{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:00:43Z","timestamp":1791046843319,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s10552-011-9755-2","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T06:16:50Z","timestamp":1300947410000},"page":"849-857","source":"Crossref","is-referenced-by-count":15,"title":["Spatial clustering of leukemia and type 1 diabetes in children in Denmark"],"prefix":"10.1007","volume":"22","author":[{"given":"Sven","family":"Schmiedel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Jacquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Blettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"issue":"12","key":"9755_CR1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/aje\/kwi146","volume":"161","author":"RG Feltbower","year":"2005","unstructured":"Feltbower RG, Manda SOM, Gilthorpe MS, Greaves MF, Parslow RC, Kinsey SE, Bodansky HJ, McKinney PA (2005) Detecting small-area similarities in the epidemiology of childhood acute lymphoblastic leukemia and diabetes mellitus, type 1: a Bayesian approach. Am J Epidemiol 161(12):1168\u20131180. doi: 10.1093\/aje\/kwi146","journal-title":"Am J Epidemiol"},{"issue":"12","key":"9755_CR2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10654-009-9391-2","volume":"24","author":"SOM Manda","year":"2009","unstructured":"Manda SOM, Feltbower RG, Gilthorpe MS (2009) Investigating spatio-temporal similarities in the epidemiology of childhood leukaemia and diabetes. Eur J Epidemiol 24(12):743\u2013752. doi: 10.1007\/s10654-009-9391-2","journal-title":"Eur J Epidemiol"},{"issue":"5","key":"9755_CR3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jpeds.2007.07.006","volume":"151","author":"AL Svendsen","year":"2007","unstructured":"Svendsen AL, Feychting M, Kl\u00e6boe L, Langmark F, Sch\u00fcz J (2007) Time trends in the incidence of acute lymphoblastic leukemia among children 1976\u20132002: a population-based Nordic study. J Pediatr 151(5):548\u2013550. doi: 10.1016\/j.jpeds.2007.07.006","journal-title":"J Pediatr"},{"issue":"1","key":"9755_CR4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1081\/CNV-46402","volume":"23","author":"PA Buffler","year":"2005","unstructured":"Buffler PA, Kwan ML, Reynolds P, Urayama KY (2005) Environmental and genetic risk factors for childhood leukemia: appraising the evidence. Cancer Invest 23(1):60\u201375. doi: 10.1081\/CNV-200046402","journal-title":"Cancer Invest"},{"issue":"12","key":"9755_CR5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.2337\/diacare.25.12.2197","volume":"25","author":"J Svensson","year":"2002","unstructured":"Svensson J, Carstensen B, M\u00f8lbak A, Christau B, Mortensen HB, Nerup J, Borch-Johnsen K (2002) Increased risk of childhood type 1 diabetes in children born after 1985. Diabetes Care 25(12):2197\u20132201. doi: 10.2337\/diacare.25.12.2197","journal-title":"Diabetes Care"},{"issue":"7332","key":"9755_CR6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/bmj.324.7332.283","volume":"324","author":"M Greaves","year":"2002","unstructured":"Greaves M (2002) Science, medicine, and the future: childhood leukaemia. BMJ 324(7332):283\u2013287. doi: 10.1136\/bmj.324.7332.283","journal-title":"BMJ"},{"issue":"1","key":"9755_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s001250050006","volume":"43","author":"EURODIAB Study Group","year":"2000","unstructured":"EURODIAB Study Group (2000) Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre casecontrol investigation. EURODIAB Substudy 2 Study Group. Diabetologia 43(1):47\u201353. doi: 10.1007\/s001250050006","journal-title":"Diabetologia"},{"issue":"5","key":"9755_CR8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ncpgasthep0471","volume":"3","author":"F Guarner","year":"2006","unstructured":"Guarner F, Bourdet-Sicard R, Brandtzaeg P, Gill HS, McGuirk P, van Eden W, Versalovic J, Weinstock JV, Rook GA (2006) Mechanisms of disease: the hygiene hypothesis revisited. Nat Clin Pract Gastroenterol Hepatol 3(5):275\u2013284. doi: 10.1038\/ncpgasthep0471","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"8624","key":"9755_CR9","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0140-6736(88)90867-7","volume":"2","author":"LJ Kinlen","year":"1988","unstructured":"Kinlen LJ (1988) Evidence for an infective cause of childhood leukaemia: comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet 2(8624):1323\u20131327. doi: 10.1016\/S0140-6736(88)90867-7","journal-title":"Lancet"},{"issue":"9451","key":"9755_CR10","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/S0140-6736(04)17550-8","volume":"364","author":"E Steliarova-Foucher","year":"2004","unstructured":"Steliarova-Foucher E, Stiller C, Kaatsch P, Berrino F, Coebergh J-W, Lacour B, Perkin M (2004) Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970\u00a0s (the ACCIS project): an epidemiological study. Lancet 364(9451):2097\u20132105. doi: 10.1016\/S0140-6736(04)17550-8","journal-title":"Lancet"},{"issue":"suppl 3","key":"9755_CR11","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1007\/PL00002950","volume":"44","author":"A Green","year":"2001","unstructured":"Green A, Patterson CC, EURODIAB TIGER Study Group (2001) Europe and Diabetes Trends in the incidence of childhood-onset diabetes in Europe 1989\u20131998. Diabetologia 44(suppl 3):B3\u2013B8. doi: 10.1007\/PL00002950","journal-title":"Diabetologia"},{"key":"9755_CR12","first-page":"49","volume-title":"GIS and Health","author":"M Kulldorff","year":"2003","unstructured":"Kulldorff M (2003) Statistical Methods for Spatial Epidemiology: Tests for Randomness. In: Gatrell AC, L\u00f6yt\u00f6nen M (eds) GIS and Health. Taylor & Francis Ltd, London, pp 49\u201362"},{"key":"9755_CR13","unstructured":"The Danish National Board of Health, Cancer incidence in Denmark (2001)"},{"issue":"7","key":"9755_CR14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/cncr.20910","volume":"103","author":"E Steliarova-Foucher","year":"2005","unstructured":"Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P (2005) International classification of childhood cancer, third edition. Cancer 103(7):1457\u20131467. doi: 10.1002\/cncr.20910","journal-title":"Cancer"},{"issue":"5","key":"9755_CR15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2337\/dc06-1813","volume":"30","author":"L Haines","year":"2007","unstructured":"Haines L, Wan KC, Lynn R, Barrett TG, Shield JP (2007) Rising incidence of type 2 diabetes in children in the UK. Diabetes Care 30(5):1097\u20131101. doi: 10.2337\/dc06-1813","journal-title":"Diabetes Care"},{"issue":"3","key":"9755_CR16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2307\/2532668","volume":"47","author":"PJ Diggle","year":"1991","unstructured":"Diggle PJ, Chetwynd AG (1991) Second-order analysis of spatial clustering for inhomogeneous populations. Biometrics 47(3):1155\u20131163. doi: 10.2307\/2532668","journal-title":"Biometrics"},{"issue":"1","key":"9755_CR17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.2517-6161.1990.tb01773.x","volume":"52","author":"J Cuzick","year":"1990","unstructured":"Cuzick J, Edwards R (1990) Spatial Clustering for Inhomogeneous Populations. J R Stat Soc (Ser B) 52(1):73\u2013104","journal-title":"J R Stat Soc (Ser B)"},{"issue":"1","key":"9755_CR18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-069X-4-4","volume":"4","author":"GM Jacquez","year":"2005","unstructured":"Jacquez GM, Kaufmann A, Meliker J, Goovaerts P, AvRuskin G, Nriagu J (2005) Global, local and focused geographic clustering for case-control data with residential histories. Environ Health 4(1):4. doi: 10.1186\/1476-069X-4-4","journal-title":"Environ Health"},{"key":"9755_CR19","unstructured":"R Development Core Team (2010) R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, Austria, http:\/\/www.R-project.org"},{"key":"9755_CR20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-072X-3-22","volume":"3","author":"GM Jacquez","year":"2004","unstructured":"Jacquez GM (2004) Current practices in the spatial analysis of cancer: flies in the ointment. Int J Health Geogr 3:22. doi: 10.1186\/1476-072X-3-22","journal-title":"Int J Health Geogr"},{"key":"9755_CR21","unstructured":"Committee on Medical Aspects of Radiation in the Environment (COMARE) (2006) Eleventh Report. The distribution of childhood leukaemia and other childhood cancer in Great Britain 1969-1993. Health Protection Agency, July 2006"},{"issue":"5","key":"9755_CR22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/bjc.1998.133","volume":"77","author":"FE Alexander","year":"1998","unstructured":"Alexander FE, Boyle P, Carli PM, Coebergh JW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Pl\u00ecsko I, Pukkala E, Rahu M, Storm H, Terracini B, Vatten L, Wray N (1998) Spatial clustering of childhood leukaemia: summary results from the EUROCLUS project. Br J Cancer 77(5):818\u2013824. doi: 10.1038\/bjc.1998.133","journal-title":"Br J Cancer"},{"issue":"4","key":"9755_CR23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/ije\/19.4.853","volume":"19","author":"KR Muir","year":"1990","unstructured":"Muir KR, Parkes SE, Mann JR, Stevens MC, Cameron AH, Raafat F, Darbyshire PJ, Ingram DR, Davis A, Gascoigne D (1990) Clustering\u2019\u2014real or apparent? Probability maps of childhood cancer in the West Midlands Health Authority Region. Int J Epidemiol 19(4):853\u2013859. doi: 10.1093\/ije\/19.4.853","journal-title":"Int J Epidemiol"},{"issue":"7\u20139","key":"9755_CR24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/(SICI)1097-0258(19960415)15:7\/9<707::AID-SIM242>3.0.CO;2-4","volume":"15","author":"U Hjalmars","year":"1996","unstructured":"Hjalmars U, Kulldorff M, Gustafsson G, Nagarwalla N (1996) Childhood leukaemia in Sweden: using GIS and a spatial scan statistic for cluster detection. Stat Med 15(7\u20139):707\u2013715. doi: 10.1002\/(SICI)1097-0258(19960415)15:7\/9<707:AID-SIM242>3.0.CO;2-4","journal-title":"Stat Med"},{"issue":"2","key":"9755_CR25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijheh.2006.08.005","volume":"210","author":"A Mosavi-Jarrahi","year":"2007","unstructured":"Mosavi-Jarrahi A, Moini M, Mohagheghi MA, Alebouyeh M, Yazdizadeh B, Shahabian A, Nahvijo A, Alizadeh R (2007) Clustering of childhood cancer in the inner city of Tehran metropolitan area: a GIS-based analysis. Int J Hyg Environ Health 210(2):113\u2013119. doi: 10.1016\/j.ijheh.2006.08.005","journal-title":"Int J Hyg Environ Health"},{"issue":"1","key":"9755_CR26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01210539","volume":"34","author":"T Westermeier","year":"1995","unstructured":"Westermeier T, Michaelis J (1995) Applicability of the Poisson distribution to model the data of the German Children\u2019s Cancer Registry. Radiat Environ Biophys 34(1):7\u201311. doi: 10.1007\/BF01210539","journal-title":"Radiat Environ Biophys"},{"issue":"9","key":"9755_CR27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10654-010-9488-7","volume":"25","author":"S Schmiedel","year":"2010","unstructured":"Schmiedel S, Blettner M, Kaatsch P, Sch\u00fcz J (2010) Spatial clustering and space-time clusters of leukemia among children in Germany, 1987\u20132007. Eur J Epidemiol 25(9):627\u2013633. doi: 10.1007\/s10654-010-9488-7","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"9755_CR28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/bjc.1997.77","volume":"75","author":"FE Alexander","year":"1997","unstructured":"Alexander FE, Chan LC, Lam TH, Yuen P, Leung NK, Ha SY, Yuen HL, Li CK, Li CK, Lau YL, Greaves MF (1997) Clustering of childhood leukaemia in Hong Kong: association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing. Br J Cancer 75(3):457\u2013463. doi: 10.1038\/bjc.1997.77","journal-title":"Br J Cancer"},{"issue":"3","key":"9755_CR29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jech.53.3.154","volume":"53","author":"JD Dockerty","year":"1999","unstructured":"Dockerty JD, Sharples KJ, Borman B (1999) An assessment of spatial clustering of leukaemias and lymphomas among young people in New Zealand. J Epidemiol Community Health 53(3):154\u2013158. doi: 10.1136\/jech.53.3.154","journal-title":"J Epidemiol Community Health"},{"issue":"5","key":"9755_CR30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.bjc.6600498","volume":"87","author":"RJQ McNally","year":"2002","unstructured":"McNally RJQ, Alexander FE, Birch JM (2002) Space\u2013time clustering analyses of childhood acute lymphoblastic leukaemia by immunophenotype. Br J Cancer 87(5):513\u2013515. doi: 10.1038\/sj.bjc.6600498","journal-title":"Br J Cancer"},{"issue":"5","key":"9755_CR31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.bjc.6602980","volume":"94","author":"S Bellec","year":"2006","unstructured":"Bellec S, H\u00e9mon D, Rudant J, Goubin A, Clavel J (2006) Spatial and space\u2013time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study. Br J Cancer 94(5):763\u2013770. doi: 10.1038\/sj.bjc.6602980","journal-title":"Br J Cancer"},{"issue":"3","key":"9755_CR32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/jech.50.3.313","volume":"50","author":"EG Knox","year":"1996","unstructured":"Knox EG, Gilman EA (1996) Spatial clustering of childhood cancers in Great Britain. J Epidemiol Community Health 50(3):313\u2013319. doi: 10.1136\/jech.50.3.313","journal-title":"J Epidemiol Community Health"},{"issue":"2","key":"9755_CR33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1018480515690","volume":"8","author":"E Petridou","year":"1997","unstructured":"Petridou E, Alexander FE, Trichopoulos D, Revinthi K, Dessypris N, Wray N, Haidas S, Koliouskas D, Kosmidis H, Piperopoulou F, Tzortzatou F (1997) Aggregation of childhood leukemia in geographic areas of Greece. Cancer Causes Control 8(2):239\u2013245. doi: 10.1023\/A:1018480515690","journal-title":"Cancer Causes Control"},{"issue":"4","key":"9755_CR34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/ijc.23965","volume":"124","author":"RJQ McNally","year":"2009","unstructured":"McNally RJQ, Alexander FE, Vincent TJ, Murphy MF (2009) Spatial clustering of childhood cancer in Great Britain during the period 1969\u20131993. Int J Cancer 124(4):932\u2013936. doi: 10.1002\/ijc.23965","journal-title":"Int J Cancer"},{"issue":"9","key":"9755_CR35","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1054\/bjoc.1999.1072","volume":"82","author":"JM Birch","year":"2000","unstructured":"Birch JM, Alexander FE, Blair V, Eden OB, Taylor GM, McNally RJQ (2000) Space\u2013time clustering patterns in childhood leukaemia support a role for infection. Br J Cancer 82(9):1571\u20131576. doi: 10.1054\/bjoc.1999.1072","journal-title":"Br J Cancer"},{"issue":"2","key":"9755_CR36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jech.49.2.158","volume":"49","author":"EA Gilman","year":"1995","unstructured":"Gilman EA, Knox EG (1995) Childhood cancers: space\u2013time distribution in Britain. J Epidemiol Community Health 49(2):158\u2013163. doi: 10.1136\/jech.49.2.158","journal-title":"J Epidemiol Community Health"},{"issue":"12","key":"9755_CR37","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1023\/A:1010953713048","volume":"16","author":"B Gustafsson","year":"2000","unstructured":"Gustafsson B, Carstensen J (2000) Space\u2013time clustering of childhood lymphatic leukaemias and non-Hodgkin\u2019s lymphomas in Sweden. Eur J Epidemiol 16(12):1111\u20131116","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"9755_CR38","first-page":"54","volume":"89","author":"RG Feltbower","year":"2004","unstructured":"Feltbower RG, McKinney P, Greaves M, Parslow RC, Bodansky H (2004) International parallels in leukaemia and diabetes epidemiology. Arch Dis Child 89(1):54\u201356","journal-title":"Arch Dis Child"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-011-9755-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-011-9755-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-011-9755-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:22:05Z","timestamp":1741108925000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-011-9755-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,25]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["9755"],"URL":"https:\/\/doi.org\/10.1007\/s10552-011-9755-2","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,25]]}}}