{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:56:17Z","timestamp":1759564577293,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000142","name":"Avon Foundation for Women","doi-asserted-by":"publisher","award":["02-2015-068"],"award-info":[{"award-number":["02-2015-068"]}],"id":[{"id":"10.13039\/100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA77398"],"award-info":[{"award-number":["CA77398"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s10552-017-0942-7","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T12:03:35Z","timestamp":1503057815000},"page":"1027-1032","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Functional IGF1R variant predicts breast cancer risk in women with preeclampsia in California Teachers Study"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-5360","authenticated-orcid":false,"given":"Mark J.","family":"Powell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Von Behren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Neuhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Benz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"issue":"8","key":"942_CR1","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3109\/0284186X.2012.750033","volume":"52","author":"JS Kim","year":"2013","unstructured":"Kim JS, Kang EJ, Woo OH, Park KH, Woo SU, Yang DS et al (2013) The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: a meta-analysis. Acta Oncol 52(8):1643\u20131648. doi:\n                    10.3109\/0284186X.2012.750033","journal-title":"Acta Oncol"},{"issue":"1","key":"942_CR2","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/bjc.2012.195","volume":"107","author":"S Opdahl","year":"2012","unstructured":"Opdahl S, Romundstad PR, Alsaker MD, Vatten LJ (2012) Hypertensive diseases in pregnancy and breast cancer risk. Br J Cancer 107(1):176\u2013182. doi:\n                    10.1038\/bjc.2012.195","journal-title":"Br J Cancer"},{"issue":"9","key":"942_CR3","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1093\/aje\/kwk105","volume":"165","author":"MB Terry","year":"2007","unstructured":"Terry MB, Perrin M, Salafia CM, Zhang FF, Neugut AI, Teitelbaum SL et al (2007) Preeclampsia, pregnancy-related hypertension, and breast cancer risk. Am J Epidemiol 165(9):1007\u20131014","journal-title":"Am J Epidemiol"},{"issue":"2","key":"942_CR4","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/ijc.20402","volume":"112","author":"KE Innes","year":"2004","unstructured":"Innes KE, Byers TE (2004) First pregnancy characteristics and subsequent breast cancer risk among young women. Int J Cancer 112(2):306\u2013311","journal-title":"Int J Cancer"},{"issue":"1","key":"942_CR5","doi-asserted-by":"publisher","first-page":"63.e1","DOI":"10.1016\/j.ajog.2008.06.057","volume":"200","author":"R Calderon-Margalit","year":"2009","unstructured":"Calderon-Margalit R, Friedlander Y, Yanetz R, Deutsch L, Perrin MC, Kleinhaus K et al (2009) Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study. Am J Obstet Gynecol 200(1):63.e1\u201363.e5. doi:\n                    10.1016\/j.ajog.2008.06.057","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"942_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/187152510792481234","volume":"8","author":"OM Reslan","year":"2010","unstructured":"Reslan OM, Khalil RA (2010) Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem 8(4):204\u2013226","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"issue":"2","key":"942_CR7","first-page":"192","volume":"27","author":"HY Peng","year":"2011","unstructured":"Peng HY, Xue M, Xia AB (2011) Study on changes of IGF-I and leptin levels in serum and placental tissue of preeclampsia patients and their associativity. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 27(2):192\u2013194","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi."},{"issue":"3","key":"942_CR8","doi-asserted-by":"publisher","first-page":"228","DOI":"10.2174\/1573402112666160729120411","volume":"12","author":"S Kharb","year":"2016","unstructured":"Kharb S, Panjeta P, Ghalaut VS, Bala J, Nanda S (2016) Biomarkers in preeclamptic women with normoglycemia and hyperglycemia. Curr Hypertens Rev 12(3):228\u2013233","journal-title":"Curr Hypertens Rev"},{"issue":"1","key":"942_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10517-014-2502-4","volume":"157","author":"EA Dubova","year":"2014","unstructured":"Dubova EA, Pavlov KA, Lyapin VM, Kulikova GV, Shchyogolev AI, Sukhikh GT (2014) Expression of insulin-like growth factors in the placenta in preeclampsia. Bull Exp Biol Med 157(1):103\u2013107. doi:\n                    10.1007\/s10517-014-2502-4","journal-title":"Bull Exp Biol Med"},{"issue":"1","key":"942_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/1573402113666170126101914","volume":"13","author":"S Kharb","year":"2017","unstructured":"Kharb S, Nanda S (2017) patterns of biomarkers in cord blood during pregnancy and preeclampsia. Curr Hypertens Rev 13(1):57\u201364","journal-title":"Curr Hypertens Rev"},{"issue":"8","key":"942_CR11","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3109\/10715762.2015.1020798","volume":"49","author":"D Robajac","year":"2015","unstructured":"Robajac D, Masnikosa R, Mikovi\u0107 \u017d, Mandi\u0107 V, Nedi\u0107 O (2015) Oxidation of placental insulin and insulin-like growth factor receptors in mothers with diabetes mellitus or preeclampsia complicated with intrauterine growth restriction. Free Radic Res 49(8):984\u2013989. doi:\n                    10.3109\/10715762.2015.1020798","journal-title":"Free Radic Res"},{"issue":"11","key":"942_CR12","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1210\/endo.140.11.7095","volume":"140","author":"W Ruan","year":"1999","unstructured":"Ruan W, Kleinberg DL (1999) Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140(11):5075\u20135081","journal-title":"Endocrinology"},{"key":"942_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12943-015-0291-7","volume":"14","author":"PF Christopoulos","year":"2015","unstructured":"Christopoulos PF, Msaouel P, Koutsilieris M (2015) The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer 14:43. doi:\n                    10.1186\/s12943-015-0291-7","journal-title":"Mol Cancer"},{"issue":"6","key":"942_CR14","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/S1470-2045(10)70095-4","volume":"11","author":"TJ Key","year":"2010","unstructured":"Key TJ, Appleby PN, Reeves GK, Roddam AW, Endogenous Hormones and Breast Cancer Collaborative Group (2010) Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol 11(6):530\u2013542. doi:\n                    10.1016\/S1470-2045(10)70095-4","journal-title":"Lancet Oncol"},{"issue":"1","key":"942_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10549-010-1313-1","volume":"128","author":"RM Tamimi","year":"2011","unstructured":"Tamimi RM, Colditz GA, Wang Y, Collins LC, Hu R, Rosner B et al (2011) Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat 128(1):243\u2013250. doi:\n                    10.1007\/s10549-010-1313-1","journal-title":"Breast Cancer Res Treat"},{"issue":"7","key":"942_CR16","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s10552-014-0386-2","volume":"25","author":"LA Prebil","year":"2014","unstructured":"Prebil LA, Ereman RR, Powell MJ, Jamshidian F, Kerlikowske K, Shepherd JA et al (2014) First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants. Cancer Causes Control 25(7):859\u2013868. doi:\n                    10.1007\/s10552-014-0386-2","journal-title":"Cancer Causes Control"},{"key":"942_CR17","doi-asserted-by":"crossref","unstructured":"Powell M, Prebil LA, Rose S, Jamshidian F, Benz C, Ereman R. Insulin-like growth factor-1 receptor variant associated with decreased breast cancer risk in women with pregnancy-induced hypertension. San Antonio Breast Cancer Symposium [abstract P3-07-03] 2013","DOI":"10.1158\/0008-5472.SABCS13-P3-07-03"},{"issue":"3","key":"942_CR18","doi-asserted-by":"publisher","first-page":"R35","DOI":"10.1186\/bcr2589","volume":"12","author":"H Ma","year":"2010","unstructured":"Ma H, Henderson KD, Sullivan-Halley J, Duan L, Marshall SF, Ursin G et al (2010) Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res 12(3):R35. doi:\n                    10.1186\/bcr2589","journal-title":"Breast Cancer Res"},{"key":"942_CR19","unstructured":"National Human Genome Research Institute, Genotype-Tissue Expression Project. GTEx Portal Version V6p, Accessed 10 January 2017"},{"issue":"3","key":"942_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0009-9120(03)00008-0","volume":"36","author":"K Altinkaynak","year":"2003","unstructured":"Altinkaynak K, Aksoy HH, Bakan E, Kumtepe Y (2003) Serum IGF-I and IGFBP-3 in healthy pregnancies and patients with preeclampsia. Clin Biochem 36(3):221\u2013223. doi:\n                    10.1016\/S0009-9120(03)00008-0","journal-title":"Clin Biochem"},{"issue":"12","key":"942_CR21","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.1158\/0008-5472.CAN-05-4235","volume":"66","author":"CM Blakely","year":"2006","unstructured":"Blakely CM, Stoddard AJ, Belka GK, Dugan KD, Notarfrancesco KL, Moody SE et al (2006) Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy. Cancer Res 66(12):6421\u20136431. doi:\n                    10.1158\/0008-5472","journal-title":"Cancer Res"},{"key":"942_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00213","author":"M Barton","year":"2014","unstructured":"Barton M, Santucci-Pereira J, Russo J (2014) Molecular pathways involved in pregnancy-induced prevention against breast cancer. Front Endocrinol (Lausanne). doi:\n                    10.3389\/fendo.2014.00213","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5595","key":"942_CR23","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1126\/science.1076997","volume":"298","author":"R Cao","year":"2002","unstructured":"Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P et al (2002) Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298(5595):1039\u20131043. doi:\n                    10.1126\/science.1076997","journal-title":"Science"},{"issue":"10","key":"942_CR24","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1158\/1940-6207.CAPR-15-0178","volume":"8","author":"TA Katz","year":"2015","unstructured":"Katz TA, Liao SG, Palmieri VJ, Dearth RK, Pathiraja TN, Huo Z et al (2015) Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of IGF1R That Persists Long after Parturition. Cancer Prev Res (Phila) 8(10):1000\u20131009. doi:\n                    10.1158\/1940-6207.CAPR-15-0178","journal-title":"Cancer Prev Res (Phila)"},{"key":"942_CR25","doi-asserted-by":"publisher","first-page":"R423","DOI":"10.1186\/bcr812","volume":"4","author":"G Thordarson","year":"2004","unstructured":"Thordarson G, Slusher N, Leong H, Ochoa D, Rajkumar L, Guzman R et al (2004) Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kinase pathway. Breast Cancer Res 4:R423\u2013R436","journal-title":"Breast Cancer Res"},{"issue":"1","key":"942_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/tpj.2013.8","volume":"14","author":"T Winder","year":"2014","unstructured":"Winder T, Giamas G, Wilson PM, Zhang W, Yang D, Bohanes P et al (2014) Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen. Pharmacogenomics J 14(1):28\u201334. doi:\n                    10.1038\/tpj.2013.8","journal-title":"Pharmacogenomics J"},{"issue":"7","key":"942_CR27","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1200\/JCO.2016.70.9386","volume":"35","author":"RT Chlebowski","year":"2017","unstructured":"Chlebowski RT (2017) Improving breast cancer risk assessment versus implementing breast cancer prevention. J Clin Oncol 35(7):702\u2013704. doi:\n                    10.1200\/JCO.2016.70.9386","journal-title":"J Clin Oncol"},{"issue":"15","key":"942_CR28","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1093\/jnci\/93.15.1133","volume":"93","author":"BA Cohn","year":"2001","unstructured":"Cohn BA, Cirillo PM, Christianson RE, van den Berg BJ, Siiteri PK (2001) Placental characteristics and reduced risk of maternal breast cancer. J Natl Cancer Inst 93(15):1133\u20131140","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"942_CR29","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1038\/bjc.2016.81","volume":"114","author":"PM Cirillo","year":"2016","unstructured":"Cirillo PM, Benz CC, Cohn BA (2016) Comment on: \u2018Hypertensive diseases in pregnancy and breast cancer risk\u2019. Br J Cancer 114(11):e10. doi:\n                    10.1038\/bjc.2016.81","journal-title":"Br J Cancer"},{"issue":"1","key":"942_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/jwh.2012.3740","volume":"22","author":"JJ Stuart","year":"2013","unstructured":"Stuart JJ, Bairey Merz CN, Berga SL, Miller VM, Ouyang P, Shufelt CL et al (2013) Maternal recall of hypertensive disorders in pregnancy: a systematic review. J Womens Health (Larchmt) 22(1):37\u201347. doi:\n                    10.1089\/jwh.2012.3740","journal-title":"J Womens Health (Larchmt)"}],"container-title":["Cancer Causes & Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-017-0942-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-017-0942-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-017-0942-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T20:16:19Z","timestamp":1589660179000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-017-0942-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["942"],"URL":"https:\/\/doi.org\/10.1007\/s10552-017-0942-7","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"type":"print","value":"0957-5243"},{"type":"electronic","value":"1573-7225"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"14 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}