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We propose a novel approach to measure LVGLS using feature-tracking software on the magnitude dataset of 4D flow cardiovascular magnetic resonance (CMR) and compare it to dynamic computed tomography (CT) and speckle tracking TTE derived measurements. In this prospective cohort study 59 consecutive adult patients with a bicuspid aortic valve (BAV) were included. The study protocol consisted of TTE, CT, and CMR on the same day. Image analysis was done using dedicated feature-tracking (4D flow CMR and CT) and speckle-tracking (TTE) software, on apical 2-, 3-, and 4-chamber long-axis multiplanar reconstructions (4D flow CMR and CT) or standard apical 2-, 3-, and 4-chamber acquisitions (TTE). CMR and CT GLS analysis was feasible in all patients. Good correlations were observed for GLS measured by CMR (\u2212\u200921\u2009\u00b1\u20093%) and CT (\u2212\u200920\u2009\u00b1\u20093%) versus TTE (\u2212\u200920\u2009\u00b1\u20093%, Pearson\u2019s r: 0.67 and 0.65, p\u2009&lt;\u20090.001). CMR also correlated well with CT (Pearson\u2019s r 0.62, p\u2009&lt;\u20090.001). The inter-observer analysis showed moderate to good reproducibility of GLS measurement by CMR, CT and TTE (Pearsons\u2019s r: 0.51, 0.77, 0.70 respectively; p\u2009&lt;\u20090.05). Additionally, ejection fraction (EF), end-diastolic and end-systolic volume measurements (EDV and ESV) correlated well between all modalities (Pearson\u2019s r\u2009&gt;\u20090.61, p\u2009&lt;\u20090.001). Feature-tracking GLS analysis is feasible using the magnitude images acquired with 4D flow CMR. GLS measurement by CMR correlates well with CT and speckle-tracking 2D TTE. GLS analysis on 4D flow CMR allows for an integrative approach, integrating flow and functional data in a single sequence. Not applicable, observational study.<\/jats:p>","DOI":"10.1007\/s10554-020-01883-9","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T15:03:35Z","timestamp":1590419015000},"page":"1771-1780","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography"],"prefix":"10.1007","volume":"36","author":[{"given":"Allard T.","family":"van den Hoven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Yilmazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca G.","family":"Chelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick W. 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Chelu works as consultant for Arterys Inc. None of the other authors have a have financial association that might pose a conflict of interest in connection with this article at the time of submission. We did not have any contact with Medis during the conception of this work; they did not aid nor influence the study, either financially or intellectually.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study complied with the Declaration of Helsinki and was approved by the medical ethical committee of the Erasmus Medical Center (MEC14-225).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was provided by all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}