{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:11:21Z","timestamp":1793211081367,"version":"4.5.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s10552-024-01884-2","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:02:04Z","timestamp":1721113324000},"page":"1413-1432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mechanisms of stress-attributed breast cancer incidence and progression"],"prefix":"10.1007","volume":"35","author":[{"given":"Elizabeth","family":"Reznik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Torjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"1884_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA 68:394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492","journal-title":"CA"},{"key":"1884_CR2","unstructured":"U.S. Breast Cancer Statistics (n.d.) https:\/\/www.breastcancer.org\/symptoms\/understand_bc\/statistics"},{"issue":"4","key":"1884_CR3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S2215-0366(17)30014-7","volume":"4","author":"MJ Cordova","year":"2017","unstructured":"Cordova MJ, Riba MB, Spiegel D (2017) Post-traumatic stress disorder and cancer. Lancet Psychiatry 4(4):330\u2013338. https:\/\/doi.org\/10.1016\/S2215-0366(17)30014-7. (Epub 2017 Jan 19. PMID: 28109647; PMCID: PMC5676567)","journal-title":"Lancet Psychiatry"},{"issue":"7","key":"1884_CR4","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s10552-014-0377-3","volume":"25","author":"JA Dumalaon-Canaria","year":"2014","unstructured":"Dumalaon-Canaria JA, Hutchinson AD, Prichard I, Wilson C (2014) What causes breast cancer? A systematic review of causal attributions among breast cancer survivors and how these compare to expert-endorsed risk factors. Cancer Causes Control 25(7):771\u2013785. https:\/\/doi.org\/10.1007\/s10552-014-0377-3","journal-title":"Cancer Causes Control"},{"key":"1884_CR5","unstructured":"Heid M (2014) How stress affects cancer risk. Focused on health. The University of Texas MD Anderson Cancer Center, Houston, TX. https:\/\/www.mdanderson.org\/publications\/focused-on-health\/how-stress-affects-cancer-risk.h21-1589046.html"},{"issue":"2","key":"1884_CR6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3109\/10253890.2011.606340","volume":"15","author":"J Kruk","year":"2011","unstructured":"Kruk J (2011) Self-reported psychological stress and the risk of breast cancer: a case-control study. Stress 15(2):162\u2013171. https:\/\/doi.org\/10.3109\/10253890.2011.606340","journal-title":"Stress"},{"issue":"5","key":"1884_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/00008469-200310000-00006","volume":"12","author":"\u00d6 Helgesson","year":"2003","unstructured":"Helgesson \u00d6, Cabrera C, Lapidus L, Bengtsson C, Lissner L (2003) Self-reported stress levels predict subsequent breast cancer in a cohort of Swedish women. Eur J Cancer Prev 12(5):377\u2013381","journal-title":"Eur J Cancer Prev"},{"key":"1884_CR8","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/(SICI)1097-0142(19960315)77:6<1089::AID-CNCR13>3.0.CO;2-Y","volume":"77","author":"FD Roberts","year":"1995","unstructured":"Roberts FD, Newcomb PA, Trentham-Dietz A, Storer BE (1995) Self-reported stress and risk of breast cancer. Cancer 77:1089\u20131093","journal-title":"Cancer"},{"issue":"1","key":"1884_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10549-009-0454-6","volume":"120","author":"PG Surtees","year":"2009","unstructured":"Surtees PG et al (2009) No evidence that social stress is associated with breast cancer incidence. Breast Cancer Res Treat 120(1):169\u2013174. https:\/\/doi.org\/10.1007\/s10549-009-0454-6","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"1884_CR10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/aje\/kwm056","volume":"166","author":"TR Taylor","year":"2007","unstructured":"Taylor TR, Williams CD, Makambi KH, Mouton C, Harrell JP, Cozier Y, Palmer JR, Rosenberg L, Adams-Campbell LL (2007) Racial discrimination and breast cancer incidence in US Black women: the Black women\u2019s health study. Am J Epidemiol 166(1):46\u201354. https:\/\/doi.org\/10.1093\/aje\/kwm056","journal-title":"Am J Epidemiol"},{"issue":"5","key":"1884_CR11","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/aje\/kwg002","volume":"157","author":"K Lillberg","year":"2003","unstructured":"Lillberg K (2003) Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol 157(5):415\u2013423. https:\/\/doi.org\/10.1093\/aje\/kwg002","journal-title":"Am J Epidemiol"},{"issue":"11","key":"1884_CR12","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/aje\/kwh327","volume":"160","author":"ES Schernhammer","year":"2004","unstructured":"Schernhammer ES, Hankinson SE, Rosner B, Kroenke CH, Willett WC, Colditz GA, Kawachi I (2004) Job stress and breast cancer risk: the nurses\u2019 health study. Am J Epidemiol 160(11):1079\u20131086. https:\/\/doi.org\/10.1093\/aje\/kwh327. (PMID: 15561987)","journal-title":"Am J Epidemiol"},{"issue":"2","key":"1884_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1037\/a0012982","volume":"28","author":"YL Michael","year":"2009","unstructured":"Michael YL et al (2009) Influence of stressors on breast cancer incidence in the women\u2019s health initiative. Health Psychol 28(2):137\u2013146. https:\/\/doi.org\/10.1037\/a0012982","journal-title":"Health Psychol"},{"issue":"1","key":"1884_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13058-016-0733-1","volume":"18","author":"MJ Schoemaker","year":"2016","unstructured":"Schoemaker MJ et al (2016) Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom. Breast Cancer Res 18(1):72. https:\/\/doi.org\/10.1186\/s13058-016-0733-1","journal-title":"Breast Cancer Res"},{"issue":"6","key":"1884_CR15","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/ijc.11504","volume":"107","author":"SF Duijts","year":"2003","unstructured":"Duijts SF, Zeegers MP, Borne BV (2003) The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer 107(6):1023\u20131029. https:\/\/doi.org\/10.1002\/ijc.11504","journal-title":"Int J Cancer"},{"issue":"5","key":"1884_CR16","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1037\/0278-6133.18.5.520","volume":"18","author":"MC McKenna","year":"1999","unstructured":"McKenna MC et al (1999) Psychosocial factors and the development of breast cancer: a meta-analysis. Health Psychol 18(5):520\u2013531. https:\/\/doi.org\/10.1037\/0278-6133.18.5.520","journal-title":"Health Psychol"},{"issue":"1","key":"1884_CR17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.15386\/cjmed-924","volume":"91","author":"V Chiriac","year":"2018","unstructured":"Chiriac V, Baban A, Dumitrascu DL (2018) Psychological stress and breast cancer incidence: a systematic review. Med Pharm Rep 91(1):18\u201326. https:\/\/doi.org\/10.15386\/cjmed-924","journal-title":"Med Pharm Rep"},{"issue":"5","key":"1884_CR18","first-page":"315","volume":"30","author":"BS McEwen","year":"2005","unstructured":"McEwen BS (2005) Stressed or stressed out: what is the difference? J Psychiatry Neurosci 30(5):315\u2013318","journal-title":"J Psychiatry Neurosci"},{"issue":"1","key":"1884_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/s0018-506x(02)00024-7","volume":"43","author":"BS McEwen","year":"2003","unstructured":"McEwen BS, Wingfield JC (2003) The concept of allostasis in biology and biomedicine. Horm Behav 43(1):2\u201315. https:\/\/doi.org\/10.1016\/s0018-506x(02)00024-7","journal-title":"Horm Behav"},{"issue":"2","key":"1884_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.31887\/DCNS.2004.6.2\/bmcewen","volume":"6","author":"BS McEwen","year":"2004","unstructured":"McEwen BS (2004) Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression. Dialogues Clin Neurosci 6(2):119\u2013133","journal-title":"Dialogues Clin Neurosci"},{"issue":"3","key":"1884_CR21","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1073\/pnas.96.3.1059","volume":"96","author":"FS Dhabhar","year":"1999","unstructured":"Dhabhar FS, McEwen BS (1999) Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci 96(3):1059\u20131064","journal-title":"Proc Natl Acad Sci"},{"issue":"7516","key":"1884_CR22","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1136\/bmj.38547.638183.06","volume":"331","author":"NR Nielsen","year":"2005","unstructured":"Nielsen NR, Zhang ZF, Kristensen TS, Netterstr\u00f8m B, Schnohr P, Gr\u00f8nbaek M (2005) Self reported stress and risk of breast cancer: prospective cohort study. BMJ 331(7516):548. https:\/\/doi.org\/10.1136\/bmj.38547.638183.06","journal-title":"BMJ"},{"issue":"4","key":"1884_CR23","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/bcr1744","volume":"9","author":"ME Falagas","year":"2007","unstructured":"Falagas ME, Zarkadoulia EA, Ioannidou EN, Peppas G, Christodoulou C, Rafailidis PI (2007) The effect of psychosocial factors on breast cancer outcome: a systematic review. Breast Cancer Res 9(4):R44. https:\/\/doi.org\/10.1186\/bcr1744","journal-title":"Breast Cancer Res"},{"issue":"8","key":"1884_CR24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/ncponc1134","volume":"5","author":"Y Chida","year":"2008","unstructured":"Chida Y, Hamer M, Wardle J, Steptoe A (2008) Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol 5(8):466\u2013475. https:\/\/doi.org\/10.1038\/ncponc1134","journal-title":"Nat Clin Pract Oncol"},{"key":"1884_CR25","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1038\/s41380-020-00865-6","volume":"25","author":"X Wang","year":"2020","unstructured":"Wang X, Wang N, Zhong L et al (2020) Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients. Mol Psychiatry 25:3186\u20133197. https:\/\/doi.org\/10.1038\/s41380-020-00865-6","journal-title":"Mol Psychiatry"},{"issue":"9","key":"1884_CR26","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1038\/bjc.2012.96","volume":"106","author":"MH Olsen","year":"2012","unstructured":"Olsen MH, Bidstrup PE, Frederiksen K, Rod NH, Gr\u00f8nbaek M, Dalton SO, Johansen C (2012) Loss of partner and breast cancer prognosis\u2014a population-based study, Denmark, 1994\u20132010. Br J Cancer 106(9):1560\u20133. https:\/\/doi.org\/10.1038\/bjc.2012.96. (Epub 2012 Mar 20. PMID: 22433966; PMCID: PMC3341857)","journal-title":"Br J Cancer"},{"issue":"2","key":"1884_CR27","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/NCC.0b013e318289a6e2","volume":"37","author":"BL Todd","year":"2014","unstructured":"Todd BL, Moskowitz MC, Ottati A, Feuerstein M (2014) Stressors, stress response, and cancer recurrence: a systematic review. Cancer Nurs 37(2):114\u2013125. https:\/\/doi.org\/10.1097\/NCC.0b013e318289a6e2. (PMID: 23619331)","journal-title":"Cancer Nurs"},{"issue":"1","key":"1884_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbi.2008.06.007","volume":"23","author":"GN Armaiz-Pena","year":"2009","unstructured":"Armaiz-Pena GN, Lutgendorf SK, Cole SW, Sood AK (2009) Neuroendocrine modulation of cancer progression. Brain Behav Immun 23(1):10\u201315. https:\/\/doi.org\/10.1016\/j.bbi.2008.06.007","journal-title":"Brain Behav Immun"},{"key":"1884_CR29","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1016\/j.bbi.2012.06.005","volume":"30","author":"GN Armaiz-Pena","year":"2013","unstructured":"Armaiz-Pena GN, Cole SW, Lutgendorf SK, Sood AK (2013) Neuroendocrine influences on cancer progression. Brain Behav Immun 30:S19\u2013S25. https:\/\/doi.org\/10.1016\/j.bbi.2012.06.005","journal-title":"Brain Behav Immun"},{"issue":"1\u20132","key":"1884_CR30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cellimm.2007.09.006","volume":"252","author":"JI Marketon","year":"2008","unstructured":"Marketon JI, Glaser R (2008) Stress hormones and immune function. Cell Immunol 252(1\u20132):16\u201326. https:\/\/doi.org\/10.1016\/j.cellimm.2007.09.006","journal-title":"Cell Immunol"},{"issue":"13","key":"1884_CR31","doi-asserted-by":"publisher","first-page":"5900","DOI":"10.1128\/mcb.24.13.5900-5913.2004","volume":"24","author":"M Razandi","year":"2004","unstructured":"Razandi M, Pedram A, Rosen EM, Levin ER (2004) BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol 24(13):5900\u20135913. https:\/\/doi.org\/10.1128\/mcb.24.13.5900-5913.2004","journal-title":"Mol Cell Biol"},{"issue":"2","key":"1884_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.canlet.2012.02.033","volume":"322","author":"J Ling","year":"2012","unstructured":"Ling J, Kumar R (2012) Crosstalk between NFkB and glucocorticoid signaling: a potential target of breast cancer therapy. Cancer Lett 322(2):119\u2013126. https:\/\/doi.org\/10.1016\/j.canlet.2012.02.033","journal-title":"Cancer Lett"},{"issue":"2","key":"1884_CR33","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/bcr2836","volume":"13","author":"L Antonova","year":"2011","unstructured":"Antonova L, Aronson K, Mueller CR (2011) Stress and breast cancer: from epidemiology to molecular biology. Breast Cancer Res 13(2):208. https:\/\/doi.org\/10.1186\/bcr2836","journal-title":"Breast Cancer Res"},{"key":"1884_CR34","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.psyneuen.2007.07.004","volume":"32","author":"A Grippo","year":"2007","unstructured":"Grippo A, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Sue CC (2007) Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 32:966\u2013980. https:\/\/doi.org\/10.1016\/j.psyneuen.2007.07.004","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"1884_CR35","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/0889-1591(89)90039-1","volume":"3","author":"J Weinberg","year":"1989","unstructured":"Weinberg J, Emerman JT (1989) Effects of psychosocial stressors on mouse mammary tumor growth. Brain Behav Immun 3(3):234\u2013246. https:\/\/doi.org\/10.1016\/0889-1591(89)90039-1","journal-title":"Brain Behav Immun"},{"key":"1884_CR36","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0031-9384(95)02126-4","volume":"59","author":"M Grimm","year":"1996","unstructured":"Grimm M, Emerman J, Weinberg J (1996) Effects of social housing condition and behavior on growth of the Shionogi mouse mammary carcinoma. Physiol Behav 59:633\u2013642. https:\/\/doi.org\/10.1016\/0031-9384(95)02126-4","journal-title":"Physiol Behav"},{"issue":"52","key":"1884_CR37","doi-asserted-by":"publisher","first-page":"22393","DOI":"10.1073\/pnas.0910753106","volume":"106","author":"GL Hermes","year":"2009","unstructured":"Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, Mcclintock MK (2009) Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci 106(52):22393\u201322398. https:\/\/doi.org\/10.1073\/pnas.0910753106","journal-title":"Proc Natl Acad Sci"},{"issue":"3\u20136","key":"1884_CR38","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0960-0760(97)80024-6","volume":"61","author":"A Brodie","year":"1997","unstructured":"Brodie A, Lu Q, Nakamura J (1997) Aromatase in the normal breast and breast cancer. J Steroid Biochem Mol Biol 61(3\u20136):281\u2013286. https:\/\/doi.org\/10.1016\/s0960-0760(97)80024-6","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"1884_CR39","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1074\/jbc.m411200200","volume":"280","author":"W Wu","year":"2004","unstructured":"Wu W, Pew T, Zou M, Pang D, Conzen SD (2004) Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem 280(6):4117\u20134124. https:\/\/doi.org\/10.1074\/jbc.m411200200","journal-title":"J Biol Chem"},{"issue":"9","key":"1884_CR40","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc3978","volume":"15","author":"SW Cole","year":"2015","unstructured":"Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK (2015) Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer 15(9):563\u2013572. https:\/\/doi.org\/10.1038\/nrc3978","journal-title":"Nat Rev Cancer"},{"key":"1884_CR41","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.neuron.2015.01.026","volume":"86","author":"M Hanoun","year":"2015","unstructured":"Hanoun M, Maryanovich M, Arnal-Estape A, Frenette PS (2015) Neural regulation of hematopoiesis, inflammation, and cancer. Neuron 86:360\u2013373","journal-title":"Neuron"},{"issue":"7","key":"1884_CR42","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2174\/1570159x14666151208113006","volume":"14","author":"E Won","year":"2016","unstructured":"Won E, Kim Y (2016) Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression. Curr Neuropharmacol 14(7):665\u2013673. https:\/\/doi.org\/10.2174\/1570159x14666151208113006","journal-title":"Curr Neuropharmacol"},{"issue":"18","key":"1884_CR43","doi-asserted-by":"publisher","first-page":"7042","DOI":"10.1158\/0008-5472.can-10-0522","volume":"70","author":"EK Sloan","year":"2010","unstructured":"Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V et al (2010) The sympathetic nervous system induces a metastatic switch in primary breast cancer. Can Res 70(18):7042\u20137052. https:\/\/doi.org\/10.1158\/0008-5472.can-10-0522","journal-title":"Can Res"},{"issue":"5","key":"1884_CR44","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/1078-0432.ccr-11-0641","volume":"18","author":"SW Cole","year":"2011","unstructured":"Cole SW, Sood AK (2011) Molecular pathways: beta-adrenergic signaling in cancer: Figure 1. Clin Cancer Res 18(5):1201\u20131206. https:\/\/doi.org\/10.1158\/1078-0432.ccr-11-0641","journal-title":"Clin Cancer Res"},{"issue":"9","key":"1884_CR45","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/bjc.2015.133","volume":"112","author":"A Reeder","year":"2015","unstructured":"Reeder A, Attar M, Nazario L, Bathula C, Zhang A, Hochbaum D et al (2015) Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Br J Cancer 112(9):1461\u20131470. https:\/\/doi.org\/10.1038\/bjc.2015.133","journal-title":"Br J Cancer"},{"issue":"1","key":"1884_CR46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.18632\/oncotarget.1083","volume":"5","author":"JK Wolter","year":"2013","unstructured":"Wolter JK, Wolter NE, Blanch A, Partridge T, Cheng L, Morgenstern DA et al (2013) Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget 5(1):161\u201372. https:\/\/doi.org\/10.18632\/oncotarget.1083","journal-title":"Oncotarget"},{"key":"1884_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.07.092","author":"G Armaiz-Pena","year":"2011","unstructured":"Armaiz-Pena G, Stone R, Nick A, Allen J, Deavers M, Jackson D et al (2011) Src activation by beta adrenoreceptors is a key switch for microenvironmental regulation of tumor metastasis. Brain Behav Immun. https:\/\/doi.org\/10.1016\/j.bbi.2011.07.092","journal-title":"Brain Behav Immun"},{"issue":"2","key":"1884_CR48","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s10549-010-0822-2","volume":"125","author":"M Shi","year":"2010","unstructured":"Shi M, Liu D, Duan H, Qian L, Wang L, Niu L et al (2010) The \u03b22-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Breast Cancer Res Treat 125(2):351\u2013362. https:\/\/doi.org\/10.1007\/s10549-010-0822-2","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"1884_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bbi.2008.04.017","volume":"22","author":"EV Yang","year":"2008","unstructured":"Yang EV, Kim S, Donovan EL, Chen M, Beickelman A, Hutzen BJ et al (2008) Norepinephrine upregulates VEGF, IL-6, and IL-8 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 22(4):3. https:\/\/doi.org\/10.1016\/j.bbi.2008.04.017","journal-title":"Brain Behav Immun"},{"key":"1884_CR50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fendo.2016.00037","volume":"7","author":"R Dumbell","year":"2016","unstructured":"Dumbell R, Matveeva O, Oster H (2016) Circadian clocks, stress, and immunity. Front Endocrinol 7:37. https:\/\/doi.org\/10.3389\/fendo.2016.00037","journal-title":"Front Endocrinol"},{"issue":"8","key":"1884_CR51","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.psyneuen.2003.11.003","volume":"29","author":"HC Abercrombie","year":"2004","unstructured":"Abercrombie HC, Giese-Davis J, Sephton S, Epel ES, Turner-Cobb JM, Spiegel D (2004) Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology 29(8):1082\u20131092. https:\/\/doi.org\/10.1016\/j.psyneuen.2003.11.003","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"1884_CR52","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1093\/jnci\/92.12.994","volume":"92","author":"SE Sephton","year":"2000","unstructured":"Sephton SE (2000) Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 92(12):994\u20131000. https:\/\/doi.org\/10.1093\/jnci\/92.12.994","journal-title":"J Natl Cancer Inst"},{"issue":"15","key":"1884_CR53","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1158\/0008-5472.can-19-0566","volume":"79","author":"AA Shafi","year":"2019","unstructured":"Shafi AA, Knudsen KE (2019) Cancer and the circadian clock. Can Res 79(15):3806\u20133814. https:\/\/doi.org\/10.1158\/0008-5472.can-19-0566","journal-title":"Can Res"},{"key":"1884_CR54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/jnci\/90.1.30","volume":"90","author":"BL Andersen","year":"1998","unstructured":"Andersen BL, Farrar WB, Golden-Kreutz D, Kutz LA, MacCallum R, Courtney ME, Glaser R (1998) Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst 90:30\u201336","journal-title":"J Natl Cancer Inst"},{"key":"1884_CR55","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00262-013-1469-8","volume":"63","author":"E Ames","year":"2014","unstructured":"Ames E, Murphy WJ (2014) Advantages and clinical applications of natural killer cells in cancer immunotherapy. Cancer Immunol Immunother 63:21\u201328. https:\/\/doi.org\/10.1007\/s00262-013-1469-8","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"1884_CR56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/epigenomes7010006","volume":"7","author":"A Kim","year":"2023","unstructured":"Kim A, Mo K, Kwon H, Choe S, Park M, Kwak W, Yoon H (2023) Epigenetic regulation in breast cancer: insights on epidrugs. Epigenomes 7(1):6. https:\/\/doi.org\/10.3390\/epigenomes7010006. (PMID: 36810560; PMCID: PMC9953240)","journal-title":"Epigenomes"},{"key":"1884_CR57","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1158\/0008-5472.CAN-08-3907","volume":"69","author":"SE Elsheikh","year":"2009","unstructured":"Elsheikh SE, Green A, Rakha EA, Powe DG, Ahmed RA, Collins HM, Soria D, Garibaldi JM, Paish CE, Ammar AA et al (2009) Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res 69:3802\u20133809. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-3907","journal-title":"Cancer Res"},{"key":"1884_CR58","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1158\/1078-0432.CCR-03-0514","volume":"10","author":"J Mehrotra","year":"2004","unstructured":"Mehrotra J, Ganpat MM, Kanaan Y, Fackler MJ, McVeigh M, Lahti-Domenici J, Polyak K, Argani P, Naab T, Garrett E et al (2004) Estrogen receptor\/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. Clin Cancer Res 10:2052\u20132057. https:\/\/doi.org\/10.1158\/1078-0432.CCR-03-0514","journal-title":"Clin Cancer Res"},{"key":"1884_CR59","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13059-015-0828-5","volume":"16","author":"AS Zannas","year":"2015","unstructured":"Zannas AS, Arloth J, Carrillo-Roa T et al (2015) Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biol 16:266. https:\/\/doi.org\/10.1186\/s13059-015-0828-5","journal-title":"Genome Biol"},{"key":"1884_CR60","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.bbi.2015.06.059","volume":"49","author":"MS Misale","year":"2015","unstructured":"Misale MS, Janusek L, Mathews H (2015) Epigenetic basis for psychological stress-induced IFNG production in women diagnosed with breast cancer. Brain Behav Immun 49:e11\u2013e12. https:\/\/doi.org\/10.1016\/j.bbi.2015.06.059","journal-title":"Brain Behav Immun"},{"key":"1884_CR61","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.psyneuen.2009.05.008","volume":"34","author":"MS Flint","year":"2009","unstructured":"Flint MS, Kim G, Hood BL, Bateman NW, Stewart NA, Conrads TP (2009) Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway. Psychoneuroendocrinology 34:1533\u20131541","journal-title":"Psychoneuroendocrinology"},{"key":"1884_CR62","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2174\/0929867043455990","volume":"11","author":"W Fan","year":"2004","unstructured":"Fan W, Sui M, Huang Y (2004) Glucocorticoids selectively inhibit paclitaxel-induced apoptosis: mechanisms and its clinical impact. Curr Med Chem 11:403\u2013411","journal-title":"Curr Med Chem"},{"key":"1884_CR63","doi-asserted-by":"publisher","first-page":"16649","DOI":"10.1074\/jbc.M010842200","volume":"276","author":"CA Mikosz","year":"2001","unstructured":"Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD (2001) Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine\/threonine survival kinase gene, sgk-1. J Biol Chem 276:16649\u201316654","journal-title":"J Biol Chem"},{"key":"1884_CR64","first-page":"389","volume":"4","author":"E Mechetner","year":"1998","unstructured":"Mechetner E, Kyshtoobayeva A, Zonis S, Kim H, Stroup R, Garcia R et al (1998) Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin. Clin Cancer Res 4:389\u2013398","journal-title":"Clin Cancer Res"},{"key":"1884_CR65","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.bbrc.2005.02.056","volume":"329","author":"F Su","year":"2005","unstructured":"Su F, Ouyang N, Zhu P, Ouyang N, Jia W, Gong C et al (2005) Psychological stress induces chemoresistance in breast cancer by upregulating mdr1. Biochem Biophys Res Commun 329:888\u2013897","journal-title":"Biochem Biophys Res Commun"},{"issue":"20","key":"1884_CR66","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1158\/0008-5472.can-17-0546","volume":"77","author":"MJ Bucsek","year":"2017","unstructured":"Bucsek MJ, Qiao G, Macdonald CR, Giridharan T, Evans L, Niedzwecki B et al (2017) \u03b2-Adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8+ T cells and undermines checkpoint inhibitor therapy. Can Res 77(20):5639\u20135651. https:\/\/doi.org\/10.1158\/0008-5472.can-17-0546","journal-title":"Can Res"},{"issue":"16","key":"1884_CR67","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1158\/1078-0432.ccr-17-0152","volume":"23","author":"L Shaashua","year":"2017","unstructured":"Shaashua L, Shabat-Simon M, Haldar R, Matzner P, Zmora O, Shabtai M et al (2017) Perioperative COX-2 and \u03b2-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial. Clin Cancer Res 23(16):4651\u20134661. https:\/\/doi.org\/10.1158\/1078-0432.ccr-17-0152","journal-title":"Clin Cancer Res"},{"issue":"19","key":"1884_CR68","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1200\/jco.2010.33.5422","volume":"29","author":"TI Barron","year":"2011","unstructured":"Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K (2011) Beta blockers and breast cancer mortality: a population-based study. J Clin Oncol 29(19):2635\u20132644. https:\/\/doi.org\/10.1200\/jco.2010.33.5422","journal-title":"J Clin Oncol"},{"issue":"22","key":"1884_CR69","doi-asserted-by":"publisher","first-page":"6163","DOI":"10.1158\/1078-0432.ccr-12-3826","volume":"19","author":"MN Skor","year":"2013","unstructured":"Skor MN et al (2013) Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res 19(22):6163\u20136172. https:\/\/doi.org\/10.1158\/1078-0432.ccr-12-3826","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1884_CR70","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13058-019-1164-6","volume":"21","author":"E Tonsing-Carter","year":"2019","unstructured":"Tonsing-Carter E et al (2019) Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res 21(1):82. https:\/\/doi.org\/10.1186\/s13058-019-1164-6","journal-title":"Breast Cancer Res"},{"issue":"8","key":"1884_CR71","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.bbi.2007.04.002","volume":"21","author":"LE Carlson","year":"2007","unstructured":"Carlson LE, Speca M, Faris P, Patel KD (2007) One year pre\u2013post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun 21(8):1038\u20131049. https:\/\/doi.org\/10.1016\/j.bbi.2007.04.002","journal-title":"Brain Behav Immun"},{"issue":"9","key":"1884_CR72","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1097\/psy.0b013e318186fb27","volume":"70","author":"KM Phillips","year":"2008","unstructured":"Phillips KM, Antoni MH, Lechner SC, Blomberg BB, Llabre MM, Avisar E et al (2008) Stress management intervention reduces serum cortisol and increases relaxation during treatment for nonmetastatic breast cancer. Psychosom Med 70(9):1044\u20131049. https:\/\/doi.org\/10.1097\/psy.0b013e318186fb27","journal-title":"Psychosom Med"},{"issue":"5","key":"1884_CR73","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.bbi.2008.09.005","volume":"23","author":"MH Antoni","year":"2009","unstructured":"Antoni MH, Lechner S, Diaz A, Vargas S, Holley H, Phillips K et al (2009) Cognitive behavioral stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer. Brain Behav Immun 23(5):580\u2013591. https:\/\/doi.org\/10.1016\/j.bbi.2008.09.005","journal-title":"Brain Behav Immun"},{"key":"1884_CR74","doi-asserted-by":"publisher","unstructured":"Qi L, Wang J, Zhang H (2017) Meta-analysis of psychological interventions on breast cancer patients\u2019 immune function. Proceedings of the 2nd 2016 international conference on sustainable development (ICSD 2016). https:\/\/doi.org\/10.2991\/icsd-16.2017.93","DOI":"10.2991\/icsd-16.2017.93"},{"issue":"38","key":"1884_CR75","doi-asserted-by":"publisher","first-page":"e17228","DOI":"10.1097\/md.0000000000017228","volume":"98","author":"P Zhang","year":"2019","unstructured":"Zhang P, Mo L, Li X, Wang Q (2019) Psychological intervention and its immune effect in cancer patients. Medicine 98(38):e17228. https:\/\/doi.org\/10.1097\/md.0000000000017228","journal-title":"Medicine"},{"key":"1884_CR76","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1017\/cbo9780511759048.03","volume":"1994","author":"D Spiegel","year":"1994","unstructured":"Spiegel D, Bloom JR, Kraemer HC, Gottheil E (1994) Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Psychosocial Processes Health 1994:468\u2013477. https:\/\/doi.org\/10.1017\/cbo9780511759048.03","journal-title":"Psychosocial Processes Health"},{"issue":"2","key":"1884_CR77","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10549-015-3626-6","volume":"154","author":"JM Stagl","year":"2015","unstructured":"Stagl JM, Lechner SC, Carver CS, Bouchard LC, Gudenkauf LM, Jutagir DR et al (2015) A randomized controlled trial of cognitive-behavioral stress management in breast cancer: survival and recurrence at 11-year follow-up. Breast Cancer Res Treat 154(2):319\u2013328. https:\/\/doi.org\/10.1007\/s10549-015-3626-6","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"1884_CR78","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1002\/cncr.23969","volume":"113","author":"BL Andersen","year":"2008","unstructured":"Andersen BL, Yang H, Farrar WB, Golden-Kreutz DM, Emery CF, Thornton LM et al (2008) Psychologic intervention improves survival for breast cancer patients. Cancer 113(12):3450\u20133458. https:\/\/doi.org\/10.1002\/cncr.23969","journal-title":"Cancer"},{"issue":"1","key":"1884_CR79","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/cam4.1895","volume":"8","author":"S Mirosevic","year":"2019","unstructured":"Mirosevic S, Jo B, Kraemer HC, Ershadi M, Neri E, Spiegel D (2019) \u201cNot just another meta-analysis\u201d: sources of heterogeneity in psychosocial treatment effect on cancer survival. Cancer Med 8(1):363\u2013373. https:\/\/doi.org\/10.1002\/cam4.1895","journal-title":"Cancer Med"},{"issue":"5\u20136","key":"1884_CR80","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/09593980902886321","volume":"25","author":"L Lemyre","year":"2009","unstructured":"Lemyre L, Chair MR, Lalande-Markon M (2009) Psychological stress measure (PSM-9): integration of an evidence-based approach to assessment, monitoring, and evaluation of stress in physical therapy practice. Physiother Theory Pract 25(5\u20136):453\u2013462. https:\/\/doi.org\/10.1080\/09593980902886321","journal-title":"Physiother Theory Pract"},{"issue":"2\u20134","key":"1884_CR81","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000288427","volume":"55","author":"A Fors\u00e9n","year":"1991","unstructured":"Fors\u00e9n A (1991) Psychosocial stress as a risk for breast cancer. Psychother Psychosom 55(2\u20134):176\u2013185. https:\/\/doi.org\/10.1159\/000288427. (PMID: 1891566)","journal-title":"Psychother Psychosom"},{"issue":"3","key":"1884_CR82","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jpsychores.2007.05.012","volume":"63","author":"O Palesh","year":"2007","unstructured":"Palesh O, Butler LD, Koopman C, Giese-Davis J, Carlson R, Spiegel D (2007) Stress history and breast cancer recurrence. J Psychosom Res 63(3):233\u2013239. https:\/\/doi.org\/10.1016\/j.jpsychores.2007.05.012","journal-title":"J Psychosom Res"},{"issue":"33","key":"1884_CR83","doi-asserted-by":"publisher","first-page":"e4547","DOI":"10.1097\/MD.0000000000004547","volume":"95","author":"SJ Chen","year":"2016","unstructured":"Chen SJ, Chang CH, Chen KC, Liu CY (2016) Association between depressive disorders and risk of breast cancer recurrence after curative surgery. Medicine 95(33):e4547. https:\/\/doi.org\/10.1097\/MD.0000000000004547","journal-title":"Medicine"},{"issue":"5","key":"1884_CR84","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000289140","volume":"66","author":"T Giraldi","year":"1997","unstructured":"Giraldi T, Rodani MG, Cartei G, Grassi L (1997) Psychosocial factors and breast cancer: a 6-year Italian follow-up study. Psychother Psychosom 66(5):229\u2013236. https:\/\/doi.org\/10.1159\/000289140. (PMID: 9311026)","journal-title":"Psychother Psychosom"},{"issue":"7351","key":"1884_CR85","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1136\/bmj.324.7351.1420","volume":"324","author":"J Graham","year":"2002","unstructured":"Graham J, Ramirez A, Love S, Richards M, Burgess C (2002) Stressful life experiences and risk of relapse of breast cancer: observational cohort study. BMJ (Clinical research ed) 324(7351):1420. https:\/\/doi.org\/10.1136\/bmj.324.7351.1420","journal-title":"BMJ (Clinical research ed)"},{"issue":"28","key":"1884_CR86","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.1200\/JCO.2007.14.8718","volume":"26","author":"KA Phillips","year":"2008","unstructured":"Phillips KA, Osborne RH, Giles GG, Dite GS, Apicella C, Hopper JL, Milne RL (2008) Psychosocial factors and survival of young women with breast cancer: a population-based prospective cohort study. J Clin Oncol 26(28):4666\u20134671. https:\/\/doi.org\/10.1200\/JCO.2007.14.8718","journal-title":"J Clin Oncol"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-024-01884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10552-024-01884-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-024-01884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T20:02:30Z","timestamp":1731528150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10552-024-01884-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":86,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["1884"],"URL":"https:\/\/doi.org\/10.1007\/s10552-024-01884-2","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"1 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"As this was a retrospective review, the research was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was waived for this research as this was a retrospective review not involving active research on human subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}