{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:05:38Z","timestamp":1778875538111,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s10552-019-01144-8","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T09:03:04Z","timestamp":1552986184000},"page":"477-488","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data"],"prefix":"10.1007","volume":"30","author":[{"given":"Dima","family":"Dandachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinn T.","family":"Ostrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insun","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Serpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Kruchko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill S.","family":"Barnholtz-Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka R.","family":"Colen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny E.","family":"Mor\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"1144_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ajh.23551","volume":"88","author":"BP O\u2019Neill","year":"2013","unstructured":"O\u2019Neill BP, Decker PA, Tieu C, Cerhan JR (2013) The changing incidence of primary central nervous system lymphoma is driven primarily by the changing incidence in young and middle-aged men and differs from time trends in systemic diffuse large B-cell non-Hodgkin\u2019s lymphoma. Am J Hematol 88:997\u20131000","journal-title":"Am J Hematol"},{"key":"1144_CR2","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1200\/JCO.2017.72.7602","volume":"35","author":"C Grommes","year":"2017","unstructured":"Grommes C, DeAngelis LM (2017) Primary CNS lymphoma. J Clin Oncol 35:2410\u20132418","journal-title":"J Clin Oncol"},{"key":"1144_CR3","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00415-015-7713-8","volume":"262","author":"A Matinella","year":"2015","unstructured":"Matinella A, Lanzafame M, Bonometti MA, Gajofatto A, Concia E, Vento S et al (2015) Neurological complications of HIV infection in pre-HAART and HAART era: a retrospective study. J Neurol 262:1317\u20131327","journal-title":"J Neurol"},{"key":"1144_CR4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40644-016-0098-9","volume":"16","author":"H Malikova","year":"2016","unstructured":"Malikova H, Koubska E, Weichet J, Klener J, Rulseh A, Liscak R et al (2016) Can morphological MRI differentiate between primary central nervous system lymphoma and glioblastoma? Cancer Imaging 16:40","journal-title":"Cancer Imaging"},{"key":"1144_CR5","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13000-015-0387-9","volume":"10","author":"IE Lloyd","year":"2015","unstructured":"Lloyd IE, Clement PW, Salzman KL, Jensen RL, Salama ME, Palmer CA (2015) An unusual and challenging case of HIV-associated primary CNS Lymphoma with Hodgkin-like morphology and HIV encephalitis. Diagn Pathol 10:152","journal-title":"Diagn Pathol"},{"key":"1144_CR6","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11060-010-0252-3","volume":"101","author":"S Bayraktar","year":"2011","unstructured":"Bayraktar S, Bayraktar UD, Ramos JC, Stefanovic A, Lossos IS (2011) Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors. J Neurooncol 101:257\u2013265","journal-title":"J Neurooncol"},{"key":"1144_CR7","doi-asserted-by":"publisher","first-page":"955","DOI":"10.2169\/internalmedicine.52.9088","volume":"52","author":"K Yanagisawa","year":"2013","unstructured":"Yanagisawa K, Tanuma J, Hagiwara S, Gatanaga H, Kikuchi Y, Oka S (2013) Epstein-Barr viral load in cerebrospinal fluid as a diagnostic marker of central nervous system involvement of AIDS-related lymphoma. Intern Med 52:955\u2013959","journal-title":"Intern Med"},{"key":"1144_CR8","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.crad.2011.03.006","volume":"66","author":"YZ Tang","year":"2011","unstructured":"Tang YZ, Booth TC, Bhogal P, Malhotra A, Wilhelm T (2011) Imaging of primary central nervous system lymphoma. Clin Radiol 66:768\u2013777","journal-title":"Clin Radiol"},{"key":"1144_CR9","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1016\/j.ejrad.2013.03.008","volume":"82","author":"TD Westwood","year":"2013","unstructured":"Westwood TD, Hogan C, Julyan PJ, Coutts G, Bonington S, Carrington B et al (2013) Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. Eur J Radiol 82:e374\u2013e379","journal-title":"Eur J Radiol"},{"key":"1144_CR10","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1002\/cncr.30965","volume":"123","author":"CH Han","year":"2017","unstructured":"Han CH, Batchelor TT (2017) Diagnosis and management of primary central nervous system lymphoma. Cancer 123:4314\u20134324","journal-title":"Cancer"},{"key":"1144_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1200\/JCO.2003.09.139","volume":"21","author":"AJ Ferreri","year":"2003","unstructured":"Ferreri AJ, Blay JY, Reni M, Pasini F, Spina M, Ambrosetti A et al (2003) Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol 21:266\u2013272","journal-title":"J Clin Oncol"},{"key":"1144_CR12","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/bjc.2011.357","volume":"105","author":"JL Villano","year":"2011","unstructured":"Villano JL, Koshy M, Shaikh H, Dolecek TA, McCarthy BJ (2011) Age, gender, and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer 105:1414\u20131418","journal-title":"Br J Cancer"},{"key":"1144_CR13","first-page":"5505","volume":"14","author":"J Liu","year":"2017","unstructured":"Liu J, Wang Y, Liu Y, Liu Z, Cui Q, Ji N et al (2017) Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: analysis of 89 cases. Oncol Lett 14:5505\u20135512","journal-title":"Oncol Lett"},{"key":"1144_CR14","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1089\/aid.2011.0259","volume":"28","author":"S Gopal","year":"2012","unstructured":"Gopal S, Martin KE, Richards KL, Eron JJ (2012) Clinical presentation, treatment, and outcomes among 65 patients with HIV-associated lymphoma treated at the University of North Carolina, 2000\u20132010. AIDS Res Hum Retroviruses 28:798\u2013805","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"6, Neuro-oncolo","key":"1144_CR15","first-page":"1601","volume":"23","author":"CH Han","year":"2017","unstructured":"Han CH, Batchelor TT (2017) Primary central nervous system lymphoma. Continuum 23(6, Neuro-oncology):1601\u20131618","journal-title":"Continuum"},{"key":"1144_CR16","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12885-016-2311-4","volume":"16","author":"E Schorb","year":"2016","unstructured":"Schorb E, Finke J, Ferreri AJ, Ihorst G, Mikesch K, Kasenda B et al (2016) High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma: a randomized phase III trial (MATRix). BMC Cancer 16:282","journal-title":"BMC Cancer"},{"key":"1144_CR17","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1097\/00002030-200308150-00007","volume":"17","author":"DJ Skiest","year":"2003","unstructured":"Skiest DJ, Crosby C (2003) Survival is prolonged by highly active antiretroviral therapy in AIDS patients with primary central nervous system lymphoma. AIDS 17:1787\u20131793","journal-title":"AIDS"},{"key":"1144_CR18","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/annonc\/mdv036","volume":"26","author":"SK Barta","year":"2015","unstructured":"Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N et al (2015) Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma. Ann Oncol 26:958\u2013966","journal-title":"Ann Oncol"},{"key":"1144_CR19","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1365-2141.2006.06464.x","volume":"136","author":"N Mounier","year":"2007","unstructured":"Mounier N, Spina M, Gisselbrecht C (2007) Modern management of non-Hodgkin lymphoma in HIV-infected patients. Br J Haematol 136:685\u2013698","journal-title":"Br J Haematol"},{"key":"1144_CR20","unstructured":"Garg N, Rayan J, Adams M, Downs R, Routbort M, McEnery K et al (2018) New search: an architecture for fast analytic search of electronic medical records. \n                    http:\/\/garglab.com\/projects\/data-mining\/\n                    \n                  . Accessed 24 Oct 2017"},{"key":"1144_CR21","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/nox158","volume":"19","author":"QT Ostrom","year":"2017","unstructured":"Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C et al (2017) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010\u20132014. Neuro Oncol 19:v1\u2013v88","journal-title":"Neuro Oncol"},{"key":"1144_CR22","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (2017) SEER*Stat Database: Incidence\u2014SEER 18 Regs Custom Data (with additional treatment fields), Nov 2016 Sub (2000\u20132014)\u2014Linked To County Attributes\u2014Total U.S., 1969\u20132015 Counties, National Cancer Institute, DCCPS, Surveillance Research Program. \n                    https:\/\/seer.cancer.gov\/data-software\/documentation\/seerstat\/nov2016\/\n                    \n                  . Accessed 10 Feb 2018"},{"key":"1144_CR23","unstructured":"National Cancer Institute (2018) Overview of the SEER Program. \n                    https:\/\/seer.cancer.gov\/about\/\n                    \n                  . Accessed 15 Jan 2018"},{"key":"1144_CR24","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (2015) Number of persons by race and hispanic ethnicity for SEER participants (2010 Census Data). \n                    https:\/\/seer.cancer.gov\/registries\/data.html\n                    \n                  . Accessed 25 April 2018"},{"key":"1144_CR25","unstructured":"R Core Team (2018) R: a language and environment for statistical computing Vienna, Austria: R Foundation for Statistical Computing. \n                    http:\/\/www.R-project.org\/\n                    \n                  . Accessed 25 Apr 2018"},{"key":"1144_CR26","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (2018) SEER*Stat software version 8.3.5: National Cancer Institute, DCCPS, Surveillance Research Program. \n                    http:\/\/www.seer.cancer.gov\/seerstat\n                    \n                  . Accessed 21 Jan 2018"},{"key":"1144_CR27","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3174\/ajnr.A2171","volume":"32","author":"IS Haldorsen","year":"2011","unstructured":"Haldorsen IS, Espeland A, Larsson EM (2011) Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol 32:984\u2013992","journal-title":"AJNR Am J Neuroradiol"},{"key":"1144_CR28","doi-asserted-by":"publisher","first-page":"E4","DOI":"10.3171\/foc.2006.21.5.5","volume":"21","author":"JL Go","year":"2006","unstructured":"Go JL, Lee SC, Kim PE (2006) Imaging of primary central nervous system lymphoma. Neurosurg Focus 21:E4","journal-title":"Neurosurg Focus"},{"key":"1144_CR29","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1148\/radiographics.17.6.9397461","volume":"17","author":"KK Koeller","year":"1997","unstructured":"Koeller KK, Smirniotopoulos JG, Jones RV (1997) Primary central nervous system lymphoma: radiologic-pathologic correlation. Radiographics 17:1497\u20131526","journal-title":"Radiographics"},{"key":"1144_CR30","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1002\/cncr.30695","volume":"123","author":"Z DeFilipp","year":"2017","unstructured":"DeFilipp Z, Li S, El-Jawahri A, Armand P, Nayak L, Wang N et al (2017) High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with primary central nervous system lymphoma in first complete remission. Cancer 123:3073\u20133079","journal-title":"Cancer"},{"key":"1144_CR31","doi-asserted-by":"publisher","first-page":"e388","DOI":"10.1016\/S2352-3026(16)30050-3","volume":"3","author":"G Illerhaus","year":"2016","unstructured":"Illerhaus G, Kasenda B, Ihorst G, Egerer G, Lamprecht M, Keller U et al (2016) High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol 3:e388\u2013e397","journal-title":"Lancet Haematol"},{"key":"1144_CR32","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1200\/JCO.2006.06.2117","volume":"24","author":"G Illerhaus","year":"2006","unstructured":"Illerhaus G, Marks R, Ihorst G, Guttenberger R, Ostertag C, Derigs G et al (2006) High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma. J Clin Oncol 24:3865\u20133870","journal-title":"J Clin Oncol"},{"key":"1144_CR33","unstructured":"Cranial radiotherapy or intensive chemotherapy with hematopoietic stem Cell rescue for primary central nervous system lymphoma in young patients (PRECIS). ClinialTrials.gov (2018) \n                    https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00863460\n                    \n                  . Accessed 9 Mar 2018"},{"key":"1144_CR34","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s15010-013-0579-8","volume":"42","author":"T Wolf","year":"2014","unstructured":"Wolf T, Kiderlen T, Atta J, Stephan C, Kann G, Brodt HR et al (2014) Successful treatment of AIDS-associated, primary CNS lymphoma with rituximab- and methotrexate-based chemotherapy and autologous stem cell transplantation. Infection 42:445\u2013447","journal-title":"Infection"},{"key":"1144_CR35","unstructured":"Centers for Disease Control and Prevention (2016) HIV Surveillance. \n                    http:\/\/www.cdc.gov\/hiv\/library\/reports\/hiv-surveillance.html\n                    \n                  . Accessed 4 Jun 2018"},{"key":"1144_CR36","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1158\/1055-9965.EPI-16-0273","volume":"25","author":"N Howlader","year":"2016","unstructured":"Howlader N, Shiels MS, Mariotto AB, Engels EA (2016) Contributions of HIV to Non-Hodgkin Lymphoma Mortality Trends in the United States. Cancer Epidemiol Biomarkers Prev 25:1289\u20131296","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1144_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx030","author":"A Jemal","year":"2017","unstructured":"Jemal A, Ward EM, Johnson CJ, Cronin KA, Ma J, Ryerson B et al (2017) Annual Report to the Nation on the Status of Cancer, 1975\u20132014, featuring survival. J Natl Cancer Inst. \n                    https:\/\/doi.org\/10.1093\/jnci\/djx030","journal-title":"J Natl Cancer Inst"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-019-01144-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-019-01144-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-019-01144-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:23:56Z","timestamp":1584491036000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-019-01144-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1144"],"URL":"https:\/\/doi.org\/10.1007\/s10552-019-01144-8","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"23 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors have read and approved this manuscript and have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}