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In this study, it was to investigated if increasing p-K to high-normal levels improves systolic- and diastolic myocardial function in patients with low-normal to moderately reduced left ventricular ejection fraction (LVEF). The study included 50 patients (mean age 58 years (SD 14), 81% men), with a mean p-K 3.95 mmol\/l (SD 0.19), mean LVEF 48% (SD 7), and mean Global Longitudinal Strain (GLS) -14.6% (SD 3.1) patients with LVEF 35\u201355% from \u201c<jats:italic>Targeted potassium levels to decrease arrhythmia burden in high-risk patients with cardiovascular diseases trial\u201d<\/jats:italic> (POTCAST). Patients were given standard therapy and randomized (1:1) to an intervention that included guidance on potassium-rich diets, potassium supplements, and mineralocorticoid receptor antagonists targeting high-normal p-K levels (4.5-5.0 mmol\/l). Echocardiography was done at baseline and after a mean follow-up of 44 days (SD 18) and the echocardiograms were analyzed for changes in GLS, mechanical dispersion, E\/A, e\u2019, and E\/e\u2019. At follow-up, mean difference in changes in p-K was 0.52 mmol\/l (95%CI 0.35;0.69), P&lt;0.001 in the intervention group compared to controls. GLS was improved with a mean difference in changes of -1.0% (-2;-0.02), P&lt;0.05 and e\u2019 and E\/e\u2019 were improved with a mean difference in changes of 0.9 cm\/s (0.02;1.7), P = 0.04 and ? 1.5 (-2.9;-0.14), P = 0.03, respectively. 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