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The clinical and prognostic significance of these patterns is unknown. Consecutive patients with non-ischaemic HF, LV ejection fraction\u2009&lt;\u200950% and LBBB underwent 1.5\u00a0T CMR. Maximal dyssynchrony time (time between the earliest and latest end-systolic peaks), systolic dyssynchrony index (standard deviation of times to peak volume change), and contractility index (maximum rate of change of pressure-normalized stress) were calculated. The endpoint was a composite of cardiovascular death, HF hospitalization, and appropriate defibrillator shock. NP was found in 29 and WP in 72 patients. WP patients had higher volumes and NT-proBNP, and lower LVEF. WP patients had a longer maximal dyssynchrony time (absolute duration: 192\u2009\u00b1\u200980 vs. 143\u2009\u00b1\u200965\u00a0ms, p\u2009&lt;\u20090.001; % of RR interval: 25\u2009\u00b1\u200911% vs. 8\u2009\u00b1\u20094%, p\u2009&lt;\u20090.001), a higher systolic dyssynchrony index (13\u2009\u00b1\u20094 vs. 7\u2009\u00b1\u20093%, p\u2009&lt;\u20090.001), and a lower contractility index (2.6\u2009\u00b1\u20091.2 vs 3.2\u2009\u00b1\u20091.7, p\u2009&lt;\u20090.05). WP patients had a shorter survival free from the composite endpoint regardless of age, NT-proBNP or LVEF. Nonetheless, WP patients responded more often to cardiac resynchronization therapy (CRT) than those with NP (24\/28 [86%] vs. 1\/11 [9%] responders, respectively; p\u2009&lt;\u20090.001). In patients with non-ischaemic systolic HF and LBBB, the WP of V\/t curves identifies a subgroup of patients with greater LV dyssynchrony and worse outcome, but better response to CRT.<\/jats:p>","DOI":"10.1007\/s10554-021-02194-3","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T11:04:00Z","timestamp":1614337440000},"page":"2245-2255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Morphologies and prognostic significance of left ventricular volume\/time curves with cardiac magnetic resonance in patients with non-ischaemic heart failure and left bundle branch block"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-9519","authenticated-orcid":false,"given":"Alberto","family":"Aimo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Valleggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Barison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Salerni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"issue":"2","key":"2194_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12410-011-9070-z","volume":"4","author":"JJ Westenberg","year":"2011","unstructured":"Westenberg JJ (2011) CMR for assessment of diastolic function. 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