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Landmark survival analyses were used to investigate how postoperative weight gain or loss (&gt;\u00a05%) or change in waist\u2013hip ratio (WHR) categories (\u2264\u20090.85 or &gt;\u20090.85) impact prognosis.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median age at inclusion was 61\u00a0years and body mass index 25.1\u00a0kg\/m<jats:sup>2<\/jats:sup>. After a median follow-up of 5.0\u00a0years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients\u2009&lt;\u200950\u00a0years (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.033). Weight loss (8.6%) was only associated with a poor prognosis in patients\u2009\u2265\u200970\u00a0years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to &lt;\u200970\u00a0years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER\u2212 tumors.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10552-019-01227-6","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T06:02:56Z","timestamp":1568268176000},"page":"1157-1170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer"],"prefix":"10.1007","volume":"30","author":[{"given":"Helga","family":"Tryggvadottir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ygland R\u00f6dstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Markkula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyian","family":"Ken\u00e9z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolin","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signe","family":"Borgquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Jernstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"1227_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.breast.2017.06.003","volume":"36","author":"G Carioli","year":"2017","unstructured":"Carioli G, Malvezzi M, Rodriguez T, Bertuccio P, Negri E, La Vecchia C (2017) Trends and predictions to 2020 in breast cancer mortality in Europe. 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