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Automated fibroglandular tissue (FGT) segmentation and BPE quantification were performed on DCE-MRI. The optimal intensity enhancement threshold by volume-based method was established against four radiologist-defined BPE categories. The area under the curve (AUC) was obtained for classification of BPE categories. Cox proportional hazards models were used to predict OS and RFS. Logistic regression was used to predict pCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Peak-contrast BPE showed strong correlation with radiologist-defined BPE, achieving the best performance at a 55% signal enhancement threshold (AUC 0.70\u20130.86). The calculated BPE decreased after neoadjuvant chemotherapy. A reduction in calculated BPE grade after neoadjuvant chemotherapy was predictive of pCR for the high baseline BPE group (adjusted odds ratio\u2009=\u20095.88 [1.03, 33.33]) and for the low baseline BPE group (adjusted odds ratio\u2009=\u20096.54 [1.26, 33.94]). Baseline BPE was independently associated with improved OS (adjusted hazard ratio 0.58 [0.34, 0.99]) but not associated with RFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Automated quantification of BPE from DCE-MRI provides an objective and reproducible imaging biomarker associated with treatment response and overall survival in breast cancer. These results support its potential utility for individualized risk stratification and therapeutic decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10549-026-07941-5","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:14:12Z","timestamp":1774314852000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Automated calculation of background parenchymal enhancement as a biomarker of treatment responses and recurrence-free survival in breast cancer"],"prefix":"10.1007","volume":"216","author":[{"given":"Yihui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roham","family":"Hadidchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Quang","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Hariharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Manh","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddarth","family":"Ragupathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takouhie","family":"Maldjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim Q.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"1","key":"7941_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1148\/radiol.11102156","volume":"260","author":"V King","year":"2011","unstructured":"King V, Brooks JD, Bernstein JL, Reiner AS, Pike MC, Morris EA (2011) Background parenchymal enhancement at breast MR imaging and breast cancer risk. 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