{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:26:46Z","timestamp":1772119606474,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970296"],"award-info":[{"award-number":["81970296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funds for Distinguished Young Scientists in Nanjing","award":["JQX20006"],"award-info":[{"award-number":["JQX20006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"DOI":"10.1007\/s10554-024-03055-5","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T11:02:08Z","timestamp":1709377328000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Growth differentiation factor-15 as a negative predictor for microvascular obstruction in ST-segment elevation myocardial infarction after primary percutaneous coronary intervention"],"prefix":"10.1007","volume":"40","author":[{"given":"Xiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"issue":"2","key":"3055_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39(2):119\u2013177","journal-title":"Eur Heart J"},{"issue":"47","key":"3055_CR2","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1093\/eurheartj\/ehx414","volume":"38","author":"S de Waha","year":"2017","unstructured":"de Waha S et al (2017) Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J 38(47):3502\u20133510","journal-title":"Eur Heart J"},{"issue":"13","key":"3055_CR3","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/eurheartj\/ehv484","volume":"37","author":"G Niccoli","year":"2016","unstructured":"Niccoli G et al (2016) Coronary microvascular obstruction in acute myocardial infarction. Eur Heart J 37(13):1024\u20131033","journal-title":"Eur Heart J"},{"issue":"4","key":"3055_CR4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.cytogfr.2013.05.003","volume":"24","author":"K Unsicker","year":"2013","unstructured":"Unsicker K, Spittau B, Krieglstein K (2013) The multiple facets of the TGF-beta family cytokine growth\/differentiation factor-15\/macrophage inhibitory cytokine-1. Cytokine Growth Factor Rev 24(4):373\u2013384","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"3055_CR5","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1161\/01.RES.0000202805.73038.48","volume":"98","author":"T Kempf","year":"2006","unstructured":"Kempf T et al (2006) The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia\/reperfusion injury. Circ Res 98(3):351\u2013360","journal-title":"Circ Res"},{"issue":"5","key":"3055_CR6","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nm.2354","volume":"17","author":"T Kempf","year":"2011","unstructured":"Kempf T et al (2011) GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 17(5):581\u2013588","journal-title":"Nat Med"},{"issue":"3","key":"3055_CR7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1161\/01.RES.0000202804.84885.d0","volume":"98","author":"J Xu","year":"2006","unstructured":"Xu J et al (2006) GDF15\/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res 98(3):342\u2013350","journal-title":"Circ Res"},{"issue":"1","key":"3055_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1373\/clinchem.2016.255174","volume":"63","author":"KC Wollert","year":"2017","unstructured":"Wollert KC, Kempf T, Wallentin L (2017) Growth differentiation factor 15 as a biomarker in cardiovascular disease. Clin Chem 63(1):140\u2013151","journal-title":"Clin Chem"},{"issue":"1","key":"3055_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12933-020-01092-7","volume":"19","author":"M Li","year":"2020","unstructured":"Li M et al (2020) Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease. Cardiovasc Diabetol 19(1):120","journal-title":"Cardiovasc Diabetol"},{"issue":"5","key":"3055_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/clc.23159","volume":"42","author":"S Xie","year":"2019","unstructured":"Xie S, Lu L, Liu L (2019) Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: a meta-analysis of prospective studies. Clin Cardiol 42(5):513\u2013523","journal-title":"Clin Cardiol"},{"issue":"9249","key":"3055_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0140-6736(00)03567-4","volume":"357","author":"E Wu","year":"2001","unstructured":"Wu E et al (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357(9249):21\u201328","journal-title":"Lancet"},{"issue":"2","key":"3055_CR12","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jacc.2019.05.024","volume":"74","author":"B Ibanez","year":"2019","unstructured":"Ibanez B et al (2019) Cardiac MRI endpoints in myocardial infarction experimental and clinical trials: JACC scientific expert panel. J Am Coll Cardiol 74(2):238\u2013256","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"3055_CR13","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.jcmg.2017.05.023","volume":"11","author":"R Symons","year":"2018","unstructured":"Symons R et al (2018) Long-term incremental prognostic value of cardiovascular magnetic resonance after ST-segment elevation myocardial infarction: a study of the collaborative registry on CMR in STEMI. JACC Cardiovasc Imaging 11(6):813\u2013825","journal-title":"JACC Cardiovasc Imaging"},{"issue":"9","key":"3055_CR14","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1002\/sim.3841","volume":"29","author":"L Desquilbet","year":"2010","unstructured":"Desquilbet L, Mariotti F (2010) Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 29(9):1037\u20131057","journal-title":"Stat Med"},{"issue":"8758","key":"3055_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0140-6736(91)90011-D","volume":"338","author":"No author","year":"1991","unstructured":"No author (1991) Troponin T and myocardial damage. Lancet 338(8758):23\u201324","journal-title":"Lancet"},{"key":"3055_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ijcard.2019.02.067","volume":"291","author":"R Garcia","year":"2019","unstructured":"Garcia R et al (2019) VEGF-A plasma levels are associated with microvascular obstruction in patients with ST-segment elevation myocardial infarction. Int J Cardiol 291:19\u201324","journal-title":"Int J Cardiol"},{"issue":"12","key":"3055_CR17","doi-asserted-by":"publisher","first-page":"e0145495","DOI":"10.1371\/journal.pone.0145495","volume":"10","author":"L Arcari","year":"2015","unstructured":"Arcari L et al (2015) Impact of heart rate on myocardial salvage in timely reperfused patients with ST-segment elevation myocardial infarction: new insights from cardiovascular magnetic resonance. PLoS ONE 10(12):e0145495","journal-title":"PLoS ONE"},{"issue":"8","key":"3055_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1136\/hrt.2010.219543","volume":"97","author":"I Eitel","year":"2011","unstructured":"Eitel I et al (2011) Growth-differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance. Heart 97(8):632\u2013640","journal-title":"Heart"},{"issue":"1","key":"3055_CR19","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3892\/mmr.2015.4573","volume":"13","author":"M Zhang","year":"2016","unstructured":"Zhang M et al (2016) Growth differentiation factor 15 may protect the myocardium from no-reflow by inhibiting the inflammatory-like response that predominantly involves neutrophil infiltration. Mol Med Rep 13(1):623\u2013632","journal-title":"Mol Med Rep"},{"issue":"10","key":"3055_CR20","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/eurheartj\/ehq077","volume":"31","author":"S Taddei","year":"2010","unstructured":"Taddei S, Virdis A (2010) Growth differentiation factor-15 and cardiovascular dysfunction and disease: malefactor or innocent bystander? Eur Heart J 31(10):1168\u20131171","journal-title":"Eur Heart J"},{"key":"3055_CR21","doi-asserted-by":"crossref","unstructured":"Thiele, H. et al. (2010) Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the LIPSIA-N-ACC (Prospective, single-blind, placebo-controlled, randomized Leipzig Immediate PercutaneouS coronary intervention acute myocardial infarction N-ACC) trial. J Am Coll Cardiol 55(20): 2201\u20132209","DOI":"10.1016\/j.jacc.2009.08.091"},{"key":"3055_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005522","author":"SL McLeod","year":"2017","unstructured":"McLeod SL, Iansavichene A, Cheskes S (2017) Remote ischemic Perconditioning to reduce reperfusion injury during acute ST-segment-elevation myocardial infarction: a systematic review and meta-analysis. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.117.005522","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"3055_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","volume":"73","author":"SM Davidson","year":"2019","unstructured":"Davidson SM et al (2019) Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week. J Am Coll Cardiol 73(1):89\u201399","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"3055_CR24","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","volume":"61","author":"DJ Hausenloy","year":"2004","unstructured":"Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 61(3):448\u2013460","journal-title":"Cardiovasc Res"},{"issue":"4","key":"3055_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s00395-020-0800-8","volume":"115","author":"J Wang","year":"2020","unstructured":"Wang J et al (2020) Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia\/reperfusion injury. Basic Res Cardiol 115(4):40","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"3055_CR26","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1182\/blood-2016-01-696617","volume":"128","author":"A Artz","year":"2016","unstructured":"Artz A, Butz S, Vestweber D (2016) GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5\/TGF-betaRII heterodimer. Blood 128(4):529\u2013541","journal-title":"Blood"},{"issue":"2","key":"3055_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.hlc.2017.10.023","volume":"28","author":"MI Hayiroglu","year":"2019","unstructured":"Hayiroglu MI et al (2019) Predictors of in-hospital mortality in patients with ST-segment elevation myocardial infarction complicated with cardiogenic shock. Heart Lung Circ 28(2):237\u2013244","journal-title":"Heart Lung Circ"},{"issue":"8","key":"3055_CR28","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/MCA.0000000000000776","volume":"30","author":"T Cinar","year":"2019","unstructured":"Cinar T et al (2019) The predictive value of age, creatinine, ejection fraction score for in-hospital mortality in patients with cardiogenic shock. Coron Artery Dis 30(8):569\u2013574","journal-title":"Coron Artery Dis"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-024-03055-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-024-03055-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-024-03055-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T06:58:04Z","timestamp":1714114684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-024-03055-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["3055"],"URL":"https:\/\/doi.org\/10.1007\/s10554-024-03055-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3475677\/v1","asserted-by":"object"}]},"ISSN":["1875-8312"],"issn-type":[{"value":"1875-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,2]]},"assertion":[{"value":"22 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}