{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:37:59Z","timestamp":1787582279997,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143328"],"award-info":[{"award-number":["FDN-143328"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10549-026-07913-9","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:22:16Z","timestamp":1770628936000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The association between pre-existing type 2 diabetes on cancer-related and all-cause mortality among women with breast cancer"],"prefix":"10.1007","volume":"216","author":[{"given":"Kristina","family":"Parsons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana H. Y.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzin","family":"Khosrow-Khavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"5","key":"7913_CR1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8010","volume":"12","author":"AO Eketunde","year":"2020","unstructured":"Eketunde AO (2020) Diabetes as a risk factor for breast cancer. Cureus 12(5):e8010. https:\/\/doi.org\/10.7759\/cureus.8010. ([published Online First: 20200507])","journal-title":"Cureus"},{"key":"7913_CR2","unstructured":"World Health Organization. Breast Cancer: World Health Organization,; 2021 [updated 12 July 2023. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/breast-cancer accessed 28 November 2022."},{"issue":"2","key":"7913_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1470-2045(05)01736-5","volume":"6","author":"I Wolf","year":"2005","unstructured":"Wolf I, Sadetzki S, Catane R et al (2005) Diabetes mellitus and breast cancer. Lancet Oncol 6(2):103\u2013111. https:\/\/doi.org\/10.1016\/S1470-2045(05)01736-5","journal-title":"Lancet Oncol"},{"issue":"1","key":"7913_CR4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1200\/JCO.2009.27.3011","volume":"29","author":"KS Peairs","year":"2011","unstructured":"Peairs KS, Barone BB, Snyder CF et al (2011) Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol 29(1):40\u201346. https:\/\/doi.org\/10.1200\/JCO.2009.27.3011. ([published Online First: 20101129])","journal-title":"J Clin Oncol"},{"issue":"7","key":"7913_CR5","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.2337\/dc10-0666","volume":"33","author":"E Giovannucci","year":"2010","unstructured":"Giovannucci E, Harlan DM, Archer MC et al (2010) Diabetes and cancer: a consensus report. Diabetes Care 33(7):1674\u20131685. https:\/\/doi.org\/10.2337\/dc10-0666","journal-title":"Diabetes Care"},{"issue":"4","key":"7913_CR6","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1677\/ERC-09-0087","volume":"16","author":"P Vigneri","year":"2009","unstructured":"Vigneri P, Frasca F, Sciacca L et al (2009) Diabetes and cancer. Endocr Relat Cancer 16(4):1103\u20131123. https:\/\/doi.org\/10.1677\/ERC-09-0087. ([published Online First: 20090720])","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"7913_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4239\/wjd.v11.i6.227","volume":"11","author":"M Wang","year":"2020","unstructured":"Wang M, Yang Y, Liao Z (2020) Diabetes and cancer: epidemiological and biological links. World J Diabetes 11(6):227\u2013238. https:\/\/doi.org\/10.4239\/wjd.v11.i6.227","journal-title":"World J Diabetes"},{"key":"7913_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.800995","volume":"13","author":"B Zhu","year":"2022","unstructured":"Zhu B, Qu S (2022) The relationship between diabetes mellitus and cancers and its underlying mechanisms. Front Endocrinol (Lausanne) 13:800995. https:\/\/doi.org\/10.3389\/fendo.2022.800995. ([published Online First: 20220211])","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"7913_CR9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14(2):88\u201398. https:\/\/doi.org\/10.1038\/nrendo.2017.151. ([published Online First: 20171208])","journal-title":"Nat Rev Endocrinol"},{"key":"7913_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00060","volume":"11","author":"H Tao","year":"2020","unstructured":"Tao H, O\u2019Neil A, Choi Y et al (2020) Pre- and post-diagnosis diabetes as a risk factor for all-cause and cancer-specific mortality in breast, prostate, and colorectal cancer survivors: a prospective cohort study. Front Endocrinol (Lausanne) 11:60. https:\/\/doi.org\/10.3389\/fendo.2020.00060. ([published Online First: 20200218])","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"49","key":"7913_CR11","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000005602","volume":"95","author":"XB Zhao","year":"2016","unstructured":"Zhao XB, Ren GS (2016) Diabetes mellitus and prognosis in women with breast cancer: a systematic review and meta-analysis. Medicine (Baltimore) 95(49):e5602. https:\/\/doi.org\/10.1097\/md.0000000000005602","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"7913_CR12","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/ans.12877","volume":"85","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Zhang X, Gu C et al (2015) Influence of diabetes mellitus on mortality in breast cancer patients. ANZ J Surg 85(12):972\u2013978. https:\/\/doi.org\/10.1111\/ans.12877. ([published Online First: 20141013])","journal-title":"ANZ J Surg"},{"key":"7913_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2823","author":"L Mu","year":"2017","unstructured":"Mu L, Zhu N, Zhang J et al (2017) Type 2 diabetes, insulin treatment and prognosis of breast cancer. Diabetes Metab Res Rev. https:\/\/doi.org\/10.1002\/dmrr.2823","journal-title":"Diabetes Metab Res Rev"},{"issue":"11","key":"7913_CR14","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s10552-012-0057-0","volume":"23","author":"MT Redaniel","year":"2012","unstructured":"Redaniel MT, Jeffreys M, May MT et al (2012) Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women. Cancer Causes Control 23(11):1785\u20131795. https:\/\/doi.org\/10.1007\/s10552-012-0057-0. ([published Online First: 20120913])","journal-title":"Cancer Causes Control"},{"issue":"5","key":"7913_CR15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/bjc.2015.249","volume":"113","author":"J Luo","year":"2015","unstructured":"Luo J, Hendryx M, Virnig B et al (2015) Pre-existing diabetes and breast cancer prognosis among elderly women. Br J Cancer 113(5):827\u2013832. https:\/\/doi.org\/10.1038\/bjc.2015.249","journal-title":"Br J Cancer"},{"issue":"11","key":"7913_CR16","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/bjs.9229","volume":"100","author":"KM De Bruijn","year":"2013","unstructured":"De Bruijn KM, Arends LR, Hansen BE et al (2013) Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer. Br J Surg 100(11):1421\u20131429. https:\/\/doi.org\/10.1002\/bjs.9229","journal-title":"Br J Surg"},{"key":"7913_CR17","unstructured":"Diabetes Canada. Diabetes in Canada Backgrounder Ottawa: Diabetes Canada; 2022 [Available from: https:\/\/www.diabetes.ca\/DiabetesCanadaWebsite\/media\/Advocacy-and-Policy\/Backgrounder\/2022_Backgrounder_Canada_English_1.pdf accessed 28 November 2022."},{"issue":"1","key":"7913_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-016-0147-7","volume":"4","author":"B Monzavi-Karbassi","year":"2016","unstructured":"Monzavi-Karbassi B, Gentry R, Kaur V et al (2016) Pre-diagnosis blood glucose and prognosis in women with breast cancer. Cancer Metab 4(1):7. https:\/\/doi.org\/10.1186\/s40170-016-0147-7","journal-title":"Cancer Metab"},{"issue":"3","key":"7913_CR19","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s10549-015-3323-5","volume":"150","author":"LL Lipscombe","year":"2015","unstructured":"Lipscombe LL, Fischer HD, Austin PC et al (2015) The association between diabetes and breast cancer stage at diagnosis: a population-based study. Breast Cancer Res Treat 150(3):613\u2013620. https:\/\/doi.org\/10.1007\/s10549-015-3323-5. ([published Online First: 20150317])","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"7913_CR20","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ije\/dyv098","volume":"44","author":"E Herrett","year":"2015","unstructured":"Herrett E, Gallagher AM, Bhaskaran K et al (2015) Data resource profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol 44(3):827\u2013836. https:\/\/doi.org\/10.1093\/ije\/dyv098. ([published Online First: 20150606])","journal-title":"Int J Epidemiol"},{"key":"7913_CR21","unstructured":"CPRD. Data: CPRD; 2022 [updated 11 October 2022; cited 2023. Available from: https:\/\/cprd.com\/data#:~:text=CPRD%20data%20are%20sourced%20from,for%2025%25%20of%20the%20patients. accessed 9 August 2023."},{"issue":"2","key":"7913_CR22","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/pds.3374","volume":"22","author":"R Boggon","year":"2013","unstructured":"Boggon R, van Staa TP, Chapman M et al (2013) Cancer recording and mortality in the General Practice Research Database and linked cancer registries. Pharmacoepidemiol Drug Saf 22(2):168\u2013175. https:\/\/doi.org\/10.1002\/pds.3374. ([published Online First: 20121213])","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"7913_CR23","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1634\/theoncologist.2011-0412","volume":"17","author":"WW Chen","year":"2012","unstructured":"Chen WW, Shao YY, Shau WY et al (2012) The impact of diabetes mellitus on prognosis of early breast cancer in Asia. Oncologist 17(4):485\u2013491. https:\/\/doi.org\/10.1634\/theoncologist.2011-0412","journal-title":"Oncologist"},{"issue":"2","key":"7913_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10552-021-01526-x","volume":"33","author":"L Fern\u00e1ndez-Arce","year":"2022","unstructured":"Fern\u00e1ndez-Arce L, Robles-Rodr\u00edguez N, Fern\u00e1ndez-Feito A et al (2022) Type 2 diabetes and all-cause mortality among Spanish women with breast cancer. Cancer Causes Control 33(2):271\u2013278. https:\/\/doi.org\/10.1007\/s10552-021-01526-x","journal-title":"Cancer Causes Control"},{"issue":"10","key":"7913_CR25","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1093\/annonc\/mdt224","volume":"24","author":"S Jiralerspong","year":"2013","unstructured":"Jiralerspong S, Kim ES, Dong W et al (2013) Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients. Ann Oncol 24(10):2506\u20132514. https:\/\/doi.org\/10.1093\/annonc\/mdt224. ([published Online First: 20130621])","journal-title":"Ann Oncol"},{"key":"7913_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101710","volume":"66","author":"WR Lawrence","year":"2020","unstructured":"Lawrence WR, Hosler AS, Gates Kuliszewski M et al (2020) Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer. Cancer Epidemiol 66:101710. https:\/\/doi.org\/10.1016\/j.canep.2020.101710. ([published Online First: 20200401])","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"7913_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232581","volume":"15","author":"KN Lee","year":"2020","unstructured":"Lee KN, Torres MA, Troeschel AN et al (2020) Type 2 diabetes, breast cancer specific and overall mortality: associations by metformin use and modification by race, body mass, and estrogen receptor status. PLoS ONE 15(5):e0232581. https:\/\/doi.org\/10.1371\/journal.pone.0232581","journal-title":"PLoS ONE"},{"issue":"4","key":"7913_CR28","doi-asserted-by":"publisher","first-page":"755","DOI":"10.2337\/dc17-2012","volume":"41","author":"IC Lega","year":"2018","unstructured":"Lega IC, Austin PC, Fischer HD et al (2018) The impact of diabetes on breast cancer treatments and outcomes: a population-based study. Diabetes Care 41(4):755\u2013761. https:\/\/doi.org\/10.2337\/dc17-2012","journal-title":"Diabetes Care"},{"issue":"3","key":"7913_CR29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s10549-018-5025-2","volume":"173","author":"G Maskarinec","year":"2019","unstructured":"Maskarinec G, Shvetsov YB, Conroy SM et al (2019) Type 2 diabetes as a predictor of survival among breast cancer patients: the multiethnic cohort. Breast Cancer Res Treat 173(3):637\u2013645. https:\/\/doi.org\/10.1007\/s10549-018-5025-2. ([published Online First: 20181026])","journal-title":"Breast Cancer Res Treat"},{"issue":"13","key":"7913_CR30","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1200\/jco.2008.17.5935","volume":"27","author":"TP Srokowski","year":"2009","unstructured":"Srokowski TP, Fang S, Hortobagyi GN et al (2009) Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer. J Clin Oncol 27(13):2170\u20132176. https:\/\/doi.org\/10.1200\/jco.2008.17.5935","journal-title":"J Clin Oncol"},{"issue":"2","key":"7913_CR31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1158\/1055-9965.Epi-14-1140","volume":"24","author":"AH Wu","year":"2015","unstructured":"Wu AH, Kurian AW, Kwan ML et al (2015) Diabetes and other comorbidities in breast cancer survival by race\/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC). Cancer Epidemiol Biomarkers Prev 24(2):361\u2013368. https:\/\/doi.org\/10.1158\/1055-9965.Epi-14-1140. ([published Online First: 20141125])","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"7913_CR32","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/ede.0000000000000786","volume":"29","author":"AV Margulis","year":"2018","unstructured":"Margulis AV, Fortuny J, Kaye JA et al (2018) Validation of cancer cases using primary care, cancer registry, and hospitalization data in the United Kingdom. Epidemiology 29(2):308\u2013313. https:\/\/doi.org\/10.1097\/ede.0000000000000786","journal-title":"Epidemiology"},{"issue":"5","key":"7913_CR33","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020827","volume":"8","author":"R Williams","year":"2018","unstructured":"Williams R, van Staa TP, Gallagher AM et al (2018) Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study. BMJ Open 8(5):e020827. https:\/\/doi.org\/10.1136\/bmjopen-2017-020827. ([published Online First: 20180526])","journal-title":"BMJ Open"},{"issue":"1","key":"7913_CR34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1200\/JCO.2010.29.3183","volume":"29","author":"K Erickson","year":"2011","unstructured":"Erickson K, Patterson RE, Flatt SW et al (2011) Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol 29(1):54\u201360. https:\/\/doi.org\/10.1200\/JCO.2010.29.3183. ([published Online First: 20101129])","journal-title":"J Clin Oncol"},{"issue":"9","key":"7913_CR35","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1007\/s00125-010-1796-7","volume":"53","author":"XH Zhou","year":"2010","unstructured":"Zhou XH, Qiao Q, Zethelius B et al (2010) Diabetes, prediabetes and cancer mortality. Diabetologia 53(9):1867\u20131876. https:\/\/doi.org\/10.1007\/s00125-010-1796-7","journal-title":"Diabetologia"},{"issue":"1","key":"7913_CR36","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1016\/j.jcjd.2017.10.004","volume":"42","author":"JM Ekoe","year":"2018","unstructured":"Ekoe JM, Goldenberg R, Katz P (2018) Screening for diabetes in adults. Can J Diabetes 42(1):S16-s19. https:\/\/doi.org\/10.1016\/j.jcjd.2017.10.004","journal-title":"Can J Diabetes"},{"issue":"3","key":"7913_CR37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4331\/wjbc.v6.i3.231","volume":"6","author":"F Lumachi","year":"2015","unstructured":"Lumachi F, Santeufemia DA, Basso SM (2015) Current medical treatment of estrogen receptor-positive breast cancer. World J Biol Chem 6(3):231\u2013239. https:\/\/doi.org\/10.4331\/wjbc.v6.i3.231","journal-title":"World J Biol Chem"},{"key":"7913_CR38","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.canep.2018.08.009","volume":"57","author":"CS Arhi","year":"2018","unstructured":"Arhi CS, Bottle A, Burns EM et al (2018) Comparison of cancer diagnosis recording between the Clinical Practice Research Datalink, Cancer Registry and Hospital Episodes Statistics. Cancer Epidemiol 57:148\u2013157. https:\/\/doi.org\/10.1016\/j.canep.2018.08.009","journal-title":"Cancer Epidemiol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-07913-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-026-07913-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-07913-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:50:48Z","timestamp":1771843848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-026-07913-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["7913"],"URL":"https:\/\/doi.org\/10.1007\/s10549-026-07913-9","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"8 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that this study was funded by the Canadian Institutes of Health Research; LA received speaking and consulting fees from Pfizer, Boehringer Ingelheim, and Roche for work unrelated to this study; no other relationships or activities that could appear to have influenced the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol was approved by the Research Data Governance of the Clinical Practice Research Datalink (protocol number 22_002073) and by the Research Ethics Board of the Jewish General Hospital, Montreal, Canada. The study was a secondary data analysis and did not include patients as study participants. Hence, the Research Data Governance of the CPRD and the Research Ethics Board deemed it exempt from the need to obtain patient consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"3"}}