume":"23","author":"JI Kang","year":"2014","unstructured":"Kang JI, Sung NY, Park SJ, Lee CG, Lee BO (2014) The epidemiology of psychiatric disorders among women with breast cancer in South Korea: analysis of national registry data. Psychooncology 23:35\u201339","journal-title":"Psychooncology"},{"key":"7648_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4143\/crt.2014.204","volume":"48","author":"M Suh","year":"2016","unstructured":"Suh M, Choi KS, Park B et al (2016) Trends in cancer screening rates among korean men and women: results of the korean national cancer screening survey, 2004\u20132013. Cancer Res Treat 48:1\u201310","journal-title":"Cancer Res Treat"},{"key":"7648_CR27","volume":"46","author":"J Lee","year":"2017","unstructured":"Lee J, Lee JS, Park SH, Shin SA, Kim K (2017) Cohort profile: the national health insurance service-national sample cohort (NHIS-NSC). South Korea Int J Epidemiol 46:e15","journal-title":"South Korea Int J Epidemiol"},{"key":"7648_CR28","doi-asserted-by":"publisher","first-page":"30329","DOI":"10.1038\/srep30329","volume":"6","author":"HK Yang","year":"2016","unstructured":"Yang HK, Han K, Kwon HS et al (2016) Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea. Sci Rep 6:30329","journal-title":"Sci Rep"},{"key":"7648_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2147\/CLEP.S144918","volume":"10","author":"B Park","year":"2018","unstructured":"Park B, Cho HM, Lee EH et al (2018) Does breast density measured through population-based screening independently increase breast cancer risk in Asian females? Clin Epidemiol 10:61\u201370","journal-title":"Clin Epidemiol"},{"key":"7648_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","volume":"10","author":"S Greenland","year":"1999","unstructured":"Greenland S, Pearl J, Robins JM (1999) Causal diagrams for epidemiologic research. Epidemiology 10:37\u201348","journal-title":"Epidemiology"},{"key":"7648_CR31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10549-022-06730-0","volume":"196","author":"N Gremke","year":"2022","unstructured":"Gremke N, Griewing S, Kalder M, Kostev K (2022) Positive association between body height and breast cancer prevalence: a retrospective study with 135,741 women in Germany. Breast Cancer Res Treat 196:349\u2013354","journal-title":"Breast Cancer Res Treat"},{"key":"7648_CR32","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13058-023-01673-w","volume":"25","author":"K Kast","year":"2023","unstructured":"Kast K, John EM, Hopper JL et al (2023) Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 cohort consortium. Breast Cancer Res 25:72","journal-title":"Breast Cancer Res"},{"key":"7648_CR33","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1158\/1055-9965.715.13.5","volume":"13","author":"PM Vacek","year":"2004","unstructured":"Vacek PM, Geller BM (2004) A prospective study of breast cancer risk using routine mammographic breast density measurements. Cancer Epidemiol Biomarker Prevent 13:715\u2013722","journal-title":"Cancer Epidemiol Biomarker Prevent"},{"key":"7648_CR34","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1148\/radiol.2016152457","volume":"280","author":"M Bahl","year":"2016","unstructured":"Bahl M, Baker JA, Bhargavan-Chatfield M, Brandt EK, Ghate SV (2016) Impact of breast density notification legislation on radiologists\u2019 practices of reporting breast density: a multi-state study. Radiology 280:701\u2013706","journal-title":"Radiology"},{"key":"7648_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju255","author":"BL Sprague","year":"2014","unstructured":"Sprague BL, Gangnon RE, Burt V et al (2014) Prevalence of mammographically dense breasts in the United States. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/dju255","journal-title":"J Natl Cancer Inst"},{"key":"7648_CR36","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1001\/jamainternmed.2013.307","volume":"173","author":"K Kerlikowske","year":"2013","unstructured":"Kerlikowske K, Zhu W, Hubbard RA et al (2013) Outcomes of screening mammography by frequency, breast density, and postmenopausal hormone therapy. JAMA Intern Med 173:807\u2013816","journal-title":"JAMA Intern Med"},{"key":"7648_CR37","doi-asserted-by":"publisher","first-page":"20150242","DOI":"10.1259\/bjr.20150242","volume":"88","author":"SL Heller","year":"2015","unstructured":"Heller SL, Hudson S, Wilkinson LS (2015) Breast density across a regional screening population: effects of age, ethnicity and deprivation. Br J Radiol 88:20150242\u201320150242","journal-title":"Br J Radiol"},{"key":"7648_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12905-024-02960-0","volume":"24","author":"S Bai","year":"2024","unstructured":"Bai S, Song D, Chen M, Lai X, Xu J, Dong F (2024) The association between mammographic density and breast cancer risk in Chinese women: a systematic review and meta-analysis. BMC Womens Health 24:131","journal-title":"BMC Womens Health"},{"key":"7648_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3961\/jpmph.16.054","volume":"49","author":"JM Bae","year":"2016","unstructured":"Bae JM, Kim EH (2016) Breast density and risk of breast cancer in asian women: a meta-analysis of observational studies. J Prev Med Public Health 49:367\u2013375","journal-title":"J Prev Med Public Health"},{"key":"7648_CR40","doi-asserted-by":"publisher","first-page":"R30","DOI":"10.1186\/bcr1507","volume":"8","author":"JK Gill","year":"2006","unstructured":"Gill JK, Maskarinec G, Pagano I, Kolonel LN (2006) The association of mammographic density with ductal carcinoma in situ of the breast: the multiethnic cohort. Breast cancer research\u202f: BCR 8:R30\u2013R30","journal-title":"Breast cancer research : BCR"},{"key":"7648_CR41","doi-asserted-by":"publisher","first-page":"R104","DOI":"10.1186\/bcr3570","volume":"15","author":"KA Bertrand","year":"2013","unstructured":"Bertrand KA, Tamimi RM, Scott CG et al (2013) Mammographic density and risk of breast cancer by age and tumor characteristics. Breast Cancer Res 15:R104","journal-title":"Breast Cancer Res"},{"key":"7648_CR42","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.acra.2006.06.005","volume":"13","author":"BT Nicholson","year":"2006","unstructured":"Nicholson BT, LoRusso AP, Smolkin M, Bovbjerg VE, Petroni GR, Harvey JA (2006) Accuracy of assigned BI-RADS breast density category definitions. Acad Radiol 13:1143\u20131149","journal-title":"Acad Radiol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-025-07648-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-025-07648-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-025-07648-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T03:16:08Z","timestamp":1744859768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-025-07648-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["7648"],"URL":"https:\/\/doi.org\/10.1007\/s10549-025-07648-z","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"30 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study complies with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Seoul St. Mary's Hospital, The Catholic University of Korean (2017\/KC17EESI0189).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was waived","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}}]}}