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We hypothesized that normalizing regurgitant volume with left ventricular end-diastolic volume or allometric scaling would eliminate the difference in regurgitant volume between women and men. The study cohort consisted of 101 patients with mitral valve prolapse undergoing cardiac MRI. Descriptive statistics and linear regression were performed to assess differences between sexes. Of the 101 patients, 46 (46%) were women. Women had a significantly smaller left and right ventricular end-diastolic volume, end-systolic volume, and stroke volume. While there was no difference in regurgitant fraction between women and men (34\u2009\u00b1\u200913% vs. 35\u2009\u00b1\u200914%; <jats:italic>p<\/jats:italic>\u2009=\u20090.71), women had a significantly smaller regurgitant volume (36\u2009\u00b1\u200918\u00a0ml vs. 49\u2009\u00b1\u200926\u00a0ml; <jats:italic>p<\/jats:italic>\u2009=\u20090.005). The slope-intercept relationship between regurgitant fraction and regurgitant volume revealed unique slopes and y-intercept values for men and women (<jats:italic>p<\/jats:italic>-value\u2009&lt;\u20090.0001). Normalizing regurgitant volume to left ventricular end-diastolic volume (RVol\/LVEDV), body surface area<jats:sup>1.5<\/jats:sup> (RVol\/BSA<jats:sup>1.5<\/jats:sup>) and height<jats:sup>2.7<\/jats:sup> (RVol\/height<jats:sup>2.7<\/jats:sup>) all had essentially identical slope-intercept relationships with regurgitant fraction for men and women, but RVol\/LVEDV had the smallest effect size. In mitral insufficiency secondary to mitral valve prolapse women have a significantly smaller regurgitant volume than men despite no difference in regurgitant fraction. The significant difference in regurgitant volume between women and men is secondary to women having a smaller left ventricular end-diastolic volume.<\/jats:p>","DOI":"10.1007\/s10554-024-03197-6","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:14:30Z","timestamp":1722932070000},"page":"2047-2055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex difference in mitral valve prolapse regurgitant volume is resolved by normalization of regurgitant volume to left ventricular end-diastolic volume"],"prefix":"10.1007","volume":"40","author":[{"given":"Chad M.","family":"House","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"3197_CR1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10554-021-02449-z","volume":"38","author":"CM House","year":"2022","unstructured":"House CM, Xi M, Moriarty KA, Nelson WB (2022) Gender differences in primary mitral regurgitant volumes at specific regurgitant fractions as assessed by magnetic resonance imaging. 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