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Patients underwent gadofosveset-enhanced cardiovascular magnetic resonance (CMR) imaging and x-ray angiography (QCA) within 24\u00a0h. CMR imaging was performed prior to and 24\u00a0h following the administration of gadofosveset. Contrast-to-noise ratios (CNRs) between segments with different grades of stenosis were compared. Overall, <jats:italic>n<\/jats:italic>\u2009=\u2009203 segments of 26 patients were included. Lesions with more than\u2009&gt;\u200970% stenosis demonstrated significantly higher CNRs compared to lesions\u2009&lt;\u200970% (7.6\u2009\u00b1\u20098.3 vs. 2.5\u2009\u00b1\u20094.9; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post-stenotic segments of lesions\u2009&gt;\u200970% stenosis showed significant higher signal enhancement compared to segments located upstream of these lesions (7.3\u2009\u00b1\u20098.8 vs. 2.8\u2009\u00b1\u20092.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.02). No difference in signal enhancement between segments proximal and distal of lesions with stenosis greater than 50% was measured (3.3\u2009\u00b1\u20092.8 vs. 2.4\u2009\u00b1\u20092.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.18). ROC analysis for the detection of lesions\u2009\u2265\u200970% revealed an area under the curve of 0.774 (95% CI 0.681\u20130.866). This study suggests that relevant coronary stenosis and their down-stream segments are associated with increased signal enhancement on Gadofosveset-enhanced CMR, suggesting a higher endothelial permeability in these lesions. An albumin-binding MR probe could represent a novel <jats:italic>in vivo<\/jats:italic> biomarker for the identification and characterization of these vulnerable coronary segments.<\/jats:p>","DOI":"10.1007\/s10554-021-02293-1","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T19:09:01Z","timestamp":1625944141000},"page":"3049-3055","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vivo assessment of endothelial permeability of coronary lesions with variable degree of stenosis using an albumin-binding MR probe"],"prefix":"10.1007","volume":"37","author":[{"given":"Leif-Christopher","family":"Engel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef S.","family":"Abdelwahed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Gigengack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wurster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantia","family":"Manes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Skurk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lauten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Noutsias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene M.","family":"Botnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Bigalke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus R.","family":"Makowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"2293_CR1","first-page":"III27","volume":"109","author":"J Davignon","year":"2004","unstructured":"Davignon J, Ganz P (2004) Role of endothelial dysfunction in atherosclerosis. 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Abdelwahed, Kevin Gigengack, Costantina Manes, Thomas Wurster, Georg Girke, Carsten Skurk, David M. Leistner, Alexander Lauten, Andreas Schuster, Michel Noutsias, Bernd Hamm, Rene M. Botnar, Boris Bigalke, Marcus R. Makowski have declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of Charite\u0301 Universit\u00e4tsmedizin Berlin and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}