{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:39:38Z","timestamp":1792625978895,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["125S228"],"award-info":[{"award-number":["125S228"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saglik Bilimleri University Scientific Research Projects Unit","award":["2024\/098"],"award-info":[{"award-number":["2024\/098"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s10549-026-08101-5","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:46:46Z","timestamp":1792345606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of DNA methylation levels before and after treatment in breast cancer patients receiving neoadjuvant chemotherapy"],"prefix":"10.1007","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-7909","authenticated-orcid":false,"given":"Halime","family":"Yildirim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-5544","authenticated-orcid":false,"given":"Ender","family":"Coskunpinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-568X","authenticated-orcid":false,"given":"Mustafa","family":"Tukenmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-044X","authenticated-orcid":false,"given":"Baran","family":"Mollavelioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-0074","authenticated-orcid":false,"given":"Aysel","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"issue":"10439","key":"8101_CR1","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/S0140-6736(24)00747-5","volume":"403","author":"CE Coles","year":"2024","unstructured":"Coles CE, Earl H, Anderson BO et al (2024) The Lancet Breast Cancer Commission. Lancet 403(10439):1895\u20131950. https:\/\/doi.org\/10.1016\/S0140-6736(24)00747-5","journal-title":"Lancet"},{"issue":"4","key":"8101_CR2","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","volume":"31","author":"J Kim","year":"2025","unstructured":"Kim J, Harper A, McCormack V et al (2025) Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med 31(4):1154\u20131162. https:\/\/doi.org\/10.1038\/s41591-025-03502-3","journal-title":"Nat Med"},{"issue":"2","key":"8101_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3390\/ph18020207","volume":"18","author":"IS Alalhareth","year":"2025","unstructured":"Alalhareth IS, Alyami SM, Alshareef AH et al (2025) Cellular Epigenetic Targets and Epidrugs in Breast Cancer Therapy: Mechanisms, Challenges, and Future Perspectives. Pharmaceuticals (Basel) 18(2):207. https:\/\/doi.org\/10.3390\/ph18020207","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"8101_CR4","doi-asserted-by":"publisher","first-page":"6894","DOI":"10.1038\/s41598-025-90150-9","volume":"15","author":"M Mohanad","year":"2025","unstructured":"Mohanad M, Hamza HM, Bahnassy AA et al (2025) Molecular profiling of breast cancer methylation pattern in triple negative versus non- triple negative breast cancer. Sci Rep 15(1):6894. https:\/\/doi.org\/10.1038\/s41598-025-90150-9","journal-title":"Sci Rep"},{"issue":"1","key":"8101_CR5","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1038\/s41467-025-58158-x","volume":"16","author":"M Aine","year":"2025","unstructured":"Aine M, Nacer DF, Arbajian E et al (2025) The DNA methylation landscape of primary triple-negative breast cancer. Nat Commun 16(1):3041. https:\/\/doi.org\/10.1038\/s41467-025-58158-x","journal-title":"Nat Commun"},{"issue":"15","key":"8101_CR6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1080\/17501911.2025.2548755","volume":"17","author":"S Williams","year":"2025","unstructured":"Williams S, Clark SJ, Pidsley R, Stirzaker C (2025) DNA methylation biomarkers for the diagnosis and treatment management of breast cancer: where are we now? Epigenomics 17(15):1107\u20131122. https:\/\/doi.org\/10.1080\/17501911.2025.2548755","journal-title":"Epigenomics"},{"key":"8101_CR7","doi-asserted-by":"publisher","first-page":"1610093","DOI":"10.3389\/fonc.2025.1610093","volume":"15","author":"Z Guo","year":"2025","unstructured":"Guo Z, Wei J, Gui A et al (2025) Analysis of methylation features associated with neoadjuvant efficacy in HER2-positive breast cancer. Front Oncol 15:1610093. https:\/\/doi.org\/10.3389\/fonc.2025.1610093","journal-title":"Front Oncol"},{"issue":"1","key":"8101_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13072-025-00624-3","volume":"18","author":"X Chen","year":"2025","unstructured":"Chen X, Chen M, Gu X et al (2025) Roles of KDM5 demethylases in therapeutic resistance of cancers. Epigenetics Chromatin 18(1):61. https:\/\/doi.org\/10.1186\/s13072-025-00624-3","journal-title":"Epigenetics Chromatin"},{"key":"8101_CR9","doi-asserted-by":"publisher","first-page":"1594400","DOI":"10.3389\/freae.2025.1594400","volume":"3","author":"L Peng","year":"2025","unstructured":"Peng L, Li X, Yang H, Chen H, Yang Y, Peng S (2025) Discovery and structural studies of histone demethylases. Front Epigenet Epigenom 3:1594400. https:\/\/doi.org\/10.3389\/freae.2025.1594400","journal-title":"Front Epigenet Epigenom"},{"key":"8101_CR10","doi-asserted-by":"publisher","first-page":"RP106249","DOI":"10.7554\/eLife.106249","volume":"14","author":"L Lau","year":"2025","unstructured":"Lau L, Henderson K, Turkoz A et al (2025) KDM5 demethylases suppress R-loop-mediated \u2018viral mimicry\u2019 and DNA damage in breast cancer cells. Elife 14:RP106249. https:\/\/doi.org\/10.7554\/eLife.106249","journal-title":"Elife"},{"issue":"44","key":"8101_CR11","doi-asserted-by":"publisher","first-page":"15626","DOI":"10.1523\/JNEUROSCI.1470-12.2012","volume":"32","author":"N Proven\u00e7al","year":"2012","unstructured":"Proven\u00e7al N, Suderman MJ, Guillemin C et al (2012) The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci 32(44):15626\u201315642. https:\/\/doi.org\/10.1523\/JNEUROSCI.1470-12.2012","journal-title":"J Neurosci"},{"issue":"7","key":"8101_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/0471142301.ns0724s60","volume":"7","author":"RR Parrish","year":"2012","unstructured":"Parrish RR, Day JJ, Lubin FD (2012) Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissues. Curr Protoc Neurosci 7(7):24. https:\/\/doi.org\/10.1002\/0471142301.ns0724s60","journal-title":"Curr Protoc Neurosci"},{"issue":"1","key":"8101_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13148-019-0641-1","volume":"11","author":"S Yao","year":"2019","unstructured":"Yao S, Hu Q, Kerns S et al (2019) Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study. Clin Epigenetics 11(1):45. https:\/\/doi.org\/10.1186\/s13148-019-0641-1","journal-title":"Clin Epigenetics"},{"issue":"4","key":"8101_CR14","doi-asserted-by":"publisher","first-page":"e0230248","DOI":"10.1371\/journal.pone.0230248","volume":"15","author":"PC Hsu","year":"2020","unstructured":"Hsu PC, Kadlubar SA, Siegel ER et al (2020) Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer. PLoS ONE 15(4):e0230248. https:\/\/doi.org\/10.1371\/journal.pone.0230248","journal-title":"PLoS ONE"},{"issue":"3","key":"8101_CR15","first-page":"247","volume":"4","author":"J Hou","year":"2012","unstructured":"Hou J, Wu J, Dombkowski A et al (2012) Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. Am J Transl Res 4(3):247\u2013256","journal-title":"Am J Transl Res"},{"issue":"6","key":"8101_CR16","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1142\/S0192415X18500702","volume":"46","author":"J Ham","year":"2018","unstructured":"Ham J, Lee S, Lee H, Jeong D, Park S, Kim SJ (2018) Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3. Am J Chin Med 46(6):1333\u20131355. https:\/\/doi.org\/10.1142\/S0192415X18500702","journal-title":"Am J Chin Med"},{"issue":"14","key":"8101_CR17","doi-asserted-by":"publisher","first-page":"7313","DOI":"10.1074\/jbc.M115.701227","volume":"291","author":"RA Varier","year":"2016","unstructured":"Varier RA, van der Carrillo de Santa Pau E et al (2016) Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. J Biol Chem 291(14):7313\u20137324. https:\/\/doi.org\/10.1074\/jbc.M115.701227","journal-title":"J Biol Chem"},{"issue":"9","key":"8101_CR18","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1158\/1541-7786.MCR-22-0466","volume":"21","author":"J Morales-Valencia","year":"2023","unstructured":"Morales-Valencia J, Petit C, Calderon A, Saini S, David G (2023) Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice. Mol Cancer Res 21(9):947\u2013957. https:\/\/doi.org\/10.1158\/1541-7786.MCR-22-0466","journal-title":"Mol Cancer Res"},{"issue":"17","key":"8101_CR19","doi-asserted-by":"publisher","first-page":"e168362","DOI":"10.1172\/JCI168362","volume":"133","author":"L Bao","year":"2023","unstructured":"Bao L, Kumar A, Zhu M et al (2023) SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. J Clin Invest 133(17):e168362. https:\/\/doi.org\/10.1172\/JCI168362","journal-title":"J Clin Invest"},{"issue":"26","key":"8101_CR20","doi-asserted-by":"publisher","first-page":"11811","DOI":"10.1073\/pnas.1006737107","volume":"107","author":"EF Farias","year":"2010","unstructured":"Farias EF, Petrie K, Leibovitch B et al (2010) Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells. Proc Natl Acad Sci USA 107(26):11811\u201311816. https:\/\/doi.org\/10.1073\/pnas.1006737107","journal-title":"Proc Natl Acad Sci USA"},{"key":"8101_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1755-8794-6-1","volume":"6","author":"D Grafodatskaya","year":"2013","unstructured":"Grafodatskaya D, Chung BH, Butcher DT et al (2013) Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C. BMC Med Genomics 6:1. https:\/\/doi.org\/10.1186\/1755-8794-6-1","journal-title":"BMC Med Genomics"},{"issue":"9","key":"8101_CR22","doi-asserted-by":"publisher","first-page":"2004635","DOI":"10.1002\/advs.202004635","volume":"8","author":"HF Shen","year":"2021","unstructured":"Shen HF, Zhang WJ, Huang Y et al (2021) The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis. Adv Sci (Weinh) 8(9):2004635. https:\/\/doi.org\/10.1002\/advs.202004635","journal-title":"Adv Sci (Weinh)"},{"issue":"17","key":"8101_CR23","doi-asserted-by":"publisher","first-page":"28558","DOI":"10.18632\/oncotarget.15331","volume":"8","author":"K Kluzek","year":"2017","unstructured":"Kluzek K, Srebniak MI, Majer W et al (2017) Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA. Oncotarget 8(17):28558\u201328574. https:\/\/doi.org\/10.18632\/oncotarget.15331","journal-title":"Oncotarget"},{"issue":"1","key":"8101_CR24","doi-asserted-by":"publisher","first-page":"BSR20222230","DOI":"10.1042\/BSR20222230","volume":"43","author":"L Luo","year":"2023","unstructured":"Luo L, Wang Z, Hu T et al (2023) Multiomics characteristics and immunotherapeutic potential of EZH2 in pan-cancer. Biosci Rep 43(1):BSR20222230. https:\/\/doi.org\/10.1042\/BSR20222230","journal-title":"Biosci Rep"},{"key":"8101_CR25","doi-asserted-by":"publisher","first-page":"116624","DOI":"10.1016\/j.biopha.2024.116624","volume":"175","author":"Y Chen","year":"2024","unstructured":"Chen Y, Zhu H, Luo Y, Tong S, Liu Y (2024) EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer. Biomed Pharmacother 175:116624. https:\/\/doi.org\/10.1016\/j.biopha.2024.116624","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"8101_CR26","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1038\/s41418-020-00615-9","volume":"27","author":"Z Li","year":"2020","unstructured":"Li Z, Wang D, Lu J et al (2020) Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis. Cell Death Differ 27(12):3226\u20133242. https:\/\/doi.org\/10.1038\/s41418-020-00615-9","journal-title":"Cell Death Differ"},{"issue":"6","key":"8101_CR27","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.ccr.2014.04.024","volume":"25","author":"S Yamamoto","year":"2014","unstructured":"Yamamoto S, Wu Z, Russnes HG et al (2014) JARID1B is a luminal lineage-driving oncogene in breast cancer. Cancer Cell 25(6):762\u2013777. https:\/\/doi.org\/10.1016\/j.ccr.2014.04.024","journal-title":"Cancer Cell"},{"issue":"2","key":"8101_CR28","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.yexcr.2019.04.006","volume":"379","author":"ZG Zhang","year":"2019","unstructured":"Zhang ZG, Zhang HS, Sun HL, Liu HY, Liu MY, Zhou Z (2019) KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. Exp Cell Res 379(2):182\u2013190. https:\/\/doi.org\/10.1016\/j.yexcr.2019.04.006","journal-title":"Exp Cell Res"},{"issue":"9","key":"8101_CR29","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1128\/MCB.06373-11","volume":"32","author":"PP Wong","year":"2012","unstructured":"Wong PP, Miranda F, Chan KV, Berlato C, Hurst HC, Scibetta AG (2012) Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol 32(9):1633\u20131644. https:\/\/doi.org\/10.1128\/MCB.06373-11","journal-title":"Mol Cell Biol"},{"issue":"23","key":"8101_CR30","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1158\/1078-0432.CCR-16-0148","volume":"22","author":"R Jeselsohn","year":"2016","unstructured":"Jeselsohn R, Barry WT, Migliaccio I et al (2016) TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer. Clin Cancer Res 22(23):5755\u20135764. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0148","journal-title":"Clin Cancer Res"},{"key":"8101_CR31","doi-asserted-by":"publisher","first-page":"217356","DOI":"10.1016\/j.canlet.2024.217356","volume":"610","author":"MJ Mughal","year":"2025","unstructured":"Mughal MJ, Zhang Y, Li Z et al (2025) TFAP2C-DDR1 axis regulates resistance to CDK4\/6 inhibitor in breast cancer. Cancer Lett 610:217356. https:\/\/doi.org\/10.1016\/j.canlet.2024.217356","journal-title":"Cancer Lett"},{"issue":"34","key":"8101_CR32","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1038\/onc.2012.400","volume":"32","author":"MV Kulak","year":"2013","unstructured":"Kulak MV, Cyr AR, Woodfield GW et al (2013) Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene 32(34):4043\u20134051. https:\/\/doi.org\/10.1038\/onc.2012.400","journal-title":"Oncogene"},{"issue":"7","key":"8101_CR33","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1083\/jcb.201611135","volume":"216","author":"F Gong","year":"2017","unstructured":"Gong F, Clouaire T, Aguirrebengoa M et al (2017) Histone demethylase KDM5A regulates the ZMYND8\u2013NuRD chromatin remodeler to promote DNA repair. J Cell Biol 216(7):1959\u20131974. https:\/\/doi.org\/10.1083\/jcb.201611135","journal-title":"J Cell Biol"},{"key":"8101_CR34","doi-asserted-by":"publisher","first-page":"906662","DOI":"10.3389\/fgene.2022.906662","volume":"13","author":"E Pavlenko","year":"2022","unstructured":"Pavlenko E, Ruengeler T, Engel P, Poepsel S (2022) Functions and interactions of mammalian KDM5 demethylases. Front Genet 13:906662. https:\/\/doi.org\/10.3389\/fgene.2022.906662","journal-title":"Front Genet"},{"issue":"1","key":"8101_CR35","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1038\/s41467-025-59184-5","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Wang Y, Bao L et al (2025) ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27. Nat Commun 16(1):3908. https:\/\/doi.org\/10.1038\/s41467-025-59184-5","journal-title":"Nat Commun"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-08101-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-026-08101-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-026-08101-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:06:10Z","timestamp":1792623970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-026-08101-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["8101"],"URL":"https:\/\/doi.org\/10.1007\/s10549-026-08101-5","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"26 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics committee approval was obtained from Saglik Bilimleri University, Hamidiye Scientific Research Ethics Committee (Date, 12.08.2024; Decision number, E-46418926-050.04\u2013385226). Informed consent was obtained from all individual participants included in the study. All procedures were conducted in accordance with the Helsinki Declaration of 1975, as revised in 2000.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"2"}}