{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:11:54Z","timestamp":1788286314211,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA176726"],"award-info":[{"award-number":["UM1 CA176726"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA09001"],"award-info":[{"award-number":["T32CA09001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32 HD060454"],"award-info":[{"award-number":["T32 HD060454"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s10552-017-0876-0","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T14:09:03Z","timestamp":1489414143000},"page":"371-383","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A prospective cohort study of oral contraceptive use and ovarian cancer among women in the United States born from 1947 to 1964"],"prefix":"10.1007","volume":"28","author":[{"given":"Amy L.","family":"Shafrir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Schock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard A.","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"876_CR1","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1158\/1055-9965.EPI-10-0747","volume":"19","author":"DJ Hunter","year":"2010","unstructured":"Hunter DJ, Colditz GA, Hankinson SE et al (2010) Oral contraceptive use and breast cancer: a prospective study of young women. Cancer Epidemiol Biomark Prev 19:2496\u20132502","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"876_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jama.1986.03370010064026","volume":"255","author":"RJ Lipnick","year":"1986","unstructured":"Lipnick RJ, Buring JE, Hennekens CH et al (1986) Oral contraceptives and breast cancer. A prospective cohort study. JAMA 255:58\u201361","journal-title":"JAMA"},{"key":"876_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ygyno.2012.11.003","volume":"128","author":"P Luhn","year":"2013","unstructured":"Luhn P, Walker J, Schiffman M et al (2013) The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol 128:265\u2013270","journal-title":"Gynecol Oncol"},{"key":"876_CR4","doi-asserted-by":"publisher","first-page":"e0151427","DOI":"10.1371\/journal.pone.0151427","volume":"11","author":"E Roura","year":"2016","unstructured":"Roura E, Travier N, Waterboer T et al (2016) Correction: the influence of hormonal factors on the risk of developing cervical cancer and pre-cancer: results from the EPIC cohort. PLoS ONE 11:e0151427","journal-title":"PLoS ONE"},{"key":"876_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0140-6736(08)60167-1","volume":"371","author":"V Beral","year":"2008","unstructured":"Beral V, Doll R CH et al (2008) Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 371:303\u2013314","journal-title":"Lancet"},{"key":"876_CR6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/oxfordjournals.bmb.a072592","volume":"49","author":"M Thorogood","year":"1993","unstructured":"Thorogood M, Villard-Mackintosh L (1993) Combined oral contraceptives: risks and benefits. Br Med Bull 49:124\u2013139","journal-title":"Br Med Bull"},{"key":"876_CR7","volume-title":"Yen and Jaffe\u2019s reproductive endocrinology: physiology, pathophysiology, and clinical management","author":"CA Schreiber","year":"2009","unstructured":"Schreiber CA, Barnhart K (2009) Contraception. In: Strauss JF, Barbieri RL (eds) Yen and Jaffe\u2019s reproductive endocrinology: physiology, pathophysiology, and clinical management, 6th edn. Saunders Elsevier Inc, Philadelphia","edition":"6"},{"key":"876_CR8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2105\/AJPH.81.1.90","volume":"81","author":"BB Gerstman","year":"1991","unstructured":"Gerstman BB, Gross TP, Kennedy DL, Bennett RC, Tomita DK, Stadel BV (1991) Trends in the content and use of oral contraceptives in the United States, 1964\u20131988. Am J Public Health 81:90\u201396","journal-title":"Am J Public Health"},{"key":"876_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/EDE.0b013e31816334c5","volume":"19","author":"G Lurie","year":"2008","unstructured":"Lurie G, Wilkens LR, Thompson PJ et al (2008) Combined oral contraceptive use and epithelial ovarian cancer risk: time-related effects. Epidemiology 19:237\u2013243","journal-title":"Epidemiology"},{"key":"876_CR10","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/aje\/kwn006","volume":"167","author":"PG Moorman","year":"2008","unstructured":"Moorman PG, Calingaert B, Palmieri RT et al (2008) Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women. Am J Epidemiol 167:1059\u20131069","journal-title":"Am J Epidemiol"},{"key":"876_CR11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1097\/01.AOG.0000255664.48970.e6","volume":"109","author":"G Lurie","year":"2007","unstructured":"Lurie G, Thompson P, McDuffie KE, Carney ME, Terada KY, Goodman MT (2007) Association of estrogen and progestin potency of oral contraceptives with ovarian carcinoma risk. Obstet Gynecol 109:597\u2013607","journal-title":"Obstet Gynecol"},{"key":"876_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/aje\/152.3.233","volume":"152","author":"RB Ness","year":"2000","unstructured":"Ness RB, Grisso JA, Klapper J et al (2000) Risk of ovarian cancer in relation to estrogen and progestin dose and use characteristics of oral contraceptives. Am J Epidemiol 152:233\u2013241","journal-title":"Am J Epidemiol"},{"key":"876_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/1097-0215(20011120)95:6<370::AID-IJC1065>3.0.CO;2-T","volume":"95","author":"J Royar","year":"2001","unstructured":"Royar J, Becher H, Chang-Claude J (2001) Low-dose oral contraceptives: protective effect on ovarian cancer risk. Int J Cancer 95:370\u2013374","journal-title":"Int J Cancer"},{"key":"876_CR14","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1007\/s10552-013-0296-8","volume":"24","author":"MT Faber","year":"2013","unstructured":"Faber MT, Jensen A, Frederiksen K et al (2013) Oral contraceptive use and impact of cumulative intake of estrogen and progestin on risk of ovarian cancer. Cancer Causes Control 24:2197\u20132206","journal-title":"Cancer Causes Control"},{"key":"876_CR15","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/sj.bjc.6601715","volume":"90","author":"M Kumle","year":"2004","unstructured":"Kumle M, Weiderpass E, Braaten T et al (2004) Risk for invasive and borderline epithelial ovarian neoplasias following use of hormonal contraceptives: the Norwegian-Swedish Women\u2019s Lifestyle and Health Cohort Study. Br J Cancer 90:1386\u20131391","journal-title":"Br J Cancer"},{"key":"876_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0010-7824(97)00172-8","volume":"56","author":"DJ Hunter","year":"1997","unstructured":"Hunter DJ, Manson JE, Colditz GA et al (1997) Reproducibility of oral contraceptive histories and validity of hormone composition reported in a cohort of US women. Contraception 56:373\u2013378","journal-title":"Contraception"},{"key":"876_CR17","volume-title":"Managing contraceptive pill patients","author":"RP Dickey","year":"1987","unstructured":"Dickey RP (1987) Managing contraceptive pill patients, 5th edn. Creative Informatics, Durant","edition":"5"},{"key":"876_CR18","volume-title":"Managing contraceptive pill patients","author":"RP Dickey","year":"2002","unstructured":"Dickey RP (2002) Managing contraceptive pill patients, 11th\u00a0edn. EMIS, Inc, Dallas","edition":"11"},{"key":"876_CR19","volume-title":"Managing contraceptive pill\/drug patients","author":"RP Dickey","year":"2010","unstructured":"Dickey RP (2010) Managing contraceptive pill\/drug patients, 14th edn. EMIS, Inc, New Orleans","edition":"14"},{"key":"876_CR20","volume-title":"Physicians\u2019 Desk Reference","author":"PDR","year":"1974","unstructured":"PDR (1974) Physicians\u2019 Desk Reference, 28th edn. Medical Economics Co., Oradell","edition":"28"},{"key":"876_CR21","volume-title":"American Drug Index","author":"ADI","year":"1974","unstructured":"ADI (1974) American Drug Index. Lippincott, Philadelphia"},{"key":"876_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/sj.bjc.6600691","volume":"88","author":"MD Althuis","year":"2003","unstructured":"Althuis MD, Brogan DR, Coates RJ et al (2003) Hormonal content and potency of oral contraceptives and breast cancer risk among young women. Br J Cancer 88:50\u201357","journal-title":"Br J Cancer"},{"key":"876_CR23","volume-title":"Reproductive endocrinology & infertility: handbook for clinicians","author":"DI Lebovic","year":"2005","unstructured":"Lebovic DI, Gordon JD, Taylor RN (2005) Reproductive endocrinology & infertility: handbook for clinicians, 1st\u00a0edn. Scrub Hill Press, Inc, Arlington","edition":"1"},{"key":"876_CR24","volume-title":"The complete pill guide: the latest information about generic and brand-name prescription drugs","author":"LA Opler","year":"2005","unstructured":"Opler LA (2005) The complete pill guide: the latest information about generic and brand-name prescription drugs, 2nd\u00a0edn. Barnes & Noble Publishing, Inc, New York","edition":"2"},{"key":"876_CR25","unstructured":"Davtyan C (2012) Four generations of progestins in oral contraceptives. Proceedings of UCLA Healthcare. UCLA Department of Medicine."},{"key":"876_CR26","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1093\/oxfordjournals.aje.a113804","volume":"119","author":"MJ Stampfer","year":"1984","unstructured":"Stampfer MJ, Willett WC, Speizer FE et al (1984) Test of the National Death Index. Am J Epidemiol 119:837\u2013839","journal-title":"Am J Epidemiol"},{"key":"876_CR27","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/sim.6793","volume":"35","author":"M Wang","year":"2016","unstructured":"Wang M, Spiegelman D, Kuchiba A et al (2016) Statistical methods for studying disease subtype heterogeneity. Stat Med 35:782\u2013800","journal-title":"Stat Med"},{"key":"876_CR28","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/sim.4780080504","volume":"8","author":"S Durrleman","year":"1989","unstructured":"Durrleman S, Richard S (1989) Flexible regression models with cubic splines. Stat Med 8:551\u2013561","journal-title":"Stat Med"},{"key":"876_CR29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0140-6736(71)92335-X","volume":"2","author":"MF Fathalla","year":"1971","unstructured":"Fathalla MF (1971) Incessant ovulation\u2014a factor in ovarian neoplasia? Lancet 2:163","journal-title":"Lancet"},{"key":"876_CR30","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/S0002-9378(99)70120-1","volume":"181","author":"R Rivera","year":"1999","unstructured":"Rivera R, Yacobson I, Grimes D (1999) The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol 181:1263\u20131269","journal-title":"Am J Obstet Gynecol"},{"key":"876_CR31","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1353\/pbm.1993.0066","volume":"36","author":"JW Goldzieher","year":"1993","unstructured":"Goldzieher JW (1993) The history of steroidal contraceptive development: the estrogens. Perspect Biol Med 36:363\u2013368","journal-title":"Perspect Biol Med"},{"key":"876_CR32","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1093\/jnci\/90.23.1774","volume":"90","author":"HA Risch","year":"1998","unstructured":"Risch HA (1998) Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 90:1774\u20131786","journal-title":"J Natl Cancer Inst"},{"key":"876_CR33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.mce.2005.09.014","volume":"247","author":"JS Fleming","year":"2006","unstructured":"Fleming JS, Beaugie CR, Haviv I, Chenevix-Trench G, Tan OL (2006) Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses. Mol Cell Endocrinol 247:4\u201321","journal-title":"Mol Cell Endocrinol"},{"key":"876_CR34","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/00001648-200003000-00005","volume":"11","author":"V Siskind","year":"2000","unstructured":"Siskind V, Green A, Bain C, Purdie D (2000) Beyond ovulation: oral contraceptives and epithelial ovarian cancer. Epidemiology 11:106\u2013110","journal-title":"Epidemiology"},{"key":"876_CR35","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/aje\/kwi046","volume":"161","author":"KH Tung","year":"2005","unstructured":"Tung KH, Wilkens LR, Wu AH et al (2005) Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis. Am J Epidemiol 161:321\u2013329","journal-title":"Am J Epidemiol"},{"key":"876_CR36","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/oxfordjournals.aje.a113523","volume":"117","author":"HA Risch","year":"1983","unstructured":"Risch HA, Weiss NS, Lyon JL, Daling JR, Liff JM (1983) Events of reproductive life and the incidence of epithelial ovarian cancer. Am J Epidemiol 117:128\u2013139","journal-title":"Am J Epidemiol"},{"key":"876_CR37","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/aje\/kwq264","volume":"172","author":"MG Braem","year":"2010","unstructured":"Braem MG, Onland-Moret NC, van den Brandt PA et al (2010) Reproductive and hormonal factors in association with ovarian cancer in the Netherlands cohort study. Am J Epidemiol 172:1181\u20131189","journal-title":"Am J Epidemiol"},{"key":"876_CR38","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1093\/aje\/kwm157","volume":"166","author":"SS Tworoger","year":"2007","unstructured":"Tworoger SS, Fairfield KM, Colditz GA, Rosner BA, Hankinson SE (2007) Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk. Am J Epidemiol 166:894\u2013901","journal-title":"Am J Epidemiol"},{"key":"876_CR39","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/bjc.2011.371","volume":"105","author":"KK Tsilidis","year":"2011","unstructured":"Tsilidis KK, Allen NE, Key TJ et al (2011) Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 105:1436\u20131442","journal-title":"Br J Cancer"},{"key":"876_CR40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.fertnstert.2004.03.013","volume":"82","author":"MC Pike","year":"2004","unstructured":"Pike MC, Pearce CL, Peters R, Cozen W, Wan P, Wu AH (2004) Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study. Fertil Steril 82:186\u2013195","journal-title":"Fertil Steril"},{"key":"876_CR41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/bjc.2016.400","volume":"116","author":"LS Cook","year":"2017","unstructured":"Cook LS, Pestak CR, Leung ACY et al (2017) Combined oral contraceptive use before the first birth and epithelial ovarian cancer risk. Br J Cancer 116:265\u2013269","journal-title":"Br J Cancer"},{"key":"876_CR42","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1023\/A:1011128408146","volume":"12","author":"F Chiaffraino","year":"2001","unstructured":"Chiaffraino F, Pelucchi C, Parazzini F et al (2001) Reproductive and hormonal factors and ovarian cancer. Ann Oncol 12:337\u2013341","journal-title":"Ann Oncol"},{"key":"876_CR43","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/sj.bjc.6603260","volume":"95","author":"M Vessey","year":"2006","unstructured":"Vessey M, Painter R (2006) Oral contraceptive use and cancer: findings in a large cohort study, 1968\u20132004. Br J Cancer 95:385\u2013389","journal-title":"Br J Cancer"},{"key":"876_CR44","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/01.AOG.0000154152.12088.48","volume":"105","author":"JB Greer","year":"2005","unstructured":"Greer JB, Modugno F, Allen GO, Ness RB (2005) Androgenic progestins in oral contraceptives and the risk of epithelial ovarian cancer. Obstet Gynecol 105:731\u2013740","journal-title":"Obstet Gynecol"},{"key":"876_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0848-9","author":"A Koushik","year":"2017","unstructured":"Koushik A, Grundy A, Abrahamowicz M, Arseneau J, Gilbert L, Gotlieb WH, Lacaille J, Mes-Masson AM, Parent M\u00c9, Provencher DM, Richardson L, Siemiatycki J (2017) Hormonal and reproductive factors and the risk of ovarian cancer. Cancer Causes Control. doi:\n                    10.1007\/s10552-016-0848-9","journal-title":"Cancer Causes Control"},{"key":"876_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0840-4","author":"TN Bethea","year":"2016","unstructured":"Bethea TN, Palmer JR, Adams-Campbell LL, Rosenberg L (2016) A prospective study of reproductive factors and exogenous hormone use in relation to ovarian cancer risk among Black women. Cancer Causes Control. doi:\n                    10.1007\/s10552-016-0840-4","journal-title":"Cancer Causes Control"},{"key":"876_CR47","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1136\/bmj.39289.649410.55","volume":"335","author":"PC Hannaford","year":"2007","unstructured":"Hannaford PC, Selvaraj S, Elliott AM, Angus V, Iversen L, Lee AJ (2007) Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner\u2019s oral contraception study. BMJ 335:651","journal-title":"BMJ"},{"key":"876_CR48","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0002-9378(98)70047-X","volume":"179","author":"MJ Rosenberg","year":"1998","unstructured":"Rosenberg MJ, Waugh MS (1998) Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons. Am J Obstet Gynecol 179:577\u2013582","journal-title":"Am J Obstet Gynecol"},{"key":"876_CR49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0010-7824(95)00074-K","volume":"51","author":"MJ Rosenberg","year":"1995","unstructured":"Rosenberg MJ, Waugh MS, Meehan TE (1995) Use and misuse of oral contraceptives: risk indicators for poor pill taking and discontinuation. Contraception 51:283\u2013288","journal-title":"Contraception"},{"key":"876_CR50","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1136\/bmj.2.5863.389","volume":"19","author":"PGT Bye","year":"1973","unstructured":"Bye PGT, Elstein M (1973) Clinical assessment of a low-oestrogen combined oral contraceptive. BMJ 19:389\u2013392","journal-title":"BMJ"},{"key":"876_CR51","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0010-7824(01)00218-9","volume":"64","author":"SA Sanders","year":"2001","unstructured":"Sanders SA, Graham CA, Bass JL, Bancroft J (2001) A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception 64:51\u201358","journal-title":"Contraception"},{"key":"876_CR52","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0015-0282(16)38469-2","volume":"22","author":"JW Goldzieher","year":"1971","unstructured":"Goldzieher JW, Moses LE, Averkin E, Scheel C, Taber BZ (1971) A placebo-controlled double-blind crossover investigation of the side effects attributed to oral contraceptives. Fertil Steril 22:609\u2013623","journal-title":"Fertil Steril"},{"key":"876_CR53","first-page":"281","volume":"16","author":"P Dionne","year":"1974","unstructured":"Dionne P, Vickerson F (1974) A double-blind comparison of two oral contraceptives containing 50 mu g. and 30 mu g. ethinyl estradiol. Curr Ther Res Clin Exp 16: 281\u2013288","journal-title":"Curr Ther Res Clin Exp"},{"key":"876_CR54","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/j.1552-4604.1997.tb04781.x","volume":"37","author":"J Schmider","year":"1997","unstructured":"Schmider J, Greenblatt DJ, von Moltke LL et al (1997) Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol 37:193\u2013200","journal-title":"J Clin Pharmacol"},{"key":"876_CR55","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.contraception.2008.02.020","volume":"78","author":"JW Goldzieher","year":"2008","unstructured":"Goldzieher JW, Stanczyk FZ (2008) Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins. Contraception 78:4\u20139","journal-title":"Contraception"},{"key":"876_CR56","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ijc.10990","volume":"104","author":"A Lukanova","year":"2003","unstructured":"Lukanova A, Lundin E, Akhmedkhanov A et al (2003) Circulating levels of sex steroid hormones and risk of ovarian cancer. Int J Cancer 104:636\u2013642","journal-title":"Int J Cancer"},{"key":"876_CR57","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1001\/jama.1995.03530240036037","volume":"274","author":"KJ Helzlsouer","year":"1995","unstructured":"Helzlsouer KJ, Alberg AJ, Gordon GB et al (1995) Serum gonadotropins and steroid hormones and the development of ovarian cancer. JAMA 274:1926\u20131930","journal-title":"JAMA"},{"key":"876_CR58","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1530\/ERC-14-0282","volume":"21","author":"H Schock","year":"2014","unstructured":"Schock H, Surcel HM, Zeleniuch-Jacquotte A et al (2014) Early pregnancy sex steroids and maternal risk of epithelial ovarian cancer. Endocr Relat Cancer 21:831\u2013844","journal-title":"Endocr Relat Cancer"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-017-0876-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-017-0876-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-017-0876-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T20:13:22Z","timestamp":1589660002000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-017-0876-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["876"],"URL":"https:\/\/doi.org\/10.1007\/s10552-017-0876-0","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]},"assertion":[{"value":"14 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}