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We assessed the relationship between LV mass\u2013voltage ratio with subsequent heart failure hospitalization (HHF) and mortality in CA. Patients with confirmed CA and comprehensive cardiovascular magnetic resonance (CMR) and EKG exams were included. CMR-derived LV mass was indexed to body surface area. EKG voltage was assessed using Sokolow, Cornell, and Limb\u2013voltage criteria. The optimal LV mass\u2013voltage ratio for predicting outcomes was determined using receiver operating characteristic curve analysis. The relationship between LV mass\u2013voltage ratio and HHF was assessed using Cox proportional hazards analysis adjusting for significant covariates. A total of 85 patients (mean 69\u2009\u00b1\u200911\u00a0years, 22% female) were included, 42 with transthyretin and 43 with light chain CA. At a median of 3.4-year follow-up, 49% of patients experienced HHF and 60% had died. In unadjusted analysis, Cornell LV mass\u2013voltage ratio was significantly associated with HHF (HR, 1.05; 95% CI 1.02\u20131.09, p\u2009=\u20090.001) and mortality (HR, 1.05; 95% CI 1.02\u20131.07, p\u2009=\u20090.001). Using ROC curve analysis, the optimal cutoff value for Cornell LV mass\u2013voltage ratio to predict HHF was 6.7 gm\/m2\/mV. After adjusting for age, NYHA class, BNP, ECV, and LVEF, a Cornell LV mass\u2013voltage ratio\u2009&gt;\u20096.7 gm\/m2\/mV was significantly associated with HHF (HR 2.25, 95% CI 1.09\u20134.61; p\u2009=\u20090.03) but not mortality. Indexed LV mass\u2013voltage ratio is associated with subsequent HHF and may be a useful prognostic marker in cardiac amyloidosis.<\/jats:p>","DOI":"10.1007\/s10554-020-02059-1","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T04:02:26Z","timestamp":1602907346000},"page":"1043-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Indexed left ventricular mass to QRS voltage ratio is associated with heart failure hospitalizations in patients with cardiac amyloidosis"],"prefix":"10.1007","volume":"37","author":[{"given":"Jeremy A.","family":"Slivnick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Wallner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Vallakati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vien T.","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed B.","family":"Elamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha V.","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-4106","authenticated-orcid":false,"given":"Karolina M.","family":"Zareba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,17]]},"reference":[{"issue":"1","key":"2059_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12968-017-0415-x","volume":"19","author":"JL Cavalcante","year":"2017","unstructured":"Cavalcante JL, Rijal S, Abdelkarim I et al (2017) Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis. 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All authors have read and approved the manuscript. This retrospective research study was approved by the Ohio State University Institutional Review Board (IRB) who agreed to waive informed consent. The authors of this study are willing to make the de-identified data available for review at the request of the editors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}