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Early recognition of aberrant cardiac contracility using cardiovascular magnetic resonance (CMR) imaging may identify women at risk of cardiac dysfunction. To define myocardial function at an early disease stage, we studied regional cardiac function using CMR imaging with tissue tagging in asymptomatic female gene variant carriers. CMR imaging with tissue tagging was done in 13 <jats:italic>MYBPC3<\/jats:italic>, 11 <jats:italic>MYH7<\/jats:italic> and 6 <jats:italic>TNNT2<\/jats:italic> gene carriers and 16 age-matched controls. Regional peak circumferential strain was derived from tissue tagging images of the basal and midventricular segments of the septum and lateral wall. Left ventricular wall thickness and global function were comparable between <jats:italic>MYBPC3<\/jats:italic>, <jats:italic>MYH7<\/jats:italic>, <jats:italic>TNNT2<\/jats:italic> carriers and controls. <jats:italic>MYH7<\/jats:italic> gene variant carriers showed a different strain pattern as compared to the other groups, with higher septal peak circumferential strain at the basal segments compared to the lateral wall, whereas <jats:italic>MYBPC3<\/jats:italic>, <jats:italic>TNNT2<\/jats:italic> carriers and controls showed higher strain at the lateral wall compared to the septum. Only subtle gene-specific changes in strain pattern occur in the myocardium preceding development of cardiac hypertrophy. Overall, our study shows that there are no major contractile deficits in asymptomatic females carrying a pathogenic gene variant, which would justify the use of CMR imaging for earlier diagnosis.<\/jats:p>","DOI":"10.1007\/s10554-020-02156-1","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T02:59:56Z","timestamp":1612925996000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regional myocardial function at preclinical disease stage of hypertrophic cardiomyopathy in female gene variant carriers"],"prefix":"10.1007","author":[{"given":"Rahana Y.","family":"Parbhudayal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Seegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Croisille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Clarysse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert C.","family":"van Rossum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjeerd","family":"Germans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanda","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"issue":"12","key":"2156_CR1","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","volume":"65","author":"C Semsarian","year":"2015","unstructured":"Semsarian C et al (2015) New perspectives on the prevalence of hypertrophic cardiomyopathy. 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