{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:07:09Z","timestamp":1762430829199},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s10552-013-0315-9","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T08:37:40Z","timestamp":1382603860000},"page":"125-132","source":"Crossref","is-referenced-by-count":4,"title":["CXCR4 pathway associated with family history of melanoma"],"prefix":"10.1007","volume":"25","author":[{"given":"Wen-Qing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans R.","family":"Widlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mick","family":"Correll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyu E.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Quackenbush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin C.","family":"Mihm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro Laga","family":"Canales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaowei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Golub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Hoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrar A.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"315_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","volume":"63","author":"R Siegel","year":"2013","unstructured":"Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63:11\u201330","journal-title":"CA Cancer J Clin"},{"key":"315_CR2","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1056\/NEJMoa1210093","volume":"367","author":"KT Flaherty","year":"2012","unstructured":"Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367:1694\u20131703","journal-title":"N Engl J Med"},{"key":"315_CR3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/jid.2009.182","volume":"130","author":"E Hacker","year":"2012","unstructured":"Hacker E, Hayward NK, Dumenil T, James MR, Whiteman DC (2012) The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population. J Invest Dermatol 130:241\u2013248","journal-title":"J Invest Dermatol"},{"key":"315_CR4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1056\/NEJMoa1112302","volume":"366","author":"JA Sosman","year":"2012","unstructured":"Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS et al (2012) Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 366:707\u2013714","journal-title":"N Engl J Med"},{"key":"315_CR5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature05660","volume":"445","author":"JY Lin","year":"2007","unstructured":"Lin JY, Fisher DE (2007) Melanocyte biology and skin pigmentation. Nature 445:843\u2013850","journal-title":"Nature"},{"key":"315_CR6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2188\/jea.JE20100145","volume":"21","author":"AA Qureshi","year":"2011","unstructured":"Qureshi AA, Zhang M, Han J (2011) Heterogeneity in host risk factors for incident melanoma and non-melanoma skin cancer in a cohort of US women. J Epidemiol 21:197\u2013203","journal-title":"J Epidemiol"},{"key":"315_CR7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1158\/1055-9965.EPI-12-1346","volume":"22","author":"AM Goldstein","year":"2013","unstructured":"Goldstein AM, Tucker MA (2013) Dysplastic nevi and melanoma. Cancer Epidemiol Biomarkers Prev 22:528\u2013532","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"315_CR8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10689-010-9356-3","volume":"9","author":"XR Yang","year":"2010","unstructured":"Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L et al (2010) Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. Fam Cancer 9:625\u2013633","journal-title":"Fam Cancer"},{"key":"315_CR9","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/humu.9247","volume":"23","author":"AM Goldstein","year":"2004","unstructured":"Goldstein AM (2004) Familial melanoma, pancreatic cancer and germline CDKN2A mutations. Hum Mutat 23:630","journal-title":"Hum Mutat"},{"key":"315_CR10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/jid.2009.258","volume":"130","author":"DL Duffy","year":"2010","unstructured":"Duffy DL, Zhao ZZ, Sturm RA, Hayward NK, Martin NG, Montgomery GW (2010) Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. J Invest Dermatol 130:520\u2013528","journal-title":"J Invest Dermatol"},{"key":"315_CR11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1126\/science.1127515","volume":"313","author":"MT Landi","year":"2006","unstructured":"Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P et al (2006) MC1R germline variants confer risk for BRAF-mutant melanoma. Science 313:521\u2013522","journal-title":"Science"},{"key":"315_CR12","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ijc.24327","volume":"125","author":"H Nan","year":"2009","unstructured":"Nan H, Kraft P, Hunter DJ, Han J (2009) Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer 125:909\u2013917","journal-title":"Int J Cancer"},{"key":"315_CR13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1101\/gr.2167504","volume":"14","author":"JB Fan","year":"2004","unstructured":"Fan JB, Yeakley JM, Bibikova M, Chudin E, Wickham E, Chen J et al (2004) A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res 14:878\u2013885","journal-title":"Genome Res"},{"key":"315_CR14","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa0804525","volume":"359","author":"Y Hoshida","year":"2008","unstructured":"Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, Camargo A et al (2008) Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 359:1995\u20132004","journal-title":"N Engl J Med"},{"key":"315_CR15","doi-asserted-by":"crossref","first-page":"e8162","DOI":"10.1371\/journal.pone.0008162","volume":"4","author":"C April","year":"2009","unstructured":"April C, Klotzle B, Royce T, Wickham-Garcia E, Boyaniwsky T, Izzo J et al (2009) Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples. PLoS One 4:e8162","journal-title":"PLoS One"},{"key":"315_CR16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2353\/jmoldx.2007.060191","volume":"9","author":"C Spittle","year":"2007","unstructured":"Spittle C, Ward MR, Nathanson KL, Gimotty PA, Rappaport E, Brose MS et al (2007) Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma. J Mol Diagn 9:464\u2013471","journal-title":"J Mol Diagn"},{"key":"315_CR17","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1093\/clinchem\/48.12.2164","volume":"48","author":"A Sivertsson","year":"2002","unstructured":"Sivertsson A, Platz A, Hansson J, Lundeberg J (2002) Pyrosequencing as an alternative to single-strand conformation polymorphism analysis for detection of N-ras mutations in human melanoma metastases. Clin Chem 48:2164\u20132170","journal-title":"Clin Chem"},{"key":"315_CR18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249\u2013264","journal-title":"Biostatistics"},{"key":"315_CR19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume-title":"Bioinformatics and computational biology solutions using R and Bioconductor","author":"GK Smyth","year":"2005","unstructured":"Smyth GK (2005) Limma: linear models for microarray data. In: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W (eds) Bioinformatics and computational biology solutions using R and Bioconductor. Springer, New York, pp 397\u2013420"},{"key":"315_CR20","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"key":"315_CR21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","volume":"34","author":"VK Mootha","year":"2003","unstructured":"Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J et al (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267\u2013273","journal-title":"Nat Genet"},{"key":"315_CR22","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","volume":"16","author":"BA Teicher","year":"2010","unstructured":"Teicher BA, Fricker SP (2010) CXCL12 (SDF-1)\/CXCR4 pathway in cancer. Clin Cancer Res 16:2927\u20132931","journal-title":"Clin Cancer Res"},{"key":"315_CR23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.1194396","volume":"330","author":"B Wu","year":"2010","unstructured":"Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V et al (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330:1066\u20131071","journal-title":"Science"},{"key":"315_CR24","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1158\/1078-0432.CCR-07-4846","volume":"14","author":"D Wong","year":"2008","unstructured":"Wong D, Korz W (2008) Translating an antagonist of chemokine receptor CXCR4: from bench to bedside. Clin Cancer Res 14:7975\u20137980","journal-title":"Clin Cancer Res"},{"key":"315_CR25","doi-asserted-by":"crossref","first-page":"e29461","DOI":"10.1371\/journal.pone.0029461","volume":"6","author":"EA Ramos","year":"2011","unstructured":"Ramos EA, Grochoski M, Braun-Prado K, Seniski GG, Cavalli IJ, Ribeiro EM et al (2011) Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. PLoS One 6:e29461","journal-title":"PLoS One"},{"key":"315_CR26","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1158\/0008-5472.CAN-10-3143","volume":"71","author":"E Righi","year":"2011","unstructured":"Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R et al (2011) CXCL12\/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. Cancer Res 71:5522\u20135534","journal-title":"Cancer Res"},{"key":"315_CR27","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1158\/1078-0432.CCR-05-1940","volume":"12","author":"S Scala","year":"2006","unstructured":"Scala S, Giuliano P, Ascierto PA, Ieran\u00f2 C, Franco R, Napolitano M et al (2006) Human melanoma metastases express functional CXCR4. Clin Cancer Res 12:2427\u20132433","journal-title":"Clin Cancer Res"},{"key":"315_CR28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc1388","volume":"4","author":"F Balkwill","year":"2004","unstructured":"Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4:540\u2013550","journal-title":"Nat Rev Cancer"},{"key":"315_CR29","doi-asserted-by":"crossref","first-page":"10411","DOI":"10.1158\/0008-5472.CAN-10-2591","volume":"70","author":"M Kim","year":"2010","unstructured":"Kim M, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K et al (2010) CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res 70:10411\u201310421","journal-title":"Cancer Res"},{"key":"315_CR30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/ijc.21269","volume":"117","author":"MI Longo-Imedio","year":"2005","unstructured":"Longo-Imedio MI, Longo N, Trevino I, Lazaro P, Sanchez-Mateos P (2005) Clinical significance of CXCR3 and CXCR4 expression in primary melanoma. Int J Cancer 117:861\u2013865","journal-title":"Int J Cancer"},{"key":"315_CR31","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1158\/1078-0432.CCR-04-1887","volume":"11","author":"S Scala","year":"2005","unstructured":"Scala S, Ottaiano A, Ascierto PA, Cavalli M, Simeone E, Giuliano P et al (2005) Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res 11:1835\u20131841","journal-title":"Clin Cancer Res"},{"key":"315_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35010517","volume":"2","author":"DJ Sieg","year":"2000","unstructured":"Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH et al (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2:249\u2013256","journal-title":"Nat Cell Biol"},{"key":"315_CR33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc1647","volume":"5","author":"GW McLean","year":"2005","unstructured":"McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC (2005) The role of focal-adhesion kinase in cancer\u2014a new therapeutic opportunity. Nat Rev Cancer 5:505\u2013515","journal-title":"Nat Rev Cancer"},{"key":"315_CR34","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1158\/1078-0432.CCR-06-0456","volume":"12","author":"PM Siesser","year":"2006","unstructured":"Siesser PM, Hanks SK (2006) The signaling and biological implications of FAK overexpression in cancer. Clin Cancer Res 12:3233\u20133237","journal-title":"Clin Cancer Res"},{"key":"315_CR35","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.2173144","volume":"250","author":"D Anderson","year":"1990","unstructured":"Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T (1990) Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science 250:979\u2013982","journal-title":"Science"},{"key":"315_CR36","doi-asserted-by":"crossref","first-page":"37222","DOI":"10.1074\/jbc.M111.294116","volume":"286","author":"C Delgado-Martin","year":"2011","unstructured":"Delgado-Martin C, Escribano C, Pablos JL, Riol-Blanco L, Rodriguez-Fernandez JL (2011) Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1\/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells. J Biol Chem 286:37222\u201337236","journal-title":"J Biol Chem"},{"key":"315_CR37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1158\/1078-0432.CCR-10-2276","volume":"17","author":"JA Ellerhorst","year":"2011","unstructured":"Ellerhorst JA, Greene VR, Ekmekcioglu S, Warneke CL, Johnson MM, Cooke CP et al (2011) Clinical correlates of NRAS and BRAF mutations in primary human melanoma. Clin Cancer Res 17:229\u2013235","journal-title":"Clin Cancer Res"},{"key":"315_CR38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","volume":"461","author":"TA Manolio","year":"2009","unstructured":"Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ et al (2009) Finding the missing heritability of complex diseases. Nature 461:747\u2013753","journal-title":"Nature"},{"key":"315_CR39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-1-60327-367-1_20","volume":"628","author":"I Pedroso","year":"2010","unstructured":"Pedroso I (2010) Gaining a pathway insight into genetic association data. Methods Mol Biol 628:373\u2013382","journal-title":"Methods Mol Biol"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-013-0315-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-013-0315-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-013-0315-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T17:37:26Z","timestamp":1596735446000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-013-0315-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,25]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["315"],"URL":"https:\/\/doi.org\/10.1007\/s10552-013-0315-9","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,25]]}}}