{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:49:46Z","timestamp":1782460186073,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10552-026-02182-9","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:19:08Z","timestamp":1779873548000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diet, ultra-processed foods, and gut dysbiosis: linking emulsifiers to colorectal cancer risk"],"prefix":"10.1007","volume":"37","author":[{"given":"Nishit","family":"Parekh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"issue":"15","key":"2182_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11152205","volume":"11","author":"M De Siena","year":"2022","unstructured":"De Siena M, Raoul P, Costantini L, Scarpellini E, Cintoni M, Gasbarrini A et al (2022) Food emulsifiers and metabolic syndrome: the role of the gut microbiota. Foods 11(15):2205. https:\/\/doi.org\/10.3390\/foods11152205. (PubMed PMID: 35892789; PubMed Central PMCID: PMC9331555.)","journal-title":"Foods"},{"key":"2182_CR2","unstructured":"NOVA-Classification-Reference-Sheet.pdf [Internet]. [cited 2025 Feb 8]. Available from: https:\/\/ecuphysicians.ecu.edu\/wp-content\/pv-uploads\/sites\/78\/2021\/07\/NOVA-Classification-Reference-Sheet.pdf"},{"key":"2182_CR3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075294","volume":"383","author":"M Touvier","year":"2023","unstructured":"Touvier M, Louzada MLdaC, Mozaffarian D, Baker P, Juul F, Srour B (2023) Ultra-processed foods and cardiometabolic health: public health policies to reduce consumption cannot wait. BMJ 383:e075294. https:\/\/doi.org\/10.1136\/bmj-2023-075294","journal-title":"BMJ"},{"issue":"8","key":"2182_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082778","volume":"13","author":"M Marino","year":"2021","unstructured":"Marino M, Puppo F, Del Bo\u2019 C, Vinelli V, Riso P, Porrini M et al (2021) A systematic review of worldwide consumption of ultra-processed foods: findings and criticisms. Nutrients 13(8):2778. https:\/\/doi.org\/10.3390\/nu13082778","journal-title":"Nutrients"},{"issue":"1","key":"2182_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-016-0223-3","volume":"12","author":"P Baker","year":"2016","unstructured":"Baker P, Friel S (2016) Food systems transformations, ultra-processed food markets and the nutrition transition in Asia. Global Health 12(1):80. https:\/\/doi.org\/10.1186\/s12992-016-0223-3","journal-title":"Global Health"},{"issue":"2","key":"2182_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020289","volume":"10","author":"C Stolfi","year":"2022","unstructured":"Stolfi C, Maresca C, Monteleone G, Laudisi F (2022) Implication of intestinal barrier dysfunction in gut dysbiosis and diseases. Biomedicines 10(2):289. https:\/\/doi.org\/10.3390\/biomedicines10020289. (PubMed PMID: 35203499; PubMed Central PMCID: PMC8869546.)","journal-title":"Biomedicines"},{"issue":"3","key":"2182_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030866","volume":"15","author":"H Pandey","year":"2023","unstructured":"Pandey H, Tang DWT, Wong SH, Lal D (2023) Gut microbiota in colorectal cancer: biological role and therapeutic opportunities. Cancers 15(3):866. https:\/\/doi.org\/10.3390\/cancers15030866. (PubMed PMID: 36765824; PubMed Central PMCID: PMC9913759.)","journal-title":"Cancers"},{"issue":"5","key":"2182_CR8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S1470-2045(10)70186-8","volume":"12","author":"D Collins","year":"2011","unstructured":"Collins D, Hogan AM, Winter DC (2011) Microbial and viral pathogens in colorectal cancer. Lancet Oncol 12(5):504\u2013512. https:\/\/doi.org\/10.1016\/S1470-2045(10)70186-8","journal-title":"Lancet Oncol"},{"issue":"2","key":"2182_CR9","first-page":"355","volume":"39","author":"GL Laqueur","year":"1967","unstructured":"Laqueur GL, McDaniel EG, Matsumoto H (1967) Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate. J Natl Cancer Inst 39(2):355\u2013371 (PubMed PMID: 18623950.)","journal-title":"J Natl Cancer Inst"},{"issue":"6103","key":"2182_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1126\/science.1224820","volume":"338","author":"JC Arthur","year":"2012","unstructured":"Arthur JC, Perez-Chanona E, M\u00fchlbauer M, Tomkovich S, Uronis JM, Fan TJ et al (2012) Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338(6103):120\u2013123. https:\/\/doi.org\/10.1126\/science.1224820. (PubMed PMID: 22903521; PubMed Central PMCID: PMC3645302.)","journal-title":"Science"},{"issue":"24","key":"2182_CR11","doi-asserted-by":"publisher","first-page":"7199","DOI":"10.1158\/0008-5472.CAN-13-0827","volume":"73","author":"Y Zhan","year":"2013","unstructured":"Zhan Y, Chen PJ, Sadler WD, Wang F, Poe S, N\u00fa\u00f1ez G et al (2013) Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res 73(24):7199\u20137210. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-0827. (PubMed PMID: 24165160; PubMed Central PMCID: PMC3883499.)","journal-title":"Cancer Res"},{"issue":"1","key":"2182_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1017\/S1368980017001379","volume":"21","author":"CA Monteiro","year":"2018","unstructured":"Monteiro CA, Moubarac JC, Levy RB, Canella DS, Louzada MLdaC, Cannon G (2018) Household availability of ultra-processed foods and obesity in nineteen European countries. Public Health Nutr 21(1):18\u201326. https:\/\/doi.org\/10.1017\/S1368980017001379","journal-title":"Public Health Nutr"},{"issue":"1","key":"2182_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88489-0","volume":"15","author":"H Lee","year":"2025","unstructured":"Lee H, Yim Y, Cho Y, Oh J, Kim S, Son Y et al (2025) Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022. Sci Rep 15(1):4131. https:\/\/doi.org\/10.1038\/s41598-025-88489-0","journal-title":"Sci Rep"},{"issue":"1","key":"2182_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-017-0122-9","volume":"4","author":"N Shi","year":"2017","unstructured":"Shi N, Li N, Duan X, Niu H (2017) Interaction between the gut microbiome and mucosal immune system. Mil Med Res 4(1):14. https:\/\/doi.org\/10.1186\/s40779-017-0122-9","journal-title":"Mil Med Res"},{"issue":"1","key":"2182_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/1541-4337.12410","volume":"18","author":"TD Vo","year":"2019","unstructured":"Vo TD, Lynch BS, Roberts A (2019) Dietary exposures to common emulsifiers and their impact on the gut microbiota: is there a cause for concern? Compr Rev Food Sci Food Saf 18(1):31\u201347. https:\/\/doi.org\/10.1111\/1541-4337.12410","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"8","key":"2182_CR16","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1136\/gutjnl-2016-313099","volume":"66","author":"B Chassaing","year":"2017","unstructured":"Chassaing B, De Bodt J, Marzorati M, Van de Wiele T, Gewirtz AT (2017) Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation. Gut 66(8):1414\u20131427. https:\/\/doi.org\/10.1136\/gutjnl-2016-313099. (PubMed PMID: 28325746; PubMed Central PMCID: PMC5940336)","journal-title":"Gut"},{"issue":"1","key":"2182_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00996-6","volume":"9","author":"S Naimi","year":"2021","unstructured":"Naimi S, Viennois E, Gewirtz AT, Chassaing B (2021) Direct impact of commonly used dietary emulsifiers on human gut microbiota. Microbiome 9(1):66. https:\/\/doi.org\/10.1186\/s40168-020-00996-6","journal-title":"Microbiome"},{"issue":"1","key":"2182_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27957-2","volume":"8","author":"JY Lock","year":"2018","unstructured":"Lock JY, Carlson TL, Wang CM, Chen A, Carrier RL (2018) Acute exposure to commonly ingested emulsifiers alters intestinal mucus structure and transport properties. Sci Rep 8(1):10008. https:\/\/doi.org\/10.1038\/s41598-018-27957-2","journal-title":"Sci Rep"},{"key":"2182_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01387","volume":"11","author":"C Peng","year":"2020","unstructured":"Peng C, Ouyang Y, Lu N, Li N (2020) The NF-\u03baB signaling pathway, the microbiota, and gastrointestinal tumorigenesis: recent advances. Front Immunol 11:1387. https:\/\/doi.org\/10.3389\/fimmu.2020.01387","journal-title":"Front Immunol"},{"issue":"3","key":"2182_CR20","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","volume":"170","author":"T Yu","year":"2017","unstructured":"Yu T, Guo F, Yu Y, Sun T, Ma D, Han J et al (2017) Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170(3):548-563.e16. https:\/\/doi.org\/10.1016\/j.cell.2017.07.008","journal-title":"Cell"},{"issue":"5","key":"2182_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700554","volume":"62","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Kang C, Wang X, Zhou M, Chen M, Zhu X et al (2018) Dietary factors modulate colonic tumorigenesis through the interaction of gut microbiota and host chloride channels. Mol Nutr Food Res 62(5):1700554. https:\/\/doi.org\/10.1002\/mnfr.201700554","journal-title":"Mol Nutr Food Res"},{"issue":"7541","key":"2182_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature14232","volume":"519","author":"B Chassaing","year":"2015","unstructured":"Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE et al (2015) Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519(7541):92\u201396. https:\/\/doi.org\/10.1038\/nature14232","journal-title":"Nature"},{"issue":"1","key":"2182_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06224-3","volume":"7","author":"S Panyod","year":"2024","unstructured":"Panyod S, Wu WK, Chang CT, Wada N, Ho HC, Lo YL et al (2024) Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice. Commun Biol 7(1):749. https:\/\/doi.org\/10.1038\/s42003-024-06224-3","journal-title":"Commun Biol"},{"issue":"10","key":"2182_CR24","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1007\/s10620-013-2744-4","volume":"58","author":"J Soldavini","year":"2013","unstructured":"Soldavini J, Kaunitz JD (2013) Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity. Dig Dis Sci 58(10):2756\u20132766. https:\/\/doi.org\/10.1007\/s10620-013-2744-4","journal-title":"Dig Dis Sci"},{"issue":"6","key":"2182_CR25","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/MCO.0b013e32833eebe5","volume":"13","author":"K Meijer","year":"2010","unstructured":"Meijer K, De Vos P, Priebe MG (2010) Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?: Curr Opin Clin Nutr Metab Care 13(6):715\u2013721. https:\/\/doi.org\/10.1097\/MCO.0b013e32833eebe5","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"11","key":"2182_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41575-024-00968-3","volume":"21","author":"A \u00d6zkan","year":"2024","unstructured":"\u00d6zkan A, LoGrande NT, Feitor JF, Goyal G, Ingber DE (2024) Intestinal organ chips for disease modelling and personalized medicine. Nat Rev Gastroenterol Hepatol 21(11):751\u2013773. https:\/\/doi.org\/10.1038\/s41575-024-00968-3. (PubMed PMID: 39192055.)","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"9","key":"2182_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091367","volume":"16","author":"P Komisarska","year":"2024","unstructured":"Komisarska P, Pinyosinwat A, Saleem M, Szczuko M (2024) Carrageenan as a potential factor of inflammatory bowel diseases. Nutrients 16(9):9. https:\/\/doi.org\/10.3390\/nu16091367","journal-title":"Nutrients"},{"issue":"2","key":"2182_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004338","volume":"21","author":"L Sellem","year":"2024","unstructured":"Sellem L, Srour B, Javaux G, Chazelas E, Chassaing B, Viennois E et al (2024) Food additive emulsifiers and cancer risk: results from the French prospective NutriNet-Sant\u00e9 cohort. PLoS Med 21(2):e1004338. https:\/\/doi.org\/10.1371\/journal.pmed.1004338","journal-title":"PLoS Med"},{"key":"2182_CR29","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v67.9575","author":"R Laatikainen","year":"2023","unstructured":"Laatikainen R, Lehto M, M\u00e4kel\u00e4-Salmi N, Hillil\u00e4 M, Groop PH, Salmenkari H (2023) Randomized controlled pilot study: effect of carrageenan emulsifier on inflammation and gastrointestinal symptoms in quiescent ulcerative colitis. Food Nutr Res. https:\/\/doi.org\/10.29219\/fnr.v67.9575","journal-title":"Food Nutr Res"},{"issue":"3","key":"2182_CR30","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1053\/j.gastro.2021.11.006","volume":"162","author":"B Chassaing","year":"2022","unstructured":"Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W et al (2022) Randomized controlled-feeding study of dietary emulsifier Carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology 162(3):743\u2013756. https:\/\/doi.org\/10.1053\/j.gastro.2021.11.006","journal-title":"Gastroenterology"},{"issue":"8","key":"2182_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002171","volume":"21","author":"M Mil\u00e0-Guasch","year":"2023","unstructured":"Mil\u00e0-Guasch M, Ram\u00edrez S, Llana SR, Fos-Dom\u00e8nech J, Dropmann LM, Pozo M et al (2023) Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice. PLoS Biol 21(8):e3002171. https:\/\/doi.org\/10.1371\/journal.pbio.3002171","journal-title":"PLoS Biol"},{"issue":"1","key":"2182_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-024-06224-3","volume":"7","author":"S Panyod","year":"2024","unstructured":"Panyod S, Wu WK, Chang CT, Wada N, Ho HC, Lo YL et al (2024) Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice. Commun Biol 7(1):1\u201314. https:\/\/doi.org\/10.1038\/s42003-024-06224-3","journal-title":"Commun Biol"},{"issue":"1","key":"2182_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-023-00475-4","volume":"10","author":"C Delaroque","year":"2024","unstructured":"Delaroque C, Chassaing B (2024) Dietary emulsifier consumption accelerates type 1 diabetes development in NOD mice. npj Biofilms Microbiomes 10(1):1. https:\/\/doi.org\/10.1038\/s41522-023-00475-4. (PubMed PMID: 38182615; PubMed Central PMCID: PMC10770373.)","journal-title":"npj Biofilms Microbiomes"},{"key":"2182_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01942","volume":"9","author":"AA Bhat","year":"2019","unstructured":"Bhat AA, Uppada S, Achkar IW, Hashem S, Yadav SK, Shanmugakonar M et al (2019) Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk. Front Physiol 9:1942. https:\/\/doi.org\/10.3389\/fphys.2018.01942","journal-title":"Front Physiol"},{"issue":"1","key":"2182_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38778-x","volume":"14","author":"KD Corbin","year":"2023","unstructured":"Corbin KD, Carnero EA, Dirks B, Igudesman D, Yi F, Marcus A et al (2023) Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial. Nat Commun 14(1):3161. https:\/\/doi.org\/10.1038\/s41467-023-38778-x","journal-title":"Nat Commun"},{"issue":"4","key":"2182_CR36","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1017\/S0029665121002834","volume":"80","author":"C Thomson","year":"2021","unstructured":"Thomson C, Garcia AL, Edwards CA (2021) Interactions between dietary fibre and the gut microbiota. Proc Nutr Soc 80(4):398\u2013408. https:\/\/doi.org\/10.1017\/S0029665121002834","journal-title":"Proc Nutr Soc"},{"key":"2182_CR37","unstructured":"Fermented-food diet increases microbiome diversity, decreases inflammatory proteins, study finds [Internet]. [cited 2025 Feb 26]. Available from: https:\/\/med.stanford.edu\/news\/all-news\/2021\/07\/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation"},{"issue":"1","key":"2182_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/nu7010017","volume":"7","author":"MA Conlon","year":"2014","unstructured":"Conlon MA, Bird AR (2014) The impact of diet and lifestyle on gut microbiota and human health. Nutrients 7(1):17\u201344. https:\/\/doi.org\/10.3390\/nu7010017. (PubMed PMID: 25545101; PubMed Central PMCID: PMC4303825.)","journal-title":"Nutrients"},{"issue":"1","key":"2182_CR39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-food-111519-014337","volume":"11","author":"Y Han","year":"2020","unstructured":"Han Y, Xiao H (2020) Whole food\u2013based approaches to modulating gut microbiota and associated diseases. Annu Rev Food Sci Technol 11(1):119\u2013143. https:\/\/doi.org\/10.1146\/annurev-food-111519-014337","journal-title":"Annu Rev Food Sci Technol"},{"key":"2182_CR40","unstructured":"Emulsifiers in Food: Facts and Health Effects [Internet]. [cited 2025 Feb 28]. Available from: https:\/\/zoe.com\/learn\/what-are-emulsifiers"},{"key":"2182_CR41","unstructured":"Food Emulsifiers - Oklahoma State University [Internet]. 2024 [cited 2025 Mar 3]. Available from: https:\/\/extension.okstate.edu\/fact-sheets\/food-emulsifiers.html"},{"key":"2182_CR42","unstructured":"EU Rules - European Commission [Internet]. [cited 2025 Mar 3]. Available from: https:\/\/food.ec.europa.eu\/food-safety\/food-improvement-agents\/additives\/eu-rules_en"},{"key":"2182_CR43","unstructured":"New European Legislation on Food Emulsifier E 471 - KHNI [Internet]. [cited 2025 Mar 3]. Available from: https:\/\/khni.kerry.com\/news\/industry-and-nutrition-news\/new-european-legislation-on-contaminants-in-food-emulsifier-e-471-what-fb-manufacturers-need-to-know\/"},{"issue":"6","key":"2182_CR44","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/NT.0000000000000512","volume":"56","author":"LG Snetselaar","year":"2021","unstructured":"Snetselaar LG, de Jesus JM, DeSilva DM, Stoody EE (2021) Dietary guidelines for Americans, 2020\u20132025. Nutr Today 56(6):287\u2013295. https:\/\/doi.org\/10.1097\/NT.0000000000000512. (PubMed PMID: 34987271; PubMed Central PMCID: PMC8713704.)","journal-title":"Nutr Today"},{"key":"2182_CR45","unstructured":"Healthline [Internet]. 2024 [cited 2025 Mar 3]. What Are Emulsifiers? And Are They Safe? Available from: https:\/\/www.healthline.com\/health\/food-nutrition\/what-are-emulsifiers"}],"container-title":["Cancer Causes & Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-026-02182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10552-026-02182-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-026-02182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:25:40Z","timestamp":1782458740000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10552-026-02182-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2182"],"URL":"https:\/\/doi.org\/10.1007\/s10552-026-02182-9","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"101"}}