{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:43:47Z","timestamp":1781581427462,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10554-021-02287-z","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T11:02:31Z","timestamp":1621162951000},"page":"2849-2859","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optical coherence tomography and coronary angioscopy assessment of healed coronary plaque components"],"prefix":"10.1007","volume":"37","author":[{"given":"Shigeki","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunmo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Misu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ohmori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Yamakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Manno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Isshiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"2287_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","volume":"89","author":"AC van der Wal","year":"1994","unstructured":"van der Wal AC, Becker AE, van der Loos CM, Das PK (1994) Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89:36\u201344","journal-title":"Circulation"},{"key":"2287_CR2","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1161\/01.ATV.20.5.1262","volume":"20","author":"R Virmani","year":"2000","unstructured":"Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20:1262\u20131275","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2287_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1136\/hrt.82.3.265","volume":"82","author":"J Mann","year":"1999","unstructured":"Mann J, Davies MJ (1999) Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart 82:265\u2013268","journal-title":"Heart"},{"key":"2287_CR4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/01.CIR.103.7.934","volume":"103","author":"AP Burke","year":"2001","unstructured":"Burke AP, Kolodgie FD, Farb A, Weber DK, Malcom GT, Smialek J et al (2001) Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 103:934\u2013940","journal-title":"Circulation"},{"key":"2287_CR5","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/j.jacc.2018.10.093","volume":"73","author":"F Fracassi","year":"2019","unstructured":"Fracassi F, Crea F, Sugiyama T, Yamamoto E, Uemura S, Vergallo R et al (2019) Healed culprit plaques in patients with acute coronary syndromes. J Am Coll Cardiol 73:2253\u20132263","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR6","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1253\/circj.CJ-19-0640","volume":"83","author":"H Okamoto","year":"2019","unstructured":"Okamoto H, Kume T, Yamada R, Koyama T, Tamada T, Imai K et al (2019) Prevalence and Clinical Significance of Layered Plaque in Patients With Stable Angina Pectoris- Evaluation With Histopathology and Optical Coherence Tomography. Circ J 83:2452\u20132459","journal-title":"Circ J"},{"key":"2287_CR7","doi-asserted-by":"publisher","first-page":"e771","DOI":"10.4244\/EIJ-D-18-01175","volume":"15","author":"C Wang","year":"2019","unstructured":"Wang C, Hu S, Wu J, Yu H, Pan W, Qin Y et al (2019) Characteristics and significance of healed plaques in patients with acute coronary syndrome and stable angina: an in vivo OCT and IVUS study. EuroIntervention 15:e771\u2013e778","journal-title":"EuroIntervention"},{"key":"2287_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02116-5","author":"M Araki","year":"2020","unstructured":"Araki M, Yonetsu T, Russo M, Kurihara O, Kim HO, Shinohara H et al (2020) Predictors for layered coronary plaques: an optical coherence tomography study. J Thromb Thrombolysis. https:\/\/doi.org\/10.1007\/s11239-020-02116-5","journal-title":"J Thromb Thrombolysis"},{"key":"2287_CR9","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.jacc.2013.05.071","volume":"62","author":"H Jia","year":"2013","unstructured":"Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H et al (2013) In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol 62:1748\u20131758","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR10","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/01.CIR.0000029927.92825.F6","volume":"106","author":"H Yabushita","year":"2002","unstructured":"Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH et al (2002) Characterization of human atherosclerosis by optical coherence tomography. Circulation 106:1640\u20131645","journal-title":"Circulation"},{"key":"2287_CR11","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1161\/01.CIR.0000159354.43778.69","volume":"111","author":"IK Jang","year":"2005","unstructured":"Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F, Iftima N et al (2005) In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 111:1551\u20131555","journal-title":"Circulation"},{"key":"2287_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0735-1097(96)00108-8","volume":"28","author":"T Thieme","year":"1996","unstructured":"Thieme T, Wernecke KD, Meyer R, Brandenstein E, Habedank D, Hinz A et al (1996) Angioscopic evaluation of atherosclerotic plaques: validation by histomorphologic analysis and association with stable and unstable coronary syndromes. J Am Coll Cardiol 28:1\u20136","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1253\/circj.CJ-13-0374","volume":"78","author":"T Inoue","year":"2014","unstructured":"Inoue T, Shinke T, Otake H, Nakagawa M, Hariki H, Osue T et al (2014) Neoatherosclerosis and mural thrombus detection after sirolimus-eluting stent implantation. Circ J 78:92\u2013100","journal-title":"Circ J"},{"key":"2287_CR14","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","volume":"18","author":"K Thygesen","year":"2018","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA et al (2018) Fourth universal definition of myocardial infarction (2018). J Am Coll Cardiol 18:2231\u20132264","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR15","doi-asserted-by":"crossref","unstructured":"TIMI Study Group (1985) The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings. N Engl J Med 312:932\u2013936","DOI":"10.1056\/NEJM198504043121437"},{"key":"2287_CR16","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1161\/01.CIR.93.5.879","volume":"93","author":"CM Gibson","year":"1996","unstructured":"Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ et al (1996) TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 93:879\u2013888","journal-title":"Circulation"},{"key":"2287_CR17","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1161\/CIRCINTERVENTIONS.111.962506","volume":"4","author":"T Lee","year":"2011","unstructured":"Lee T, Yonetsu T, Koura K, Hishikari K, Murai T, Iwai T et al (2011) Impact of coronary plaque morphology assessed by optical coherence tomography on cardiac troponin elevation in patients with elective stent implantation. Circ Cardiovasc Interv 4:378\u2013386","journal-title":"Circ Cardiovasc Interv"},{"key":"2287_CR18","unstructured":"Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG et al International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT). Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation"},{"key":"2287_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2018.05.025","volume":"275","author":"A Shimokado","year":"2018","unstructured":"Shimokado A, Matsuo Y, Kubo T, Nishiguchi T, Taruya A, Teraguchi I et al (2018) In vivo optical coherence tomography imaging and histopathology of healed coronary plaques. Atherosclerosis 275:35\u201342","journal-title":"Atherosclerosis"},{"key":"2287_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jamacardio.2019.0275","volume":"4","author":"R Vergallo","year":"2019","unstructured":"Vergallo R, Porto I, D\u2019Amario D, Annibali G, Galli M, Benenati S et al (2019) Coronary atherosclerotic phenotype and plaque healing in patients with recurrent acute coronary syndromes compared with patients with long-term clinical stability: an in vivo optical coherence tomography study. JAMA Cardiol 4:321\u2013329","journal-title":"JAMA Cardiol"},{"key":"2287_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/eurheartj\/ehr284","volume":"33","author":"S Uemura","year":"2012","unstructured":"Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H et al (2012) Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques. Eur Heart J 33:78\u201385","journal-title":"Eur Heart J"},{"key":"2287_CR22","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1161\/CIRCULATIONAHA.114.014704","volume":"132","author":"T Soeda","year":"2015","unstructured":"Soeda T, Uemura S, Park SJ, Jang Y, Lee S, Cho JM et al (2015) Incidence and clinical significance of poststent optical coherence tomography findings: one-year follow-up study from a Multicenter Registry. Circulation 132:1020\u20131029","journal-title":"Circulation"},{"key":"2287_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ahj.2004.03.047","volume":"148","author":"Y Ueda","year":"2004","unstructured":"Ueda Y, Ohtani T, Shimizu M, Hirayama A, Kodama K (2004) Assessment of plaque vulnerability by angioscopic classification of plaque color. Am Heart J 148:333\u2013335","journal-title":"Am Heart J"},{"key":"2287_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0735-1097(95)00186-4","volume":"26","author":"F Alfonso","year":"1995","unstructured":"Alfonso F, Goicolea J, Hernandez R, Goncalves M, Segovia J, Ba\u00f1uelos C et al (1995) Angioscopic findings during coronary angioplasty of coronary occlusions. J Am Coll Cardiol 26:135\u2013141","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR25","doi-asserted-by":"publisher","first-page":"7S","DOI":"10.1016\/S0735-1097(02)02833-4","volume":"41","author":"R Corti","year":"2003","unstructured":"Corti R, Fuster V, Badimon JJ (2003) Pathogenetic concepts of acute coronary syndromes. J Am Coll Cardiol 41:7S-14S","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR26","doi-asserted-by":"crossref","unstructured":"Domingueti CP, Dusse LM, Carvalho Md, de Sousa LP, Gomes KB, Fernandes AP (2016) Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complications 30:738\u201345","DOI":"10.1016\/j.jdiacomp.2015.12.018"},{"key":"2287_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1161\/ATVBAHA.116.306256","volume":"37","author":"K Yahagi","year":"2017","unstructured":"Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero M, Finn AV (2017) Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus. Arterioscler Thromb Vasc Biol 37:191\u2013204","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2287_CR28","doi-asserted-by":"publisher","first-page":"e009245","DOI":"10.1161\/JAHA.118.009245","volume":"7","author":"T Sugiyama","year":"2018","unstructured":"Sugiyama T, Yamamoto E, Bryniarski K, Xing L, Fracassi F, Lee H et al (2018) Coronary plaque characteristics in patients with diabetes mellitus who presented with acute coronary syndromes. J Am Heart Assoc 7:e009245","journal-title":"J Am Heart Assoc"},{"key":"2287_CR29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrcardio.2014.62","volume":"11","author":"F Otsuka","year":"2014","unstructured":"Otsuka F, Joner M, Prati F, Virmani R, Narula J (2014) Clinical classification of plaque morphology in coronary disease. Nat Rev Cardiol 11:379\u2013389","journal-title":"Nat Rev Cardiol"},{"key":"2287_CR30","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.amjcard.2011.01.016","volume":"107","author":"K Okada","year":"2011","unstructured":"Okada K, Ueda Y, Matsuo K, Nishio M, Hirata A, Kashiwase K et al (2011) Frequency and healing of nonculprit coronary artery plaque disruptions in patients with acute myocardial infarction. Am J Cardiol 107:1426\u20131429","journal-title":"Am J Cardiol"},{"key":"2287_CR31","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jacc.2004.09.077","volume":"45","author":"M Takano","year":"2005","unstructured":"Takano M, Inami S, Ishibashi F, Okamatsu K, Seimiya K, Ohba T et al (2005) Angioscopic follow-up study of coronary ruptured plaques in nonculprit lesions. J Am Coll Cardiol 45:652\u2013658","journal-title":"J Am Coll Cardiol"},{"key":"2287_CR32","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1161\/ATVBAHA.120.314298","volume":"40","author":"M Russo","year":"2020","unstructured":"Russo M, Fracassi F, Kurihara O, Kim HO, Thondapu V, Araki M et al (2020) Healed plaques in patients with stable angina pectoris. Arterioscler Thromb Vasc Biol 40:1587\u20131597","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2287_CR33","doi-asserted-by":"publisher","unstructured":"Araki M , Yonetsu T, Kurihara O, Nakajima A, Lee H, Soeda T et al (2020) Predictors of rapid plaque progression: an optical coherence tomography study. JACC Cardiovasc Imaging. https:\/\/doi.org\/10.1016\/j.jcmg.2020.08.014.","DOI":"10.1016\/j.jcmg.2020.08.014"},{"key":"2287_CR34","doi-asserted-by":"publisher","unstructured":"Usui E, Mintz GS, Lee T, Matsumura M, Zhang Y, Hada M et al (2020) Prognostic impact of healed coronary plaque in non-culprit lesions assessed by optical coherence tomography. Atherosclerosis. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2020.07.005.","DOI":"10.1016\/j.atherosclerosis.2020.07.005"},{"key":"2287_CR35","doi-asserted-by":"publisher","unstructured":"Dai J, Fang C, Zhang S, Li L, Wang Y, Xing L et al (2020) Frequency, predictors, distribution, and morphological characteristics of layered culprit and nonculprit plaques of patients with acute myocardial infarction. Circ Cardiovasc Interv. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.120.009125.","DOI":"10.1161\/CIRCINTERVENTIONS.120.009125"},{"key":"2287_CR36","doi-asserted-by":"publisher","unstructured":"Kurihara O, Shinohara H , Kim HO, Russo M, Araki M, Nakajima A et al (2020) Comparison of post-stent optical coherence tomography findings: Layered versus non-layered culprit lesions. Catheter Cardiovasc Interv. https:\/\/doi.org\/10.1002\/ccd.28940.","DOI":"10.1002\/ccd.28940"},{"key":"2287_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jcmg.2011.09.015","volume":"5","author":"M Nakano","year":"2012","unstructured":"Nakano M, Vorpahl M, Otsuka F, Taniwaki M, Yazdani SK, Finn AV et al (2012) Ex vivo assessment of vascular response to coronary stents by optical frequency domain imaging. JACC Cardiovasc Imaging 5:71\u201382","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-021-02287-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-021-02287-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-021-02287-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T06:52:41Z","timestamp":1633589561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-021-02287-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,16]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2287"],"URL":"https:\/\/doi.org\/10.1007\/s10554-021-02287-z","relation":{},"ISSN":["1569-5794","1573-0743"],"issn-type":[{"value":"1569-5794","type":"print"},{"value":"1573-0743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,16]]},"assertion":[{"value":"20 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest'.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}