{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:51:49Z","timestamp":1788040309496,"version":"build-2784847793"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Cancer Institute","award":["T32CA229110"],"award-info":[{"award-number":["T32CA229110"]}]},{"name":"National Cancer Institute","award":["R01 CA209798"],"award-info":[{"award-number":["R01 CA209798"]}]},{"name":"National Cancer Institute","award":["R01 CA209798"],"award-info":[{"award-number":["R01 CA209798"]}]},{"name":"National Cancer Institute","award":["R01 CA209798"],"award-info":[{"award-number":["R01 CA209798"]}]},{"name":"National Cancer Institute","award":["R01 CA209798"],"award-info":[{"award-number":["R01 CA209798"]}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Risk factors for pancreatic cancer include racial\/ethnic disparities and smoking. However, risk trajectories by smoking history and race\/ethnicity are unknown. We examined the association of smoking with pancreatic cancer by race\/ethnicity to generate age-specific incidence estimates by smoking history.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We modeled pancreatic cancer incidence by race\/ethnicity, age, pack-years, and years-quit using an excess relative risk model for 182,011 Multiethnic Cohort participants. We tested heterogeneity of smoking variables and pancreatic cancer by race\/ethnicity and predicted incidence by smoking history.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified 1,831 incident pancreatic cancer cases over an average 19.3 years of follow-up. Associations of pack-years (<jats:italic>p<\/jats:italic> interaction by race\/ethnicity\u2009=\u20090.41) and years-quit (<jats:italic>p<\/jats:italic> interaction\u2009=\u20090.83) with pancreatic cancer did not differ by race\/ethnicity. Fifty pack-years smoked was associated with 91% increased risk (95% CI 54%, 127%) relative to never smokers in the combined sample. Every year quit corresponded to 9% decreased excess risk (95% CI 2%, 15%) from pack-years smoked. Differences in baseline pancreatic cancer risk across racial\/ethnic groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) translated to large differences in risk for smokers at older ages across racial\/ethnic groups (65\u2013122 cases per 100,000 at age 70).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Smoking pack-years were positively associated with elevated pancreatic cancer risk. Predicted risk trajectories showed a high impact of smoking cessation at\u2009&lt;\u200965 years. Although we did not identify significant heterogeneity in the association of pack-years or years quit with pancreatic cancer risk, current smoker risk varied greatly by race\/ethnicity in later life due to large differences in baseline risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10552-023-01811-x","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T06:02:50Z","timestamp":1699077770000},"page":"541-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Excess pancreatic cancer risk due to smoking and modifying effect of quitting smoking: The Multiethnic Cohort\u00a0Study"],"prefix":"10.1007","volume":"35","author":[{"given":"David","family":"Bogumil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Pandol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"McKean-Cowdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David V.","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Wendy","family":"Setiawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,4]]},"reference":[{"issue":"1","key":"1811_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. 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