{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:15:40Z","timestamp":1770671740333,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10552-025-02092-2","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T09:43:10Z","timestamp":1766569390000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of vitamin D levels on risk and prognosis of ovarian cancer: a systematic review"],"prefix":"10.1007","volume":"37","author":[{"given":"Emily","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Iannello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Minelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meaghan","family":"Holub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"2092_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN et al (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"key":"2092_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010172","volume":"23","author":"K Piatek","year":"2021","unstructured":"Piatek K, Kutner A, Cacsire Castillo-Tong D et al (2021) Vitamin D analogs regulate the vitamin D system and cell viability in ovarian cancer cells. Int J Mol Sci 23:172. https:\/\/doi.org\/10.3390\/ijms23010172","journal-title":"Int J Mol Sci"},{"key":"2092_CR3","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1001\/jama.2025.9495","volume":"334","author":"G Caruso","year":"2025","unstructured":"Caruso G, Weroha SJ, Cliby W (2025) Ovarian cancer: a review. JAMA 334:1278\u20131291. https:\/\/doi.org\/10.1001\/jama.2025.9495","journal-title":"JAMA"},{"key":"2092_CR4","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/ijc.34002","volume":"151","author":"CJ Cabasag","year":"2022","unstructured":"Cabasag CJ, Fagan PJ, Ferlay J et al (2022) Ovarian cancer today and tomorrow: a global assessment by world region and Human Development Index using GLOBOCAN 2020. Int J Cancer 151:1535\u20131541. https:\/\/doi.org\/10.1002\/ijc.34002","journal-title":"Int J Cancer"},{"key":"2092_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.062","volume":"203","author":"LS Cook","year":"2010","unstructured":"Cook LS, Neilson HK, Lorenzetti DL, Lee RC (2010) A systematic literature review of vitamin D and ovarian cancer. Am J Obstet Gynecol 203:70.e1\u20138. https:\/\/doi.org\/10.1016\/j.ajog.2010.01.062","journal-title":"Am J Obstet Gynecol"},{"key":"2092_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12038-020-00038-1","volume":"45","author":"J Ji","year":"2020","unstructured":"Ji J, Cheng X, Wang W, Zhang J (2020) Vitamin D regulates cell viability, migration and proliferation by suppressing galectin-3 (Gal-3) gene in ovarian cancer cells. J Biosci 45:69","journal-title":"J Biosci"},{"key":"2092_CR7","first-page":"561","volume":"91","author":"SM Penny","year":"2020","unstructured":"Penny SM (2020) Ovarian cancer: an overview. Radiol Technol 91:561\u2013575","journal-title":"Radiol Technol"},{"key":"2092_CR8","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1210\/er.2008-0004","volume":"29","author":"R Bouillon","year":"2008","unstructured":"Bouillon R, Carmeliet G, Verlinden L et al (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726\u2013776. https:\/\/doi.org\/10.1210\/er.2008-0004","journal-title":"Endocr Rev"},{"key":"2092_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266\u2013281. https:\/\/doi.org\/10.1056\/NEJMra070553","journal-title":"N Engl J Med"},{"key":"2092_CR10","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1210\/en.2011-1600","volume":"153","author":"S Swami","year":"2012","unstructured":"Swami S, Krishnan AV, Wang JY et al (2012) Dietary vitamin D\u2083 and 1,25-dihydroxyvitamin D\u2083 (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology 153:2576\u20132587. https:\/\/doi.org\/10.1210\/en.2011-1600","journal-title":"Endocrinology"},{"key":"2092_CR11","unstructured":"(2023) Vitamin D and Cancer - NCI. https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/diet\/vitamin-d-fact-sheet. Accessed 20 Dec 2023"},{"key":"2092_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0038-9","volume":"50","author":"S-M Jeon","year":"2018","unstructured":"Jeon S-M, Shin E-A (2018) Exploring vitamin D metabolism and function in cancer. Exp Mol Med 50:1\u201314. https:\/\/doi.org\/10.1038\/s12276-018-0038-9","journal-title":"Exp Mol Med"},{"key":"2092_CR13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mce.2011.02.023","volume":"338","author":"Z Shen","year":"2011","unstructured":"Shen Z, Zhang X, Tang J et al (2011) The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells. Mol Cell Endocrinol 338:58\u201367. https:\/\/doi.org\/10.1016\/j.mce.2011.02.023","journal-title":"Mol Cell Endocrinol"},{"key":"2092_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081285","volume":"17","author":"Y-F Hou","year":"2016","unstructured":"Hou Y-F, Gao S-H, Wang P et al (2016) &lt;article-title update=\"added\"&gt;1\u03b1,25(OH)2D3 suppresses the migration of ovarian cancer SKOV-3 cells through the inhibition of epithelial\u2013mesenchymal transition. Int J Mol Sci 17:1285. https:\/\/doi.org\/10.3390\/ijms17081285","journal-title":"Int J Mol Sci"},{"key":"2092_CR15","doi-asserted-by":"publisher","first-page":"53213","DOI":"10.1074\/jbc.M410395200","volume":"279","author":"F Jiang","year":"2004","unstructured":"Jiang F, Bao J, Li P et al (2004) Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. J Biol Chem 279:53213\u201353221. https:\/\/doi.org\/10.1074\/jbc.M410395200","journal-title":"J Biol Chem"},{"key":"2092_CR16","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.18632\/oncotarget.27803","volume":"11","author":"T Pejovic","year":"2020","unstructured":"Pejovic T, Joshi S, Campbell S et al (2020) Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers. Oncotarget 11:4104\u20134114. https:\/\/doi.org\/10.18632\/oncotarget.27803","journal-title":"Oncotarget"},{"key":"2092_CR17","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s10552-012-0076-x","volume":"23","author":"C Bodelon","year":"2012","unstructured":"Bodelon C, Cushing-Haugen KL, Wicklund KG et al (2012) Sun exposure and risk of epithelial ovarian cancer. Cancer Causes Control CCC 23:1985\u20131994. https:\/\/doi.org\/10.1007\/s10552-012-0076-x","journal-title":"Cancer Causes Control CCC"},{"key":"2092_CR18","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.3390\/cancers5041577","volume":"5","author":"J Prescott","year":"2013","unstructured":"Prescott J, Bertrand KA, Poole EM et al (2013) Surrogates of long-term vitamin d exposure and ovarian cancer risk in two prospective cohort studies. Cancers 5:1577\u20131600. https:\/\/doi.org\/10.3390\/cancers5041577","journal-title":"Cancers"},{"key":"2092_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3390\/cells9020335","volume":"9","author":"A Dovnik","year":"2020","unstructured":"Dovnik A, Dovnik NF (2020) Vitamin D and ovarian cancer: systematic review of the literature with a focus on molecular mechanisms. Cells 9:335. https:\/\/doi.org\/10.3390\/cells9020335","journal-title":"Cells"},{"issue":"2","key":"2092_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5195\/jmla.2020.834","volume":"108","author":"JM Clark","year":"2020","unstructured":"Clark JM, Sanders S, Carter M et al (2020) Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial. J Med Libr Assoc 108(2):195\u2013207. https:\/\/doi.org\/10.5195\/jmla.2020.834","journal-title":"J Med Libr Assoc"},{"key":"2092_CR21","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan\u2014a web and mobile app for systematic reviews. Syst Rev 5:210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"2092_CR22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"2092_CR23","unstructured":"Takats S, Stillman D, Cheslack-Postava F, et al (2025) Zotero"},{"key":"2092_CR24","unstructured":"McGuinness LA (2019) robvis: An R package and web application for visualising risk-of-bias assessments"},{"key":"2092_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/672492","volume":"2009","author":"AA Arslan","year":"2009","unstructured":"Arslan AA, Clendenen TV, Koenig KL et al (2009) Circulating vitamin D and risk of epithelial ovarian cancer. J Oncol 2009:672492. https:\/\/doi.org\/10.1155\/2009\/672492","journal-title":"J Oncol"},{"key":"2092_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/aje\/kwq118","volume":"172","author":"W Zheng","year":"2010","unstructured":"Zheng W, Danforth KN, Tworoger SS et al (2010) Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol 172:70\u201380. https:\/\/doi.org\/10.1093\/aje\/kwq118","journal-title":"Am J Epidemiol"},{"key":"2092_CR27","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejca.2009.08.002","volume":"46","author":"AT Toriola","year":"2010","unstructured":"Toriola AT, Surcel H-M, Agborsangaya C et al (2010) Serum 25-hydroxyvitamin D and the risk of ovarian cancer. Eur J Cancer 46:364\u2013369. https:\/\/doi.org\/10.1016\/j.ejca.2009.08.002","journal-title":"Eur J Cancer"},{"key":"2092_CR28","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1016\/j.ejca.2010.05.019","volume":"46","author":"AT Toriola","year":"2010","unstructured":"Toriola AT, Surcel H-M, Calypse A et al (2010) Independent and joint effects of serum 25-hydroxyvitamin D and calcium on ovarian cancer risk: a prospective nested case-control study. Eur J Cancer 46:2799\u20132805. https:\/\/doi.org\/10.1016\/j.ejca.2010.05.019","journal-title":"Eur J Cancer"},{"key":"2092_CR29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ygyno.2010.07.006","volume":"119","author":"A Bakhru","year":"2010","unstructured":"Bakhru A, Mallinger JB, Buckanovich RJ, Griggs JJ (2010) Casting light on 25-hydroxyvitamin D deficiency in ovarian cancer: a study from the NHANES. Gynecol Oncol 119:314\u2013318. https:\/\/doi.org\/10.1016\/j.ygyno.2010.07.006","journal-title":"Gynecol Oncol"},{"key":"2092_CR30","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/j.clinbiochem.2012.07.110","volume":"45","author":"M Walentowicz-Sadlecka","year":"2012","unstructured":"Walentowicz-Sadlecka M, Grabiec M, Sadlecki P et al (2012) 25(OH)D3 in patients with ovarian cancer and its correlation with survival. Clin Biochem 45:1568\u20131572. https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.07.110","journal-title":"Clin Biochem"},{"key":"2092_CR31","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s13277-015-4055-1","volume":"37","author":"T Granato","year":"2016","unstructured":"Granato T, Manganaro L, Petri L et al (2016) Low 25-OH vitamin D levels at time of diagnosis and recurrence of ovarian cancer. Tumor Biol 37:2177\u20132181. https:\/\/doi.org\/10.1007\/s13277-015-4055-1","journal-title":"Tumor Biol"},{"key":"2092_CR32","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2020.1078","volume":"14","author":"EA Sajo","year":"2020","unstructured":"Sajo EA, Okunade KS, Olorunfemi G et al (2020) Serum vitamin D deficiency and risk of epithelial ovarian cancer in Lagos, Nigeria. Ecancermedicalscience 14:1078. https:\/\/doi.org\/10.3332\/ecancer.2020.1078","journal-title":"Ecancermedicalscience"},{"key":"2092_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3945\/ajcn.114.102681","volume":"102","author":"PM Webb","year":"2015","unstructured":"Webb PM, de Fazio A, Protani MM et al (2015) Circulating 25-hydroxyvitamin D and survival in women with ovarian cancer. Am J Clin Nutr 102:109\u2013114. https:\/\/doi.org\/10.3945\/ajcn.114.102681","journal-title":"Am J Clin Nutr"},{"key":"2092_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-023-01757-0","author":"TL Ross","year":"2023","unstructured":"Ross TL, Neale RE, Na R et al (2023) Vitamin D status during and after treatment and ovarian cancer survival. Cancer Causes Control. https:\/\/doi.org\/10.1007\/s10552-023-01757-0","journal-title":"Cancer Causes Control"},{"key":"2092_CR35","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10637-009-9284-y","volume":"28","author":"TS Lange","year":"2010","unstructured":"Lange TS, Stuckey AR, Robison K et al (2010) Effect of a vitamin D(3) derivative (B3CD) with postulated anti-cancer activity in an ovarian cancer animal model. Invest New Drugs 28:543\u2013553. https:\/\/doi.org\/10.1007\/s10637-009-9284-y","journal-title":"Invest New Drugs"},{"key":"2092_CR36","doi-asserted-by":"publisher","first-page":"14481","DOI":"10.18632\/oncotarget.24520","volume":"9","author":"AK Srivastava","year":"2018","unstructured":"Srivastava AK, Rizvi A, Cui T et al (2018) Depleting ovarian cancer stem cells with calcitriol. Oncotarget 9:14481\u201314491. https:\/\/doi.org\/10.18632\/oncotarget.24520","journal-title":"Oncotarget"},{"key":"2092_CR37","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3892\/ol.2018.8718","volume":"16","author":"Y Chen","year":"2018","unstructured":"Chen Y, Sun Z, Xu J et al (2018) Vitamin D and DDX4 regulate the proliferation and invasion of ovarian cancer cells. Oncol Lett 16:905\u2013909. https:\/\/doi.org\/10.3892\/ol.2018.8718","journal-title":"Oncol Lett"},{"key":"2092_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062151","volume":"21","author":"N Han","year":"2020","unstructured":"Han N, Jeschke U, Kuhn C et al (2020) H3K4me3 is a potential mediator for antiproliferative effects of calcitriol (1\u03b1,25(OH)2D3) in ovarian cancer biology. Int J Mol Sci 21:2151. https:\/\/doi.org\/10.3390\/ijms21062151","journal-title":"Int J Mol Sci"},{"key":"2092_CR39","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.3389\/fonc.2020.01258","volume":"10","author":"P Wang","year":"2020","unstructured":"Wang P, Xu J, You W et al (2020) Knockdown of CYP24A1 aggravates 1\u03b1,25(OH)2D3-inhibited migration and invasion of mouse ovarian epithelial cells by suppressing EMT. Front Oncol 10:1258. https:\/\/doi.org\/10.3389\/fonc.2020.01258","journal-title":"Front Oncol"},{"key":"2092_CR40","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.matbio.2022.03.003","volume":"109","author":"K Kitami","year":"2022","unstructured":"Kitami K, Yoshihara M, Tamauchi S et al (2022) Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-\u03b21\/thrombospondin-1 axis. Matrix Biol 109:70\u201390. https:\/\/doi.org\/10.1016\/j.matbio.2022.03.003","journal-title":"Matrix Biol"},{"key":"2092_CR41","doi-asserted-by":"publisher","DOI":"10.1177\/02601060231202565","author":"PR Mueller","year":"2023","unstructured":"Mueller PR, Kershner AJ, Breitrick BI et al (2023) Vitamin D and docosahexaenoic acid inhibit proliferation of the ovarian cancer cell line OVCAR4. Nutr Health. https:\/\/doi.org\/10.1177\/02601060231202565","journal-title":"Nutr Health"},{"key":"2092_CR42","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s13277-015-4055-1","volume":"37","author":"T Granato","year":"2016","unstructured":"Granato T, Manganaro L, Petri L et al (2016) Low 25-OH vitamin D levels at time of diagnosis and recurrence of ovarian cancer. Tumour Biol 37:2177\u20132181. https:\/\/doi.org\/10.1007\/s13277-015-4055-1","journal-title":"Tumour Biol"},{"key":"2092_CR43","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3322\/caac.21456","volume":"68","author":"LA Torre","year":"2018","unstructured":"Torre LA, Trabert B, DeSantis CE et al (2018) Ovarian cancer statistics, 2018. CA Cancer J Clin 68:284\u2013296. https:\/\/doi.org\/10.3322\/caac.21456","journal-title":"CA Cancer J Clin"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-025-02092-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10552-025-02092-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-025-02092-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:00:23Z","timestamp":1770609623000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10552-025-02092-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2092"],"URL":"https:\/\/doi.org\/10.1007\/s10552-025-02092-2","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"16 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"2"}}