{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:10:43Z","timestamp":1789027843348,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10552-026-02191-8","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:37:36Z","timestamp":1785220656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Second primary cancers among females with a first primary cervical, uterine and ovarian cancer: a population-based study in North Portugal"],"prefix":"10.1007","volume":"37","author":[{"given":"Elisabete","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Rocha","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Calisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Bento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-0179","authenticated-orcid":false,"given":"Samantha","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"3","key":"2191_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"2191_CR2","unstructured":"International Agency for Cancer Research. Cancer Today [Available from: https:\/\/gco.iarc.fr\/today\/home."},{"issue":"4","key":"2191_CR3","first-page":"284","volume":"68","author":"LA Torre","year":"2018","unstructured":"Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD et al (2018) Ovarian cancer statistics, 2018. CA Cancer J Clin 68(4):284\u2013296","journal-title":"CA Cancer J Clin"},{"key":"2191_CR4","unstructured":"RON. Registo Oncol\u00f3gico Nacional de Todos os Tumores da Popula\u00e7\u00e3o Residente em Portugal. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil - EPE. 2022."},{"issue":"suppl_8","key":"2191_CR5","doi-asserted-by":"publisher","first-page":"viii8","DOI":"10.1093\/annonc\/mdx445","volume":"28","author":"LR Duska","year":"2017","unstructured":"Duska LR, Kohn EC (2017) The new classifications of ovarian, fallopian tube, and primary peritoneal cancer and their clinical implications. Ann Oncol 28(suppl_8):viii8\u2013viii12","journal-title":"Ann Oncol"},{"issue":"15","key":"2191_CR6","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1016\/j.ejca.2015.07.022","volume":"51","author":"M Sant","year":"2015","unstructured":"Sant M, Chirlaque Lopez MD, Agresti R, S\u00e1nchez P\u00e9rez MJ, Holleczek B, Bielska-Lasota M et al (2015) Survival of women with cancers of breast and genital organs in Europe 1999\u20132007: results of the EUROCARE-5 study. Eur J Cancer 51(15):2191\u20132205","journal-title":"Eur J Cancer"},{"issue":"1","key":"2191_CR7","first-page":"7","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70(1):7\u201330","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2191_CR8","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1186\/s12885-018-4700-3","volume":"18","author":"MC Lim","year":"2018","unstructured":"Lim MC, Won YJ, Lim J, Salehi T, Yoo CW, Bristow RE (2018) Second primary cancer after primary peritoneal, epithelial ovarian, and fallopian tubal cancer: a retrospective study. BMC Cancer 18(1):800","journal-title":"BMC Cancer"},{"issue":"43","key":"2191_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001803","volume":"94","author":"CJ Teng","year":"2015","unstructured":"Teng CJ, Huon LK, Hu YW, Yeh CM, Chao Y, Yang MH et al (2015) Secondary primary malignancy risk in patients with cervical cancer in taiwan: a nationwide population-based study. Medicine 94(43):e1803","journal-title":"Medicine"},{"issue":"3","key":"2191_CR10","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ygyno.2020.06.492","volume":"158","author":"E Adjei Boakye","year":"2020","unstructured":"Adjei Boakye E, Grubb L, Peterson CE, Osazuwa-Peters N, Grabosch S, Ladage HD et al (2020) Risk of second primary cancers among survivors of gynecological cancers. Gynecol Oncol 158(3):719\u2013726","journal-title":"Gynecol Oncol"},{"issue":"9","key":"2191_CR11","doi-asserted-by":"publisher","first-page":"3836","DOI":"10.18632\/aging.204047","volume":"14","author":"K Huang","year":"2022","unstructured":"Huang K, Xu L, Jia M, Liu W, Wang S, Han J et al (2022) Second primary malignancies in cervical cancer and endometrial cancer survivors: a population-based analysis. Aging 14(9):3836\u20133855","journal-title":"Aging"},{"issue":"17","key":"2191_CR12","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.21037\/atm-21-1393","volume":"9","author":"Y Wu","year":"2021","unstructured":"Wu Y, Chong Y, Han C, Kang K, Liu Z, Zhang F (2021) Second primary malignancies associated with radiation therapy in cervical cancer patients diagnosed between 1975 and 2011: a population-based competing-risk study. Ann Transl Med 9(17):1375","journal-title":"Ann Transl Med"},{"issue":"2","key":"2191_CR13","doi-asserted-by":"publisher","first-page":"641","DOI":"10.4143\/crt.2014.326","volume":"48","author":"MC Lim","year":"2016","unstructured":"Lim MC, Won YJ, Lim J, Kim YJ, Seo SS, Kang S et al (2016) Second primary cancer after diagnosis and treatment of cervical cancer. Cancer Res Treat 48(2):641\u2013649","journal-title":"Cancer Res Treat"},{"issue":"2","key":"2191_CR14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ygyno.2008.12.039","volume":"113","author":"S Kumar","year":"2009","unstructured":"Kumar S, Shah JP, Bryant CS, Awonuga AO, Imudia AN, Ruterbusch JJ et al (2009) Second neoplasms in survivors of endometrial cancer: impact of radiation therapy. Gynecol Oncol 113(2):233\u2013239","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2191_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ijrobp.2009.07.1692","volume":"78","author":"AP Brown","year":"2010","unstructured":"Brown AP, Neeley ES, Werner T, Soisson AP, Burt RW, Gaffney DK (2010) A population-based study of subsequent primary malignancies after endometrial cancer: genetic, environmental, and treatment-related associations. Int J Radiat Oncol Biol Phys 78(1):127\u2013135","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2191_CR16","unstructured":"Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil - EPE. Registo Oncol\u00f3gico Regional do Norte 2011. Porto, (2015)"},{"key":"2191_CR17","unstructured":"Parkin D, Chen C, Ferlay J, Galceran J, Storm H, Whelan S. Comparability and quality control in cancer registration. 19: (1994)"},{"key":"2191_CR18","unstructured":"World Health Organization. International Classification of Diseases for Oncology 3rd (ICD-O-3). 2000"},{"key":"2191_CR19","unstructured":"World Health Organization. International Statistical Classification of Diseases and Related Health Problems 10th Revision. 1992"},{"issue":"4","key":"2191_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1097\/00008469-200508000-00002","volume":"14","author":"World Health Organisation","year":"2005","unstructured":"World Health Organisation (2005) International rules for multiple primary cancers (ICD-0 third edition). Eur J Cancer Prev 14(4):307\u2013308","journal-title":"Eur J Cancer Prev"},{"issue":"2","key":"2191_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/ijgo.14923","volume":"162","author":"JS Berek","year":"2023","unstructured":"Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S et al (2023) FIGO staging of endometrial cancer: 2023. Int J Gynaecol Obstet 162(2):383\u2013394","journal-title":"Int J Gynaecol Obstet"},{"key":"2191_CR22","unstructured":"Curtis RE, Freedman DM, Ron E, Ries LAG, Hacker DG, Edwards BK, et al. New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973\u20132000. In: National Cancer Institute NPN-, editor. Bethesda2006."},{"key":"2191_CR23","volume-title":"A review of the definition for multiple primary cancers in the United States","author":"H Howe","year":"2003","unstructured":"Howe H (2003) A review of the definition for multiple primary cancers in the United States. North American Association of Central Cancer Registries, New Jersey"},{"key":"2191_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-83","volume":"11","author":"DR Youlden","year":"2011","unstructured":"Youlden DR, Baade PD (2011) The relative risk of second primary cancers in Queensland, Australia: a retrospective cohort study. BMC Cancer 11:83","journal-title":"BMC Cancer"},{"key":"2191_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/9781118032985","volume-title":"The statistical analysis of failure time data","author":"J Kalbfleisch","year":"2002","unstructured":"Kalbfleisch J, Prentice R (2002) The statistical analysis of failure time data. John Wiley & Songs, New York"},{"issue":"19","key":"2191_CR26","doi-asserted-by":"publisher","first-page":"6845","DOI":"10.1002\/cam4.3861","volume":"10","author":"YL Lai","year":"2021","unstructured":"Lai YL, Chiang CJ, Chen YL, You SL, Chen YY, Chiang YC et al (2021) Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: a population-based analysis. Cancer Med 10(19):6845\u20136854","journal-title":"Cancer Med"},{"key":"2191_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1426-3","volume":"15","author":"KD Lee","year":"2015","unstructured":"Lee KD, Chen CY, Huang HJ, Wang TY, Teng D, Huang SH et al (2015) Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period. BMC Cancer 15:393","journal-title":"BMC Cancer"},{"issue":"3","key":"2191_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.radonc.2014.04.011","volume":"111","author":"M Arnold","year":"2014","unstructured":"Arnold M, Liu L, Kenter GG, Creutzberg CL, Coebergh JW, Soerjomataram I (2014) Second primary cancers in survivors of cervical cancer in The Netherlands: implications for prevention and surveillance. Radiother Oncol 111(3):374\u2013381","journal-title":"Radiother Oncol"},{"issue":"30","key":"2191_CR29","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1200\/JCO.2012.41.8681","volume":"30","author":"ME Wood","year":"2012","unstructured":"Wood ME, Vogel V, Ng A, Foxhall L, Goodwin P, Travis LB (2012) Second malignant neoplasms: assessment and strategies for risk reduction. J Clin Oncol 30(30):3734\u20133745","journal-title":"J Clin Oncol"},{"issue":"21","key":"2191_CR30","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1093\/jnci\/djm201","volume":"99","author":"AK Chaturvedi","year":"2007","unstructured":"Chaturvedi AK, Engels EA, Gilbert ES, Chen BE, Storm H, Lynch CF et al (2007) Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk. J Natl Cancer Inst 99(21):1634\u20131643","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"2191_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","volume":"189","author":"JM Walboomers","year":"1999","unstructured":"Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189(1):12\u201319","journal-title":"J Pathol"},{"issue":"7","key":"2191_CR32","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s10552-012-9957-2","volume":"23","author":"JM Underwood","year":"2012","unstructured":"Underwood JM, Rim SH, Fairley TL, Tai E, Stewart SL (2012) Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992-2008. Cancer Causes Control 23(7):1009\u20131016","journal-title":"Cancer Causes Control"},{"issue":"4","key":"2191_CR33","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.adro.2019.05.003","volume":"4","author":"C Wang","year":"2019","unstructured":"Wang C, Kishan AU, Yu JB, Raldow A, King CR, Iwamoto KS et al (2019) Association between long-term second malignancy risk and radiation: a comprehensive analysis of the entire surveillance, epidemiology, and end results database (1973-2014). Adv Radiat Oncol 4(4):738\u2013747","journal-title":"Adv Radiat Oncol"},{"issue":"4","key":"2191_CR34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s10147-004-0402-8","volume":"9","author":"K Banno","year":"2004","unstructured":"Banno K, Susumu N, Yanokura M, Hirao T, Iwata T, Hirasawa A et al (2004) Association of HNPCC and endometrial cancers. Int J Clin Oncol 9(4):262\u2013269","journal-title":"Int J Clin Oncol"},{"key":"2191_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143127","author":"SC Liao","year":"2021","unstructured":"Liao SC, Yeh HZ, Chang CS, Chen WC, Muo CH, Sung FC (2021) Colorectal cancer risk in women with gynecologic cancers-a population retrospective cohort study. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10143127","journal-title":"J Clin Med"},{"issue":"38","key":"2191_CR36","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001626","volume":"94","author":"YP Hung","year":"2015","unstructured":"Hung YP, Liu CJ, Hu YW, Chen MH, Li CP, Yeh CM et al (2015) Secondary primary malignancy risk in patients with ovarian cancer in Taiwan: a nationwide population-based study. Medicine 94(38):e1626","journal-title":"Medicine"},{"issue":"1","key":"2191_CR37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.tjog.2021.11.015","volume":"61","author":"Z Yang","year":"2022","unstructured":"Yang Z, Liu X, Yang X, Liao QP (2022) Second primary malignancies after ovarian cancer: a SEER-based analysis (1975-2016). Taiwan J Obstet Gynecol 61(1):80\u201385","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"2","key":"2191_CR38","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.ygyno.2021.05.034","volume":"162","author":"AC Casper","year":"2021","unstructured":"Casper AC, Parsons MW, Chipman J, Burt LM Jr, Suneja G, Maurer KA et al (2021) Risk of secondary malignancies in ovarian cancer survivors: 52,680 patients analyzed with over 40 years of follow-up. Gynecol Oncol 162(2):454\u2013460","journal-title":"Gynecol Oncol"},{"key":"2191_CR39","unstructured":"European Society of Gynaecological Oncology. ESGO Guidelines and Quality Indicators 2025 [Available from: https:\/\/guidelines.esgo.org\/."},{"key":"2191_CR40","doi-asserted-by":"crossref","unstructured":"Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53(282):457\u2013481","DOI":"10.1080\/01621459.1958.10501452"}],"container-title":["Cancer Causes &amp; Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-026-02191-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10552-026-02191-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-026-02191-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:49:07Z","timestamp":1789026547000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10552-026-02191-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2191"],"URL":"https:\/\/doi.org\/10.1007\/s10552-026-02191-8","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"27 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Portuguese Institute of Oncology of Porto (Ref. CES IPO: 332\/020) and the analyses were performed according to RORENO guidelines ensuring the anonymity of information used.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"136"}}