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Seventy-one patients with PAH and 20 sex- and age-matched healthy controls underwent CMR. Myocardial borders and RV insertion points were defined at end diastole and end systole in cine short-axis stacks to compute biventricular volumes, lateral (SV<jats:sub>lat%<\/jats:sub>) and septal (SV<jats:sub>sept%<\/jats:sub>) contribution to stroke volume. Eight atrioventricular points were defined at end diastole and end systole in 2-, 3- and 4-chamber cine long-axis views for computation of AVPD and longitudinal contribution to stroke volume (SV<jats:sub>long%<\/jats:sub>). Cut-off values for survival analysis were defined as two standard deviations above or below the mean of the controls. Outcome was defined as death or lung transplantation. Median follow-up time was 3.6 [IQR 3.7] years. Patients were 57\u2009\u00b1\u200919\u00a0years (65% women) and controls 58\u2009\u00b1\u200915\u00a0years (70% women). Biventricular AVPD, SV<jats:sub>long%<\/jats:sub> and ejection fraction (EF) were lower and SV<jats:sub>lat%<\/jats:sub> was higher, while SV<jats:sub>sept%<\/jats:sub> was lower in PAH compared with controls. In PAH, transplantation-free survival was lower below cut-off for LV-AVPD (hazard ratio [HR]\u2009=\u20092.1, 95%CI 1.2\u20133.9, p\u2009=\u20090.02) and RV-AVPD (HR\u2009=\u20099.8, 95%CI 4.6\u201321.1, p\u2009=\u20090.005). In Cox regression analysis, lower LV-AVPD and RV-AVPD inferred lower transplantation-free survival (LV: HR\u2009=\u20091.16, p\u2009=\u20090.007; RV: HR\u2009=\u20091.11, p\u2009=\u20090.01; per mm decrease). LV-SV<jats:sub>long%<\/jats:sub>, RV-SV<jats:sub>long%<\/jats:sub>, LV-SV<jats:sub>lat%<\/jats:sub>, RV-SV<jats:sub>lat%<\/jats:sub>, SV<jats:sub>sept%<\/jats:sub> and LV- and RVEF did not affect outcome. Low left and right AVPD were associated with outcome in PAH, but regional contributions to stroke volume and EF were not.<\/jats:p>","DOI":"10.1007\/s10554-022-02616-w","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T05:02:35Z","timestamp":1650690155000},"page":"2235-2248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Atrioventricular plane displacement and regional function to predict outcome in pulmonary arterial hypertension"],"prefix":"10.1007","volume":"38","author":[{"given":"Anthony","family":"Lindholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbro","family":"Kjellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Seemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Hesselstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-2423","authenticated-orcid":false,"given":"Ellen","family":"Ostenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"2616_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"N Gali\u00e8","year":"2016","unstructured":"Gali\u00e8 N, Humbert M, Vachiery J-L et al (2016) 2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. 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