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While studies have shown high levels\u00a0of public\u00a0interest\u00a0in\u00a0MCED\u00a0screening,\u00a0little\u00a0is\u00a0known\u00a0about\u00a0factors\u00a0shaping\u00a0individuals\u2019\u00a0perception of the emerging technology.\u00a0Guided by the PRECEDE\u2013PROCEED framework,\u00a0we\u00a0aimed\u00a0to\u00a0identify\u00a0factors\u00a0associated\u00a0with\u00a0the perception\u00a0of value of MCED testing among\u00a0American\u00a0adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a\u00a0cross-sectional secondary analysis of the Health Information National Trends Survey\u00a0cycle 7\u00a0(HINTS 7)\u00a0to identify factors associated with the perceived value of MCED screening. After\u00a0removing\u00a0respondents with missing outcome data,\u00a0our final sample size was\u00a06,728.\u00a0Using\u00a0the PRECEDE\u2013PROCEED\u00a0framework, candidate predictors were grouped into predisposing, reinforcing, and enabling factors.\u00a0We used descriptive, survey-weighted analyses, spearman correlation analyses, survey-weighted multivariable logistic regression, and supervised machine learning\u00a0analyses\u00a0(logistic regression and random forest) to\u00a0explore\u00a0the associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 74.9% of\u00a0the sample\u00a0perceived MCED testing as\u00a0very\u00a0valuable. Trust-related\u00a0domains\u00a0showed\u00a0the strongest associations with\u00a0the\u00a0outcome, including trust in physicians (OR = 1.89), trust in science (OR = 1.80), and trust in the healthcare system (OR = 1.64). Cancer information seeking (OR = 1.59), online health information use (OR = 1.63), smartphone access (OR = 1.54), cancer fatalistic beliefs (OR = 1.52), trust in government (OR = 1.50), knowledge of hepatitis B as a cancer risk factor (OR = 1.48), and family history of cancer (OR = 1.45) were also significantly associated with higher perceived value. Machine learning analyses demonstrated consistent predictor rankings, highlighting trust and health information engagement as the most influential determinants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The\u00a0value of MCED\u00a0screening\u00a0was\u00a0largely\u00a0driven\u00a0by\u00a0trust,\u00a0cancer\u00a0information seeking, and access to healthcare and\u00a0health information\u00a0resources.\u00a0Our\u00a0study\u00a0highlights\u00a0the\u00a0efficacy\u00a0of the PRECEDE\u2013PROCEED\u00a0approach\u00a0to\u00a0studying\u00a0factors associated with\u00a0complex health outcomes. Future implementation strategies should prioritize equitable communication, strengthen public trust, and improve access to reliable health information to facilitate informed decision-making regarding MCED testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10552-026-02242-0","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:26:08Z","timestamp":1789907168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of perceived value of multi-cancer early detection testing: a national PRECEDE\u2013PROCEED framework study"],"prefix":"10.1007","volume":"37","author":[{"given":"Duxiao","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Jian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Elkefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"issue":"1","key":"2242_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41698-018-0066-x","volume":"2","author":"DA Ahlquist","year":"2018","unstructured":"Ahlquist DA (2018) Universal cancer screening: revolutionary, rational, and realizable. 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