{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:07:23Z","timestamp":1785899243989,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"name":"Swedish Research Council for \u201cKnowledge gaps in clinical medicine\u201d","award":["521-2011-404"],"award-info":[{"award-number":["521-2011-404"]}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["10857"],"award-info":[{"award-number":["10857"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Cardiovasc Imaging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To study the relationship between myocardial infarction size (IS), myocardial edema, and diastolic dysfunction after acute myocardial infarction (MI) both in the acute phase, and in the development of diastolic dysfunction in the follow-up setting. A further purpose is to study diastolic function using a mechanistic model as well as conventional parameters. Patients underwent cardiovascular magnetic resonance (CMR) imaging and echocardiography including mechanistic analysis using the parameterized diastolic filling method within 4\u20137\u00a0days (acute) and 6\u00a0months after a first acute anterior MI (n\u2009=\u200974). Linear regression modeling of echocardiographic diastolic parameters using CMR IS with and without inclusion of the myocardium at risk (MAR) and model comparisons with likelihood ratio tests were performed. Diastolic parameters at 6\u00a0months follow-up were modelled using final IS. For most parameters there was no association with acute IS, except for deceleration time (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.24, p\u2009&lt;\u20090.001), left atrial volume index (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.13, p\u2009=\u20090.01) and the mechanistic stiffness parameter (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.21, p\u2009&lt;\u20090.001). Adding MAR improved only the e\u2032 model (adjusted R\n                    <jats:sup>2<\/jats:sup>\n                    increase: 0.08, p\u2009=\u20090.02). At 6\u00a0months follow-up, final IS was only associated with viscoelastic energy loss (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.22, p\u2009=\u20090.001). In acute MI, both IS and MAR are related to diastolic function but only to a limited extent. At 6\u00a0months after infarction, increasing IS is related to less viscoelastic energy loss, albeit also to a limited extent. The relationship between IS and diastolic dysfunction seems to be mediated by mechanisms beyond simply the spatial extent of ischemia or infarction.\n                  <\/jats:p>","DOI":"10.1007\/s10554-024-03294-6","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:03:01Z","timestamp":1733392981000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The size of myocardial infarction and peri-infarction edema are not major determinants of diastolic impairment after acute myocardial infarction"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-761X","authenticated-orcid":false,"given":"Martin G.","family":"Sundqvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinos","family":"Verouhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder","family":"S\u00f6rensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loghman","family":"Henareh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawzad","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Settergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pernow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Tornvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ugander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"3294_CR1","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1136\/hrt.2005.083055","volume":"92","author":"GA Whalley","year":"2006","unstructured":"Whalley GA, Gamble GD, Doughty RN (2006) Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies. Heart Br Card Soc 92:1588\u20131594. https:\/\/doi.org\/10.1136\/hrt.2005.083055","journal-title":"Heart Br Card Soc"},{"key":"3294_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0735-1097(19)30673-4","volume":"73","author":"K Yajima","year":"2019","unstructured":"Yajima K, Ikehara N, Yamase Y et al (2019) Left ventricular diastolic dysfunction in patients with ST-elevation myocardial infarction: 10 years follow-up. J Am Coll Cardiol 73:64. https:\/\/doi.org\/10.1016\/S0735-1097(19)30673-4","journal-title":"J Am Coll Cardiol"},{"key":"3294_CR3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1161\/01.CIR.92.3.334","volume":"92","author":"TD Miller","year":"1995","unstructured":"Miller TD, Christian TF, Hopfenspirger MR et al (1995) Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. Circulation 92:334\u2013341. https:\/\/doi.org\/10.1161\/01.CIR.92.3.334","journal-title":"Circulation"},{"key":"3294_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0735-1097(01)01711-9","volume":"39","author":"RJ Burns","year":"2002","unstructured":"Burns RJ, Gibbons RJ, Yi Q et al (2002) The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol 39:30\u201336. https:\/\/doi.org\/10.1016\/S0735-1097(01)01711-9","journal-title":"J Am Coll Cardiol"},{"key":"3294_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/ehjci\/jes271","volume":"14","author":"J L\u00f8nborg","year":"2013","unstructured":"L\u00f8nborg J, Vejlstrup N, Kelb\u00e6k H et al (2013) Final infarct size measured by cardiovascular magnetic resonance in patients with ST elevation myocardial infarction predicts long-term clinical outcome: an observational study. Eur Heart J Cardiovasc Imaging 14:387\u2013395. https:\/\/doi.org\/10.1093\/ehjci\/jes271","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"3294_CR6","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","volume":"43","author":"S Frantz","year":"2022","unstructured":"Frantz S, Hundertmark MJ, Schulz-Menger J et al (2022) Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J 43:2549\u20132561. https:\/\/doi.org\/10.1093\/eurheartj\/ehac223","journal-title":"Eur Heart J"},{"key":"3294_CR7","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/0002-9149(90)90242-S","volume":"65","author":"KA Johannessen","year":"1990","unstructured":"Johannessen KA, Cerqueira MD, Stratton JR (1990) Influence of myocardial infarction size on radionuclide and doppler echocardiographic measurements of diastolic function. Am J Cardiol 65:692\u2013697","journal-title":"Am J Cardiol"},{"key":"3294_CR8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1540-8175.2008.00679.x","volume":"25","author":"A Barbieri","year":"2008","unstructured":"Barbieri A, Bursi F, Politi L et al (2008) Echocardiographic diastolic dysfunction and magnetic resonance infarct size in healed myocardial infarction treated with primary angioplasty. Echocardiography 25:575\u2013583. https:\/\/doi.org\/10.1111\/j.1540-8175.2008.00679.x","journal-title":"Echocardiography"},{"key":"3294_CR9","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1161\/01.RES.68.6.1713","volume":"68","author":"GA Laine","year":"1991","unstructured":"Laine GA, Allen SJ (1991) Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res 68:1713\u20131721","journal-title":"Circ Res"},{"key":"3294_CR10","doi-asserted-by":"publisher","first-page":"H2428","DOI":"10.1152\/ajpheart.00860.2007","volume":"294","author":"KV Desai","year":"2008","unstructured":"Desai KV, Laine GA, Stewart RH et al (2008) Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol 294:H2428-2434. https:\/\/doi.org\/10.1152\/ajpheart.00860.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3294_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-7120-12-6","volume":"12","author":"H Chung","year":"2014","unstructured":"Chung H, Yoon J-H, Yoon YW et al (2014) Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction. Cardiovasc Ultrasound 12:6. https:\/\/doi.org\/10.1186\/1476-7120-12-6","journal-title":"Cardiovasc Ultrasound"},{"key":"3294_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3109\/14017431.2016.1163416","volume":"50","author":"H S\u00f8holm","year":"2016","unstructured":"S\u00f8holm H, L\u00f8nborg J, Andersen MJ et al (2016) Association diastolic function by echo and infarct size by magnetic resonance imaging after STEMI. Scand Cardiovasc J SCJ 50:172\u2013179. https:\/\/doi.org\/10.3109\/14017431.2016.1163416","journal-title":"Scand Cardiovasc J SCJ"},{"key":"3294_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1161\/01.CIR.45.1.11","volume":"45","author":"G Diamond","year":"1972","unstructured":"Diamond G, Forrester JS (1972) Effect of coronary artery disease and acute myocardial infarction on left ventricular compliance in man. Circulation 45:11\u201319. https:\/\/doi.org\/10.1161\/01.CIR.45.1.11","journal-title":"Circulation"},{"key":"3294_CR14","first-page":"H178","volume":"252","author":"SJ Kov\u00e1cs Jr","year":"1987","unstructured":"Kov\u00e1cs SJ Jr, Barzilai B, P\u00e9rez JE (1987) Evaluation of diastolic function with Doppler echocardiography: the PDF formalism. Am J Physiol 252:H178-187","journal-title":"Am J Physiol"},{"key":"3294_CR15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ahj.2016.08.004","volume":"181","author":"D Verouhis","year":"2016","unstructured":"Verouhis D, S\u00f6rensson P, Gourine A et al (2016) Effect of remote ischemic conditioning on infarct size in patients with anterior ST-elevation myocardial infarction. Am Heart J 181:66\u201373. https:\/\/doi.org\/10.1016\/j.ahj.2016.08.004","journal-title":"Am Heart J"},{"key":"3294_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2342-10-1","volume":"10","author":"E Heiberg","year":"2010","unstructured":"Heiberg E, Sj\u00f6gren J, Ugander M et al (2010) Design and validation of segment\u2013freely available software for cardiovascular image analysis. BMC Med Imaging 10:1. https:\/\/doi.org\/10.1186\/1471-2342-10-1","journal-title":"BMC Med Imaging"},{"key":"3294_CR17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1532-429X-12-25","volume":"12","author":"P S\u00f6rensson","year":"2010","unstructured":"S\u00f6rensson P, Heiberg E, Saleh N et al (2010) Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. J Cardiovasc Magn Reson 12:25. https:\/\/doi.org\/10.1186\/1532-429X-12-25","journal-title":"J Cardiovasc Magn Reson"},{"key":"3294_CR18","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/jmri.23814","volume":"37","author":"E Vermes","year":"2013","unstructured":"Vermes E, Childs H, Carbone I et al (2013) Auto-threshold quantification of late gadolinium enhancement in patients with acute heart disease. J Magn Reson Imaging JMRI 37:382\u2013390. https:\/\/doi.org\/10.1002\/jmri.23814","journal-title":"J Magn Reson Imaging JMRI"},{"key":"3294_CR19","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1148\/radiol.2461062164","volume":"246","author":"E Heiberg","year":"2008","unstructured":"Heiberg E, Ugander M, Engblom H et al (2008) Automated quantification of myocardial infarction from MR images by accounting for partial volume effects: animal, phantom, and human study. Radiology 246:581\u2013588. https:\/\/doi.org\/10.1148\/radiol.2461062164","journal-title":"Radiology"},{"key":"3294_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12880-016-0162-8","volume":"16","author":"MG Sundqvist","year":"2016","unstructured":"Sundqvist MG, Salman K, Tornvall P, Ugander M (2016) Kinematic analysis of diastolic function using the freely available software Echo E-waves - feasibility and reproducibility. BMC Med Imaging 16:60. https:\/\/doi.org\/10.1186\/s12880-016-0162-8","journal-title":"BMC Med Imaging"},{"key":"3294_CR21","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.ultrasmedbio.2006.11.003","volume":"33","author":"W Zhang","year":"2007","unstructured":"Zhang W, Chung CS, Riordan MM et al (2007) The kinematic filling efficiency index of the left ventricle: contrasting normal vs. Diabetic Physiol Ultrasound Med Biol 33:842\u2013850. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2006.11.003","journal-title":"Diabetic Physiol Ultrasound Med Biol"},{"key":"3294_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s13239-014-0176-8","volume":"5","author":"S Mossahebi","year":"2014","unstructured":"Mossahebi S, Kov\u00e1cs SJ (2014) Kinematic modeling based decomposition of transmitral flow (doppler E-wave) deceleration time into stiffness and relaxation components. Cardiovasc Eng Technol 5:25\u201334","journal-title":"Cardiovasc Eng Technol"},{"key":"3294_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis","author":"F Harrell","year":"2015","unstructured":"Harrell F (2015) Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis, 2nd edn. Springer International Publishing, New York","edition":"2"},{"key":"3294_CR24","unstructured":"R Core Team (2019) R: The R Project for Statistical Computing. https:\/\/www.r-project.org\/. Accessed 3 May 2019"},{"key":"3294_CR25","doi-asserted-by":"crossref","unstructured":"Harrell FE (2019) rms: Regression Modeling Strategies","DOI":"10.32614\/CRAN.package.rmsb"},{"key":"3294_CR26","unstructured":"Wickham H, Chang W, Henry L, et al (2019) ggplot2: Create Elegant Data Visualisations Using the Grammar of Graphics"},{"key":"3294_CR27","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.hlc.2020.04.016","volume":"29","author":"SB Prasad","year":"2020","unstructured":"Prasad SB, Lin A, Kwan C et al (2020) Determinants of diastolic dysfunction following myocardial infarction: evidence for causation beyond infarct size. Heart Lung Circ 29:1815\u20131822. https:\/\/doi.org\/10.1016\/j.hlc.2020.04.016","journal-title":"Heart Lung Circ"},{"key":"3294_CR28","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.echo.2019.09.022","volume":"33","author":"L Wang","year":"2020","unstructured":"Wang L, Singh H, Mulyala RR et al (2020) The association between left ventricular diastolic dysfunction and myocardial scar and their collective impact on all-cause mortality. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr 33:161\u2013170. https:\/\/doi.org\/10.1016\/j.echo.2019.09.022","journal-title":"J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr"},{"key":"3294_CR29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1161\/01.cir.91.1.161","volume":"91","author":"CH Conrad","year":"1995","unstructured":"Conrad CH, Brooks WW, Hayes JA et al (1995) Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation 91:161\u2013170. https:\/\/doi.org\/10.1161\/01.cir.91.1.161","journal-title":"Circulation"},{"key":"3294_CR30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027690","volume":"12","author":"D Hong","year":"2023","unstructured":"Hong D, Lee SH, Shin D et al (2023) Prognostic impact of cardiac diastolic function and coronary microvascular function on cardiovascular death. J Am Heart Assoc 12:e027690. https:\/\/doi.org\/10.1161\/JAHA.122.027690","journal-title":"J Am Heart Assoc"}],"container-title":["The International Journal of Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-024-03294-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10554-024-03294-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10554-024-03294-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T23:07:04Z","timestamp":1737068824000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10554-024-03294-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["3294"],"URL":"https:\/\/doi.org\/10.1007\/s10554-024-03294-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.01.22277049","asserted-by":"object"}]},"ISSN":["1875-8312"],"issn-type":[{"value":"1875-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"assertion":[{"value":"23 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki and good clinical practice and was approved by the Stockholm Regional Board of Ethics (2013\/385\u201331\/1). All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}