{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:06:27Z","timestamp":1791378387492,"version":"4.3.2"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s10554-016-0837-9","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T16:48:40Z","timestamp":1452617320000},"page":"767-776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Detection of radiotherapy-induced myocardial changes by ultrasound tissue characterisation in patients with breast cancer"],"prefix":"10.1007","volume":"32","author":[{"given":"Suvi Sirkku","family":"Tuohinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Skytt\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Luukkaala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko-Liisa","family":"Kellokumpu-Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Raatikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"issue":"2","key":"837_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.radonc.2012.02.008","volume":"103","author":"A Sardaro","year":"2012","unstructured":"Sardaro A, Petruzzelli MF, D\u2019Errico MP, Grimaldi L, Pili G, Portaluri M (2012) Radiation-induced cardiac damage n early left breast cancer patients: risk factors, biological mechanisms, radiobiology, and dosimetric constraints. Radiother Oncol 103(2):133\u2013142","journal-title":"Radiother Oncol"},{"issue":"23","key":"837_CR2","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.jacc.2013.01.090","volume":"61","author":"C Jaworski","year":"2013","unstructured":"Jaworski C, Mariani JA, Wheeler G, Kaye DM (2013) Cardiac complications of thoracic irradiation. J Am Coll Cardiol 61(23):2319\u20132328","journal-title":"J Am Coll Cardiol"},{"issue":"9503","key":"837_CR3","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","volume":"366","author":"M Clarke","year":"2005","unstructured":"Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087\u20132106","journal-title":"Lancet"},{"issue":"11","key":"837_CR4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D et al (2013) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368(11):987\u2013998","journal-title":"N Engl J Med"},{"issue":"8","key":"837_CR5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/ehjci\/jet123","volume":"14","author":"P Lancellotti","year":"2013","unstructured":"Lancellotti P, Nkomo VT, Badano LP, Bergler J, Bogaert J, Davin L et al (2013) Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging 14(8):721\u2013740","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"4","key":"837_CR6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/sj.bjc.6605191","volume":"101","author":"T Wethal","year":"2009","unstructured":"Wethal T, Lund MB, Edvardsen T, Fossa SD, Pripp AH, Holte H et al (2009) Valvular dysfunction and left ventricular changes in Hodgkin\u2019s lymphoma survivors. A longitudinal study. Br J Cancer 101(4):575\u2013581","journal-title":"Br J Cancer"},{"issue":"2","key":"837_CR7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0967-2109(96)82320-9","volume":"4","author":"M Chello","year":"1996","unstructured":"Chello M, Mastroroberto P, Romano R, Zofrea S, Bevacqua I, Marchese AR (1996) Changes in the proportion of types I and III collagen in the left ventricular wall of patients with post-irradiative pericarditis. Cardiovasc Surg 4(2):222\u2013226","journal-title":"Cardiovasc Surg"},{"issue":"2","key":"837_CR8","first-page":"299","volume":"59","author":"LF Fajardo","year":"1970","unstructured":"Fajardo LF, Stewart JR (1970) Experimental radiation-induced heart disease I. Light microscopic studies. Am J Pathol 59(2):299\u2013316","journal-title":"Am J Pathol"},{"issue":"1","key":"837_CR9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/01.RES.47.1.49","volume":"47","author":"JW Mimbs","year":"1980","unstructured":"Mimbs JW, O\u2019Donnell M, Bauwens D, Miller JW, Sobel BE (1980) The dependence of ultrasonic attenuation and backscatter on collagen content in dog and rabbit hearts. Circ Res 47(1):49\u201358","journal-title":"Circ Res"},{"issue":"4","key":"837_CR10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/01.CIR.71.4.740","volume":"71","author":"RH Hoyt","year":"1985","unstructured":"Hoyt RH, Collins SM, Skorton DJ, Ericksen EE, Conyers D (1985) Assessment of fibrosis in infarcted human hearts by analysis of ultrasonic backscatter. Circulation 71(4):740\u2013744","journal-title":"Circulation"},{"key":"837_CR11","doi-asserted-by":"crossref","unstructured":"Romano MM, Pazin-Filho A, O\u2019Connel JL, Simoes MV, Schmidt A, Campos EC et al (2012) Early detection of doxorubicin myocardial injury by ultrasonic tissue characterization in an experimental animal model. Cardiovasc Ultrasound 10:40-7120-10-40","DOI":"10.1186\/1476-7120-10-40"},{"issue":"3","key":"837_CR12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ejechocard\/jer021","volume":"12","author":"V Mor-Avi","year":"2011","unstructured":"Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G et al (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE\/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr 12(3):167\u2013205","journal-title":"Eur J Echocardiogr"},{"issue":"1","key":"837_CR13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.CIR.81.1.58","volume":"81","author":"E Picano","year":"1990","unstructured":"Picano E, Pelosi G, Marzilli M, Lattanzi F, Benassi A, Landini L et al (1990) In vivo quantitative ultrasonic evaluation of myocardial fibrosis in humans. Circulation 81(1):58\u201364","journal-title":"Circulation"},{"issue":"6","key":"837_CR14","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/0735-1097(95)00026-Z","volume":"25","author":"V Bello Di","year":"1995","unstructured":"Di Bello V, Talarico L, Picano E, Di Muro C, Landini L, Paterni M et al (1995) Increased echodensity of myocardial wall in the diabetic heart: an ultrasound tissue characterization study. J Am Coll Cardiol 25(6):1408\u20131415","journal-title":"J Am Coll Cardiol"},{"key":"837_CR15","doi-asserted-by":"crossref","unstructured":"Romano MM, Maciel LM, Almeida-Filho OC, Pazin-Filho A, Schmidt A, Maciel BC (2010) Myocardial ultrasonic tissue characterization in patients with thyroid dysfunction. Cardiovasc Ultrasound 8:15-7120-8-15","DOI":"10.1186\/1476-7120-8-15"},{"issue":"3","key":"837_CR16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/01.CIR.87.3.748","volume":"87","author":"F Lattanzi","year":"1993","unstructured":"Lattanzi F, Bellotti P, Picano E, Chiarella F, Mazzarisi A, Melevendi C et al (1993) Quantitative ultrasonic analysis of myocardium in patients with thalassemia major and iron overload. Circulation 87(3):748\u2013754","journal-title":"Circulation"},{"issue":"1","key":"837_CR17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.CIR.95.1.140","volume":"95","author":"CE Angermann","year":"1997","unstructured":"Angermann CE, Nassau K, Stempfle HU, Kruger TM, Drewello R, Junge R et al (1997) Recognition of acute cardiac allograft rejection from serial integrated backscatter analyses in human orthotopic heart transplant recipients. Comparison with conventional echocardiography. Circulation 95(1):140\u2013150","journal-title":"Circulation"},{"issue":"4","key":"837_CR18","first-page":"2141","volume":"35","author":"SS Tuohinen","year":"2015","unstructured":"Tuohinen SS, Skytta T, Virtanen V, Luukkaala T, Kellokumpu-Lehtinen PL, Raatikainen P (2015) Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function. Anticancer Res 35(4):2141\u20132147","journal-title":"Anticancer Res"},{"issue":"3","key":"837_CR19","first-page":"1559","volume":"35","author":"T Skytta","year":"2015","unstructured":"Skytta T, Tuohinen S, Virtanen V, Raatikainen P, Kellokumpu-Lehtinen PL (2015) The concurrent use of aromatase inhibitors and radiotherapy induces echocardiographic changes in patients with breast cancer. Anticancer Res 35(3):1559\u20131566","journal-title":"Anticancer Res"},{"issue":"2","key":"837_CR20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/01.CIR.77.2.478","volume":"77","author":"KB Sagar","year":"1988","unstructured":"Sagar KB, Pelc LE, Rhyne TL, Wann LS, Waltier DC (1988) Influence of heart rate, preload, afterload, and inotropic state on myocardial ultrasonic backscatter. Circulation 77(2):478\u2013483","journal-title":"Circulation"},{"issue":"5","key":"837_CR21","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0735-1097(91)90836-X","volume":"17","author":"F Lattanzi","year":"1991","unstructured":"Lattanzi F, Spirito P, Picano E, Mazzarisi A, Landini L, Distante A et al (1991) Quantitative assessment of ultrasonic myocardial reflectivity in hypertrophic cardiomyopathy. J Am Coll Cardiol 17(5):1085\u20131090","journal-title":"J Am Coll Cardiol"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-016-0837-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10554-016-0837-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-016-0837-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T17:13:45Z","timestamp":1559236425000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10554-016-0837-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["837"],"URL":"https:\/\/doi.org\/10.1007\/s10554-016-0837-9","relation":{},"ISSN":["1569-5794","1573-0743"],"issn-type":[{"value":"1569-5794","type":"print"},{"value":"1573-0743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,12]]}}}