{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:24:06Z","timestamp":1791923046306,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer , France","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canc\u00e9ropole Est"},{"name":"Universit\u00e9 Marie et Louis Pasteur"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with localized breast cancer receiving adjuvant chemotherapy often experience sleep disturbances, especially insomnia, which significantly impacts quality of life. This study primarily aimed to evaluate the effects of a 12-week exercise program on insomnia, with secondary outcomes on sleep quality, anxiety\/depression, fatigue, pain, and exercise adaptation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized controlled multicenter trial, 20 women with non-metastatic breast cancer and clinically diagnosed insomnia were assigned to a control or training group. The training group underwent a 12-week supervised intermittent aerobic exercise program during chemotherapy. The primary outcome was objective total sleep time; secondary outcomes included insomnia severity, sleep architecture, sleep quality, anxiety\/depression, fatigue, pain, and cardiorespiratory capacity. Assessments were performed before chemotherapy (T-1), at baseline (T0), and post-intervention (T3) using polysomnography, actigraphy, validated questionnaires, and a maximal graded exercise test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of clinical insomnia increased from 47% before diagnosis to 71% at T-1, reaching 100% at T0. Total sleep time did not increase after training (p\u2009=\u20090.97), although sleep fragmentation decreased. Clinical improvement was observed in physical and activity-related fatigue. Finally, both submaximal exercise adaptation parameters (power and VO\n                      <jats:sub>2<\/jats:sub>\n                      \/HR) and maximal parameters (power, VO\n                      <jats:sub>2<\/jats:sub>\n                      peak, VO\n                      <jats:sub>2<\/jats:sub>\n                      \/HR) significantly improved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The training did not increase total sleep time, likely due to insomnia\u2019s multifactorial origin. However, training yielded beneficial effects on objective sleep quality and exercise-induced adaptation. Future research is needed to investigate the various etiologies of insomnia to develop tailored and personalized management approaches.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trials Number:<\/jats:bold>\n                      NCT04867096\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10549-026-07923-7","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:21:48Z","timestamp":1772079708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a supervised intermittent exercise program on insomnia in breast cancer patients undergoing chemotherapy"],"prefix":"10.1007","volume":"216","clinical-trial-number":[{"clinical-trial-number":"nct04867096","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Chlo\u00e9","family":"Drozd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Curtit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Jacquinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Paget-Bailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Meneveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Mougin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"issue":"3","key":"7923_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1200\/JCO.2001.19.3.895","volume":"19","author":"J Savard","year":"2001","unstructured":"Savard J, Morin CM (2001) Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol 19(3):895\u2013908","journal-title":"J Clin Oncol"},{"issue":"9","key":"7923_CR2","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/S0277-9536(01)00043-0","volume":"54","author":"JR Davidson","year":"2002","unstructured":"Davidson JR, Maclean AW, Brundage MD, Schulze K (2002) Sleep disturbance in cancer patients. Soc Sci Med 54(9):1309\u20131321","journal-title":"Soc Sci Med"},{"issue":"6","key":"7923_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.smrv.2006.03.005","volume":"10","author":"L Fiorentino","year":"2006","unstructured":"Fiorentino L, Ancoli-Israel S (2006) Insomnia and its treatment in women with breast cancer. Sleep Med Rev 10(6):419\u2013429. https:\/\/doi.org\/10.1016\/j.smrv.2006.03.005","journal-title":"Sleep Med Rev"},{"issue":"5 suppl","key":"7923_CR4","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.5664\/jcsm.26929","volume":"3","author":"T Roth","year":"2007","unstructured":"Roth T (2007) Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med 3(5 suppl):S7\u2013S10","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"7923_CR5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/wps.20989","volume":"21","author":"MB First","year":"2022","unstructured":"First MB, Yousif LH, Clarke DE, Wang PS, Gogtay N, Appelbaum PS (2022) DSM-5-TR: overview of what\u2019s new and what\u2019s changed. World Psychiatry 21(2):218\u2013219. https:\/\/doi.org\/10.1002\/wps.20989","journal-title":"World Psychiatry"},{"issue":"5","key":"7923_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/sleep\/24.5.583","volume":"24","author":"J Savard","year":"2001","unstructured":"Savard J, Simard S, Blanchet J, Ivers H, Morin CM (2001) Prevalence, clinical characteristics, and risk factors for insomnia in the context of breast cancer. Sleep 24(5):583\u2013590. https:\/\/doi.org\/10.1093\/sleep\/24.5.583","journal-title":"Sleep"},{"issue":"2","key":"7923_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1200\/JCO.2009.22.5011","volume":"28","author":"OG Palesh","year":"2010","unstructured":"Palesh OG, Roscoe JA, Mustian KM, Roth T, Savard J, Ancoli-Israel S et al (2010) Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center\u2013Community Clinical Oncology Program. J Clin Oncol 28(2):292\u2013298","journal-title":"J Clin Oncol"},{"issue":"1","key":"7923_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s10549-023-07058-z","volume":"202","author":"CM Beverly Hery","year":"2023","unstructured":"Beverly Hery CM, Janse SA, Van Zee KJ, Naftalis EZ, Paskett ED, Naughton MJ (2023) Factors associated with insomnia symptoms over three years among premenopausal women with breast cancer. Breast Cancer Res Treat 202(1):155\u2013165. https:\/\/doi.org\/10.1007\/s10549-023-07058-z","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"7923_CR9","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1017\/S1478951516000900","volume":"15","author":"PR Gehrman","year":"2017","unstructured":"Gehrman PR, Garland SN, Matura LA, Mao J (2017) Insomnia in breast cancer: independent symptom or symptom cluster? Palliat Support Care 15(3):369\u2013375. https:\/\/doi.org\/10.1017\/S1478951516000900","journal-title":"Palliat Support Care"},{"issue":"12","key":"7923_CR10","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.6004\/jnccn.2020.7682","volume":"18","author":"DL Hall","year":"2020","unstructured":"Hall DL, Peppercorn JM (2020) Wake up oncologists! It\u2019s time to help our patients with insomnia. J Natl Compr Canc Netw 18(12):1738\u20131740. https:\/\/doi.org\/10.6004\/jnccn.2020.7682","journal-title":"J Natl Compr Canc Netw"},{"key":"7923_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10549-020-05635-0","volume":"181","author":"A Kwak","year":"2020","unstructured":"Kwak A, Jacobs J, Haggett D, Jimenez R, Peppercorn J (2020) Evaluation and management of insomnia in women with breast cancer. Breast Cancer Res Treat 181:269\u2013277. https:\/\/doi.org\/10.1007\/s10549-020-05635-0","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"7923_CR12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5664\/jcsm.6470","volume":"13","author":"MJ Sateia","year":"2017","unstructured":"Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(2):307\u2013349. https:\/\/doi.org\/10.5664\/jcsm.6470","journal-title":"J Clin Sleep Med"},{"key":"7923_CR13","unstructured":"Graci G, Lurie RH (2005) Pathogenesis and management of cancer-related insomnia"},{"issue":"6","key":"7923_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/jsr.12594","volume":"26","author":"D Riemann","year":"2017","unstructured":"Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG et al (2017) European guideline for the diagnosis and treatment of insomnia. J Sleep Res 26(6):675\u2013700","journal-title":"J Sleep Res"},{"issue":"9","key":"7923_CR15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/pon.1818","volume":"20","author":"J Savard","year":"2011","unstructured":"Savard J, Villa J, Simard S, Ivers H, Morin CM (2011) Feasibility of a self-help treatment for insomnia comorbid with cancer. Psycho-Oncol 20(9):1013\u20131019. https:\/\/doi.org\/10.1002\/pon.1818","journal-title":"Psycho-Oncol"},{"issue":"2","key":"7923_CR16","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/annonc\/mds342","volume":"24","author":"M Carayol","year":"2013","unstructured":"Carayol M, Bernard P, Boich\u00e9 J, Riou F, Mercier B, Cousson-G\u00e9lie F et al (2013) Psychological effect of exercise in women with breast cancer receiving adjuvant therapy: what is the optimal dose needed? Ann Oncol 24(2):291\u2013300","journal-title":"Ann Oncol"},{"issue":"5","key":"7923_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.12788\/jcso.0225","volume":"14","author":"CM Fairman","year":"2016","unstructured":"Fairman CM, Focht BC, Lucas AR, Lustberg MB (2016) Effects of exercise interventions during different treatments in breast cancer. J Community Support Oncol 14(5):200","journal-title":"J Community Support Oncol"},{"key":"7923_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1000846","volume":"9","author":"Q Jacquinot","year":"2022","unstructured":"Jacquinot Q, Meneveau N, Falcoz A, Bouhaddi M, Roux P, Degano B et al (2022) Cardiotoxicity is mitigated after a supervised exercise program in HER2-positive breast cancer undergoing adjuvant trastuzumab. Front Cardiovasc Med 9:1000846. https:\/\/doi.org\/10.3389\/fcvm.2022.1000846","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"7923_CR19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4103\/jomfp.JOMFP_20_17","volume":"21","author":"G Kokila","year":"2017","unstructured":"Kokila G, Smitha T (2017) Cancer and physical activity. J Oral Maxillofac Pathol 21(1):4\u20137","journal-title":"J Oral Maxillofac Pathol"},{"issue":"22","key":"7923_CR20","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1200\/JCO.22.00687","volume":"40","author":"JA Ligibel","year":"2022","unstructured":"Ligibel JA, Bohlke K, May AM, Clinton SK, Demark-Wahnefried W, Gilchrist SC et al (2022) Exercise, diet, and weight management during cancer treatment: ASCO guideline. J Clin Oncol 40(22):2491\u20132507","journal-title":"J Clin Oncol"},{"issue":"6","key":"7923_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14035","volume":"32","author":"D Riemann","year":"2023","unstructured":"Riemann D, Espie CA, Altena E, Arnardottir ES, Baglioni C, Bassetti CL et al (2023) The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. J Sleep Res 32(6):e14035","journal-title":"J Sleep Res"},{"issue":"1","key":"7923_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10902-6","volume":"23","author":"C Drozd","year":"2023","unstructured":"Drozd C, Curtit E, Jacquinot Q, Marquine C, Mansi L, Chaigneau L et al (2023) A randomized trial to evaluate the effects of a supervised exercise program on insomnia in patients with non-metastatic breast cancer undergoing chemotherapy: design of the FATSOMCAN study. BMC Cancer 23(1):449. https:\/\/doi.org\/10.1186\/s12885-023-10902-6","journal-title":"BMC Cancer"},{"issue":"10","key":"7923_CR23","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1185\/03007990903167415","volume":"25","author":"M Yang","year":"2009","unstructured":"Yang M, Morin CM, Schaefer K, Wallenstein GV (2009) Interpreting score differences in the Insomnia Severity Index: using health-related outcomes to define the minimally important difference. Curr Med Res Opin 25(10):2487\u20132494. https:\/\/doi.org\/10.1185\/03007990903167415","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"7923_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1136\/aim.2009.000760","volume":"27","author":"CM Hughes","year":"2009","unstructured":"Hughes CM, McCullough CA, Bradbury I, Boyde C, Hume D, Yuan J et al (2009) Acupuncture and reflexology for insomnia: a feasibility study. Acupunct Med 27(4):163\u2013168","journal-title":"Acupunct Med"},{"issue":"1","key":"7923_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13681-4","volume":"25","author":"BL Hayes","year":"2025","unstructured":"Hayes BL, Fleming L, Mahmoud O, Martin RM, Lawlor DA, Robinson T et al (2025) The impact of sleep on breast cancer-specific mortality: a Mendelian randomisation study. BMC Cancer 25(1):357","journal-title":"BMC Cancer"},{"key":"7923_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy245","author":"L Fleming","year":"2019","unstructured":"Fleming L, Randell K, Stewart E, Espie CA, Morrison DS, Lawless C et al (2019) Insomnia in breast cancer: a prospective observational study. Sleep. https:\/\/doi.org\/10.1093\/sleep\/zsy245","journal-title":"Sleep"},{"issue":"31","key":"7923_CR27","doi-asserted-by":"publisher","first-page":"5233","DOI":"10.1200\/JCO.2008.21.6333","volume":"27","author":"J Savard","year":"2009","unstructured":"Savard J, Villa J, Ivers H, Simard S, Morin CM (2009) Prevalence, natural course, and risk factors of insomnia comorbid with cancer over a 2-month period. J Clin Oncol 27(31):5233\u20135239","journal-title":"J Clin Oncol"},{"key":"7923_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.sleep.2022.04.020","volume":"96","author":"A Amidi","year":"2022","unstructured":"Amidi A, Buskbjerg CR, Damholdt MF, Dahlgaard J, Thorndike FP, Ritterband L et al (2022) Changes in sleep following internet-delivered cognitive-behavioral therapy for insomnia in women treated for breast cancer: A 3-year follow-up assessment. Sleep Med 96:35\u201341. https:\/\/doi.org\/10.1016\/j.sleep.2022.04.020","journal-title":"Sleep Med"},{"issue":"4","key":"7923_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ddmod.2011.05.001","volume":"8","author":"L Fiorentino","year":"2011","unstructured":"Fiorentino L, Rissling M, Liu L, Ancoli-Israel S (2011) The symptom cluster of sleep, fatigue and depressive symptoms in breast cancer patients: severity of the problem and treatment options. Drug Discov Today Dis Models 8(4):167\u2013173","journal-title":"Drug Discov Today Dis Models"},{"issue":"5","key":"7923_CR30","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1007\/s00520-020-05786-2","volume":"29","author":"BD Gonzalez","year":"2021","unstructured":"Gonzalez BD, Eisel SL, Qin B, Llanos AAM, Savard J, Hoogland AI et al (2021) Prevalence, risk factors, and trajectories of sleep disturbance in a cohort of African-American breast cancer survivors. Support Care Cancer 29(5):2761\u20132770. https:\/\/doi.org\/10.1007\/s00520-020-05786-2","journal-title":"Support Care Cancer"},{"issue":"4","key":"7923_CR31","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s00520-012-1612-7","volume":"21","author":"SD Sanford","year":"2013","unstructured":"Sanford SD, Wagner LI, Beaumont JL, Butt Z, Sweet JJ, Cella D (2013) Longitudinal prospective assessment of sleep quality: before, during, and after adjuvant chemotherapy for breast cancer. Support Care Cancer 21(4):959\u2013967. https:\/\/doi.org\/10.1007\/s00520-012-1612-7","journal-title":"Support Care Cancer"},{"issue":"3","key":"7923_CR32","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1552-6909.2009.01030.x","volume":"38","author":"AM Berger","year":"2009","unstructured":"Berger AM, Treat Marunda HA, Agrawal S (2009) Influence of menopausal status on sleep and hot flashes throughout breast cancer adjuvant chemotherapy. J Obstet Gynecol Neonatal Nurs 38(3):353\u2013366. https:\/\/doi.org\/10.1111\/j.1552-6909.2009.01030.x","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"issue":"2","key":"7923_CR33","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1097\/NCC.0b013e3181e4588d","volume":"34","author":"Y-J Wang","year":"2011","unstructured":"Wang Y-J, Boehmke M, Wu Y-WB, Dickerson SS, Fisher N (2011) Effects of a 6-week walking program on Taiwanese women newly diagnosed with early-stage breast cancer. Cancer Nurs 34(2):E1\u2013E13","journal-title":"Cancer Nurs"},{"key":"7923_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.maturitas.2017.04.003","volume":"100","author":"J\u00c1 Rubio-Arias","year":"2017","unstructured":"Rubio-Arias J\u00c1, Mar\u00edn-Cascales E, Ramos-Campo DJ, Hernandez AV, P\u00e9rez-L\u00f3pez FR (2017) Effect of exercise on sleep quality and insomnia in middle-aged women: a systematic review and meta-analysis of randomized controlled trials. Maturitas 100:49\u201356. https:\/\/doi.org\/10.1016\/j.maturitas.2017.04.003","journal-title":"Maturitas"},{"issue":"4","key":"7923_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ddmod.2011.07.002","volume":"8","author":"DJ Buysse","year":"2011","unstructured":"Buysse DJ, Germain A, Hall M, Monk TH, Nofzinger EA (2011) A neurobiological model of insomnia. Drug Discov Today Dis Models 8(4):129\u2013137","journal-title":"Drug Discov Today Dis Models"},{"issue":"1","key":"7923_CR36","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1152\/jappl.1997.83.1.160","volume":"83","author":"MD Fitzgerald","year":"1997","unstructured":"Fitzgerald MD, Tanaka H, Tran ZV, Seals DR (1997) Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J Appl Physiol 83(1):160\u2013165","journal-title":"J Appl Physiol"},{"issue":"6","key":"7923_CR37","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.jshs.2023.07.001","volume":"12","author":"A Isanejad","year":"2023","unstructured":"Isanejad A, Nazari S, Gharib B, Motlagh AG (2023) Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers, cardiorespiratory fitness, and quality of life in breast cancer patients. J Sport Health Sci 12(6):674\u2013689. https:\/\/doi.org\/10.1016\/j.jshs.2023.07.001","journal-title":"J Sport Health Sci"},{"key":"7923_CR38","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00520-015-2749-y","volume":"24","author":"LB Dolan","year":"2016","unstructured":"Dolan LB, Campbell K, Gelmon K, Neil-Sztramko S, Holmes D, McKenzie DC (2016) Interval versus continuous aerobic exercise training in breast cancer survivors\u2014a pilot RCT. Support Care Cancer 24:119\u2013127. https:\/\/doi.org\/10.1007\/s00520-015-2749-y","journal-title":"Support Care Cancer"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-07923-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-026-07923-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-07923-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:02:24Z","timestamp":1773522144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-026-07923-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["7923"],"URL":"https:\/\/doi.org\/10.1007\/s10549-026-07923-7","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The FATSOMCAN study was approved by the Ethics Committee \u201cComit\u00e9 de Protection des Personnes Ouest III\u201d on 15\/09\/2020 under the number 2020-A00511-38, and by the National Health Products Safety Agency (N\u00b0 IDRCB 2020-A00511-38). This study is registered at the National Clinical Trials (NPSGCT02433067) since 30 April 2021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants were fully informed of the experimental procedures and provided written informed consent. All methods were carried out in accordance with relevant guidelines and regulations. The current study was performed in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"20"}}