{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:06:36Z","timestamp":1747973196225,"version":"3.41.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10552-025-01967-8","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T14:49:58Z","timestamp":1738766998000},"page":"633-640","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demographic and temporal variations in gallbladder adenocarcinoma and neuroendocrine carcinoma: insights from a retrospective analysis of the national cancer database"],"prefix":"10.1007","volume":"36","author":[{"given":"Mena","family":"Louis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya K.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawras","family":"Silin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahani","family":"Dakkak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ania Izabela","family":"Rynarzewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Cawthon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Grabill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson A.","family":"Royall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"1967_CR1","unstructured":"Menon G, Babiker HM (2024) Gallbladder carcinoma. StatPearls. StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC"},{"issue":"2","key":"1967_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5114\/ceh.2019.85166","volume":"5","author":"P Rawla","year":"2019","unstructured":"Rawla P, Sunkara T, Thandra KC, Barsouk A (2019) Epidemiology of gallbladder cancer. Clin Exp Hepatol 5(2):93\u2013102. https:\/\/doi.org\/10.5114\/ceh.2019.85166","journal-title":"Clin Exp Hepatol"},{"key":"1967_CR3","doi-asserted-by":"publisher","unstructured":"Gore RM, Shelhamer RP (2007) Biliary tract neoplasms: diagnosis and staging. Cancer Imaging 7 Spec No A(Special issue A):S15\u2013S23. https:\/\/doi.org\/10.1102\/1470-7330.2007.9016","DOI":"10.1102\/1470-7330.2007.9016"},{"issue":"43","key":"1967_CR4","doi-asserted-by":"publisher","first-page":"12211","DOI":"10.3748\/wjg.v21.i43.12211","volume":"21","author":"TO Goetze","year":"2015","unstructured":"Goetze TO (2015) Gallbladder carcinoma: prognostic factors and therapeutic options. World J Gastroenterol 21(43):12211\u201312217. https:\/\/doi.org\/10.3748\/wjg.v21.i43.12211","journal-title":"World J Gastroenterol"},{"issue":"8","key":"1967_CR5","doi-asserted-by":"publisher","first-page":"e28260","DOI":"10.7759\/cureus.28260","volume":"14","author":"SA Halaseh","year":"2022","unstructured":"Halaseh SA, Halaseh S, Shakman R (2022) A review of the etiology and epidemiology of gallbladder cancer: what you need to know. Cureus 14(8):e28260. https:\/\/doi.org\/10.7759\/cureus.28260","journal-title":"Cureus"},{"issue":"24","key":"1967_CR6","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1158\/1078-0432.Ccr-22-1954","volume":"28","author":"NA Giraldo","year":"2022","unstructured":"Giraldo NA, Drill E, Satravada BA et al (2022) Comprehensive molecular characterization of gallbladder carcinoma and potential targets for intervention. Clin Cancer Res 28(24):5359\u20135367. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-22-1954","journal-title":"Clin Cancer Res"},{"key":"1967_CR7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78636","author":"M Kang","year":"2022","unstructured":"Kang M, Na HY, Ahn S et al (2022) Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors. Elife. https:\/\/doi.org\/10.7554\/eLife.78636","journal-title":"Elife"},{"key":"1967_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215257","author":"H Kuipers","year":"2021","unstructured":"Kuipers H, de Bitter TJJ, de Boer MT et al (2021) Gallbladder cancer: current insights in genetic alterations and their possible therapeutic implications. Cancers. https:\/\/doi.org\/10.3390\/cancers13215257","journal-title":"Cancers"},{"key":"1967_CR9","doi-asserted-by":"publisher","first-page":"117693512092215","DOI":"10.1177\/1176935120922154","volume":"19","author":"V D'Afonseca","year":"2020","unstructured":"D\u2019Afonseca V, Arencibia AD, Echeverr\u00eda-Vega A et al (2020) Identification of altered genes in gallbladder cancer as potential driver mutations for diagnostic and prognostic purposes: a computational approach. Cancer Inform 19:1176935120922154. https:\/\/doi.org\/10.1177\/1176935120922154","journal-title":"Cancer Inform"},{"key":"1967_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153880","author":"H Y\u0131ld\u0131r\u0131m","year":"2023","unstructured":"Y\u0131ld\u0131r\u0131m H, Kavgaci G, Chalabiyev E, Dizdar O (2023) Advances in the early detection of hepatobiliary cancers. Cancers. https:\/\/doi.org\/10.3390\/cancers15153880","journal-title":"Cancers"},{"key":"1967_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133222","author":"PM Rodrigues","year":"2021","unstructured":"Rodrigues PM, Vogel A, Arrese M, Balderramo DC, Valle JW, Banales JM (2021) Next-generation biomarkers for cholangiocarcinoma. Cancers. https:\/\/doi.org\/10.3390\/cancers13133222","journal-title":"Cancers"},{"issue":"2","key":"1967_CR12","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00330016-4394-3","volume":"27","author":"T-H Kim","year":"2016","unstructured":"Kim T-H, Kim SH, Lee KB, Han JK (2016) Outcome and CT differentation of gallbladder neuroendocrine tumors from adenocarcinomas. Eur Radiol 27(2):507\u2013517. https:\/\/doi.org\/10.1007\/s00330016-4394-3","journal-title":"Eur Radiol"},{"issue":"3","key":"1967_CR13","doi-asserted-by":"publisher","first-page":"e7487","DOI":"10.7759\/cureus.7487","volume":"12","author":"S Siddamreddy","year":"2020","unstructured":"Siddamreddy S, Meegada S, Syed A, Sarwar M, Muppidi V (2020) Gallbladder neuroendocrine carcinoma: a rare endocrine tumor. Cureus 12(3):e7487. https:\/\/doi.org\/10.7759\/cureus.7487","journal-title":"Cureus"},{"issue":"11","key":"1967_CR14","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1245\/s10434-019-07440-6","volume":"26","author":"RI Ayabe","year":"2019","unstructured":"Ayabe RI, Wach M, Ruff S et al (2019) Primary gallbladder neuroendocrine tumors: insights into a rare histology using a large national database. Ann Surg Oncol 26(11):3577\u20133585. https:\/\/doi.org\/10.1245\/s10434-019-07440-6","journal-title":"Ann Surg Oncol"},{"issue":"23","key":"1967_CR15","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.12998\/wjcc.v10.i23.8212","volume":"10","author":"XC Cai","year":"2022","unstructured":"Cai XC, Wu SD (2022) Gallbladder neuroendocrine carcinoma diagnosis, treatment and prognosis based on the SEER database: a literature review. World J Clin Cases 10(23):8212\u20138223. https:\/\/doi.org\/10.12998\/wjcc.v10.i23.8212","journal-title":"World J Clin Cases"},{"issue":"1","key":"1967_CR16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40792-021-01152-4","volume":"7","author":"T Ishikawa","year":"2021","unstructured":"Ishikawa T, Nakano K, Osaka M et al (2021) Mixed neuroendocrine-non-neuroendocrine neoplasms of the gallbladder: a case report. Surg Case Rep 7(1):70. https:\/\/doi.org\/10.1186\/s40792-021-01152-4","journal-title":"Surg Case Rep"},{"key":"1967_CR17","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3332\/ecancer.2021.1174","volume":"15","author":"J Ghosh","year":"2021","unstructured":"Ghosh J, Chatterjee M, Ganguly S, Dabkara D, Biswas B (2021) Outcomes of metastatic neuroendocrine carcinoma of the gallbladder. Ecancermedicalscience 15:1174. https:\/\/doi.org\/10.3332\/ecancer.2021.1174","journal-title":"Ecancermedicalscience"},{"issue":"10","key":"1967_CR18","doi-asserted-by":"publisher","first-page":"11344","DOI":"10.1002\/cam4.5846","volume":"12","author":"X Wu","year":"2023","unstructured":"Wu X, Li B, Hong T, Liu W, He X, Zheng C (2023) Neuroendocrine neoplasm of the gallbladder: clinical features, surgical efficacy, and prognosis. Cancer Med 12(10):11344\u201311350. https:\/\/doi.org\/10.1002\/cam4.5846","journal-title":"Cancer Med"},{"issue":"3","key":"1967_CR19","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/cam4.4463","volume":"11","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Guo T, Huang X, Xie P, Wang L, Yu Y (2022) Age-specific clinicopathological characteristics and prognostic analysis of neuroendocrine carcinomas of the gallbladder. Cancer Med 11(3):641\u2013653. https:\/\/doi.org\/10.1002\/cam4.4463","journal-title":"Cancer Med"},{"issue":"3","key":"1967_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.4103\/sajc.sajc_364_18","volume":"8","author":"RS Kulkarni","year":"2019","unstructured":"Kulkarni RS, Anand AS, Parikh SK et al (2019) Clinical and epidemiological profile of neuroendocrine tumors: an experience from a regional cancer center from Western India. South Asian J Cancer 8(3):198\u2013202. https:\/\/doi.org\/10.4103\/sajc.sajc_364_18","journal-title":"South Asian J Cancer"},{"issue":"6","key":"1967_CR21","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1093\/annonc\/mdu006","volume":"25","author":"SG Barreto","year":"2014","unstructured":"Barreto SG, Dutt A, Chaudhary A (2014) A genetic model for gallbladder carcinogenesis and its dissemination. Ann Oncol 25(6):1086\u20131097. https:\/\/doi.org\/10.1093\/annonc\/mdu006","journal-title":"Ann Oncol"},{"issue":"4","key":"1967_CR22","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/cncr.32607","volume":"126","author":"R Gosain","year":"2020","unstructured":"Gosain R, Ball S, Rana N et al (2020) Geographic and demographic features of neuroendocrine tumors in the United States of America: a population-based study. Cancer 126(4):792\u2013799. https:\/\/doi.org\/10.1002\/cncr.32607","journal-title":"Cancer"},{"issue":"14","key":"1967_CR23","doi-asserted-by":"publisher","first-page":"e25449","DOI":"10.1097\/md.0000000000025449","volume":"100","author":"H Chu","year":"2021","unstructured":"Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C (2021) Update in clinical management for gallbladder neuroendocrine carcinoma. Medicine 100(14):e25449. https:\/\/doi.org\/10.1097\/md.0000000000025449","journal-title":"Medicine"},{"key":"1967_CR24","doi-asserted-by":"publisher","DOI":"10.1200\/po.20.00487","author":"TJJ de Bitter","year":"2021","unstructured":"de Bitter TJJ, Kroeze LI, de Reuver PR et al (2021) Unraveling neuroendocrine gallbladder cancer: comprehensive clinicopathologic and molecular characterization. JCO Precis Oncol. https:\/\/doi.org\/10.1200\/po.20.00487","journal-title":"JCO Precis Oncol"},{"key":"1967_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061863","author":"BE White","year":"2023","unstructured":"White BE, Russell B, Remmers S et al (2023) Sex differences in survival from neuroendocrine neoplasia in England 2012\u20132018: a retrospective, population-based study. Cancers. https:\/\/doi.org\/10.3390\/cancers15061863","journal-title":"Cancers"},{"key":"1967_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16132376","author":"M Mortagy","year":"2024","unstructured":"Mortagy M, El Asmar ML, Chandrakumaran K, Ramage J (2024) Sex differences in the survival of patients with neuroendocrine neoplasms: a comparative study of two national databases. Cancers. https:\/\/doi.org\/10.3390\/cancers16132376","journal-title":"Cancers"},{"issue":"4","key":"1967_CR27","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jhep.2020.04.046","volume":"73","author":"SS Jackson","year":"2020","unstructured":"Jackson SS, Adami HO, Andreotti G et al (2020) Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project. J Hepatol 73(4):863\u2013872. https:\/\/doi.org\/10.1016\/j.jhep.2020.04.046","journal-title":"J Hepatol"},{"issue":"10","key":"1967_CR28","first-page":"737","volume":"4","author":"EA Shaffer","year":"2008","unstructured":"Shaffer EA (2008) Gallbladder cancer: the basics. Gastroenterol Hepatol 4(10):737\u2013741","journal-title":"Gastroenterol Hepatol"},{"issue":"22","key":"1967_CR29","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.3748\/wjg.v23.i22.3978","volume":"23","author":"A Sharma","year":"2017","unstructured":"Sharma A, Sharma KL, Gupta A, Yadav A, Kumar A (2017) Gallbladder cancer epidemiology, pathogenesis and molecular genetics: recent update. World J Gastroenterol 23(22):3978\u20133998. https:\/\/doi.org\/10.3748\/wjg.v23.i22.3978","journal-title":"World J Gastroenterol"},{"issue":"8","key":"1967_CR30","doi-asserted-by":"publisher","first-page":"e42796","DOI":"10.7759\/cureus.42796","volume":"15","author":"C Xie","year":"2023","unstructured":"Xie C, Shi D, Lin H, Liu Y, Liu W, Yin P (2023) Spatial patterns of gallbladder and biliary tract carcinoma in China From 1990 to 2019: an analysis at the provincial level. Cureus 15(8):e42796. https:\/\/doi.org\/10.7759\/cureus.42796","journal-title":"Cureus"},{"issue":"7","key":"1967_CR31","doi-asserted-by":"publisher","first-page":"e26858","DOI":"10.7759\/cureus.26858","volume":"14","author":"SR Nuthulaganti","year":"2022","unstructured":"Nuthulaganti SR, Sharma R, Candula N, Gujarathi R, Saremian J (2022) A rare case of stage IV mixed neuroendocrine small cell and adenosquamous cell carcinoma of the gallbladder. Cureus 14(7):e26858. https:\/\/doi.org\/10.7759\/cureus.26858","journal-title":"Cureus"},{"key":"1967_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12155138","author":"Q Sultana","year":"2023","unstructured":"Sultana Q, Kar J, Verma A et al (2023) A comprehensive review on neuroendocrine neoplasms: presentation, pathophysiology and management. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12155138","journal-title":"J Clin Med"}],"container-title":["Cancer Causes & Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-025-01967-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10552-025-01967-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-025-01967-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:44:00Z","timestamp":1747903440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10552-025-01967-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1967"],"URL":"https:\/\/doi.org\/10.1007\/s10552-025-01967-8","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"type":"print","value":"0957-5243"},{"type":"electronic","value":"1573-7225"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"6 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author(s) declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict interest"}},{"value":"The Ethics Committee of Brenau University waived the need for ethics approval and patient consent for the collection, analysis, and publication of the retrospectively obtained and anonymized data for this non-interventional study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent statements"}}]}}