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We compared tumor features, treatment, and recurrence free survival (RFS) in patients with ILC-alone versus ILC\u2009+\u2009LCIS stratified by ILC tumor subtype. Multivariable Cox proportional hazards models were used for multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 786 cases of ILC, 542 were classic and 92 were pleomorphic, with 70.6% overall having concurrent LCIS. Overall, ILC\u2009+\u2009LCIS cases were less often T3 (p\u2009=\u20090.037) and had lower rates of N2\/N3 disease (p\u2009=\u20090.026) than ILC-alone. Concomitant LCIS was also associated with greater progesterone receptor (PR) positivity (p\u2009=\u20090.016), and was more commonly grade 2 and less often grade 1 compared to ILC-alone (p\u2009=\u20090.008). Treatment differed, with ILC\u2009+\u2009LCIS cases receiving less chemotherapy (p\u2009=\u20090.016) and more mastectomy (p\u2009=\u20090.015). Among patients with classic ILC, the presence of concomitant LCIS was not associated with different RFS. However, among those with pleomorphic ILC, ILC\u2009+\u2009LCIS was associated with significantly improved RFS compared to ILC-alone (HR 0.31, 95% confidence interval 0.10\u20130.96, p\u2009=\u20090.043).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While the presence of LCIS was not associated with RFS in classic ILC in this dataset, it is a favorable prognostic factor in pleomorphic ILC, suggesting a potentially differential role in ILC subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10549-025-07864-7","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:51:45Z","timestamp":1764226305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of concurrent lobular carcinoma in situ on recurrence outcomes in patients with classic and pleomorphic invasive lobular carcinoma of the breast"],"prefix":"10.1007","volume":"215","author":[{"given":"Mandeep","family":"Kaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Quirarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vertido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taron","family":"Torosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Mouabbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita A.","family":"Mukhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"7864_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1200\/EDBK_100002","volume":"36","author":"GW Sledge","year":"2016","unstructured":"Sledge GW, Chagpar A, Perou C (2016) Collective wisdom: lobular carcinoma of the breast. 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