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This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A population-based case\u2013control study was conducted in Ontario, Canada during 2018\u20132019. EO-CRC cases aged 20\u201349\u00a0years (<jats:italic>n<\/jats:italic>\u2009=\u2009175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (<jats:italic>n<\/jats:italic>\u2009=\u2009253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47\u20133.84), longer sedentary time (\u2265\u200910 vs.\u2009&lt;\u20095\u00a0h\/day, OR 1.93; 95% CI 1.02\u20133.65), greater consumption of sugary drinks (\u2265\u20097 vs.\u2009&lt;\u20091 drinks\/week, OR 2.99; 95% CI 1.57\u20135.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01\u20133.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31\u20130.92), history of allergy or asthma (OR 0.62; 95% CI 0.39\u20130.98), and greater parity in females (\u2265\u20093 vs. nulliparity, OR 0.29; 95% CI 0.11\u20130.76) were each associated with a reduced risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10552-021-01456-8","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T07:02:16Z","timestamp":1623567736000},"page":"1063-1083","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Risk factors for early-onset colorectal cancer: a population-based case\u2013control study in Ontario, Canada"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9387","authenticated-orcid":false,"given":"Vicky C.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cotterchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithwish","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Tinmouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"1456_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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