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We sought to explore the relationship between left atrial strain and left ventricular (LV) diastolic function in patients with normal left ventricular ejection fraction (LVEF) by invasive left-heart catheterization. 55 consecutive individuals with LVEF\u2009&gt;\u200950% underwent LV catheterization. Standard transthoracic echocardiography was performed during 12\u00a0h before or after the procedure. Left atrial (LA) strain were obtained by speckle tracking echocardiography. When LVEF\u2009\u2265\u200950%, the group with elevated left ventricular end-diastolic pressure (LVEDP) (n\u2009=\u200935) showed decreased left atrial reservoir strain (LASr) (35.2\u2009\u00b1\u20097.7% vs 21.3\u2009\u00b1\u20097.2%, p\u2009&lt;\u20090.001), left atrial conduit strain (LASct) (17.6\u2009\u00b1\u20096.3% vs 11.9\u2009\u00b1\u20094.1%, p\u2009&lt;\u20090.001), left atrial contraction strain (LAScd) (16.6\u2009\u00b1\u20097.2% vs 9.5\u2009\u00b1\u20095.0%, p\u2009&lt;\u20090.001) and increased E\/e\u2032 ration(8.9\u2009\u00b1\u20092.6 vs 10.1\u2009\u00b1\u20093.5, p\u2009=\u20090.17). LVEDP negatively correlated with LASr (R\u2009=\u20090.662, p\u2009&lt;\u20090.001), LASct (R\u2009=\u20090.575, p\u2009&lt;\u20090.001) and LAScd (R\u2009=\u20090.456, p\u2009&lt;\u20090.001), but not with E\/e\u2032. LASr, LASct and LAScd were all independent predictors of elevated LVEDP (p\u2009&lt;\u20090.05), with a higher C-statistic for the model including LASr (0.95, 0.86 and 0.93 respectively). The area under the curve (AUC) for LASr is 0.914 (cutoff value is 26.7%, sensitivity is 90%, specificity is 82.9%). In patients with normal LV ejection fraction, left atrial strain presented good correlation with LVEDP, and LASr was superior to LASct and LAScd to predict LVEDP. LA strain demonstrated better agreement with the invasive reference than E\/e\u2032.<\/jats:p>","DOI":"10.1007\/s10554-020-01869-7","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T04:02:22Z","timestamp":1588478542000},"page":"1659-1666","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Correlation of left atrial strain with left ventricular end-diastolic pressure in patients with normal left ventricular ejection fraction"],"prefix":"10.1007","volume":"36","author":[{"given":"Jia-Li","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Sheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Da","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jiao","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"issue":"2","key":"1869_CR1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1001\/jama.289.2.194","volume":"289","author":"MM Redfield","year":"2003","unstructured":"Redfield MM, Jacobsen SJ, Burnett JC et al (2003) Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. 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