{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:12:01Z","timestamp":1768273921253,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,3,19]],"date-time":"2011-03-19T00:00:00Z","timestamp":1300492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s10552-011-9754-3","type":"journal-article","created":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T04:59:11Z","timestamp":1300424351000},"page":"837-847","source":"Crossref","is-referenced-by-count":67,"title":["Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis"],"prefix":"10.1007","volume":"22","author":[{"given":"Hong-Bo","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,3,19]]},"reference":[{"key":"9754_CR1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2004-828889","volume":"24","author":"Y Shaib","year":"2004","unstructured":"Shaib Y, El-Serag HB (2004) The epidemiology of cholangiocarcinoma. Semin Liver Dis 24:115\u2013125","journal-title":"Semin Liver Dis"},{"key":"9754_CR2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<435::AID-IJC1>3.0.CO;2-J","volume":"83","author":"F Jin","year":"1999","unstructured":"Jin F, Devesa SS, Chow WH et al (1999) Cancer incidence trends in urban shanghai, 1972\u20131994: an update. Int J Cancer 83:435\u2013440","journal-title":"Int J Cancer"},{"key":"9754_CR3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jhep.2003.11.030","volume":"40","author":"YH Shaib","year":"2004","unstructured":"Shaib YH, Davila JA, McGlynn K, El-Serag HB (2004) Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase? J Hepatol 40:472\u2013477","journal-title":"J Hepatol"},{"key":"9754_CR4","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3748\/wjg.v13.i10.1505","volume":"13","author":"Y Seyama","year":"2007","unstructured":"Seyama Y, Makuuchi M (2007) Current surgical treatment for bile duct cancer. World J Gastroenterol 13:1505\u20131515","journal-title":"World J Gastroenterol"},{"key":"9754_CR5","doi-asserted-by":"crossref","unstructured":"Jarnagin WR, Fong Y, DeMatteo RP et al. (2001) Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 234:507\u2013517; discussion 517\u2013509","DOI":"10.1097\/00000658-200110000-00010"},{"key":"9754_CR6","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.bjc.6603703","volume":"96","author":"SC Larsson","year":"2007","unstructured":"Larsson SC, Wolk A (2007) Obesity and the risk of gallbladder cancer: a meta-analysis. Br J Cancer 96:1457\u20131461","journal-title":"Br J Cancer"},{"key":"9754_CR7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cgh.2007.05.020","volume":"5","author":"TM Welzel","year":"2007","unstructured":"Welzel TM, Graubard BI, El-Serag HB et al (2007) Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case\u2013control study. Clin Gastroenterol Hepatol 5:1221\u20131228","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9754_CR8","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1572-0241.2007.01104.x","volume":"102","author":"YH Shaib","year":"2007","unstructured":"Shaib YH, El-Serag HB, Nooka AK et al (2007) Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case\u2013control study. Am J Gastroenterol 102:1016\u20131021","journal-title":"Am J Gastroenterol"},{"key":"9754_CR9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ijc.22283","volume":"120","author":"TM Welzel","year":"2007","unstructured":"Welzel TM, Mellemkjaer L, Gloria G et al (2007) Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case\u2013control study. Int J Cancer 120:638\u2013641","journal-title":"Int J Cancer"},{"key":"9754_CR10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cgh.2005.12.007","volume":"4","author":"HB El-Serag","year":"2006","unstructured":"El-Serag HB, Hampel H, Javadi F (2006) The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 4:369\u2013380","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9754_CR11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejca.2010.07.010","volume":"48","author":"Q Ben","year":"2011","unstructured":"Ben Q, Cai Q, Li Z et al (2011) The relationship between new-onset diabetes mellitus and pancreatic cancer risk: a case\u2013control study. Eur J Cancer 48:248\u2013254","journal-title":"Eur J Cancer"},{"key":"9754_CR12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/13813450801969715","volume":"114","author":"F Frasca","year":"2008","unstructured":"Frasca F, Pandini G, Sciacca L et al (2008) The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem 114:23\u201337","journal-title":"Arch Physiol Biochem"},{"key":"9754_CR13","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","volume":"4","author":"EE Calle","year":"2004","unstructured":"Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579\u2013591","journal-title":"Nat Rev Cancer"},{"key":"9754_CR14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00051670","volume":"2","author":"HO Adami","year":"1991","unstructured":"Adami HO, McLaughlin J, Ekbom A et al (1991) Cancer risk in patients with diabetes mellitus. Cancer Causes Control 2:307\u2013314","journal-title":"Cancer Causes Control"},{"key":"9754_CR15","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.26.4.1047","volume":"26","author":"G Verlato","year":"2003","unstructured":"Verlato G, Zoppini G, Bonora E, Muggeo M (2003) Mortality from site-specific malignancies in type 2 diabetic patients from Verona. Diabetes Care 26:1047\u20131051","journal-title":"Diabetes Care"},{"key":"9754_CR16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188","journal-title":"Control Clin Trials"},{"key":"9754_CR17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539\u20131558","journal-title":"Stat Med"},{"key":"9754_CR18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088\u20131101","journal-title":"Biometrics"},{"key":"9754_CR19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629\u2013634","journal-title":"BMJ"},{"key":"9754_CR20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/sj.bjc.6604765","volume":"100","author":"MJ Grainge","year":"2009","unstructured":"Grainge MJ, West J, Solaymani-Dodaran M, Aithal GP, Card TR (2009) The antecedents of biliary cancer: a primary care case\u2013control study in the United Kingdom. Br J Cancer 100:178\u2013180","journal-title":"Br J Cancer"},{"key":"9754_CR21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/sj.bjc.6605706","volume":"103","author":"FM Shebl","year":"2010","unstructured":"Shebl FM, Andreotti G, Rashid A et al (2010) Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China. Br J Cancer 103:115\u2013119","journal-title":"Br J Cancer"},{"key":"9754_CR22","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/bjc.1994.427","volume":"70","author":"C La Vecchia","year":"1994","unstructured":"La Vecchia C, Negri E, Franceschi S, D\u2019Avanzo B, Boyle P (1994) A case\u2013control study of diabetes mellitus and cancer risk. Br J Cancer 70:950\u2013953","journal-title":"Br J Cancer"},{"key":"9754_CR23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1572-0241.1999.00786.x","volume":"94","author":"ZR Khan","year":"1999","unstructured":"Khan ZR, Neugut AI, Ahsan H, Chabot JA (1999) Risk factors for biliary tract cancers. Am J Gastroenterol 94:149\u2013152","journal-title":"Am J Gastroenterol"},{"key":"9754_CR24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/01.cej.0000228404.37858.40","volume":"16","author":"K Kuriki","year":"2007","unstructured":"Kuriki K, Hirose K, Tajima K (2007) Diabetes and cancer risk for all and specific sites among Japanese men and women. Eur J Cancer Prev 16:83\u201389","journal-title":"Eur J Cancer Prev"},{"key":"9754_CR25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1478-3231.2009.02149.x","volume":"30","author":"LY Tao","year":"2010","unstructured":"Tao LY, He XD, Qu Q et al (2010) Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case\u2013control study in China. Liver Int 30:215\u2013221","journal-title":"Liver Int"},{"key":"9754_CR26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.22606","volume":"49","author":"HB El-Serag","year":"2009","unstructured":"El-Serag HB, Engels EA, Landgren O et al (2009) Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: a population-based study of US veterans. Hepatology 49:116\u2013123","journal-title":"Hepatology"},{"key":"9754_CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.23641","volume":"52","author":"HF Chen","year":"2010","unstructured":"Chen HF, Chen P, Li CY (2010) Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications. Hepatology 52:155\u2013163","journal-title":"Hepatology"},{"key":"9754_CR28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0021-9681(82)90025-X","volume":"35","author":"M Ragozzino","year":"1982","unstructured":"Ragozzino M, Melton LJ III, Chu CP, Palumbo PJ (1982) Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus. J Chronic Dis 35:13\u201319","journal-title":"J Chronic Dis"},{"key":"9754_CR29","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/jnci\/88.20.1472","volume":"88","author":"HO Adami","year":"1996","unstructured":"Adami HO, Chow WH, Nyren O et al (1996) Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst 88:1472\u20131477","journal-title":"J Natl Cancer Inst"},{"key":"9754_CR30","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/jnci\/89.18.1360","volume":"89","author":"L Wideroff","year":"1997","unstructured":"Wideroff L, Gridley G, Mellemkjaer L et al (1997) Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 89:1360\u20131365","journal-title":"J Natl Cancer Inst"},{"key":"9754_CR31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.293.2.194","volume":"293","author":"SH Jee","year":"2005","unstructured":"Jee SH, Ohrr H, Sull JW et al (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293:194\u2013202","journal-title":"JAMA"},{"key":"9754_CR32","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1001\/archinte.166.17.1871","volume":"166","author":"M Inoue","year":"2006","unstructured":"Inoue M, Iwasaki M, Otani T et al (2006) Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 166:1871\u20131877","journal-title":"Arch Intern Med"},{"key":"9754_CR33","first-page":"253","volume":"7","author":"M Khan","year":"2006","unstructured":"Khan M, Mori M, Fujino Y et al (2006) Site-specific cancer risk due to diabetes mellitus history: evidence from the Japan collaborative cohort (JACC) study. Asian Pac J Cancer Prev 7:253\u2013259","journal-title":"Asian Pac J Cancer Prev"},{"key":"9754_CR34","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.3748\/wjg.15.5274","volume":"15","author":"MM Jamal","year":"2009","unstructured":"Jamal MM, Yoon EJ, Vega KJ, Hashemzadeh M, Chang KJ (2009) Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans. World J Gastroenterol 15:5274\u20135278","journal-title":"World J Gastroenterol"},{"key":"9754_CR35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/(SICI)1097-0215(19971009)73:2<204::AID-IJC7>3.0.CO;2-#","volume":"73","author":"C La Vecchia","year":"1997","unstructured":"La Vecchia C, Negri E, Decarli A, Franceschi S (1997) Diabetes mellitus and the risk of primary liver cancer. Int J Cancer 73:204\u2013207","journal-title":"Int J Cancer"},{"key":"9754_CR36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/aje\/kwh161","volume":"159","author":"SS Coughlin","year":"2004","unstructured":"Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ (2004) Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol 159:1160\u20131167","journal-title":"Am J Epidemiol"},{"key":"9754_CR37","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1349-7006.2004.tb03328.x","volume":"95","author":"K Yagyu","year":"2004","unstructured":"Yagyu K, Lin Y, Obata Y et al (2004) Bowel movement frequency, medical history and the risk of gallbladder cancer death: a cohort study in Japan. Cancer Sci 95:674\u2013678","journal-title":"Cancer Sci"},{"key":"9754_CR38","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/sj.bjc.6602611","volume":"92","author":"AJ Swerdlow","year":"2005","unstructured":"Swerdlow AJ, Laing SP, Qiao Z et al (2005) Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study. Br J Cancer 92:2070\u20132075","journal-title":"Br J Cancer"},{"key":"9754_CR39","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1056\/NEJMoa0908292","volume":"362","author":"W Yang","year":"2010","unstructured":"Yang W, Lu J, Weng J, et al (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362:1090\u20131101","journal-title":"N Engl J Med"},{"key":"9754_CR40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","volume":"414","author":"P Zimmet","year":"2001","unstructured":"Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782\u2013787","journal-title":"Nature"},{"key":"9754_CR41","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/(SICI)1097-0215(19980130)75:3<368::AID-IJC7>3.0.CO;2-0","volume":"75","author":"AW Hsing","year":"1998","unstructured":"Hsing AW, Gao YT, Devesa SS, Jin F, Fraumeni JF Jr (1998) Rising incidence of biliary tract cancers in Shanghai, China. Int J Cancer 75:368\u2013370","journal-title":"Int J Cancer"},{"key":"9754_CR42","first-page":"76","volume":"7","author":"HH Cai","year":"2008","unstructured":"Cai HH, Sun YM, Bai JF et al (2008) Relationship between the GH-IGFs axis and the proliferation of bile duct cancer cell line QBC939 in vitro. Hepatobiliary Pancreat Dis Int 7:76\u201381","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"9754_CR43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2353\/ajpath.2006.050464","volume":"169","author":"D Alvaro","year":"2006","unstructured":"Alvaro D, Barbaro B, Franchitto A et al (2006) Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol 169:877\u2013888","journal-title":"Am J Pathol"},{"key":"9754_CR44","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.3748\/wjg.14.5282","volume":"14","author":"D Festi","year":"2008","unstructured":"Festi D, Dormi A, Capodicasa S et al (2008) Incidence of gallstone disease in Italy: results from a multicenter, population-based Italian study (the MICOL project). World J Gastroenterol 14:5282\u20135289","journal-title":"World J Gastroenterol"},{"key":"9754_CR45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-2008-1041754","volume":"5","author":"BG Stone","year":"1985","unstructured":"Stone BG, Van Thiel DH (1985) Diabetes mellitus and the liver. Semin Liver Dis 5:8\u201328","journal-title":"Semin Liver Dis"},{"key":"9754_CR46","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nm1785","volume":"14","author":"SB Biddinger","year":"2008","unstructured":"Biddinger SB, Haas JT, Yu BB et al (2008) Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 14:778\u2013782","journal-title":"Nat Med"},{"key":"9754_CR47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","volume":"371","author":"AG Renehan","year":"2008","unstructured":"Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569\u2013578","journal-title":"Lancet"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-011-9754-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-011-9754-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-011-9754-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T05:50:28Z","timestamp":1560059428000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-011-9754-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,19]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["9754"],"URL":"https:\/\/doi.org\/10.1007\/s10552-011-9754-3","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,19]]}}}