{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:24:47Z","timestamp":1792193087712,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We assessed the diagnostic performance of both ultra-high-resolution (UHR) and high-resolution (HR) modes of photon-counting detector (PCD)-CT within the confines of standard pre-TAVI CT scans, as well as the performance of UHR mode adjusted specifically for coronary imaging, using quantitative coronary angiography (QCA) as the reference. We included 60 patients undergoing pre-TAVI planning CT scans. Patients were divided into 3 groups: 20 scanned in HR mode, 20 in UHR mode, and 20 in adjusted UHR mode, on a dual-source PCD-CT. The adjusted UHR mode employed a lower tube voltage (90\u00a0kV vs. 120\u00a0kV) and a higher image quality level (65 vs. 34) to enhance coronary artery visualization. Patients underwent invasive coronary angiography as part of clinical routine. CCTA and QCA were reviewed to assess CAD presence defined as stenosis\u2009\u2265\u200950% in proximal and middle coronary segments. We included 60 patients (mean age 79\u2009\u00b1\u20097 years; 39(65%) men). Mean heart rate during scanning was 72\u2009\u00b1\u200913\u00a0bpm. Median coronary calcium score was 973\u00a0[379\u20132007]. QCA identified significant CAD in 24 patients (40%): 9 patients scanned with HR mode, 10 patients with the UHR mode, and 5 patients with the UHR adjusted mode. Per-patient area under the curves were 0.57 for HR, 0.80 for UHR, and 0.80 for adjusted UHR, with no significant differences between the scan modes, and per-vessel the area under the curves were 0.73 for HR, 0.69 for UHR, and 0.87 for adjusted UHR, with significant differences between UHR and adjusted UHR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). UHR and adjusted UHR modes of dual source PCD-CT show potential for improved sensitivity and negative predictive value for detecting CAD in patients undergoing pre-TAVI scans, however, no statistically significant difference from HR mode was observed.\n                  <\/jats:p>","DOI":"10.1007\/s10554-024-03273-x","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T02:08:40Z","timestamp":1730686120000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnostic performance of high and ultra-high-resolution photon counting CT for detection of coronary artery disease in patients evaluated for transcatheter aortic valve implantation"],"prefix":"10.1007","volume":"42","author":[{"given":"Simran P.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Verhemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"van der Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel L.","family":"Dijkshoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"van Mieghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P. 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The ethics committee waived full review and approval because of the observational, retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"S. Sharma received institutional support to Erasmus MC from Siemens Healthineers. S. Verhemel has no relevant financial or non-financial interest to discose. A. Hirsch received a research grant from GE Healthcare and consultancy\/speaker fees from GE Healthcare, Bayer, and Bristol Myers Squibb. He is advisory board member of Medis Medical Imaging Systems and was MRI corelab supervisor of Cardialysis BV until 2022. J. van der Bie received institutional support to Erasmus MC from Siemens Healthineers. M. Dijkshoorn received consulting fees from Siemens Healthineers. J. Daemen has received institutional grant\/research support from Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Microport, Pie Medical, and ReCor Medical; receives consultancy and speaker fees from Abbott Vascular, Abiomed, Acist Medical, Boston Scientific, Cardialysis BV, CardiacBooster, Kaminari Medical, ReCor Medical, PulseCath, Pie Medical, Sanofi, Siemens Health Care, and Medtronic. N. van Mieghem has received grant support\/research contracts from Abbott Vascular, Boston Scientific, Medtronic, Edwards Lifesciences, Daiichy Sankyo, AstraZeneca, and PulseCath BV; and has received consulting\/speaker fees from Abbot Vascular, Boston Scientific Corporation, Medtronic, Daiichy Sankyo, PulseCath BV, JenaValve, and Amgen. R. Budde received institutional support to Erasmus MC from Siemens Healthineers; lecture fee and travel reimbursement from Siemens Healthineers paid directly to Erasmus MC; lecture fee from Bayer; board member of the European Society of Cardiovascular Radiology and the Cardiovascular section of the Dutch Society of Radiology; editorial board member of Radiology: Cardiothoracic Imaging, European Heart Journal \u2013 Digital Health, and the European Journal of Hybrid Imaging; grant from HeartFlow to Erasmus MC. The Erasmus MC received institutional support by Siemens Healthineers and HeartFlow.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}