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Whether HALT affects left ventricular (LV) reverse remodeling, a favorable effect of LV afterload reduction after transcatheter aortic valve implantation (TAVI) is unknown. The aim of this study was to examine the association of HALT after TAVI with LV reverse remodeling. In this multicenter case\u2013control study, patients with HALT on MDCT were identified, and patients without HALT were propensity matched for valve type and size, LV ejection fraction (LVEF), sex, age and time of scan. LV dimensions and function were assessed by transthoracic echocardiography before and 12\u00a0months after TAVI. Clinical outcomes (stroke or transient ischemic attack, heart failure hospitalization, new-onset atrial fibrillation, all-cause mortality) were recorded. 106 patients (age 81\u2009\u00b1\u20097\u00a0years, 55% male) with MDCT performed 37\u00a0days [IQR 32\u201352] after TAVI were analyzed (53 patients with HALT and 53 matched controls). Before TAVI, all echocardiographic parameters were similar between the groups. At 12\u00a0months follow-up, patients with and without HALT showed a significant reduction in LV end-diastolic volume, LV end-systolic volume and LV mass index (from 125\u2009\u00b1\u200937 to 105\u2009\u00b1\u200946\u00a0g\/m<jats:sup>2<\/jats:sup>, p\u2009=\u20090.001 and from 127\u2009\u00b1\u200935 to 101\u2009\u00b1\u200927\u00a0g\/m<jats:sup>2<\/jats:sup>, p\u2009&lt;\u20090.001, respectively, p for interaction\u2009=\u20090.48). Moreover, LVEF improved significantly in both groups. In addition, clinical outcomes were not statistically different. Improvement in LVEF and LV reverse remodeling at 12\u00a0months after TAVI were not limited by HALT.<\/jats:p>","DOI":"10.1007\/s10554-021-02438-2","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T15:22:29Z","timestamp":1634397749000},"page":"695-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subclinical leaflet thrombosis after transcatheter aortic valve implantation: no association with left ventricular reverse remodeling at 1-year follow-up"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-2768","authenticated-orcid":false,"given":"Jurrien H.","family":"Kuneman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaj C.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen H.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Fortuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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Dr. Bax received speaker fees from Abbot Vascular. Dr. Delgado received speaker fees from Abbott Vascular, Edwards Lifesciences, GE Healthcare, MSD and Medtronic. Dr. N\u00f8rgaard received institutional research grants from Siemens, Heartflow, and Edwards Lifesciences. Dr. Pontone received institutional research grant and fee from GE Healthcare, Boehringer, Bracco, Medtronic, Bayer and Heartflow. Dr. Ajmone Marsan received speaker fees from Abbot Vascular. The department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands has received unrestricted research grants from Bayer, Abbott Vascular, Medtronic, Biotronik, Boston Scientific, GE Healthcare and Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}