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The morphometrics may play a crucial role in this RF discrepancy. Cardiovascular MR of 79 rTOF patients and 20 healthy controls were retrospectively enrolled. Forty-four from the 79 patients were matched in age, sex and body surface area\u00a0to the 20 controls and\u00a0were investigated for: (1) phase-contrast flow of main pulmonary artery (MPA), LPA, and RPA; (2) vascular angles: the angles between the thoracic anterior\u2013posterior line (TAPL) with MPA (\u03b8<jats:sub>M\u2013AP<\/jats:sub>), MPA with RPA (\u03b8<jats:sub>M\u2013R<\/jats:sub>), and MPA with LPA (\u03b8<jats:sub>M\u2013L<\/jats:sub>); (3) cardiac angle, the angle between TAPL and the interventricular septum; (4) area ratio of bilateral lung and hemithorax regions. Compared with the 20 controls, the 44 rTOF patients exhibited wider \u03b8<jats:sub>M\u2013AP<\/jats:sub>, sharper \u03b8<jats:sub>M\u2013L<\/jats:sub> angle, and a smaller \u03b8<jats:sub>M\u2013L<\/jats:sub>\/\u03b8<jats:sub>M\u2013R<\/jats:sub> ratio. In the 79 rTOF patients, LPA showed lower forward, backward, and net flow, and greater RF as compared with RPA. Multivariate analysis showed that the RF of LPA was negatively associated with the \u03b8<jats:sub>M\u2013L<\/jats:sub>\/\u03b8<jats:sub>M\u2013R<\/jats:sub> ratio and the age at surgery (R<jats:sup>2<\/jats:sup>\u2009=\u20090.255). Conversely, the RF of RPA was negatively associated with the left lung\/left hemithorax area ratio and cross-sectional area (CSA) of LPA, and positively associated with CSA of RPA and MPA (R<jats:sup>2<\/jats:sup>\u2009=\u20090.366). In rTOF patients, the RF of LPA is more severe than that of RPA, which may be related to the vascular morphometrics. Different morphometric parameters are\u00a0independently associated with the RF of LPA or RPA, which may offer potential insights for surgical strategies.<\/jats:p>","DOI":"10.1007\/s10554-023-03035-1","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:02:32Z","timestamp":1708077752000},"page":"655-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphometrics predicts the differential regurgitant fraction in bilateral pulmonary arteries of patients with repaired tetralogy of fallot"],"prefix":"10.1007","volume":"40","author":[{"given":"Hui-Chung","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Pen","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Wen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"9","key":"3035_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1056\/NEJM199308263290901","volume":"329","author":"JG Murphy","year":"1993","unstructured":"Murphy JG, Gersh BJ, Mair DD et al (1993) Long-term outcome in patients undergoing surgical repair of tetralogy of fallot. 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