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Pulmonary regurgitation (PR) is more commonly found following surgery in repaired TOF. We aimed to evaluate the haemodynamic effects of PS and PR on cardiac physiology in a porcine model using cardiac magnetic resonance-based feature tracking (CMR-FT) deformation imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>CMR-FT was performed in 14 pigs before and 10\u201312 weeks after surgery. Surgery included either pulmonary artery banding to simulate PS (<jats:italic>n<\/jats:italic>\u2009=\u20097), or an incision to the pulmonary valve to simulate PR (<jats:italic>n<\/jats:italic>\u2009=\u20097). CMR-FT assessment included left and right ventricular global longitudinal (LV\/RV GLS) and LV circumferential (GCS) strain and strain rates (SR) as well as left and right atrial reservoir\/conduit\/booster pump (LA\/RA Es, Ee, Ea) strain and SR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>RV GLS was significantly reduced following PS compared to PR induction (PS -7.51 vs. PR -23.84, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). RV GLS improved after induction of PR (before \u2212\u200920.50 vs. after \u2212\u200923.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) as opposed to PS (before \u2212\u200911.73 vs. after \u2212\u20097.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.128). Similarly, RA Es (PS 14.22 vs. PR 27.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) and Ee (PS 8.65 vs. PR 20.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) were decreased in PS compared to PR with detrimental impact of PS (Es before 23.20 vs. after 14.22, <jats:italic>p<\/jats:italic>\u2009=\u20090.018, Ee before 15.04 vs. after 8.65, <jats:italic>p<\/jats:italic>\u2009=\u20090.028) but not PR (Es before 31.65 vs. after 27.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.176, Ee before 20.63 vs. after 20.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.499).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In a porcine model of RV pressure vs. volume overload, increased after- but not preload shows detrimental impact on RV and RA physiology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10554-024-03305-6","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T19:52:07Z","timestamp":1737575527000},"page":"257-268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating pulmonary stenosis and regurgitation impact on cardiac strain and strain rate in a porcine model via magnetic resonance feature tracking"],"prefix":"10.1007","volume":"41","author":[{"given":"Simon F.","family":"R\u00f6sel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6ren J.","family":"Backhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes T.","family":"Kowallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritika","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Treiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel T.","family":"Sossalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Hasenfu\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"issue":"21","key":"3305_CR1","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","volume":"58","author":"D van der Linde","year":"2011","unstructured":"van der Linde D, Konings EEM, Slager MA et al (2011) Birth prevalence of congenital heart Disease Worldwide: a systematic review and Meta-analysis. 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