{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:22Z","timestamp":1790790922065,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s10554-021-02366-1","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T07:26:01Z","timestamp":1628580361000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical insights into a tertiary care center cohort of patients with bicuspid aortic valve"],"prefix":"10.1007","volume":"38","author":[{"given":"Alexis","family":"Th\u00e9ron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa","family":"Touil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"R\u00e9sseguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenaelle","family":"Collod-Beroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Norscini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Simoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Odelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Collart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-418X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Zaffran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Avierinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"2366_CR1","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","volume":"133","author":"H-H Sievers","year":"2007","unstructured":"Sievers H-H, Schmidtke C (2007) A classification system for the bicuspid aortic valve from 304 surgical specimens. J Thorac Cardiovasc Surg 133:1226\u20131233","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2366_CR2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nature03940","volume":"437","author":"V Garg","year":"2005","unstructured":"Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D (2005) Mutations in NOTCH1 cause aortic valve disease. Nature 437:270\u2013274","journal-title":"Nature"},{"key":"2366_CR3","doi-asserted-by":"publisher","first-page":"e004211","DOI":"10.1161\/JAHA.116.004211","volume":"5","author":"HI Michelena","year":"2016","unstructured":"Michelena HI, Suri RM, Katan O, Eleid MF, Clavel M, Maurer MJ, Pellikka PA, Mahoney D, Enriquez-Sarano M (2016) Sex differences and survival in adults with bicuspid aortic valves: verification in 3 contemporary echocardiographic cohorts. J Am Heart Assoc 5:e004211","journal-title":"J Am Heart Assoc"},{"key":"2366_CR4","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JIE Hoffman","year":"2002","unstructured":"Hoffman JIE, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39:1890\u20131900","journal-title":"J Am Coll Cardiol"},{"key":"2366_CR5","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0002-9149(84)90418-1","volume":"53","author":"EW Larson","year":"1984","unstructured":"Larson EW, Edwards WD (1984) Risk factors for aortic dissection: a necropsy study of 161 cases. Am J Cardiol 53:849\u2013855","journal-title":"Am J Cardiol"},{"key":"2366_CR6","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1161\/CIRCULATIONAHA.113.007851","volume":"129","author":"HI Michelena","year":"2014","unstructured":"Michelena HI, Prakash SK, Della Corte A, Bissell MM, Anavekar N, Mathieu P, Boss\u00e9 Y, Limongelli G, Bossone E, Benson DW, Lancellotti P, Isselbacher EM, Enriquez-Sarano M, Sundt TM, Pibarot P, Evangelista A, Milewicz DM, Body SC, BAVCon Investigators (2014) Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation 129:2691\u20132704","journal-title":"Circulation"},{"key":"2366_CR7","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","volume":"117","author":"HI Michelena","year":"2008","unstructured":"Michelena HI, Desjardins VA, Avierinos J-F, Russo A, Nkomo VT, Sundt TM, Pellikka PA, Tajik AJ, Enriquez-Sarano M (2008) Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation 117:2776\u20132784","journal-title":"Circulation"},{"key":"2366_CR8","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jama.2011.1286","volume":"306","author":"HI Michelena","year":"2011","unstructured":"Michelena HI, Khanna AD, Mahoney D, Margaryan E, Topilsky Y, Suri RM, Eidem B, Edwards WD, Sundt TM, Enriquez-Sarano M (2011) Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 306:1104\u20131112","journal-title":"JAMA"},{"key":"2366_CR9","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","volume":"38","author":"H Baumgartner","year":"2017","unstructured":"Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Mu\u00f1oz DR, Rosenhek R, Sj\u00f6gren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group (2017) 2017 ESC\/EACTS guidelines for the management of valvular heart disease. Eur Heart J 38:2739\u20132791","journal-title":"Eur Heart J"},{"key":"2366_CR10","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","volume":"70","author":"RA Nishimura","year":"2017","unstructured":"Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O\u2019Gara PT, Rigolin VH, Sundt TM, Thompson A (2017) 2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease. J Am Coll Cardiol 70:252\u2013289","journal-title":"J Am Coll Cardiol"},{"key":"2366_CR11","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.4330\/wjc.v6.i12.1227","volume":"6","author":"SK Atkins","year":"2014","unstructured":"Atkins SK, Sucosky P (2014) Etiology of bicuspid aortic valve disease: focus on hemodynamics. World J Cardiol 6:1227\u20131233","journal-title":"World J Cardiol"},{"key":"2366_CR12","doi-asserted-by":"publisher","first-page":"e48843","DOI":"10.1371\/journal.pone.0048843","volume":"7","author":"L Sun","year":"2012","unstructured":"Sun L, Chandra S, Sucosky P (2012) Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS ONE 7:e48843","journal-title":"PLoS ONE"},{"key":"2366_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","volume":"80","author":"D Firth","year":"1993","unstructured":"Firth D (1993) Bias reduction of maximum likelihood. Biometrika 80:27\u201338","journal-title":"Biometrika"},{"key":"2366_CR14","doi-asserted-by":"publisher","first-page":"e006123","DOI":"10.1161\/CIRCIMAGING.117.006123","volume":"10","author":"HI Michelena","year":"2017","unstructured":"Michelena HI, Mankad SV (2017) Sex differences in bicuspid aortic valve adults: who deserves our attention, men or women? Circ Cardiovasc Imaging 10:e006123","journal-title":"Circ Cardiovasc Imaging"},{"key":"2366_CR15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","volume":"111","author":"WC Roberts","year":"2005","unstructured":"Roberts WC, Ko JM (2005) Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation 111:920\u2013925","journal-title":"Circulation"},{"key":"2366_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcmg.2012.11.007","volume":"6","author":"J-W Kang","year":"2013","unstructured":"Kang J-W, Song HG, Yang DH, Baek S, Kim D-H, Song J-M, Kang D-H, Lim T-H, Song J-K (2013) Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction and bicuspid aortopathy. JACC Cardiovasc Imaging 6:150\u2013161","journal-title":"JACC Cardiovasc Imaging"},{"key":"2366_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1001\/jamacardio.2016.5228","volume":"2","author":"WKF Kong","year":"2017","unstructured":"Kong WKF, Delgado V, Poh KK, Regeer MV, Ng ACT, McCormack L, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Liang M, Yip JW, Ma LCW, Kamperidis V, Van Rosendael PJ, Van Der Velde ET, Ajmone Marsan N, Bax JJ (2017) Prognostic implications of raphe in bicuspid aortic valve anatomy. JAMA Cardiol 2:285\u2013292","journal-title":"JAMA Cardiol"},{"key":"2366_CR18","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/cvr\/cvt040","volume":"99","author":"M B\u00e4ck","year":"2013","unstructured":"B\u00e4ck M, Gasser TC, Michel J-B, Caligiuri G (2013) Biomechanical factors in the biology of aortic wall and aortic valve diseases. Cardiovasc Res 99:232\u2013241","journal-title":"Cardiovasc Res"},{"key":"2366_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0003-4975(03)01249-9","volume":"77","author":"F Robicsek","year":"2004","unstructured":"Robicsek F, Thubrikar MJ, Cook JW, Fowler B (2004) The congenitally bicuspid aortic valve: how does it function? Why does it fail? Ann Thorac Surg 77:177\u2013185","journal-title":"Ann Thorac Surg"},{"key":"2366_CR20","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s11517-013-1055-4","volume":"51","author":"G Marom","year":"2013","unstructured":"Marom G, Kim H-S, Rosenfeld M, Raanani E, Haj-Ali R (2013) Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics. Med Biol Eng Comput 51:839\u2013848","journal-title":"Med Biol Eng Comput"},{"key":"2366_CR21","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/ehjci\/jez294","volume":"21","author":"L-T Yang","year":"2020","unstructured":"Yang L-T, Enriquez-Sarano M, Michelena HI (2020) The bicuspid aortic valve raphe: an evolving structure. Eur Hear J Cardiovasc Imaging 21:590\u2013590","journal-title":"Eur Hear J Cardiovasc Imaging"},{"issue":"12","key":"2366_CR22","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1161\/hh2401.101070","volume":"89","author":"SA Steitz","year":"2001","unstructured":"Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM (2001) Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 89(12):1147\u20131154","journal-title":"Circ Res"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-021-02366-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-021-02366-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-021-02366-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T13:02:50Z","timestamp":1644152570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-021-02366-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s10554-021-02366-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.15.431243","asserted-by":"object"}]},"ISSN":["1569-5794","1573-0743"],"issn-type":[{"value":"1569-5794","type":"print"},{"value":"1573-0743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]},"assertion":[{"value":"26 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}